Allergic Disease

Pathophysiology and Immunopathology
  • Mark H. Moss
  • Randy J. Horwitz
  • Robert F. LemanskeJr.
Part of the Current Clinical Practice book series (CCP)


Primary care physicians deal with allergic conditions far more often than they may suspect. Asthma, allergic rhinitis, and atopic dermatitis are some of the most common examples of these immunological diseases. On a daily basis, physicians obtain an allergy history before prescribing any antibiotic because of the high incidence of drug reactions in the population, illustrating one example of the importance of these disorders in clinical medicine.


Mast Cell Atopic Dermatitis Allergic Rhinitis Allergic Disease Platelet Activate Factor 
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Suggested Reading

  1. Charlesworth EN. The skin as a model to study the pathogenesis of IgE-mediated acute and late phase responses. J Allergy Clin Immunol 1994; 94: 1240–1250.PubMedCrossRefGoogle Scholar
  2. Costa J, et al. The cells of the allergic response: Mast cells, basophile, and eosinophils. JAMA 1997; 278: 1815–1822.PubMedCrossRefGoogle Scholar
  3. De Vries J. The role of IL-13 and its receptor in allergy and inflammatory responses. JAllergy Clin Immunol 1998; 102: 165–169.CrossRefGoogle Scholar
  4. Galli SJ. New concepts about the mast cell. N Engl J Med 1993; 328: 257–265.PubMedCrossRefGoogle Scholar
  5. Kaliner MA, Lemanske R. Rhinitis and asthma. JAMA 1992; 268: 2807–2829.PubMedCrossRefGoogle Scholar
  6. Marshall JS, Bienenstock J. The role of mast cells in inflammatory reactions of the airways, skin and intestine. Curr Opin Immunol 1994; 6: 853–859.PubMedCrossRefGoogle Scholar
  7. Mosmann T, Sad S. The expanding universe of T-cell subsets: Thl, Th2, and more. Immunol Today 1996; 17: 138–146.PubMedCrossRefGoogle Scholar
  8. Peters SP, Zangrilli JG, Fish JE. In: Middleton E, Reed CE, et al., eds. Late Phase Allergic Reactions in Allergy: Principles and Practice. St. Louis; Mosby, 1998, pp. 342–365.Google Scholar
  9. Wasserman S. Mast cells and airway inflammation in asthma. Am J Respir Crit Care Med 1994; 150: S39 - S41.PubMedCrossRefGoogle Scholar
  10. White M. Mediators of inflammation and the inflammatory process. J Allergy Clin Immunol 1999; 103: 5378 - S381.Google Scholar

Copyright information

© Springer Science+Business Media New York 2000

Authors and Affiliations

  • Mark H. Moss
  • Randy J. Horwitz
  • Robert F. LemanskeJr.

There are no affiliations available

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