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Toxicologic Pathology for Non-Pathologists pp 483–535Cite as

Pathology of the Integumentary System

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Abstract

The skin, the largest organ in the human body, is anatomically quite complex and serves a diverse array of biologic functions in all species. In this chapter, we provide an overview of the structure and function of the skin. Some basic concepts of dermatotoxicology are discussed. The various responses to injury of the skin including inflammation, irritation and corrosion, and hypersensitivity reactions are presented. Phototoxicity and metabolic and endocrine effects on the skin are addressed. Various tumors of the skin as they relate to drug development are provided. Some of the important animal models for studying cutaneous disease, including the pros and cons of each, are discussed. There are several case examples presented to highlight applications of dermatopathology in nonclinical species.

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Change history

  • 12 February 2020

    This chapter was inadvertently published without including the following contributors’ names: Lars Mecklenburg, Lydia Andrews-Jones, and David F. Adams. The correct authorship for this chapter should have been Kelly L. Diegel, Lars Mecklenburg, Lydia Andrews-Jones, and David F. Adams, and this correction is updated in the chapter.

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Author information

Authors and Affiliations

  1. GlaxoSmithKline, Collegeville, PA, USA

    Kelly L. Diegel & David F. Adams

  2. Covance Preclinical Services GmbH, Münster, Germany

    Lars Mecklenburg

  3. Allergan, Irvine, CA, USA

    Lydia Andrews-Jones

Authors
  1. Kelly L. Diegel
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  2. Lars Mecklenburg
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  3. Lydia Andrews-Jones
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  4. David F. Adams
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Correspondence to Kelly L. Diegel .

Editor information

Editors and Affiliations

  1. North Carolina Laboratory, Experimental Pathology Laboratories, Inc., Durham, NC, USA

    Thomas J. Steinbach

  2. Charles River Laboratories, Inc., Mattawan, MI, USA

    Daniel J. Patrick

  3. MEC Regulatory and Toxicology Consulting, LLC, Moorpark, CA, USA

    Mary Ellen Cosenza

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Diegel, K.L., Mecklenburg, L., Andrews-Jones, L., Adams, D.F. (2019). Pathology of the Integumentary System. In: Steinbach, T., Patrick, D., Cosenza, M. (eds) Toxicologic Pathology for Non-Pathologists. Humana, New York, NY. https://doi.org/10.1007/978-1-4939-9777-0_12

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