Skip to main content
SpringerLink
Log in

The Porcine Model of Coronary Restenosis

  • Chapter
Vascular Disease and Injury

Part of the book series: Contemporary Cardiology ((CONCARD))

  • 160 Accesses

Abstract

Human coronary restenosis remains an elusive problem, and a major limitation of all percutaneous interventional coronary revascularization procedures, despite intracoronary stenting (1–9). Restenosis has recently gained even greater importance, since trials comparing PTCA with coronary bypass surgery (BARI, EAST, CABRI) suggest that angioplasty is comparable therapy for cardiac events and symptoms, but the two differ strikingly regarding the need for repeat interventions and cost (10–12). Restenosis lies at the center of these problematic differences.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Holmes D, Fitzgerald P, Goldberg S, LaBlanche J, Lincoff AM, Savage M, et al. The PRESTO (Prevention of restenosis with tranilast and its outcomes) protocol: a double-blind, placebo-controlled trial. Am Heart J 2000; 139: 23–31.

    Article  PubMed  CAS  Google Scholar 

  2. Ruygrok PN, Melkert R, Morel MA, Ormiston JA, Bar FW, Fernandez-Aviles F, et al. Does angiography six months after coronary intervention influence management and outcome? Benestent II Investigators. J Am Coll Cardiol 1999; 34: 1507–1511.

    Article  PubMed  CAS  Google Scholar 

  3. de Feyter PJ, Kay P, Disco C, Serruys P. Reference chart derived from post-stent-implantation intravascular ultrasound predictors of 6–month expected restenosis on quantitative coronary angiography. Circulation 1999; 100: 1777–1783.

    Article  PubMed  CAS  Google Scholar 

  4. van Domburg RT, Foley DP, de Jaegere PP, de Feyter P, van den Brand M, van der Giessen W, et al. Long term outcome after coronary stent implantation: a 10 year single centre experience of 1000 patients. Heart 1999; (Suppl 2)II82:27–34.

    Google Scholar 

  5. Di Luzio V, De Remigis F, De Curtis G, Paparoni S, Pecce P, Di Emidio L, et al. Coronary restenosis after optimal (stent-like) initial angiographic results obtained by traditional balloon angioplasty. (Review). Giornale Ital Cardiol 1997; 27: 645–653.

    Google Scholar 

  6. Kastrati A, Schuhlen H, Hausleiter J, Walter H, Zitzmann-Roth E, Hadamitzky M, et al. Restenosis after coronary stent placement and randomization to a 4–week combined antiplatelet or anticoagulant therapy: six-month angiographic follow-up of the Intracoronary Stenting and Antithrombotic Regimen (ISAR) Trial (see comments). Circulation 1997; 96: 462–467.

    PubMed  CAS  Google Scholar 

  7. Kastrati A, Schomig A, Elezi S, Schuhlen H, et al. —Predictive factors of restenosis after coronary stent placement J Am Coll Cardiol 1997; 30: 1428–1436.

    Article  CAS  Google Scholar 

  8. Hoffmann R, Mintz G, Dussaillant G, Popma J, Pichard A, Satler L, et al. Patterns and mechanisms of in-stent restenosis. A serial intravascular ultrasound study. Circulation 1996; 94: 1247–1254.

    Article  PubMed  CAS  Google Scholar 

  9. Shiran A, Mintz GS, Waksman R, Mehran R, Abizaid A, Kent KM, et al. Early lumen loss after treatment of in-stent restenosis: an intravascular ultrasound study. Circulation 1998; 98: 200–203.

    Article  PubMed  CAS  Google Scholar 

  10. BARI, CABRI, EAST, GABI, and RITA: coronary angioplasty on trial. Lancet 1990; 335: 1315–1316 (editorial).

    Google Scholar 

  11. Alazraki NP, Krawczynska EG, Kosinski AS, DePuey EG, 3rd, Ziffer JA, Taylor AT, Jr., et al. Prognostic value of thallium-201 single-photon emission computed tomography for patients with multivessel coronary artery disease after revascularization (the Emory Angioplasty versus Surgery Trial [EAST]). Am J Cardiol 1999; 84: 1369–1374.

    Article  PubMed  CAS  Google Scholar 

  12. Dagres N, Erbel R. Comparison between PTCA and bypass operation. Results of large randomized studies. Med Klin 1998; 93: 22–26, 58.

    Google Scholar 

  13. Freed M, Safian RD, O’Neill WW, Safian M, Jones D, Grines CL. Combination of lovastatin, enalapril, and colchicine does not prevent restenosis after percutaneous transluminal coronary angioplasty. Am J Cardiol 1995; 76: 1185–1188.

    Article  PubMed  CAS  Google Scholar 

  14. Schulman SP, Goldschmidt-Clermont PJ, Topol EJ, Califf RM, Navetta FI, Willerson JT, et al. Effects of integrelin, a platelet glycoprotein IIb/IIIa receptor antagonist, in unstable angina. A randomized multicenter trial. Circulation 1996; 94: 2083–2089.

    Article  PubMed  CAS  Google Scholar 

  15. Faxon DP. Effect of high dose angiotensin-converting enzyme inhibition on restenosis: final results of the MARCATOR Study, a multicenter, double-blind, placebo-controlled trial of cilazapril. The Multicenter American Research Trial With Cilazapril After Angioplasty to Prevent Transluminal Coronary Obstruction and Restenosis (MARCATOR) Study Group. J Am Coll Cardiol 1995; 25: 362–369.

    Article  PubMed  CAS  Google Scholar 

  16. Califf RM, Lincoff AM, Tcheng JE, Topol EJ. An overview of the results of the EPIC trial. Eur Heart J 1995; 16: 43–49.

    Article  PubMed  Google Scholar 

  17. Ohman EM, Harrington RA, Lincoff AM, Kitt MM, Kleiman NS, Tcheng JE. Early clinical experience with integrelin, an inhibitor of the platelet glycoprotein IIb/IIIa integrin receptor. Eur Heart J 1995; 16: 50–55.

    Article  PubMed  CAS  Google Scholar 

  18. Schafer AI. Antiplatelet therapy with glycoprotein IIb/IIIa receptor inhibitors and other novel agents. Tex Heart Inst J 1997; 24: 90–96.

    PubMed  CAS  Google Scholar 

  19. Gapinski JP, VanRuiswyk JV, Heudebert GR, Schectman GS. Preventing restenosis with fish oils following coronary angioplasty. A meta-analysis. Arch Intern Med 1993; 153:1595– 1601.

    Google Scholar 

  20. Austin GE. Lipids and vascular restenosis. Circulation 1992; 85: 1613–1615.

    Article  PubMed  CAS  Google Scholar 

  21. Bell L, Madri JA. Original Contributions: effect of Platelet Factors on Migration of Cultured Bovine Aortic Endothelial and Smooth Muscle Cells. Circ Res 1989; 65: 1057–1065.

    Article  PubMed  CAS  Google Scholar 

  22. Bowles MH, Klonis D, Plavac TG, Gonzales B, Francisco DA, Roberts RW, et al. EPA in the prevention of restenosis post PTCA. Angiology 1991; 42: 187–194.

    Article  PubMed  CAS  Google Scholar 

  23. Califf R, Ohmann E, Frid D, Fortin D, Mark D, Hlatky M, et al. Restenosis: the clinical issues. In: Topol E., ed. Textbook of Interventional Cardiology. W.B. Saunders, Philadelphia, 1990, pp. 363–394.

    Google Scholar 

  24. Finci L, Hofling B, Ludwig B, Bulitta M, Steffenino G, Etti H, et al. Sulotroban during and after coronary angioplasty. A double-blind, placebo controlled study. Z Kardiol 1989; 3: 50–54.

    Google Scholar 

  25. Israel DH, Gorlin R. Fish oils in the prevention of atherosclerosis. J Am Coll Cardiol 1992; 19: 174–185.

    Article  PubMed  CAS  Google Scholar 

  26. OKeefe JHJ, McCallister BD, Bateman TM, Kuhnlein DL, Ligon RW, Hartzler GO. Ineffectiveness of colchicine for the prevention of restenosis after coronary angioplasty. J Am Coll Cardiol 1992; 19: 1597–1600.

    Article  Google Scholar 

  27. Taylor R, Gibbons F, Cope G, Cumpston G, Mews G, Luke P. Effects of low dose aspirin on restenosis after coronary angioplasty. Am J Cardiol 1991; 68: 874–878.

    Article  PubMed  CAS  Google Scholar 

  28. Kimura T, Kaburagi S, Tamura T, Yokoi H, Nakagawa Y, Hamasaki N, et al. Remodeling of human coronary arteries undergoing coronary angioplasty or atherectomy. Circulation 1997; 96: 475–483.

    Article  PubMed  CAS  Google Scholar 

  29. Schwartz RS, Murphy JG, Edwards WD, Camrud AR, Vlietstra RE. Restenosis occurs with internal elastic lamina laceration and is proportional to severity of vessel injury in a porcine coronary artery model. [abstract]. Circulation 1990; 82: III–656.

    Article  Google Scholar 

  30. Schwartz RS, Murphy JG, Edwards WD, Camrud AR, Vlietstra RE, Holmes DR. Restenosis after balloon angioplasty: a practical proliferative model in porcine coronary arteries. Circulation 1990; 82: 2190–2200.

    Article  PubMed  CAS  Google Scholar 

  31. Schwartz RS, Murphy JG, Edwards WD, Camrud AR, Garratt KN, Vlietstra RE, et al. Coronary artery restenosis and the “virginal membrane”: smooth muscle cell proliferation and the intact internal elastic lamina. J Inv Card 1991; 3: 3–8.

    Google Scholar 

  32. Bonan R, Paiement P, Scortichini D, Cloutier MJ, Leung TK. Objective Evaluation of a restenosis-injury index in porcine arteries. Proceedings of the Restenosis Summit IV, Cleveland, OH, 1992.

    Google Scholar 

  33. Bonan R, Paiement P, Scortichini D, Cloutier MJ, Leung TK. Coronary restenosis: evaluation of a restenosis injury index in a swine model. Am Heart J 1993; 126: 1334–1340.

    Article  PubMed  CAS  Google Scholar 

  34. Bonan R, Paiement P, Leung TK. Swine model of coronary restenosis: effect of a second injury. Catheterization Cardiovasc Diagn 1996; 38: 44–49.

    Article  CAS  Google Scholar 

  35. Ellis SG, Muller DW. Arterial injury and the enigma of coronary restenosis. J Am Coll Cardiol 1992; 19: 275–277.

    Article  PubMed  CAS  Google Scholar 

  36. Ferns GA, Stewart LAL, Anggard EE. Arterial response to mechanical injury: balloon catheter de-endothelialization. Atherosclerosis 1992; 92: 89–104.

    Article  PubMed  CAS  Google Scholar 

  37. Indolfi C, Esposito G, Di Lorenzo E, Rapacciuolo A, Feliciello A, Porcellini A, et al. Smooth muscle cell proliferation is proportional to the degree of balloon injury in a rat model of angioplasty. Circulation 1995; 92: 1230–1235.

    Article  PubMed  CAS  Google Scholar 

  38. Karas SP, Gravanis MB, Santoian EC, Robinson KA, Anderberg KA, King SB, 3d. Coronary intimal proliferation after balloon injury and stenting in swine: an animal model of restenosis. J Am Coll Cardiol 1992; 20: 467–474.

    Article  PubMed  CAS  Google Scholar 

  39. Back MR, White RA, Kwack EY, Back LH. Hemodynamic consequences of stenosis remodeling during coronary angioplasty. Angiology 1997; 48: 99–109.

    Article  PubMed  CAS  Google Scholar 

  40. Mintz GS, Kent KM, Pichard AD, Satler LF, Popma JJ, Leon MB. Contribution of inadequate arterial remodeling to the development of focal coronary artery stenoses. An intravascular ultrasound study. Circulation 1997; 95: 1791–1798.

    Article  PubMed  CAS  Google Scholar 

  41. Schwartz RS, Topol EJ, Serruys PW, Sangiorgi G, Holmes DR, Jr. Artery size, neointima, and remodeling: time for some standards. J Am Coll Cardiol 1998; 32: 2087–2094.

    Article  PubMed  CAS  Google Scholar 

  42. Sabate M, Serruys PW, van der Giessen WJ, Ligthart JM, Coen VL, Kay IP, et al. Geometric vascular remodeling after balloon angioplasty and beta-radiation therapy: a three-dimensional intravascular ultrasound study. Circulation 1999; 100: 1182–1188.

    Article  PubMed  CAS  Google Scholar 

  43. Strauss BH, Chisholm RJ, Keeley FW, Gotlieb AI, Logan RA, Armstrong PW. Extracellular matrix remodeling after balloon angioplasty injury in a rabbit model of restenosis. Circ Res 1994; 75: 650–658.

    Article  PubMed  CAS  Google Scholar 

  44. Chesebro JH, Badimon L, Fuster V. Importance of antithrombin therapy during coronary angioplasty. J Am Coll Cardiol 1991; (suppl B): 96B–100B.

    Google Scholar 

  45. Clowes A, Reidy M, Clowes M. Kinetics of cellular proliferation after arterial injury: I. Smooth muscle growth in absence of endothelium. Lab Investig 1983; 49: 327–332.

    CAS  Google Scholar 

  46. Foley DP, Hermans WM, Rensing BJ, de Feyter PJ, Serruys PW. Restenosis after percutaneous transluminal coronary angioplasty. Herz 1992; 17: 1–17.

    PubMed  CAS  Google Scholar 

  47. Lam JYT, Chesebro JH, Steele PM, Dewanjee MK, Badimon L, Fuster V. Deep arterial injury during experimental angioplasty: relationship to a positive Indium-111 labeled platelet scintigram, quantitative platelet deposition and mural thrombus. J Am Coll Cardiol 1986; 8: 1380–1386.

    Article  PubMed  CAS  Google Scholar 

  48. Liu MW, Roubin GS, King SB, 3rd. Restenosis after coronary angioplasty. Potential biologic determinants and the role of intimal hyperplasia. Circulation 1989; 79: 1374–1387.

    Article  PubMed  CAS  Google Scholar 

  49. Zijlstra F, den Boer A, Reiber JH, van Es GA, Lubsen J, Serruys PW. Assessment of immediate and long-term functional results of percutaneous transluminal coronary angioplasty. Circulation 1988; 78: 15–24.

    Article  PubMed  CAS  Google Scholar 

  50. Mintz G, Kent K, Pichard A, Popma J, Satler L, Leon M. Intravascular ultrasound insights into mechanisms of stenosis formation. Cardiol Clin 1997; 15: 17–29.

    Article  PubMed  CAS  Google Scholar 

  51. Schwartz R, Holmes DJ. Pigs, Dogs, Baboons, and Man: lessons for Stenting from Animal Studies. J Interven Cardiol 1994; 7: 355–368.

    Article  Google Scholar 

  52. Carter AJ, Laird JR, Farb A, Kufs W, Wortham DC, Virmani R. Morphologic characteristics of lesion formation and time course of smooth muscle cell proliferation in a porcine proliferative restenosis model. J Am Coll Cardiol 1994; 24: 1398–1405.

    Article  PubMed  CAS  Google Scholar 

  53. Schwartz R, Huber K, Murphy J, Edwards W, Camrud A, Vlietstra R, et al. Restenosis and the proportional neointimal response to coronary artery injury: results in a porcine model. J Am Coll Cardiol 1992; 19: 267–274.

    Article  PubMed  CAS  Google Scholar 

  54. Schwartz RS, Murphy JG, Edwards WD, Camrud AR, Vlietstra RE, Holmes DR, Jr. Restenosis and the Proportional Neointimal Response to Coronary Artery Injury: results in a Porcine Model. J Am Coll Cardiol 1991.

    Google Scholar 

  55. Huber KC, Schwartz RS, Edwards WD, Camrud AR, Murphy JG, Jorgenson MA, et al. Restenosis and angiotensin converting enzyme inhibition: effects on neointimal proliferation in a porcine coronary injury model. Circulation 1991; 84: II–298.

    Article  Google Scholar 

  56. Bonan R, Paiement P, Leung TK. Swine model of coronary restenosis: effect of a second injury. Catheterization Cardiovasc Diagn 1996; 38: 44–49.

    Article  CAS  Google Scholar 

  57. Barnathan E, Schwartz J, Taylor L, Laskey W, Kleavland J, Kussmaul W, et al. Aspirin and dipyridamole in the prevention of acute coronary thrombosis complicating coronary angioplasty. Circulation 1987; 76: 125–134.

    Article  PubMed  CAS  Google Scholar 

  58. Grigg LE, Kay TW, Valentine PA, Larkins R, Flower DJ, Manolas EG, et al. Determinants of restenosis and lack of effect of dietary supplementation with eicosapentaenoic acid on the incidence of coronary artery restenosis after angioplasty. J Am Coll Cardiol 1989; 13: 665–672.

    Article  PubMed  CAS  Google Scholar 

  59. Koster JK Jr., Tryka AF, H’Doubler P, Collins JJJ. The effect of low-dose aspirin and dipyridamole upon atherosclerosis in the rabbit. Artery 1981; 9: 405–413.

    PubMed  CAS  Google Scholar 

  60. Riess H, Hofling B, von Arnim T, Hiller E. Thromboxane receptor blockade versus cyclooxygenase inhibition: antiplatelet effects in patients. Thromb Res 1986; 42: 235–245.

    Article  PubMed  CAS  Google Scholar 

  61. Schwartz L, Bourassa MG, Lesperance J, Aldridge HE, Kazim F, Salvatori VA, et al. Aspirin and dipyridamole in the prevention of restenosis after percutaneous transluminal coronary angioplasty. N Engl J Med 1988; 318: 1714–1719.

    Article  PubMed  CAS  Google Scholar 

  62. Thornton MA, Gruentzig AR, Hollman J, King SB, 3rd, Douglas JS, Jr. Coumadin and aspirin in prevention of recurrence after transluminal coronary angioplasty: a randomized study. Circulation 1984; 69: 721–727.

    Article  PubMed  CAS  Google Scholar 

  63. Corcos T, David PR, Bal PG, Renkin J, Dangoisse V, Rapold HG, et al. Failure of diltiazem to prevent restenosis after percutaneous transluminal coronary angioplasty. Am Heart J 1985; 109: 926–931.

    Article  PubMed  CAS  Google Scholar 

  64. O’Keefe JHJ, Giorgi LV, Hartzler GO, Good TH, Ligon RW, Webb DL, et al. Effects of diltiazem on complications and restenosis after coronary angioplasty. Am J Cardiol 1991; 67: 373–6.

    Article  PubMed  Google Scholar 

  65. Anonymous. Does the new angiotensin converting enzyme inhibitor cilazapril prevent restenosis after percutaneous transluminal coronary angioplasty? Results of the MERCATOR study: a multicenter, randomized, double-blind placebo-controlled trial. Circulation 1992; 86: 100–110.

    Article  Google Scholar 

  66. Fingerle J, Johnson R, Clowes AW, Majesky MW, Reidy MA. Role of platelets in smooth muscle cell proliferation and migration after vascular injury in rat carotid artery. Proc Natl Acad Sci USA 1989; 86: 8412–8416.

    Article  PubMed  CAS  Google Scholar 

  67. Hanke H, Strohschneider T, Oberhoff M, Betz E, Karsch K. Time course of smooth muscle cell proliferation in the intima and media of arteries following experimental angioplasty. Circ Res 1990; 67: 651–659.

    Article  PubMed  CAS  Google Scholar 

  68. Hanke H, Haase KK, Hanke S, Oberhoff M, Hassenstein S, Betz E, et al. Morphological changes and smooth muscle cell proliferation after experimental excimer laser treatment. Circulation 1991; 83: 1380–9.

    Article  PubMed  CAS  Google Scholar 

  69. Williams DO. Radiation vascular therapy: a novel approach to preventing restenosis. Am J Cardiol 1998; 81: 18E - 20E.

    Article  PubMed  CAS  Google Scholar 

  70. Kay IP, Sabate M, Van Langenhove G, Costa MA, Wardeh AJ, Gijzel AL, et al. Outcome from balloon induced coronary artery dissection after intracoronary beta radiation. Heart 2000; 83: 332–337.

    Article  PubMed  CAS  Google Scholar 

  71. Meerkin D, Tardif JC, Crocker IR, Arsenault A, Joyal M, Lucier G, et al. Effects of intracoronary beta-radiation therapy after coronary angioplasty: an intravascular ultrasound study. Circulation 1999; 99: 1660–1665.

    Article  PubMed  CAS  Google Scholar 

  72. Teirstein PS. Prevention of vascular restenosis with radiation. Tex Heart Inst J 1998; 25: 30–33.

    PubMed  CAS  Google Scholar 

  73. Schwartz R, Koval T, Edwards W, Camrud A, Bailey K, Browne K, et al. Effect of external beam irradiation on neointimal hyperplasia after experimental coronary artery injury. J Am Coll Card 1992; 19: 1106–1113.

    Article  CAS  Google Scholar 

  74. Preisack MB, Karsch KR. The paradigm of restenosis following percutaneous transluminal coronary angioplasty. Eur Heart J 1993; 14 (1): 187–192.

    PubMed  Google Scholar 

  75. Bauters C, Labalanche J, McFadden E, Hamon M, Bertrand M. Angioscopic thrombus is associated with a high risk of restenosis. Circulation 1995; 92: 1912.

    Google Scholar 

  76. Powell J, Muller R, Baumgartner H. Suppression of the vascular response to injury: the role of angiotensin-converting enzyme inhibitors. J Am Coll Cardiol 1991; 17: 137B - 142B.

    Article  PubMed  CAS  Google Scholar 

  77. Powell J, Clozel J, Muller R, Kuhn H, Hefti F, Hosang M, et al. Inhibitors of angiotensinconverting enzyme prevent myointimal proliferation after vascular injury. Science 1989; 245: 186–188.

    Article  PubMed  CAS  Google Scholar 

  78. Bilazarian S, Currier J, Haudenschild C, Heyman D, Powell J, Ryan T, et al. Angiotensin converting enzyme inhibition reduces restenosis in experimental angioplasty. J Am Coll Cardiol 1991; 17: 268A.

    Google Scholar 

  79. Berk B, Vekshtein V, Gordon H. Angiotensin II-stimulated protein synthesis in cultured vascular smooth muscle cells. Hypertension 1989; 13: 305–314.

    Article  PubMed  CAS  Google Scholar 

  80. Brozovich FV, Morganroth J, Gottlieb NB, Gottlieb RS. Effect of angiotensin converting enzyme inhibition on the incidence of restenosis after percutaneous transluminal coronary angioplasty. Catheterization Cardiovasc Diagn 1991; 23: 263–267.

    Article  CAS  Google Scholar 

  81. Daemen MJ, Lombardi DM, Bosman FT, Schwartz SM. Angiotensin II induces smooth muscle cell proliferation in the normal and injured rat arterial wall. Circ Res 1991; 68: 450–456.

    Article  PubMed  CAS  Google Scholar 

  82. Faxon DP. Angiotensin converting Enzyme Inhibition and restenosis: the final results of the MARCATOR Trial [abstract]. Circulation 1992; 86: I–53.

    Google Scholar 

  83. Bauriedel G, Heimerl J, Beinert T, Welsch U, Hofling B. Colchicine antagonizes the activity of human smooth muscle cells cultivated from arteriosclerotic lesions after atherectomy. Coron Artery Dis 1994; 5: 531–539.

    PubMed  CAS  Google Scholar 

  84. Gradus-Pizlo I, Wilensky RL, March KL, Fineberg N, Michaels M, Sandusky GE, et al. Local delivery of biodegradable microparticles containing colchicine or a colchicine analogue: effects on restenosis and implications for catheter-based drug delivery. J Am Coll Cardiol 1995; 26: 1549–1557.

    Article  PubMed  CAS  Google Scholar 

  85. O’Keefe J, McCallister B, Bateman T, Kuhnlein D, Ligon R, Hartzler G. Colchicine for the prevention of restenosis after coronary angioplasty. J Am Coll Cardiol 1991; 17: 181A.

    Google Scholar 

  86. Grines C, Rizik D, Levine A, Schreiber T, Gangadharan V, Ramos R, et al. Colchicine angioplasty restenosis trial (CART) [abstract]. Circulation 1991; 84: II–365.

    Article  Google Scholar 

  87. Roubin GS, Douglas JS, Jr, King SB, 3rd, Lin SF, Hutchison N, Thomas RG, et al. Influence of balloon size on initial success, acute complications, and restenosis after percutaneous transluminal coronary angioplasty. A prospective randomized study. Circulation 1988; 78: 557–565.

    Article  PubMed  CAS  Google Scholar 

  88. Nichols A, Smith R, Berke A, Shlofmitz R, Powers E. Importance of balloon size on initial success, acute complications, and restenosis after percutaneous transluminal coronary angioplasty. A prospective randomized study. J Am Coll Cardiol 1989; 13: 1094–2000.

    CAS  Google Scholar 

  89. van der Giessen WJ, Hermans WRM, Rensing BJ, Foley DP, Serruys PW. Clinical and angiographic definitions of restenosis: recommendations for clinical trials. In Schwartz RS, ed. Coronary Restenosis. Blackwell Scientific, Boston, 1992, pp 169–191.

    Google Scholar 

  90. Serruys PW, Luijten HE, Beatt KJ, Geuskens R, de Feyter PJ, van den Brand M, et al. Incidence of restenosis after successful coronary angioplasty: a time-related phenomenon. A quantitative angiographic study in 342 consecutive patients at 1, 2, 3, and 4 months. Circulation 1988; 77: 361–371.

    CAS  Google Scholar 

  91. Serruys PW, Juilliere Y, Bertrand ME, Puel J, Rickards AF, Sigwart U. Additional improvement of stenosis geometry in human coronary arteries by stenting after balloon dilatation. Am J Cardiol 1988; 61: 71G - 76G.

    Article  PubMed  CAS  Google Scholar 

  92. Serruys P, Hermans R. The new angiotensin converting enzyme inhibitor cilazapril does not prevent restenosis after coronary angioplasty: the results of the MERCATOR trial [abstract]. J Am Coll Cardiol 1992; 19: 258A.

    Google Scholar 

  93. Strauss BH, Juilliere Y, Rensing BJ, Riber JH, Serruys PW. Edge detection versus densitometry for assessing coronary stenting quantitatively. Am J Cardiol 1991; 67: 484–490.

    Article  PubMed  CAS  Google Scholar 

  94. Gellman J, Ezekowitz MD, Sarembock IJ, Azrin MA, Nochomowitz LE, Lerner E, et al. Effect of lovastatin on intimal hyperplasia after balloon angioplasty: a study in an atherosclerotic hypercholesterolemic rabbit. J Am Coll Cardiol 1991; 17: 251–259.

    Article  PubMed  CAS  Google Scholar 

Additional Reading and Background

  1. Hong MK, Kent KM, Tio FO, Foegh M, Kornowski R, Bramwell O, et al. Single-dose intramuscular administration of sustained-release Angiopeptin reduces neointimal hyperplasia in a porcine coronary in-stent restenosis model. Coron Artery Dis 1997; 8: 101–104.

    Article  PubMed  CAS  Google Scholar 

  2. Howell MH, Adams MM, Wolfe MS, Foegh ML, Ramwell PW. Angiopeptin inhibition of myointimal hyperplasia after balloon angioplasty of large arteries in hypercholesterolaemic rabbits. Clin Sci 1993; 85: 183–188.

    PubMed  CAS  Google Scholar 

  3. Santoian ED, Schneider JE, Gravanis MB, Foegh M, Tarazona N, Cipolla GD, et al. Angiopeptin inhibits intimal hyperplasia after angioplasty in porcine coronary arteries. Circulation 1993; 88: 11–14.

    Article  PubMed  CAS  Google Scholar 

  4. Veinot JP, Edwards WD, Camrud AR, Jorgenson MA, Holmes DR, Jr., Schwartz RS. The effects of lovastatin on neointimal hyperplasia following injury in a porcine coronary artery model. Can J Cardiol 1996; 12: 65–70.

    PubMed  CAS  Google Scholar 

  5. Ragosta M, Barry WL, Gimple LW, Gertz SD, McCoy KW, Stouffer GA, et al. Effect of thrombin inhibition with desulfatohirudin on early kinetics of cellular proliferation after balloon angioplasty in atherosclerotic rabbits. Circulation 1996; 93: 1194–2000.

    Article  PubMed  CAS  Google Scholar 

  6. Meyer BJ, Fernandez-Ortiz A, Mailhac A, Falk E, Badimon L, Michael AD, et al. Local delivery of r-hirudin by a double-balloon perfusion catheter prevents mural thrombosis and minimizes platelet deposition after angioplasty. Circulation 1994; 90: 2474–2480.

    Article  PubMed  CAS  Google Scholar 

  7. Schwartz R, Holder D, Holmes DJ, Veinot J, Camrud A, Jorgenson M, et al. Neointimal thickening after severe coronary artery injury is limited by short term administration of a factor Xa inhibitor: results in a porcine model. Circulation 1996; 83: 1542–1548.

    Article  Google Scholar 

  8. Muller DWM, Topol EJ, Abrams GD, Gallagher KP, Ellis SG. Intramural methotrexate therapy for the prevention of neointimal thickening after balloon angioplasty. J Am Coll Cardiol 1992; 20: 460–462.

    Article  PubMed  CAS  Google Scholar 

  9. Schneider J, Berk B, Santoian E, Gravanis M, Cipolla G, Tarazona N, et al. Oxidative stress is important in restenosis: reduction of neointimal formation by the antioxidant probucol in a swine model of restenosis. Circulation 1992; 86: I–186.

    Google Scholar 

  10. Huber KC, Schwartz RS, Edwards WD, Camrud AR, Bailey KR. Effects of angiotensin converting enzyme inhibition on neointimal hyperplasia in a porcine coronary injury model. Am Heart J 1993; 125: 695–701.

    Article  PubMed  CAS  Google Scholar 

  11. Churchill DA, Siegel CO, Dougherty KG, Raizner AE, Minor ST. Failure of enalapril to reduce coronary restenosis in a swine model [abstract]. Circulation 1991; 84: II–297.

    Google Scholar 

  12. Huckle WR, Drag MD, Acker WR, Powers M, McFall RC, Holder DJ, et al. Effects of subtype-selective and balanced angiotensin II receptor antagonists in a porcine coronary artery model of vascular restenosis. Circulation 1996; 93: 1009–1119.

    Article  PubMed  CAS  Google Scholar 

  13. Waksman R, Robinson KA, Crocker IR, Wang C, Gravanis MB, Cipolla GD, et al. Intracoronary low-dose beta-irradiation inhibits neointima formation after coronary artery balloon injury in the swine restenosis model. Circulation 1995; 92: 3025–3031.

    Article  PubMed  CAS  Google Scholar 

  14. Waksman R, Robinson KA, Crocker IR, Gravanis MB, Palmer SJ, Wang C, et al. Intracoronary radiation before stent implantation inhibits neointima formation in stented porcine coronary arteries. Circulation 1995; 92: 1383–1386.

    Article  PubMed  CAS  Google Scholar 

  15. Waksman R, Robinson KA, Crocker IR, Gravanis MB, Cipolla GD, King SB, 3rd. Endovascular low-dose irradiation inhibits neointima formation after coronary artery balloon injury in swine. A possible role for radiation therapy in restenosis prevention. Circulation 1995; 91: 1533–1539.

    Article  PubMed  CAS  Google Scholar 

  16. Waksman R, Robinson KA, Crocker IR, Wang C, Gravanis MB, Cipolla GD, et al. Intracoronary low-dose beta-irradiation inhibits neointima formation after coronary artery balloon injury in the swine restenosis model. Circulation 1995; 92: 3025–3031.

    Article  PubMed  CAS  Google Scholar 

  17. Waksman R, Robinson KA, Crocker IR, Gravanis MB, Palmer SJ, Wang C, et al. Intracoronary radiation before stent implantation inhibits neointima formation in stented porcine coronary arteries. Circulation 1995; 92: 1383–1386.

    Article  PubMed  CAS  Google Scholar 

  18. Waksman R, Robinson KA, Crocker IR, Gravanis MB, Cipolla GD, King SB, 3rd. Endovascular low-dose irradiation inhibits neointima formation after coronary artery balloon injury in swine. A possible role for radiation therapy in restenosis prevention. Circulation 1995; 91: 1533–9.

    Article  PubMed  CAS  Google Scholar 

  19. Waksman R, Robinson KA, Crocker IR, Wang C, Gravanis MB, Cipolla GD, et al. Intracoronary low-dose beta-irradiation inhibits neointima formation after coronary artery balloon injury in the swine restenosis model. Circulation 1995; 92: 3025–3031.

    Article  PubMed  CAS  Google Scholar 

  20. Waksman R, Kosinski AS, Klein L, Boccuzzi SJ, King SB, 3rd, Ghazzal ZM, et al. Relation of lumen size to restenosis after percutaneous transluminal coronary balloon angioplasty. Lovastatin Restenosis Trial Group. Am J Cardiol 1996; 78: 221–224.

    PubMed  CAS  Google Scholar 

  21. Wilcox JN, Waksman R, King SB, 3rd, Scott NA. The role of the adventitia in the arterial response to angioplasty: the effect of intravascular radiation. Int J Radiat Oncol Biol Phys 1996; 36: 789–796.

    Article  PubMed  CAS  Google Scholar 

  22. Wiedermann JG, Marboe C, Amols H, Schwartz A, Weinberger J. Intracoronary irradiation markedly reduces restenosis after balloon angioplasty in a porcine model. J Am Coll Cardiol 1994; 23: 1491–1498.

    Article  PubMed  CAS  Google Scholar 

  23. Weinberger J, Amols H, Ennis RD, Schwartz A, Wiedermann JG, Marboe C. Intracoronary irradiation: dose response for the prevention of restenosis in swine. Int J Radiat Oncol Biol Phys 1996; 36: 767–775.

    Article  PubMed  CAS  Google Scholar 

  24. Burke SE, Lubbers NL, Gagne GD, Wessale JL, Dayton BD, Wegner CD, et al. Selective antagonism of the ET(A) receptor reduces neointimal hyperplasia after balloon-induced vascular injury in pigs. J Cardiovasc Pharmacol 1997; 30: 33–41.

    Article  PubMed  CAS  Google Scholar 

  25. Robinson KA, Chronos NA, Schieffer E, Palmer SJ, Cipolla GD, Milner PG, et al. Endoluminal local delivery of PCNA/cdc2 antisense oligonucleotides by porous balloon catheter does not affect neointima formation or vessel size in the pig coronary artery model of postangioplasty restenosis. Catheterization Cardiovasc Diagn 1997; 41: 348–353.

    Article  CAS  Google Scholar 

  26. Nunes GL, Sgoutas DS, Redden RA, Sigman SR, Gravanis MB, King SB 3rd, et al. Combination of vitamins C and E alters the response to coronary balloon injury in the pig. Arterioscler Thromb Vasc Biol 1995; 15: 156–165.

    Article  CAS  Google Scholar 

Download references

Authors
  1. Robert S. Schwartz MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Birgit Kantor MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. David R. Holmes Jr. MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Cardiovascular Division, Brigham and Women’s Hospital, Boston, MA, USA

    Daniel I. Simon MD  & Campbell Rogers MD,FACC  & 

Rights and permissions

Reprints and permissions

Copyright information

© 2001 Springer Science+Business Media New York

About this chapter

Cite this chapter

Schwartz, R.S., Kantor, B., Holmes, D.R. (2001). The Porcine Model of Coronary Restenosis. In: Simon, D.I., Rogers, C. (eds) Vascular Disease and Injury. Contemporary Cardiology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-003-2_2

Download citation

  • DOI: https://doi.org/10.1007/978-1-59259-003-2_2

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-169-1

  • Online ISBN: 978-1-59259-003-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation