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How Proteins Recognize RNA

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Biophysics of RNA-Protein Interactions

Part of the book series: Biological and Medical Physics, Biomedical Engineering ((BIOMEDICAL))

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Abstract

RNA and protein interact to form ribonucleoprotein complex (RNP) that performs structural, catalytic and regulatory roles in the cell. These RNA–protein interactions are facilitated either by the primary RNA sequence or by the RNA secondary structural motifs. Once formed, these RNP complexes undergo multiple conformational changes in either or both RNA and protein. Understanding the interactions and conformational dynamics of RNA–protein complexes is significant but quite challenging. Recent advances and structural information about different RNA–protein complexes open the possibility of dissecting the interactions in the molecular level. This review is an overview of different types of RNA-binding proteins and how they recognize their target RNAs.

This chapter is based on a dissertation submitted in 2011 (Department of Chemistry, Wayne State University, Detroit MI).

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Acknowledgements

RL would like to thank Dr. Amanda Solem and Dr. Sharla Wood for their help and Dr. David Rueda for comments and suggestions on the manuscripts. RL is supported by the start-up funds from  the University of Tennessee, Knoxville.

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  1. Department of Biochemistry & Cellular and Molecular Biology, University of Tennessee, Knoxville, TN, 37996, USA

    Rajan Lamichhane

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  1. Rajan Lamichhane
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Correspondence to Rajan Lamichhane .

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  1. Kavli Institute of NanoScience, Delft University of Technology, Delft, Zuid-Holland, The Netherlands

    Chirlmin Joo

  2. Department of Medicine, Imperial College London, London, UK

    David Rueda

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Lamichhane, R. (2019). How Proteins Recognize RNA. In: Joo, C., Rueda, D. (eds) Biophysics of RNA-Protein Interactions. Biological and Medical Physics, Biomedical Engineering. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-9726-8_1

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  • DOI: https://doi.org/10.1007/978-1-4939-9726-8_1

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