Glucocorticoid Therapy in Asthma
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Glucocorticoid (GC) therapy remains one of the most valuable treatment methods in the management of both the acute and chronic manifestations of asthma. GCs have been used in the treatment of asthma for the past 50 yr. Initial studies evaluating the effect of cortisone on asthma revealed significant improvements in asthma symptoms and pulmonary function. Unfortunately, much of the early enthusiasm for oral GC use was dampened with the realization that long-term use of this medication resulted in multiple adverse effects. The subsequent development of highly effective inhaled GC preparations has revolutionized asthma care. By virtue of high topical to systemic potency, inhaled GC therapy has proven to be safe and effective in the treatment of asthma. This chapter will provide a broad overview of the structure, mechanisms of action, pharmacokinetics, efficacy, adverse effects and current issues associated with GC therapy in asthma.
KeywordsFluticasone Propionate Acute Asthma Triamcinolone Acetonide Peak Expiratory Flow Rate Beclomethasone Dipropionate
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