Skip to main content

Medical Evacuation Risk and Crew Transport

  • Chapter
  • First Online:
Principles of Clinical Medicine for Space Flight

Abstract

Space is a uniquely remote and hazardous environment. For humans to live and work effectively in low Earth orbit (LEO) and beyond, significant technological support must be provided to overcome the physical and psychological challenges of space flight. This operational environment places great demands on a crew, particularly during emergency situations, where the life of a crewmember may rest in the hands of a crew medical officer (CMO) who is also a colleague. In over five decades of human space flight and exploration, our knowledge, activities, and capabilities have grown tremendously, resulting in the International Space Station (ISS) and a permanent human presence in LEO. The need for an evacuation capability from a LEO space station derives from basic principles underlying escape and egress systems of the earliest manned spacecraft.

This chapter will examine key aspects of present-day spaceflight medical transport and evacuation and its terrestrial parallels, enumerate current challenges, and suggest possible solutions for future spaceflight activities. This will include a discussion on present and future standards of medical care on the ISS and the current transport vehicle used for travel to and from the station, the Russian Soyuz. Programs now under active development such as the NASA/Lockheed Orion Multi-Purpose Crew Vehicle, Space Exploration Technologies’ (SpaceX) Crew Dragon Capsule, and the Boeing CST-100 Capsule may also be developed with limited medical transport capability.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 189.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Kovit B. ‘Space Rescue’, Space and aeronautics, May 1966, pp. 99–103.

    Google Scholar 

  2. Petersen NV. Recovery techniques for manned Earth satellites. In: Proceedings of the VIII International Astronomical Congress, 1957; pp 310–319. American Institute of Aeronautics and Astronautics.

    Google Scholar 

  3. Romick DC, Knight RE, Black S. A preliminary design of a medium sized ferry rocket vehicle of the Meteor concept. In: Proceedings of the VIII International Astronomical Congress, 1957, pp 349–358, American Institute of Aeronautics and Astronautics.

    Google Scholar 

  4. Krufft E. The considerations required in the use of a “lifeboat”, Second International Symposium on Physics and Medicine of the Upper Atmosphere and Space. 1958 American Institute of Aeronautics and Astronautics.

    Google Scholar 

  5. Space safety and rescue 1992; Proceedings of the 25th International Symposium, Washington, DC, Aug. 28–Sept. 5, 1992. San Diego, CA, Univelt, Inc. (Science and Technology Series, Vol. 84), 1994.

    Google Scholar 

  6. Carliele B, Shen B. Polar medicine. In: Auerbach PS, editor. Wilderness medicine. 4th ed: Mosby-Year Book Inc.; 2001. p. 226–39.

    Google Scholar 

  7. Daniher C E, Cureton K L. A lifeboat for space station: the assured crew return vehicle (ACRV). In: Space safety and rescue 1992, 43rd Congress of the International Astronautical Federation, Washington, DC, Aug. 28–Sep. 5; 1992. IAA-92-0389.

    Google Scholar 

  8. Halsell J, Widhalm J, Whitsett C. Design of an interim space rescue ferry vehicle. J Spacecraft Rockets. (ISSN 0022-4650. 1988;25:180–6.

    Google Scholar 

  9. Buning H. Project EGRESS: the design of an assured crew return vehicle for the space station. In Proceedings of the 6th Annual Summer Conference: NASA University Advanced Design Program (USRA), University of Michigan, April 1990. NASA-CR-186657.

    Google Scholar 

  10. Charles, JB. A snapshot of MOL in 1968. Accessed http://thespacereview.com/article/2898/1.

  11. Winfrey D. The last spacemen: MOL and what might have been. The Space Review, Monday Nov 16, 2015. Accessed from: http://www.thespacereview.com/article/2866/1.

  12. Contingency Return Vehicle for Space Station: A design Study, Engineering Team Report. NASA JSC, Houston, TX. NASA JSC-32025, 1987.

    Google Scholar 

  13. Grimard M, Debas G. Escape Vehicle concepts for manned space Stations. In: 40th Congress of the International Astronautical Federation, Malaga, Spain, Oct. 7–13, 1989. # IAF 89-245.

    Google Scholar 

  14. Grimard M, Debas G. European ACRV—a solution for space station crew assured return. In: 44th Congress of the IAF, International Astronautical Congress, Graz, Austria, Oct. 16–22, 1993. # IAA 6.1-93-733.

    Google Scholar 

  15. Assured Crew Return Capability-Crew Emergency Return Vehicle Phase; A Report 1988, JSC 23321, NASA Johnson Space Center, Houston, TX.

    Google Scholar 

  16. Stone et al. Assured crew Return Vehicle, 42nd Congress of the International Astronautical Federation, Oct 5–11, 1991 Montreal, Canada. IAF-91-088.

    Google Scholar 

  17. Manley M, Basile L, Sanchez M. Crew return vehicle (CRV) and crew transfer vehicle (CTV) accommodations study. 49th Congress of the IAF, International Astronautical Congress, Melbourne, Australia, Sept. 28–Oct. 2, 1998. # IAF/IAA-98-G.3.01.

    Google Scholar 

  18. Gibbs, Y. NASA Armstrong Fact Sheet: X-38 Prototype Crew Return Vehicle, 28 Feb, 2014. Accessed from http://www.nasa.gov/centers/armstrong/news/FactSheets/FS-038-DFRC.html) transport.

  19. Qian Z, Hao X. Autonomous rescue system. Space safety and rescue 1995. In: Proceedings of the IAA Symposium, Oslo, Norway, Oct. 2–6, 1995, San Diego, CA, Univelt, Inc. (Science and Technology Series. Vol. 93), 1997, p. 77-83. (IAA 95-6.1.08).

    Google Scholar 

  20. Fabian J. An historical perspective on crew rescue and the role of the association of space explorers, IAA 89-618, 22nd IAA International Space Safety and Rescue Symposium, Space Safety and Rescue 1988-89 Volume 77. pp. 227–38.

    Google Scholar 

  21. In-Flight Breakup During Test Flight; Scaled Composites SpaceShipTwo, N339SS. Aerospace Accident Report NTSB/AAR-15/02; PB2015-105454.

    Google Scholar 

  22. Myers H. Assured Crew Return Capability Crew Emergency Return Vehicle (CERV) Avionics. In NASA, Washington, Space Transportation Avionics Technology Symposium. Nov 7-9 1989, JSC-IA131, Volume 2: Conference Proceedings, pp. 163–77 (N91-17025).

    Google Scholar 

  23. Gonzales, et al. An integrated logistics support system for training crew medical officers in advanced cardiac life support management. Comput Methods Prog Biomed. 1999;59:115–29.

    Google Scholar 

  24. Percy RL, Raasch RF. Space station crew safety: space station crew safety alternatives study, 1985, Volume 1, NASA CR 3854, Contract NASI-17242.

    Google Scholar 

  25. Burluka O, Dimitiadi D. JPRS-USP-91-002, Limited current capabilities for cosmonaut rescue. In: Joint Publications Research Service (Arlington, VA, United States) Report: Science and Technology. USSR: Space, pp. 50–51 (N91-27179) 1991.

    Google Scholar 

  26. Apollo Soyuz Test Project Medical Report. Compiled by A. Nicogossian. NASA SP-411; 1977.

    Google Scholar 

  27. NASA/SP–2010–578: NASA Astronauts on Soyuz: Experience and Lessons for the Future.

    Google Scholar 

  28. Levy JS, Head JW, Marchant DR, Dickson JL, Morgan GA. Geologically recent gully–polygon relationships on Mars: Insights from the Antarctic Dry Valleys on the roles of permafrost, microclimates, and water sources for surface flow. Icarus. 2009;201(1):113–26.

    Google Scholar 

  29. Wentworth SJ, Gibson EK, Velbel MA, McKay DS. Antarctic Dry Valleys and indigenous weathering in Mars meteorites: implications for water and life on Mars. Icarus. 2005;174(2):383–95.

    CAS  Google Scholar 

  30. Marchant DR, Head JW III. Antarctic dry valleys: microclimate zonation, variable geomorphic processes, and implications for assessing climate change on Mars. Icarus. 2007;192(1):187–222.

    Google Scholar 

  31. Pattarini JM, Scarborough JR, Sombito VL, Parazynski SE. Primary care in extreme environments: medical clinic utilization at antarctic stations, 2013–2014. Wilderness Environ Med. 2016;27(1):69–77.

    PubMed  Google Scholar 

  32. Pattarini JM, Reyes DP, Parazynski SE. Emergency medical evacuations from US Antarctic Stations, 2002–2014. Orlando: Aerospace Medical Association 86th Annual Scientific Meeting; 2015.

    Google Scholar 

  33. Wallace P. Fatalities on past antarctic exploration expeditions as manned spaceflight hazard identification guides. In: 48th AIAA Aerospace Sciences Meeting Including the New Horizons Forum and Aerospace Exposition; 2010.

    Google Scholar 

  34. Hasegawa Y, Watanabe K. International comparative study of medical service at Antarctic wintering-over stations (in Japanese). Antarctic Record-Tokyo. 2007;51(3):251.

    Google Scholar 

  35. Johnston SL. Medical Care at the South Pole, Presented at the 1st “Pushing the Envelope” Conference. Nassau Bay Hilton, Clear Lake: University of Texas Medical Branch, Department of Preventive, Occupational and Environmental Medicine; 1998.

    Google Scholar 

  36. Safety in Earth Orbit Study, Volume 3 – An Analysis of Tumbling Spacecraft and Escape and Rescue, North American Rockwell July 1972, 209p, NAS 9 – 12004, NASA-CR-128509.

    Google Scholar 

  37. Rodney GA. NASA’s post-Challenger safety program – Themes and thrusts, IAF, 39th International Astronautical Congress, Bangalore, India, Oct. 8–15, 1988. IAF 88-510.

    Google Scholar 

  38. Scheuring RA, Mathers CH, Jones JA, Wear NL. Musculoskeletal injuries and minor trauma in space: incidence and injury mechanisms in U.S. astronauts. Aviat Space Environ Med. 2009;80(2):117–24.

    PubMed  Google Scholar 

  39. Johnston S L, Marshburn T H, Lindgren K. Predicted incidence of evacuation-level illness/injury during space station operation. In: 71st Annual Scientific Meeting of the Aerospace Medical Association, Houston, TX, May 2000.

    Google Scholar 

  40. NASA (2017b) Integrated medical model incidence update for the exploration medical capability evidence, Update 2017. National Aeronautics and Space Administration, NASA Johnson Space Center.

    Google Scholar 

  41. Antonsen E. Risk of adverse health outcomes and decrements in performance due to in-flight medical conditions. National Aeronautics and Space Administration, NASA Johnson Space Center 2017.

    Google Scholar 

  42. Billica RD, Simmons SC, Mathes KL, et al. Perception of the medical risk of spaceflight. Aviat Space Environ Med. 1996;67(5):467–73.

    CAS  PubMed  Google Scholar 

  43. Arellano J, Young M, Boley L, Garcia Y, Saile L, Walton M, Kerstman E, Reyes D, Goodenow D, Myers J. Integrated Medical Model (IMM) Optimization Version 4.0 Functional Improvements. Galveston: Human Research Program Investigators’ Workshop; 2016.

    Google Scholar 

  44. Minard CG, de Carvalho MF, Iyengar MS. Optimizing medical resources for spaceflight using the integrated medical model. Aviat Space Environ Med. 2011;82(9):890–4.

    PubMed  Google Scholar 

  45. Guiford FR, Soboroff BJ. Air Evacuation. J Aviat Med. 1947;18(6):601.

    Google Scholar 

  46. Beattie RM Jr. Modifications of conventional medical-surgical techniques for use in null gravity. In: The case for mars; Proceedings of the Conference, Boulder, CO, April 29–May 2, 1981 (A84-39226 18–91). San Diego: Univelt Inc.; 1984. p. 181–4.

    Google Scholar 

  47. Johnston SL, Campbell MR, Billica RD, et al. Validation of a parabolic flight microgravity CPR animal model KRUG life sciences and medical operations. In: Presented at the 67th Annual Scientific Meeting of the Aerospace Medical Association, Atlanta, Georgia, 1996. Houston: NASA Johnson Space Center; 1996.

    Google Scholar 

  48. Garshnek V. Applications of space communications technology to critical human needs—rescue, disaster relief, and remote medical assistance. Space Commun. 1991;8:311–7. (ISSN 0924-8625) Science Communications Studies and the Space Policy Institute, The George Washington University, Washington, DC 20052, USA

    CAS  PubMed  Google Scholar 

  49. Descartin KS, Menger RP, Watkins SD. Applications of Advances in Telemedicine for Long-Duration Spaceflight. 2015 NASA/TM-2015-218562.

    Google Scholar 

  50. Compton, H., Findlay, J., Kelly, G., & Heck, M. L. (1981). Shuttle/STS-1/entry trajectory reconstruction. In 1st Flight Test Conference (p. 2459).

    Google Scholar 

  51. NASA Space flight human system standard—Volume II: Habitability and environmental health, NASA-STD-3001, vol. II, 2007.

    Google Scholar 

  52. Begeman PC, King AI, Prasad P. Spinal loads resulting from-Gx acceleration. SAE Technical Paper; 1973 Feb 1.

    Google Scholar 

  53. Balldin U. Acceleration effects on fighter pilots. Med Aspects Harsh Environ. 2002;2:1014–27.

    Google Scholar 

  54. Fraser TM. Human response to sustained acceleration: a literature review. Washington: Scientific and Technical Information Division, National Aeronautics and Space Administration; 1966. Report Number: NASA SP-103

    Google Scholar 

  55. Pendergast DR, Olszowka A, Farhi LE. Cardiovascular and pulmonary responses to increased acceleration forces during rest and exercise. Aviat Space Environ Med. 2012;83:488–95.

    PubMed  Google Scholar 

  56. Shanahan DF. Human tolerance and crash survivability. Pathological aspects and associate biodynamics in aircraft accident investigation; 2004.

    Google Scholar 

  57. Kumar KV, Norfleet WT. Issues on human acceleration tolerance after long-duration space flights. NASA Technical Memorandum 104753, 1992.

    Google Scholar 

  58. Diedrich A, Mandsager KT, Robertson D. Orthostatic intolerance and vasovagal syncope after spaceflight. In: Vasovagal syncope. Cham: Springer; 2015. p. 309–317.P23.

    Google Scholar 

  59. Pattarini JM, Watkins SD, Somers JT, Barratt MR RCTS.216 (3.10.2.1) Sustained Translational Acceleration Update Recommendation. National Aeronautics and Space Administration, NASA Johnson Space Center 2015.

    Google Scholar 

  60. Blue RS, Pattarini JM, Reyes DP, Mulcahy RA, Garbino A, Mathers CH, Vardiman JL, Castleberry TL, Vanderploeg JM. Tolerance of centrifuge-simulated suborbital spaceflight by medical condition. Aviat Space Environ Med. 2014;85(7):721–9.

    PubMed  Google Scholar 

  61. Pattarini JM, et al. Preflight screening techniques for centrifuge-simulated suborbital spaceflight. Aviat Space Environ Med. 2014;85(12):1217–21.

    PubMed  Google Scholar 

  62. Gohmert D, Brinkley JW, Somers JT. Application of the Brinkley dynamic response criterion to spacecraft transient dynamic events. NASA/TM-2017-217380-REV1.

    Google Scholar 

  63. Mohler SR, Nicogossian AET, McCormack PD, Mohler SR. Tumbling and spaceflight: the Gemini VIII experience. Aviat Space Environ Med. 1990;61:62–6.

    CAS  PubMed  Google Scholar 

  64. Pattarini JM, Blue RS, Aikins LT, Law J, Walshe AD, Garbino A, Turney MW, Clark JB. Flat spin and negative Gz in high-altitude free fall: pathophysiology, prevention, and treatment. Aviat Space Environ Med. 2013 Sep 1;84(9):961–70.

    PubMed  Google Scholar 

  65. NASA/TM-2013-217380: Application of the Brinkley Dynamic Response Criterion to Spacecraft Transient Dynamic Events.

    Google Scholar 

  66. Restraint Systems for Civil Aircraft. SAE Aerospace Standard, AS8043B, 2014.

    Google Scholar 

  67. The Russian Soyuz Spacecraft [Internet]. European Space Agency. 2015. [cited 2 February 2018]. Available from http://m.esa.int/Our_Activities/Space_Transportation/Launch_vehicles/.

    Google Scholar 

  68. Sibonga JD. Spaceflight-induced bone loss: is there an osteoporosis risk? Curr Osteoporosis Rep. 2013;11:92–8.

    Google Scholar 

  69. Sibonga JD, Evans HJ, Smith SA, Spector ER, Yardley G, Myer J. Evidence report: Risk of bone fracture due to spaceflight-induced changes to bone. National Aeronautics and Space Administration, NASA Johnson Space Center May 12th, 2017. https://humanresearchroadmap.nasa.gov/evidence/reports/Fracture.pdf.

  70. Mader TH, Gibson CR, Pass AF, et al. Optic disc edema, globe flattening, choroidal folds, and hyperopic shifts observed in astronauts after long-duration space flight. Ophthalmology. 2011;118(10):2058–69.

    PubMed  Google Scholar 

  71. Stenger MB, Tarver WJ. Risk of Spaceflight Associated Neuro-ocular Syndrome. Evidence Report, NASA Human Research Program. 2017. ntrs.nasa.gov/archive/nasa/casi.ntrs.nasa.gov/20180000936.pdf

    Google Scholar 

  72. Lee AG, et al. Space flight–associated neuro-ocular syndrome. JAMA Ophthalmol. 2017;135(9):992–4.

    PubMed  Google Scholar 

  73. Stenger MB, Lee SM, Westby CM, Ribeiro LC, Phillips TR, Martin DS, et al. Abdomen-high elastic gradient compression garments during post-spaceflight stand tests. Aviat Space Environ Med. 2013;84(5):459–66.

    PubMed  Google Scholar 

  74. Bungo MW, Charles JB, Johnson PC Jr. Cardiovascular deconditioning during space flight and the use of saline as a countermeasure to orthostatic intolerance. Aviat Space Environ Med. 1985;56(10):985–90.

    CAS  PubMed  Google Scholar 

  75. Petersen LG, Petersen JC, Andresen M, Secher NH, Juhler M. Postural influence on intracranial and cerebral perfusion pressure in ambulatory neurosurgical patients. Am J Physiol Regul Integr Comp Physiol 2015:ajpregu 00302 2015. doi:https://doi.org/10.1152/ajpregu.00302.2015

  76. Tankisi A, Rasmussen M, Juul N, Cold GE. The effects of 10 degrees reverse Trendelenburg position on subdural intracranial pressure and cerebral perfusion pressure in patients subjected to craniotomy for cerebral aneurysm. J Neurosurg Anesthesiol. 2006;18(1):11–7.

    PubMed  Google Scholar 

  77. Ng I, Lim J, Wong HB. Effects of head posture on cerebral hemodynamics: its influences on intracranial pressure, cerebral perfusion pressure, and cerebral oxygenation. Neurosurgery. 2004;54(3):593–7. discussion 8

    PubMed  Google Scholar 

  78. Larsen JR, Haure P, Cold GE. Reverse Trendelenburg position reduces intracranial pressure during craniotomy. J Neurosurg Anesthesiol. 2002;14(1):16–21.

    Google Scholar 

  79. Durward QJ, Amacher AL, Del Maestro RF, Sibbald WJ. Cerebral and cardiovascular responses to changes in head elevation in patients with intracranial hypertension. J Neurosurg. 1983;59(6):938–44. https://doi.org/10.3171/jns.1983.59.6.0938.

    Article  CAS  PubMed  Google Scholar 

  80. Palinkas LA, Johnson JC, Boster JS. Social support and depressed mood in isolated and confined environments. Acta Astronaut. 2004;54:639–47.

    PubMed  Google Scholar 

  81. Palinkas LA, Suedfeld P. Psychological effects of polar expeditions. Lancet. 2008;371:153–63.

    PubMed  Google Scholar 

  82. Ursin H. Psychobiological studies of individuals in small isolated groups in the Antarctic and space analogues. Environ Behav. 1991;23:766–81.

    Google Scholar 

  83. Kleitman. The sleep-wakefulness cycle in submarine personnel. In: Human factors in undersea warfare, NRC, sleep and wakefulness study, 1963.

    Google Scholar 

  84. Weybrew. The Mental Health of Nuclear Submariners in the US Navy, Military Medicine, March 1979, pp 188–191.

    Google Scholar 

  85. Palinkas LA, Suedfeld P, Steel GD. Psychological functioning among members of a small polar expedition. Aviat Space Environ Med. 1995;66(10):943–50.

    CAS  PubMed  Google Scholar 

  86. Johnston SL, Jones JA, Ross CE, Cerimele CJ, Fox JL. NASA International Space Station (ISS) Crew Return Vehicle (CRV) Seat and Cockpit configuration and design challenges. In: 70th Annual Scientific Meeting of the Aerospace Medical Association, Detroit, Michigan, 1998.

    Google Scholar 

  87. Smart K. Considerations for crew rescue from the ISS. J Brit Interplanetary Soc. 2001;54(3/4)

    Google Scholar 

  88. Smart K. Issues in life support and human factors in crew rescue from the ISS. Life Support Biosph Sci. 2001;7(4):319–25.

    CAS  PubMed  Google Scholar 

  89. Bagian J, Allen R. Aeromedical transport. In: Auerbach PS, editor. Wilderness medicine. 4th ed: Mosby-Year Book Inc.; 2001. p. 640–72.

    Google Scholar 

  90. Owen M, Galea ER, Lawrence PJ, Filippidis L. AASK, aircraft accident statistics and knowledge—a database of human experience in evacuation, derived from aviation accident reports. Aeronaut J (0001-9240). 1998;102(1017):353–63.

    Google Scholar 

  91. Brinkley JW. Impact accelerations. In: Foundations of space biology and medicine; 1975, vol. 2, Book 1, Part 2, Chapter 6, pp 214–246 NASA Special Publication No. 374. AMRL-TR-73-68 (AD 771612).

    Google Scholar 

  92. Nicogossian A, Sawin C, Huntoon C. Overall physiological response to spaceflight. In: Nicogossian AE, Pool SL, Huntoon CL, editors. Space physiology and medicine. 3rd ed. Malvern: Lea & Febiger; 1993. p. 213–27.

    Google Scholar 

  93. ISS Crew Transportation and Serviced Requirements Document, CCT-REQ-1130, Rev E 2016.

    Google Scholar 

  94. Olofinboba O, Hamblin C, Dorneich MC, DeMers R, Wise J.(2008) “The design of controls for NASA’s Orion Crew exploration Vehicle. In: Proceedings of the European Association for Aviation Psychology 2008 Conference.

    Google Scholar 

  95. Brinkley JW. Human crashworthiness and crash load limits. In: Advisory Group for Aerospace Research and Development (AGARD) - CP443 “Energy absorption of aircraft structures as an aspect of crashworthiness”, AGARD, Nevilly sur Seine, France, 1988, NASA ID 19890009068 N (89N18439).

    Google Scholar 

  96. Brinkley JW, Specker LJ, Mosher ME. Development of acceleration exposure limits for advanced escape systems” In: Implications of Advanced Technologies for Air and Spacecraft Escape, NATO AGARD Proceedings, AGARD-CP-472; 1990.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to James M. Pattarini .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Science+Business Media, LLC, part of Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Johnston, S.L., Smart, K.T., Pattarini, J.M. (2019). Medical Evacuation Risk and Crew Transport. In: Barratt, M., Baker, E., Pool, S. (eds) Principles of Clinical Medicine for Space Flight. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-9889-0_10

Download citation

  • DOI: https://doi.org/10.1007/978-1-4939-9889-0_10

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4939-9887-6

  • Online ISBN: 978-1-4939-9889-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics