Skip to main content
SpringerLink
Log in

Folts Cyclic Flow Animal Model for Studying in Vivo Platelet Activity and Platelet Interactions with Damaged Arterial Walls

  • Chapter
Vascular Disease and Injury

Part of the book series: Contemporary Cardiology ((CONCARD))

  • 161 Accesses

Abstract

Many attempts have been made to create partially obstructed coronary arteries in animals that can then be studied and manipulated to produce controlled decreases in coronary flow so that controlled increments of ischemia would be induced. Such a model would require the production of a fixed amount of stenosis, which would allow for essentially normal coronary flow with the animal at rest, but would cause ischemia and sudden death under many of the conditions known to increase the likelihood of sudden death in humans.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Reference

  1. Folts JD. Experimental arterial platelet thrombosis, platelet inhibitors, and their possible clinical relevance. Cardiovasc Rev Rep 1982; 3: 370–382.

    Google Scholar 

  2. Folts JD. An in vivo model of experimental arterial stenosis, intimal damage and periodic thrombosis. Circulation 1991; Suppl 4:IV3–14.

    Google Scholar 

  3. Folts JD, Gallagher K, Rowe GG. Hemodynamic effects of controlled degrees of coronary artery stenosis in short-term and long-term studies in dogs. J Thorac Cardiovasc Surg 1977; 73: 722–727.

    PubMed  CAS  Google Scholar 

  4. Folts JD. A model of experimental arterial platelet thrombosis, platelet inhibitors, and their possible clinical relevance: an update. Cardiovasc Rev Rep 1990; 11: 10–26.

    Google Scholar 

  5. Ashton JH, Ogletree ML, Michel intramuscularly, Golino P, McNatt JM, Taylor AL, et al. Cooperative mediation by serotonin S2 and thromboxane A2/prostaglandin H2 receptor activation of cyclic flow variations in dogs with severe coronary artery stenoses. Circulation 1987; 76: 952–959.

    Article  PubMed  CAS  Google Scholar 

  6. Golino P, Ambrosio G, Ragni M, Pascucci I, Triggiani M, Oriente A, et al. Short-term and long-term role of platelet activating factor as a mediator of in vivo platelet aggregation. Circulation 1993; 88: 1205–1214.

    Article  PubMed  CAS  Google Scholar 

  7. Maalej N, Holden JE, Folts JD. Effect of shear stress on acute platelet thrombus formation in canine stenosed carotid arteries: An in vivo quantitative study. Journal of Thrombosis and Thrombolysis 1998; 5: 231–238.

    Article  PubMed  Google Scholar 

  8. Folts JD, Gallagher K, Rowe GG. Blood flow reductions in stenosed canine coronary arteries: vasospasm or platelet aggregation? Circulation 1982; 65: 248–255.

    Article  PubMed  CAS  Google Scholar 

  9. Bush LR, Shebuski RJ. In vivo models of arterial thrombosis and thrombolysis. FASEB. J 1990; 4: 3087–3098.

    CAS  Google Scholar 

  10. Gering SA, Folts JD. Exacerbation of acute platelet thrombus formation in stenosed dog coronary arteries with smoke from a non-tobacco-burning cigarette. J Lab Clin Med 1990; 116: 728–736.

    PubMed  CAS  Google Scholar 

  11. Bolli R, Ware A, Brandon TA, Weilbaecher DG, Mace ML. Platelet-mediated thrombosis in stenosed canine coronary arteries: inhibition by nicergoline, a platelet-active alpha-adrenergic antagonist. J Am Coll Cardiol 1984; 3: 1417–1426.

    Article  PubMed  CAS  Google Scholar 

  12. Bush LR, Campbell WB, Buja M, Tilton G, Willerson JT. Effects of the selective thromboxane synthetase inhibitor dazoxiben on variations in cyclic blood flow in stenosed canine coronary arteries. Circulation 1984; 69: 1161–1170.

    Article  PubMed  CAS  Google Scholar 

  13. O’Rourke ST, Folts JD, Albrecht RM. Inhibition of canine platelet aggregation by barbiturates. J Lab Clin Med 1986; 108: 206–212.

    PubMed  Google Scholar 

  14. Bertha BG, Folts JD, Nugent M, Rusy BF. Halothane, but not isoflurane or enflurane, protects against spontaneous and epinephrine-exacerbated acute thrombus formation in stenosed dog coronary arteries. Anesthesiology 1989; 71: 96–102.

    Article  PubMed  CAS  Google Scholar 

  15. Folts JD, Crowell EB, Rowe GG. Platelet aggregation in partially obstructed coronary arteries and their inhibition with aspirin. Clin Res 1974; 22: 595A.

    Google Scholar 

  16. Folts JD, Crowell EB, Rowe GG. Platelet aggregation in partially obstructed vessels and its elimination with aspirin. Circulation 1976; 54: 365–370.

    Article  PubMed  CAS  Google Scholar 

  17. Rao GH, Escolar G, White JG. Epinephrine reverses the inhibitory influences of aspirin on platelet-vessel wall interactions. Thromb Res 1986; 44: 65–74.

    Article  PubMed  CAS  Google Scholar 

  18. Folts JD. Drugs for the prevention of coronary thrombosis: from an animal model to clinical trials. Cardiovasc Drugs Ther 1995; 9: 31–43.

    Article  Google Scholar 

  19. Maalej N, Folts JD. Effect of shear stress on acute platelet thrombus formation in canine stenosed carotid arteries: An in vitro quantitative study.

    Google Scholar 

  20. Sherry S. Aspirin and antiplatelet drugs: the clinical approach. Cardiovasc Rev Rep 1984; 5: 1208–1219.

    Google Scholar 

  21. Ikeda H, Koga Y, Kuwano K, Nakayama H, Ueno T, Yoshida N, et al. Cyclic flow variations in a conscious dog model of coronary artery stenosis and endothelial injury correlate with acute ischemic heart disease syndromes in humans. J Am Coll Cardiol 1993; 21: 1008–1017.

    Article  PubMed  CAS  Google Scholar 

  22. Willerson JT, Golino P, Eidt J, Campbell WB, Buja LM. Specific platelet mediators and unstable coronary artery lesions. Experimental evidence and potential clinical implications. Circulation 1989; 80: 198–205.

    Article  PubMed  CAS  Google Scholar 

  23. Demrow HS, Slane PR, Folts JD. Administration of wine and grape juice inhibits in vivo platelet activity and thrombosis in stenosed canine coronary arteries. Circulation 1995; 91: 1182–1188.

    Article  PubMed  CAS  Google Scholar 

  24. Osman HE, Maalej N, Shanmuganayagam D. Grape juice but not orange or grapefruit juice inhibits platelet activity in dogs and monkeys. J Nutr 1998; 128: 2307–2312.

    PubMed  CAS  Google Scholar 

  25. Slane PR, Folts JD. Platelet inhibition in stenosed canine coronary arteries by quercetin and rutin, polyphenolic flavonoids found in red wine. Clin Res 1994; 42: 162A.

    Google Scholar 

  26. Folts JD. Commercial mixture of flavonoids, ProVex CV, inhibits in vivo thrombosis and ex vivo platelet aggregation in dogs and humans. J Invest Med 1998; 46: 199A.

    Google Scholar 

  27. Hill DS, Smith SR, Folts JD. The rabbit as a model for carotid artery stenosis, and periodic acute thrombosis. Fed Proc 1987; 46: 421.

    Google Scholar 

  28. Folts JD, Mosher DF. Transient declines in stenosed monkey carotid artery blood flow due to acute platelet thrombus formation. Thromb Haemostasis 1983; 50: 20.

    Google Scholar 

  29. Coller BS, Folts JD, Smith SR, Scudder LE, Jordan R. Abolition of in vivo platelet thrombus formation in primates with monoclonal antibodies to the platelet GPIIb/IIIa receptor. Correlation with bleeding time, platelet aggregation, and blockade of GPIIb/IIIa receptors. Circulation 1989; 80: 1766–1774.

    Article  PubMed  CAS  Google Scholar 

  30. Schumacher WA, Goldenberg HJ, Harris DN, Ogletree ML. Effect of thromboxane receptor antagonists on renal artery thrombosis in the cynomologus monkey. J Pharmacol Exp Ther 1987; 243: 460–466.

    PubMed  CAS  Google Scholar 

  31. Pawashe AB, Golino P, Ambrosio G, Migliaccio F, Ragni M, Pascucci I, et al. A monoclonal antibody against rabbit tissue factor inhibits thrombus formation in stenotic injured rabbit carotid arteries. Circ Res 1994; 74: 56–63.

    Article  PubMed  CAS  Google Scholar 

  32. Willerson JT, Yao SK, McNatt J, Benedict CR, Anderson HV, Golino P, et al. Frequency and severity of cyclic flow alternations and platelet aggregation predict the severity of neointimal proliferation following experimental coronary stenosis and endothelial injury. Proc Natl Acad Sci USA 1991; 88:10, 624–10, 628.

    Google Scholar 

  33. Eidt J, Ashton J, Golino P, McNatt J, Buja LM, Willerson JT. Treadmill exercise promotes cyclic alterations in coronary blood flow in dogs with coronary artery stenoses and endothelial injury. J Clin Invest 1989; 84: 517–527.

    Article  PubMed  CAS  Google Scholar 

  34. Folts JD, Gering SA, Laibly SW, Bertha BG, Bonebrake FC, Keller JW. Effects of cigarette smoke and nicotine on platelets and experimental coronary artery thrombosis. Adv Exp Med Biol 1990; 273: 339–58: 339–358.

    Google Scholar 

  35. Folts JD, Bonebrake FC. The effects of cigarette smoke and nicotine on platelet thrombus formation in stenosed dog coronary arteries: inhibition with phentolamine. Circulation 1982; 65: 465–470.

    Article  PubMed  CAS  Google Scholar 

  36. Eichhorn EJ, Grayburn PA, Willard JE, Anderson HV, Bedotto JB, Carry M, et al. Spontaneous alterations in coronary blood flow velocity before and after coronary angioplasty in patients with severe angina. J Am Coll Cardiol 1991; 17: 43–52.

    Article  PubMed  CAS  Google Scholar 

  37. Folts JD. Cigarette smoking and thrombus formation. Am Heart J 1988; 116: 1657–1658.

    Article  PubMed  CAS  Google Scholar 

  38. Anderson HV, Kirkeeide RL, Krishnaswami A, Weigelt LA, Revana M, Weisman HF, et al. Cyclic flow variations after coronary angiogplasty in humans: clinical and angiographic characteristics and elimination with 7E3 monoclonal antiplatelet antibody. J Am Coll Cardiol 1994; 23: 1031–1037.

    Article  PubMed  CAS  Google Scholar 

  39. Yao SK, McNatt J, Cui K, Anderson HV, Maffrand JP, Buja LM, et al. Combined ADP and thromboxane A2 antagonism prevents cyclic flow variations in stenosed and endothelium-injured arteries in nonhuman primates. Circulation 1993; 88: 2888–2893.

    Article  PubMed  CAS  Google Scholar 

  40. Folts JD. Inhibition of platelet activity in vivo by amlodipine alone and combined with aspirin. Int J Cardiol 1997; 62: S111–S117.

    Article  PubMed  Google Scholar 

  41. Folts JD, Stamler J, Loscalzo J. Intravenous nitroglycerin infusion inhibits cyclic blood flow responses caused by periodic platelet thrombus formation in stenosed canine coronary arteries. Circulation 1991; 83: 2122–2127.

    Article  PubMed  CAS  Google Scholar 

  42. Rovin JD, Stamler JS, Loscalzo J, Folts JD. Sodium nitroprusside, an endothelium-derived relaxing factor congener, increases platelet cyclic GMP levels and inhibits epinephrine-exacerbated in vivo platelet thrombus formation in stenosed canine coronary arteries. J Cardiovasc Pharmacol 1993; 22: 626–631.

    Article  PubMed  CAS  Google Scholar 

  43. Folts JD, Rowe GG. Dipyridamole does not inhibit thrombus formation in stenosed canine coronary arteries nor does it augment the inhibitory effect of low dose aspirin. Journal of Vascular Medicine and Biology 1989; 1: 255–261.

    Google Scholar 

  44. Schafer AI. Antiplatelet therapy. Am J Med 1996; 101: 199–209X.

    Article  PubMed  CAS  Google Scholar 

  45. Fitzgerald GA. Dipyridamole. N Engl J Med 1987; 316: 1247–1257.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. John D. Folts PhD, FACC
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Cardiovascular Division, Brigham and Women’s Hospital, Boston, MA, USA

    Daniel I. Simon MD  & Campbell Rogers MD,FACC  & 

Rights and permissions

Reprints and permissions

Copyright information

© 2001 Springer Science+Business Media New York

About this chapter

Cite this chapter

Folts, J.D. (2001). Folts Cyclic Flow Animal Model for Studying in Vivo Platelet Activity and Platelet Interactions with Damaged Arterial Walls. In: Simon, D.I., Rogers, C. (eds) Vascular Disease and Injury. Contemporary Cardiology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-003-2_11

Download citation

  • DOI: https://doi.org/10.1007/978-1-59259-003-2_11

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-169-1

  • Online ISBN: 978-1-59259-003-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation