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Coating Arterial and Blood-Contacting Surfaces with NO⋅-Donating Compounds

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Nitric Oxide and the Cardiovascular System

Part of the book series: Contemporary Cardiology ((CONCARD))

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Abstract

Platelet activity is known to enhance the progression of coronary atherosclerosis and to precipitate platelet-mediated coronary thrombosis and acute ischemic events (1). Over the past 30 years, considerable research has been conducted to examine ways by which to inhibit abnormal platelet interaction with acutely damaged arterial walls, stents, and synthetic arterial grafts (1–3). These interactions contribute to the development of atherosclerosis, arterial thrombosis, and restenosis from intimal hyperplasia after interventional procedures, such as angioplasty or atherectomy, and also leads to failure of synthetic vascular grafts (4,5).

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Authors
  1. John D. Folts
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  2. Joseph Loscalzo
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Editors and Affiliations

  1. Boston University Medical Center, Boston, MA, USA

    Joseph Loscalzo MD, PHD  & Joseph A. Vita MD  & 

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Folts, J.D., Loscalzo, J. (2000). Coating Arterial and Blood-Contacting Surfaces with NO⋅-Donating Compounds. In: Loscalzo, J., Vita, J.A. (eds) Nitric Oxide and the Cardiovascular System. Contemporary Cardiology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-002-5_27

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  • DOI: https://doi.org/10.1007/978-1-59259-002-5_27

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-101-1

  • Online ISBN: 978-1-59259-002-5

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