Abstract
Complement activation is part of the normal homeostatic process, removing foreign particles, effete cells, and immune complexes and killing invading microorganisms. However, there are situations in which complement activation may, if uncontrolled, contribute significantly to the pathogenesis of certain disease processes. In the latter case, a means by which control over complement activation could be reestablished would enable the physician to prevent damage to tissues and thereby decrease the morbidity and mortality caused by uncontrolled activation. It is the purpose of this chapter to describe some of the methods by which potential complement inhibitors can be screened and evaluated in vitro.
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Giclas, P.C. (2000). Evaluation of Complement Inhibitors. In: Lambris, J.D., Holers, V.M. (eds) Therapeutic Interventions in the Complement System. Contemporary Immunology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-017-9_9
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DOI: https://doi.org/10.1007/978-1-59259-017-9_9
Publisher Name: Humana Press, Totowa, NJ
Print ISBN: 978-1-4684-9612-3
Online ISBN: 978-1-59259-017-9
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