Advertisement

Antihistamines

  • Phil Lieberman
Chapter
  • 113 Downloads
Part of the Current Clinical Practice book series (CCP)

Abstract

To prescribe antihistamines rationally it is important to be familiar with the role of histamine in the production of allergic disease. Histamine is widely distributed through the body with the highest concentrations in the lung, skin and gastrointestinal tract. Mast cells and basophils contain the majority of histamine, but it is also found in gastric mucosa, epidermal cells, rapidly growing tissue, enterochromaffin cells and the central nervous system.

Keywords

Atopic Dermatitis Allergic Rhinitis Peak Serum Concentration Federal Aviation Administration Generation Antihistamine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Suggested Reading

  1. Casale TB, et al. Safety and efficacy of once daily fexofenadine, HCL hydrochloride ACL, in the treatment of autumn seasonal allergic rhinitis. Allergy Asthma Proc 1999; 20: 193–198.PubMedCrossRefGoogle Scholar
  2. D’Agostino RB, et al. The effectiveness of antihistamines in reducing the severity of runny nose and sneezing: A meta-analysis. Clin Pharmacol Ther 1998; 64: 579–596.PubMedCrossRefGoogle Scholar
  3. Dykewicz MS, Fineman S. Diagnosis and management of rhinitis: Parameter documents of the joint task force on practice parameters in allergy, asthma, and immunology. Ann Allergy, Asthma Immunol 1998; 81: 501–505.Google Scholar
  4. Horak F, Stubner UP. Comparative tolerability of second generation antihistamines. Drug Saf 1999; 20: 365–401.CrossRefGoogle Scholar
  5. Lieberman P. Antihistamines. In: Rich RR, Mosby, eds. Clinical Immunology Principles and Practice, vol. 2. St. Louis, Mosby, 1996, pp 1968–1979.Google Scholar
  6. Nathan RA. The new antihistamines In Kaliner, M, ed. Allergic Diseases Philadelphia, Current Medicine, 1999, pp 87–100.Google Scholar
  7. Simons FER. Antihistamines. In: Middleton E, et al, eds. Allergy Principles and Practice, vol. 2. 1998; pp 612–637.Google Scholar
  8. Slater JW, Zechnich AD, Haxby DG. Second generation antihistamines, a comparative review. Drugs 1999; 57: 31–47.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2000

Authors and Affiliations

  • Phil Lieberman

There are no affiliations available

Personalised recommendations