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Abstract

The subspecialty of neuro-oncology is a relatively young one. Many advances in diagnosis and therapy relevant to neuro-oncology have occurred within the past 25 years. Patients with brain tumors are challenging to manage and require the involvement of neurosurgeons, neuropathologists, neurologists, oncologists or neuro-oncologists, radiologists, radiation oncologists, physical medicine and rehabilitation specialists, and palliative care specialists.

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References

  1. Jemal A, Siegel R, Ward E, et al.: Cancer statistics, 2007. CA Cancer J Clin 2007, 57:43–66.

    PubMed  Google Scholar 

  2. Chamberlain MC, Kormanik PA: Practical guidelines for the treatment of malignant gliomas. West J Med 1998, 168:114–120.

    PubMed  CAS  Google Scholar 

  3. Hoffman S, Propp JM, McCarthy BJ: Temporal trends in incidence of primary brain tumors in the United States, 1985–1999. Neuro Oncol 2006, 8:27–37.

    PubMed  Google Scholar 

  4. Davis FG, Kupelian V, Freels S, et al.: Prevalence estimates for primary brain tumors in the United States by behavior and major histology groups. Neuro Oncol 2001 3:152–158.

    PubMed  CAS  Google Scholar 

  5. Wrensch M, Minn Y, Chew T, et al.: Epidemiology of primary brain tumors: current concepts and review of the literature. Neuro Oncol 2002, 4:278–299.

    PubMed  Google Scholar 

  6. Schoenberg BS, Christine BW, Whisnant JP: The resolution of discrepancies in the reported incidence of primary brain tumors. Neurology 1978, 28:817–823.

    PubMed  CAS  Google Scholar 

  7. Pell MF, Thomas DGT: General introduction to the clinical features of malignant brain tumours. In Malignant Brain Tumours. Edited by Thomas DGT, Graham DI. London: Springer-Verlag; 1995:109–114.

    Google Scholar 

  8. Cascino GD: Epilepsy and brain tumours: implications for treatment. Epilepsia 1990, 31:537–544.

    Google Scholar 

  9. Salander P, Bergenheim AT, Hamberg K, et al.: Pathways from symptoms to medical care: a descriptive study of symptom development and obstacles to early diagnosis in brain tumour patients. Fam Pract 1999, 162:143–148.

    Google Scholar 

  10. Henry C, Despland PA, Regli F: Initial epileptic crisis after the age of 60: aetiology, clinical aspect and EEG. Schweiz Med Wochenschr 1990, 120:787–792.

    Google Scholar 

  11. Salcman M, Kaplan RS: Intracranial tumors in adults. In Comprehensive Textbook of Oncology. Edited by Moosa AR, Bobson MD, Schimpff SD. Baltimore: Williams & Wilkins; 1986:617–629.

    Google Scholar 

  12. Black P, Wen PY: Clinical, imaging and laboratory diagnosis of brain tumors. In Brain Tumors: An Encyclopedic Approach. Edited by Kaye AH, Laws ER Jr. Hong Kong: Churchill Livingstone; 1995:191–214.

    Google Scholar 

  13. Kraemer DL, Bullard DE: Clinical presentation of the brain tumor patient. In Brain Tumors: A Comprehensive Text. Edited by Morantz RA, Walsh JW. New York: Marcel Dekker; 1994:183–211.

    Google Scholar 

  14. Kleihues P, Louis DN, Scheithauer BW, et al.: The WHO classification of tumors of the nervous system. Neuropathol Exp Neurol 2002, 61:215–225.

    Google Scholar 

  15. Giles GG, Gonzales MF: Epidemiology of brain tumors and factors in prognosis. In Brain Tumors: An Encyclopedic Approach. Edited by Kaye AH, Laws ER Jr. New York: Churchill Livingstone; 1994:47–67.

    Google Scholar 

  16. Shaw EG, Daumas-Duport C, Scheithauer BW, et al.: Radiation therapy in the treatment of low-grade supratentorial astrocytomas. J Neurosurg 1989, 70:853–861.

    PubMed  CAS  Google Scholar 

  17. Guthrie BL, Laws ER Jr: Supratentorial low-grade gliomas. Neurosurg Clin North Am 1990, 1:37–48.

    CAS  Google Scholar 

  18. Daumas-Duport C, Scheithauer BW, O’Fallon JR, et al.: Grading of astrocytomas: a simple and reproducible method. Cancer 1988, 62:2152–2165.

    PubMed  CAS  Google Scholar 

  19. Laurent JJ, Webb KM, Jane JA Jr, et al.: Pituitary adenomas. In Textbook of Neuro-Oncology. Edited by Berger MS, Prados MD. Philadelphia: Elsevier; 2005:351–356.

    Google Scholar 

  20. Someya M, Sakata KI, Oouchi A, et al.: Four cases of meningeal hemangiopericytoma treated with surgery and radiotherapy. Jpn J Clin Oncol 2001, 31:548–552.

    PubMed  CAS  Google Scholar 

  21. Carew JF, Singh B, Kraus DH: Hemangiopericytoma of the head and neck. Laryngoscope 1999, 109:1409–1411.

    PubMed  CAS  Google Scholar 

  22. Segall HD, Destian S, Nelson MD Jr, et al.: CT and MR imaging in malignant gliomas. In Malignant Cerebral Glioma. Edited by Apuzzo MLJ. Park Ridge, IL: American Association of Neurological Surgeons 1991:63–78.

    Google Scholar 

  23. Salcman M: Intracranial hemorrhage caused by brain tumor. In Intracerebral Hematomas. Edited by Kaufman HH. New York: Raven Press; 1992:95–106.

    Google Scholar 

  24. Al-Okaili RN, Krejza J, Woo JH, et al.: Intraaxial brain masses: MR imaging-based diagnostic strategy-initial experience. Radiology 2007, 243:539–550.

    PubMed  Google Scholar 

  25. Leibel SA, Sheline GE: Radiation therapy for neoplasms of the brain. J Neurosurg 1987, 66:1–22.

    PubMed  CAS  Google Scholar 

  26. Valk PE, Budinger TF, Levin VA, et al.: PET of malignant cerebral tumors after interstitial brachytherapy. Demonstration of metabolic activity and correlation with clinical outcome. J Neurosurg 1988, 69:830–838.

    PubMed  CAS  Google Scholar 

  27. Scharfen CO, Sneed PK, Wara WM, et al.: High activity iodine-125 interstitial implant for gliomas. Int J Radiat Oncol Biol Phys 1992, 24:583–591.

    PubMed  CAS  Google Scholar 

  28. Kleihues P, Burger PC, Scheithauer BW: Histological Typing of Tumours of the Central Nervous System, edn 2. Berlin: Springer-Verlag; 1993.

    Google Scholar 

  29. Wilson CB: Glioblastoma: the past, the present, and the future. Clin Neurosurg 1992, 38:32–48.

    PubMed  CAS  Google Scholar 

  30. Tso CL, Freije WA, Day A, et al.: Distinct transcription profiles of primary and secondary glioblastoma subgroups. Cancer Res 2006, 66:159–167.

    PubMed  CAS  Google Scholar 

  31. Maher EA, Brennan C, Wen PY, et al.: Marked genomic differences characterize primary and secondary glioblastoma subtypes and identify two distinct molecular and clinical secondary glioblastoma entities. Cancer Res 2006, 66:11502–11513.

    PubMed  CAS  Google Scholar 

  32. Ohgaki H: Genetic pathways to glioblastomas. Neuropathology 2005, 25:1–7.

    PubMed  Google Scholar 

  33. Biernat W, Tohma Y, Yonekawa Y, et al.: Alterations of cell cycle regulatory genes in primary (de novo) and secondary glioblastomas. Acta Neuropathol 1997, 94:303–309.

    PubMed  CAS  Google Scholar 

  34. Tohma Y, Gratas C, Biernat W, et al.: PTEN (MMAC1) mutations are frequent in primary glioblastomas (de novo) but not in secondary glioblastomas. J Neuropathol Exp Neurol 1998, 57:684–689.

    PubMed  CAS  Google Scholar 

  35. Macdonald D: Low grade gliomas, mixed gliomas and oligodendrogliomas. Semin Oncol 1994, 21:236–248.

    PubMed  CAS  Google Scholar 

  36. Cairncross G, Macdonald D, Ludwin S, et al.: Chemotherapy for anaplastic oligodendroglioma: National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 1994, 12:2013–2021.

    PubMed  CAS  Google Scholar 

  37. Jeuken JW, Sprenger SH, Vermeer H, et al.: Chromosomal imbalances in primary oligodendroglial tumors and their recurrences: clues about malignant progression detected using comparative genomic hybridization. J Neurosurg 2002, 96:559–564.

    PubMed  Google Scholar 

  38. Ino Y, Betensky RA, Zlatescu MC, et al.: Molecular subtypes of anaplastic oligodendroglioma: implications for patient management at diagnosis. Clin Cancer Res 2001, 7:839–845.

    PubMed  CAS  Google Scholar 

  39. Fujii K, Fujita N, Hirabuki N, et al.: Neuromas and meningiomas: evaluation of early enhancement with dynamic MR imaging. AJNR Am J Neuroradiol 1992, 13:1215–1220.

    PubMed  CAS  Google Scholar 

  40. Goldsher D, Litt AW, Pinto RS, et al.: Dural “tail” associated with meningiomas on Gd-DTPA-enhanced MR images: characteristics, differential diagnostic value, and possible implications of treatment. Radiology 1990, 176:447–450.

    PubMed  CAS  Google Scholar 

  41. Tien RD, Yang PJ, Chu PK: “Dural tail sign”: a specific MR sign for meningioma? J Comput Assist Tomogr 1991, 15:64–66.

    PubMed  CAS  Google Scholar 

  42. Chen TC, Zee CS, Miller CA, et al.: MRI and pathological correlates of meningiomas. Neurosurgery 1992, 31:1015–1022.

    PubMed  CAS  Google Scholar 

  43. Jaaskelainen J: Seemingly complete removal of histologically benign intracranial meningioma: late recurrence rate and factors predicting recurrence in 657 patients. Surg Neurol 1986, 25:461–469.

    Google Scholar 

  44. DeMonte F, Al-Mefty O: Meningiomas. In Brain Tumors: An Encyclopedic Approach. Edited by Kaye AH, Laws ER Jr. Hong Kong: Churchill Livingstone; 1995:675–704.

    Google Scholar 

  45. Sherman ME, Erozan YS, Mann RB, et al.: Stereotactic brain biopsy in the diagnosis of malignant lymphoma. Am J Clin Pathol 1991, 95:878–883.

    PubMed  CAS  Google Scholar 

  46. Gavrilovic IT, Hormigo A, Yahalom J, et al.: Long-term follow-up of high-dose methotrexate-based therapy with and without whole brain irradiation for newly diagnosed primary CNS lymphoma. J Clin Oncol 2006, 24:4570–4574.

    PubMed  CAS  Google Scholar 

  47. Brada M, Thomas DGT: Craniopharyngioma revisited. Int J Radiat Oncol Biol Phys 1993, 27:471–475.

    PubMed  CAS  Google Scholar 

  48. Rushing EJ, Rorke LB, Sutton L: Problems in the nosology of desmoplastic tumors of childhood. Pediatr Neurosurg 1993; 19:57–62.

    PubMed  CAS  Google Scholar 

  49. Vandenberg SR: Current diagnostic concepts of astrocytic tumors. J Neuropathol Exp Neurol 1992, 51:644–657.

    PubMed  CAS  Google Scholar 

  50. Chen TC, Gonzalez-Gomez I, McComb JG: Uncommon glial tumors. In Brain Tumors. Edited by Kaye AH, Laws ER Jr. New York: Churchill Livingstone; 1995:525–557.

    Google Scholar 

  51. Mena H, Rushing EJ, Ribas JL, et al.: Tumors of pineal parenchymal cells: a correlation of histological features, including nucleolar organizer regions, with survival in 35 cases. Hum Pathol 1995, 26:20–30.

    PubMed  CAS  Google Scholar 

  52. Russell DS, Rubinstein LJ: Pathology of Tumors of the Nervous System, edn 5. Baltimore: Williams & Wilkins; 1989.

    Google Scholar 

  53. Lutterbach J, Fauchon F, Schild SE, et al.: Malignant pineal parenchymal tumors in adult patients: patterns of care and prognostic factors. Neurosurgery 2002, 51:44–56.

    PubMed  Google Scholar 

  54. Ho DM, Wong TT, Liu HC: Choroid plexus tumors in childhood: histopathologic study and clinicopathological correlation. Childs Nerv Sys 1991, 7:437–441.

    CAS  Google Scholar 

  55. Jannetta PJ: Vestibular neurilemmomas. Clin Neurosurg 1997: 44:529–548.

    PubMed  CAS  Google Scholar 

  56. Tucker T, Wolkenstain P: Association between benign and malignant peripheral nerve sheath tumors in NF1. Neurology 2005, 65:205–211.

    PubMed  CAS  Google Scholar 

  57. Roach ES: Neurocutaneous syndromes. Pediatr Clin North Am 1992, 39:591–619.

    PubMed  CAS  Google Scholar 

  58. National Institutes of Health Consensus Development Conference statement on acoustic neuroma. Dec. 11–13, 1991. Arch Neurol 1994, 51: 201–207.

    Google Scholar 

  59. Ng H, Lau K, Tse JYM, et al.: Combined molecular genetic studies of chromosome 22q and the neurofibromatosis type 2 gene in central nervous system tumors. Neurosurgery 1995, 37:764–773.

    PubMed  CAS  Google Scholar 

  60. Sobel RA: Vestibular (acoustic) schwannomas: histologic features in neurofibromatosis 2 and unilateral cases. J Neuropathol Exp Neurol 1993, 52:106–113.

    PubMed  CAS  Google Scholar 

  61. Ho VB, Smirniotopoulos JG, Murphy FM, et al.: Radiologic-pathologic correlation: hemangioblastoma. AJNR Am J Neuroradiol 1992, 13:1343–1352.

    PubMed  CAS  Google Scholar 

  62. Lonser RR, Glenn GM, McClellan W, et al.: von Hippel-Lindau disease. Lancet 2003, 361:2059–2067.

    PubMed  CAS  Google Scholar 

  63. Knudson AG Jr: Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci U S A 1971, 68:820–823.

    PubMed  Google Scholar 

  64. Wanebo JE, Lonser RR, Glenn GM, et al.: The natural history of hemangioblastomas of the central nervous system in patients with von Hippel-Lindau disease. J Neurosurg 2003, 98:82–94.

    PubMed  Google Scholar 

  65. Hirose T, Scheithauer BW, Lopes MBS, et al.: Tuber and subependymal giant cell astrocytoma associated with tuberous sclerosis: an immunohistochemical, ultrastructural, and immunoelectron microscopic study. Acta Neuropathol 1995, 90:387–399.

    PubMed  CAS  Google Scholar 

  66. Nixon Jr, Miller GM, Okazaki H, et al.: Cerebral tuberous sclerosis: postmortem MRI and pathologic anatomy. Mayo Clin Proc 1989, 64:305–311.

    PubMed  CAS  Google Scholar 

  67. Roach ES, Smith M, Huttenlocher P, et al.: Diagnostic criteria: tuberous sclerosis complex. Report of the Diagnostic Criteria Committee of the National Tuberous Sclerosis Association. J Child Neurol 1992, 7:221–224.

    PubMed  CAS  Google Scholar 

  68. Cohen ME, Duffner PK: Medulloblastomas. In Brain Tumors in Children. Principles of Diagnosis and Treatment. Edited by Cohen ME, Duffner PK. New York: Raven Press; 1995:177–201.

    Google Scholar 

  69. Evans RG: The role of radiation therapy in the treatment of brain tumors in children. In Brain Tumors: A Comprehensive Text. Edited by Morantz RA, Walsh JW. New York: Marcel Dekker; 1994:659–677.

    Google Scholar 

  70. Thomas DGT: Neuro-oncology: Primary Malignant Brain Tumors. Edited by Thomas DGT. Baltimore: Johns Hopkins University Press; 1990:165–167.

    Google Scholar 

  71. Wilne SH, Ferris RC, Nathwani A, et al.: The presenting features of brain tumours: a review of 200 cases. Arch Dis Child 2006, 91:502–506.

    PubMed  CAS  Google Scholar 

  72. Cohen ME, Duffner PK: Brain stem tumors. In Brain Tumors in Children. Principles of Diagnosis and Treatment. Edited by Cohen ME, Duffner PK. New York: Raven Press; 1995; 241–262.

    Google Scholar 

  73. Albright AL, Packer RJ, Zimmerman R, et al.: Magnetic resonance scans should replace biopsies for the diagnosis of diffuse brain stem gliomas: a report from Children’s Cancer Group. Neurosurgery 1993, 33:1026–1029.

    PubMed  CAS  Google Scholar 

  74. Artigas J, Ferszt R, Brock M, et al.: The relevance of pathological diagnosis for therapy and outcome of brain stem gliomas. Acta Neurochir 1988, 42:166–169.

    CAS  Google Scholar 

  75. Packer RJ, Sutton LN, Goldwein JW, et al.: Improved survival with the use of adjuvant chemotherapy in the treatment of medulloblastoma. J Neurosurg 1991, 74:433–440.

    PubMed  CAS  Google Scholar 

  76. Tomita T, McClone DG: Medulloblastoma in childhood: results of radical resection and low-dose neuraxis radiation therapy. J Neurosurg 1986, 64:238–242.

    PubMed  CAS  Google Scholar 

  77. Farwell Jr, Dohrmann GJ, Flannery JT: Medulloblastoma in childhood: an epidemiological study. J Neurosurg 1984, 61:593–664.

    Google Scholar 

  78. Evans AE, Jenkin DT, Sposto R, et al.: The treatment of medulloblastoma. Results of prospective randomized trial of radiation therapy with and without CCNU, vincristine, and prednisone. J Neurosurg 1990, 72:572–582.

    PubMed  CAS  Google Scholar 

  79. Packer RJ: Diagnosis, treatment, and outcome of primary central nervous system tumors of childhood. Curr Opin Oncol 1994, 6:240–246.

    PubMed  CAS  Google Scholar 

  80. Kovnar EH, Kellie SJ, Horowitz ME, et al.: Preirradiation cisplatin and etoposide in the treatment of high-risk medulloblastomas and other malignant embryonal tumors of the central nervous system: a phase II study. J Clin Oncol 1990, 8:330–336.

    PubMed  CAS  Google Scholar 

  81. Eberhart CG, Kepner JL, Goldthwaite PT, et al.: Histopathologic grading of medulloblastomas: a Pediatric Oncology Group study. Cancer 2002, 94:552–560.

    PubMed  Google Scholar 

  82. Friedman AH, McLendon RE, Provenzale JN, et al.: Ependymoma. In Textbook of Neuro-Oncology. Edited by Berger MS, Prados MD. Philadelphia: Elsevier; 2005:190–198.

    Google Scholar 

  83. Cohen ME, Duffner PK: Cerebellar astrocytomas. In Brain Tumors in Children. Principles of Diagnosis and Treatment. Edited by Cohen ME, Duffner PK. New York: Raven Press; 1995:203–218.

    Google Scholar 

  84. Sutton LN, Molloy PT, Sernyak H, et al.: Long-term outcome of hypothalamic/ chiasmatic astrocytomas in children treated with conservative surgery. J Neurosurg 1995, 83:583–589.

    PubMed  CAS  Google Scholar 

  85. Green SB, Byar DP, Walker MD, et al.: Comparisons of carmustine, procarbazine and high-dose methylprednisolone as additions to surgery and radiotherapy for the treatment of malignant glioma. Cancer Treat Rep 1983, 67:123–132.

    Google Scholar 

  86. Forsyth PA, Weaver S, Fulton D, et al.: Prophylactic anticonvulsants in patients with brain tumour. Can J Neurol Sci 2003, 30:106–112.

    PubMed  Google Scholar 

  87. Fink KF: Chemotherapy and anti-epileptic drug interactions. In Handbook of Brain Tumor Chemotherapy. Edited by Newton H. Academic Press; 2006:44–57.

    Google Scholar 

  88. Lacroix M, Abi-Said D, Fourney DR, et al.: A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival. J Neurosurg 2001, 95:190–198.

    PubMed  CAS  Google Scholar 

  89. Nomiya T, Nemoto K, Kumabe T, et al.: Prognostic significance of surgery and radiation therapy in cases of anaplastic astrocytoma: retrospective analysis of 170 cases. J Neurosurg 2007, 106:575–581.

    PubMed  Google Scholar 

  90. Walker MD, Alexander E Jr, Hunt WE, et al.: Evaluation of BCNU and/or radiotherapy in the treatment of anaplastic gliomas: a cooperative clinical trial. J Neurosurg 1978, 49:333–343.

    PubMed  CAS  Google Scholar 

  91. Stupp R, Mason WP, van den Bent MJ, et al.: Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 2005, 352:987–996.

    PubMed  CAS  Google Scholar 

  92. Hegi ME, Diserens AC, Gorlia T, et al.: MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med 2005, 352:997–1003.

    PubMed  CAS  Google Scholar 

  93. Pope WB, Lai A, Nghiemphu P, et al.: MRI in patients with high-grade gliomas treated with bevacizumab and chemotherapy. Neurology 2006, 66:1258–1260.

    PubMed  CAS  Google Scholar 

  94. Vredenburgh JJ, Desjardins A, Herndon JE, et al.: Bevacizumab, a monoclonal antibody to vascular endothelial growth factor (VEGF), and irinotecan for treatment of malignant gliomas [ASCO abstract]. J Clin Oncol 2006, 24(18S):1506.

    Google Scholar 

  95. Wen PY, Schiff D, Kesari S, et al.: Medical management of patients with brain tumors. J Neuro Oncol 2006, 80:313–32.

    CAS  Google Scholar 

  96. Knovich MA, Lesser GJ: The management of thromboembolic disease in patients with central nervous system malignancies. Curr Treat Options Oncol 2004, 5:511–517.

    PubMed  Google Scholar 

  97. Duffner PK, Cohen ME, Thomas PRM, et al.: The long-term effects of cranial irradiation on the central nervous system. Cancer 1985, 56:1841–1846.

    PubMed  CAS  Google Scholar 

  98. Packer RJ, Sutton LN, Atkins TE, et al.: A prospective study of cognitive function in children receiving whole-brain radiotherapy and chemotherapy: 2-year results. J Neurosurg 1987, 70:707–713.

    Google Scholar 

  99. Twijnstra A, Boon PJ, Lormans ACM, et al.: Neurotoxicity of prophylactic cranial irradiation in patients with small cell carcinoma of the lung. Eur J Cancer Clin Oncol 1987, 23:983–986.

    PubMed  CAS  Google Scholar 

  100. Hochberg FH, Slotnick B: Neuropsychologic impairment in astrocytoma survivors. Neurology 1980, 30:172–177.

    PubMed  CAS  Google Scholar 

  101. Constine LS, Woolf PD, Cann D, et al.: Hypothalamic-pituitary dysfunction after radiation for brain tumors. N Engl J Med 1993, 328:87–94.

    PubMed  CAS  Google Scholar 

  102. Delanian S, Lefaix JL: Current management for late normal tissueinjury: radiation-induced fibrosis and necrosis. Semin Radiat Oncol 2007, 17:99–107.

    PubMed  Google Scholar 

  103. Gonzalez J, Kumar AJ, Conrad CA, et al.: Effect of bevacizumab on radiation necrosis of the brain. Int J Radiat Oncol Biol Phys 2007, 67:323–326.

    PubMed  CAS  Google Scholar 

  104. Valk PE, Dillon WP: Radiation injury of the brain. AJNR Am J Neuroradiol 1991, 12:45–62.

    PubMed  CAS  Google Scholar 

  105. Soffer D, Gomori JM, Siegal T, et al.: Intracranial meningiomas after high-dose irradiation. Cancer 1989, 63:1514–1519.

    PubMed  CAS  Google Scholar 

  106. Dodick DW, Mokri B, Shaw EG, et al.: Sarcomas of calvarial bones: rare remote effect of radiation therapy for brain tumors. Neurology 1994, 44:908–912.

    PubMed  CAS  Google Scholar 

  107. Posner JB: Neurologic complications of cancer. In Contemporary Neurology Series, vol 45. Philadelphia: FA Davis; 1995.

    Google Scholar 

  108. Cairncross JG, Kim JH, Posner JB: Radiation therapy for brain metastases. Ann Neurol 1980, 7:529–541.

    PubMed  CAS  Google Scholar 

  109. Young DF, Posner JB, Chu F, et al.: Rapid-course radiation therapy of cerebral metastases: results and complications. Cancer 1974, 4:1069–1076.

    Google Scholar 

  110. Patchell RA, Tibbs PA, Walsh JW, et al.: A randomized trial of surgery in the treatment of single metastases to the brain. N Engl J Med 1990, 322:494–500.

    PubMed  CAS  Google Scholar 

  111. Soffietti R, Cornu P, Delattre JY, et al.: EFNS guidelines on diagnosis and treatment of brain metastases: report of an EFNS Task Force. Eur J Neurol 2006, 13:674–681.

    PubMed  CAS  Google Scholar 

  112. Gaspar L, Scott C, Rotman M, et al.: Recursive partitioning analysis (RPA) of prognostic factors in three Radiation Therapy Oncology Group (RTOG) brain metastases trials. Int J Radiat Oncol Biol Phys 1997, 37:745–751.

    PubMed  CAS  Google Scholar 

  113. Sampson JH, Carter JH Jr, Friedman AH, et al.: Demographics, prognosis, and therapy in 702 patients with brain metastases from malignant melanoma. J Neurosurg 1998, 88:11–20.

    PubMed  CAS  Google Scholar 

  114. Patchell RA, Tibbs PA, Regine WF, et al.: Postoperative radiotherapy in the treatment of single metastases to the brain: a randomized trial. JAMA 1998, 280:1485–1489.

    PubMed  CAS  Google Scholar 

  115. Peacock KH Lesser GJ: Current therapeutic approaches in patients with brain metastases. Curr Treat Options Oncol 2006, 7:479–489.

    PubMed  Google Scholar 

  116. Greenberg HS, Kim JH, Posner JB: Epidural spinal cord compression from metastatic tumor: results with a new treatment protocol. Ann Neurol 1980, 8:361–366.

    PubMed  CAS  Google Scholar 

  117. Wasserstrom W, Glass JP, Posner JB: Diagnosis and treatment of leptomeningeal metastases from solid tumors: experience with 90 patients. Cancer 1982, 49:759–772.

    PubMed  CAS  Google Scholar 

  118. Choucair AK, Leven VA, Gutin PH, et al.: Development of multiple lesions during radiation therapy and chemotherapy in patients with gliomas. J Neurosurg 1986, 65:654–658.

    PubMed  CAS  Google Scholar 

  119. Furneaux HM, Rosenblum MK, Dalmau J, et al.: Selective expression of Purkinje cell antigens in tumor tissue from patients with paraneoplastic cerebellar degeneration. N Engl J Med 1990, 322:1844–1851.

    PubMed  CAS  Google Scholar 

  120. Hetzel DJ, Stanhope CR, O’Neil BP, et al.: Gynecologic cancer in patients with subacute cerebellar degeneration predicted by anti-Purkinje cell antibodies and limited in metastatic volume. Mayo Clin Proc 1990, 65:1558–1563.

    PubMed  CAS  Google Scholar 

  121. Hewett SJ, Atchison WD: Specificity of Lambert-Eaton myasthenic syndrome immunoglobulin for nerve terminal calcium channels. Brain Res 1992, 599:324–332.

    PubMed  CAS  Google Scholar 

  122. Darnell RB: Paraneoplastic neurologic disorders: windows into neuronal function and tumor immunity. Arch Neurol 2004, 61:30–32.

    PubMed  Google Scholar 

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Fink, K.L., Rushing, E.J. (2009). Neuro-oncology. In: Rosenberg, R.N. (eds) Atlas of Clinical Neurology. Current Medicine Group. https://doi.org/10.1007/978-1-57340-359-7_8

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