• Dennis K. Ledford
Part of the Current Clinical Practice book series (CCP)


The nasal airway, which includes the nasal cavity and the nasopharynx, begins at the nasal vestibule and extends through the nasopharynx (Fig. 1). The epithelium is a ciliated, pseudostratified, columnar mucosa except for the squamous epithelium lining the vestibule and anterior third of the nasal airway. The mucosa of the nasal airway is contiguous with that of the paranasal sinuses and eustachian tubes. The blood flow to the nasal mucosa is one of the highest for any tissue of the body, with the flow controlled by a combination of resistance and capicitance vessels. The latter permit pooling of blood in the submucosa, resulting in swelling or congestion. The microcirculation is fenestrated to facilitate the transfer of water from the vascular space to the mucosa. The high blood flow and fenestrated vessels facilitate heating and humidification of the airstream.


Allergic Rhinitis Nasal Mucosa Nasal Polyp Nasal Congestion Seasonal Allergic Rhinitis 
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Suggested Reading

  1. Beckman DB, Grammer LC. Pharmacotherapy to prevent the complications of allergic rhinitis. Allergy Ashtma Proc 1999; 20: 215–223.CrossRefGoogle Scholar
  2. Dykewicz MS, Fineman S, Skoner D, et al. Diagnosis and management of rhinitis: complete guidelines of the joint task force on practice parameters in allergy, asthma and immunology. Ann Allergy Asthma Immunol 1998; 81: 478–518.PubMedCrossRefGoogle Scholar
  3. Howarth P. The cellular basis for allergic rhinitis. Clin Exp Allergy 1995; 50 (Suppl 23): 6–10.Google Scholar
  4. Ledford DK. Efficacy of immunotherapy. In: Bukantz S, Lockey RF, eds. Allergens and allergen immunotherapy, ed. 2nd. New York, Marcel Dekker Inc., 1998, pp. 359–381.Google Scholar
  5. Lee BJ, Naclerio RM, Bochner BS, et al. Nasal challenge with allergen upregulates the local expression of vascular endothelial cell adhesion molecules. J Allergy Clin Immunol 1994; 94: 1006–16.PubMedCrossRefGoogle Scholar
  6. Meltzer EO. The pharmacological basis for the treatment of perennial allergic rhinitis and non-allergic rhinitis with topical corticosteroids. Allergy 1997; 52 (Suppl 36): 33–40.PubMedCrossRefGoogle Scholar
  7. Mygind N, Naclerio RM. Definition, classification, terminology. In: Mygind N, Naclerio RM, Eds. Allergic and non-allergic rhinitis. Copenhagen, Bunksgaard, 1993, pp. 11–14.Google Scholar
  8. Naclerio RM. Pathophysiology of perennial allergic rhinitis. Allergy 1997; 52 (Suppl 36): 7–13.PubMedCrossRefGoogle Scholar
  9. Philip G, Togias AC. Nonallergic rhinitis: pathophysiology and models of study. EurArch Otorhinolaryngol 1995; 1: 27–32.CrossRefGoogle Scholar
  10. Settipane R, Hagy G, Settipane G. Long-term risk factors for developing asthma and allergic rhinitis:a 23-year follow-up study of college students. Allergy Proc 1994; 15: 21–25.PubMedCrossRefGoogle Scholar
  11. Sims TC, Reece LM, Hilsmeier KA. et al. Secretions of chemokines and other cytokines in allergen-induced nasal responses: inhibition by topical steroid treatment. Am J Respir Crit Care Med 1995; 152: 922–933.Google Scholar

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© Springer Science+Business Media New York 2000

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  • Dennis K. Ledford

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