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To prescribe antihistamines rationally it is important to be familiar with the role of histamine in the production of allergic disease. Histamine is widely distributed through the body with the highest concentrations in the lung, skin and gastrointestinal tract. Mast cells and basophils contain the majority of histamine, but it is also found in gastric mucosa, epidermal cells, rapidly growing tissue, enterochromaffin cells and the central nervous system.
KeywordsAtopic Dermatitis Allergic Rhinitis Peak Serum Concentration Federal Aviation Administration Generation Antihistamine
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