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Environmental Allergens

  • Scott H. Sicherer
  • Peyton A. Eggleston
Chapter
  • 106 Downloads
Part of the Current Clinical Practice book series (CCP)

Abstract

Allergens are low-molecular-weight proteins capable of inducing IgE antibody and triggering an allergic response. For those with an atopic predisposition, exposure to these environmental allergens causes not only the immunological sensitization required for the development of atopic disease but also the provocation of acute symptoms and the maintenance of chronic symptoms. Several allergenic proteins usually are derived from any specific allergenic source (e.g., several proteins derived from grass pollen are allergenic). When a particular protein is recognized by IgE antibody from more than half of individuals allergic to the source, it is termed a major allergen. The major allergens are named with the first three letters of the genus and then the first letter of the species name followed by a group designation. Examples include Amb a 1 (Ambrosia artemisiifolia—ragweed), Lol p 1 (Lolium perenne—ryegrass); and Fel d 1 (Fells domesticus—domestic cat). For many allergenic proteins, DNA sequences are known and allergenic epitopes—sites on the protein binding IgE antibody and/or T cell receptors—have been delineated. It has become evident that allergic sensitization to particular proteins is not only related to environmental exposure but also, in part, dependent upon individual human leukocyte antigen (HLA) molecules that play a role in processing these allergens and presenting them to the immune system.

Keywords

Pollen Season Grass Pollen House Dust Mite Major Allergen Allergenic Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Suggested Reading

  1. Bollinger ME, Eggleston PA, Flanagan E, Wood RA. Cat antigen in homes with and without cats may induce allergic symptoms. JAllergy Clin Immunol 1996; 97: 907–914.CrossRefGoogle Scholar
  2. Burge HA. Fungus allergens. Clin Rev Allergy 1985; 3: 319–329.PubMedCrossRefGoogle Scholar
  3. Custovic A, Green R, Fletcher A, Smith A, Pickering CA, Chapman MD, et al. Aerodynamic properties of the major dog allergen Can f 1: Distribution in homes, concentration, and particle size of allergen in the air. Am J Respir Crit Care Med 1997; 155: 94–98.PubMedCrossRefGoogle Scholar
  4. Einarsson R, Aukrust, L. Allergens of the Fungi Imperfecti. Clin Rev Allergy 1992; 10: 165–190.PubMedGoogle Scholar
  5. Hamilton RG, Eggleston P. Environmental allergen analyses. Methods 1997; 13: 53–60.PubMedCrossRefGoogle Scholar
  6. Knox RB. Grass pollen, thunderstorms and asthma Clin Exp Allergy 1993; 23: 354–359.PubMedCrossRefGoogle Scholar
  7. Ledford D. Indoor allergens. J Allergy Clin Immunol 1994; 94: 327–334.PubMedCrossRefGoogle Scholar
  8. Lewis WH, Vinay P, Zenger VE. Airborne and Allergenic Pollen of North America. Baltimore, Johns Hopkins University Press, 1983.Google Scholar
  9. Mathews KP. Inhalant insect-derived allergens. Immunol Allergy Clin North Am 1989; 9: 321–338.Google Scholar
  10. Platts-Mills TAE, Ward GW, Sporik R, Gelber LE, Chapman MD, Heymann PW. Epidemiology of the relationship between exposure to indoor allergens and asthma. Int Arch Allergy Appl Immunol 1991; 94: 339–345.PubMedCrossRefGoogle Scholar
  11. Pope AM, Patterson R, Burge H, eds. Indoor allergens: Assessing and controlling adverse health effects. Google Scholar
  12. Report of the Committee on the Health Effects of Indoor Allergens, Division of Health Promotion andGoogle Scholar
  13. Disease Prevention, Institute of Medicine. Washington, DC, National Academy Press, 1993.Google Scholar
  14. Smith EG. Sampling and Identifying Allergenic Pollens and Molds. San Antonio, Bluestone Press, 1990. Stewart GA, Thompson PJ. The biochemistry of common aeroallergens. Clin Exp Allergy 1996;Google Scholar
  15. 26:.
  16. Weber R, Nelson H. Pollen allergens and their interrelationships. Clin Rev Allergy 1985; 3: 291–318.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2000

Authors and Affiliations

  • Scott H. Sicherer
  • Peyton A. Eggleston

There are no affiliations available

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