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The Interaction Between L7Ae Family of Proteins and RNA Kink Turns

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Biophysics of RNA-Protein Interactions

Part of the book series: Biological and Medical Physics, Biomedical Engineering ((BIOMEDICAL))

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Abstract

The L7Ae superfamily of proteins are widespread, with important roles in the ribosome, snoRNP structures, and spliceosome assembly. They bind extremely tightly and selectively to k-turn structures in RNA. An alpha helix is placed in the widened major groove on the outside of the RNA kink in order to make both sequence-specific and non-specific interactions. The interaction is disrupted by N6-methylation of adenine at a specific position, and this can modulate the assembly of human box C/D snoRNP. L7Ae-k-turn complexes can be used in nanoconstruction to generate a variety of molecular objects.

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  1. Cancer Research UK Nucleic Acid Structure Research Group, MSI/WTB Complex, The University of Dundee, Dow Street, Dundee, DD1 5EH, UK

    Lin Huang & David M. J. Lilley

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  1. Lin Huang
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  2. David M. J. Lilley
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Correspondence to David M. J. Lilley .

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  1. Kavli Institute of NanoScience, Delft University of Technology, Delft, Zuid-Holland, The Netherlands

    Chirlmin Joo

  2. Department of Medicine, Imperial College London, London, UK

    David Rueda

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Huang, L., Lilley, D.M.J. (2019). The Interaction Between L7Ae Family of Proteins and RNA Kink Turns. In: Joo, C., Rueda, D. (eds) Biophysics of RNA-Protein Interactions. Biological and Medical Physics, Biomedical Engineering. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-9726-8_2

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