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The Fibroblast and Nitric Oxide

  • Chapter
Nitric Oxide and the Cardiovascular System

Part of the book series: Contemporary Cardiology ((CONCARD))

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Abstract

The fibroblast typically is found in loose connective tissue where it is considered to be the principal cell type. Fibroblasts are responsible for the synthesis of the extracellular matrix proteins including collagen, elastin, and reticular fibers, as well as the complex carbohydrates of the ground substance. In addition, during pathophysiological processes such as wound healing, the fibroblast can change phenotype, differentiate into a myofibroblast, and exhibit properties characteristic of both smooth muscle and conventional fibroblast cells. The role of fibroblasts during wound repair was reviewed recently, and the diverse functions for fibroblasts and their interaction with other cell types during wound healing was discussed (1,2). In addition to matrix production, those functions include growth factor production, proliferation and migration, protease release, formation and contraction of granulation tissue, and phenotypic changes to a myofibroblast or to apoptosis.

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  1. Peter Brecher
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  1. Boston University Medical Center, Boston, MA, USA

    Joseph Loscalzo MD, PHD  & Joseph A. Vita MD  & 

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Brecher, P. (2000). The Fibroblast and Nitric Oxide. In: Loscalzo, J., Vita, J.A. (eds) Nitric Oxide and the Cardiovascular System. Contemporary Cardiology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-002-5_11

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  • DOI: https://doi.org/10.1007/978-1-59259-002-5_11

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-101-1

  • Online ISBN: 978-1-59259-002-5

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