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Monocytes and Macrophages

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Principles of Molecular Rheumatology

Part of the book series: Current Molecular Medicine ((CMM,volume 1))

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Abstract

Rheumatoid arthritis (RA) is a disease characterized by an inflammatory response within the joint resulting in cartilage and bone destruction. Infiltration of mononuclear cells, including monocytes and macrophages, in synovial tissues is characteristic of RA. The role of macrophages is essential in the development of a normal inflammatory immune response and host defense. In addition to their functions against infectious agents and tumor cells, and as antigen-presenting cells, macrophages secrete and respond to multiple cytokines and other mediators that control key events in the initiation, resolution, and repair processes of inflammation and the immune response (Table 1). Although macrophages are essential for these events in innate and adaptive host defense, persistent activation of this population may have negative consequences.

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Authors
  1. James M. K. Chan
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  2. Sharon M. Wahl
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Editors and Affiliations

  1. Walter Reed Army Institute of Research, Silver Spring, MD, USA

    George C. Tsokos MD

  2. Uniformed Services University of the Health Sciences, Bethesda, MD, USA

    George C. Tsokos MD

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Chan, J.M.K., Wahl, S.M. (2000). Monocytes and Macrophages. In: Tsokos, G.C. (eds) Principles of Molecular Rheumatology. Current Molecular Medicine, vol 1. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-018-6_14

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  • DOI: https://doi.org/10.1007/978-1-59259-018-6_14

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-182-0

  • Online ISBN: 978-1-59259-018-6

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