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Nitric Oxide and Cardiomyocyte Function

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Nitric Oxide and the Cardiovascular System

Part of the book series: Contemporary Cardiology ((CONCARD))

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Abstract

There is ample evidence that all three isoforms of nitric oxide synthase (NOS) are expressed within the various cell types in the myocardium (see Table 1). The coordinate physiological regulation of cardiac muscle contraction by the NO• (see Table 2) produced by each of these isoforms mandates a tight regulation of both the expression and the activity of each NOS isoform within a specific cell type. Therefore, despite the apparent promiscuity of having all three NOS isoforms within cardiac muscle, the predominant cellular source of the NO• that is produced in the heart may vary according to specific transcriptional and posttranscriptional stimuli differentially affecting each cell type and/or isoform (as will subsequently be illustrated for eNOS).

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Authors
  1. Jean-Luc Balligand
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  2. Paul J. Cannon
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  1. Boston University Medical Center, Boston, MA, USA

    Joseph Loscalzo MD, PHD  & Joseph A. Vita MD  & 

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Balligand, JL., Cannon, P.J. (2000). Nitric Oxide and Cardiomyocyte Function. In: Loscalzo, J., Vita, J.A. (eds) Nitric Oxide and the Cardiovascular System. Contemporary Cardiology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-002-5_10

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