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Enterobacteriaceae in Transplantation

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Principles and Practice of Transplant Infectious Diseases

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Abstract

Enterobacteriaceae comprise important pathogens for recipients of solid organ and hematopoietic stem cell transplants. Especially common in the early posttransplant period when transplant recipients are still hospitalized, they can occur at any time following the procedure. Increasing frequency of colonization and invasive disease due to antimicrobial-resistant pathogens has been described in recipients of solid organ and hematopoietic stem cell transplants. In solid organ transplant recipients, surgical considerations may affect the development of these infections, and transplant organ-specific infections are frequently seen. In stem cell recipients, blood stream infections are among the most common manifestations. In cases of respiratory tract, superficial wound, and urinary tract isolation of Enterobacteriaceae, it is important to differentiate colonization from true infection. The choice of appropriate antimicrobials should include consideration of the risk for antimicrobial resistance. Source control may be critical to cure infection, especially when the patient has either line-related bloodstream infection or surgical site/wound involvement. Transplant recipients may also be at risk for infection with Enterobacteriaceae that are not typically considered pathogenic in the normal host; consequently, all cultures should be carefully interpreted with respect to clinical presentation and the source of the culture.

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References

  1. Meatherall BL, Gregson D, Ross T, et al. Incidence, risk factors, and outcomes of Klebsiella pneumoniae bacteremia. Am J Med. 2009;122:866.

    Article  PubMed  Google Scholar 

  2. Centers for Disease Control and Prevention. Surveillance for Emerging Antimicrobial Resistance Connected to Healthcare (S.E.A.R.C.H.) http://www.cdc.gov/hai/. Accessed 4/12/2017.

  3. Antimicrobial resistance surveillance in Europe 2015. http://ecdc.europa.eu/en/publications/_layouts/forms/Publication_DispForm.aspx?List=4f55ad51-4aed-4d32-b960-af70113dbb90&ID=1637. Accessed 4/12/2017.

  4. Kawecki D, Kwiatkowski A, Sawicka-Grzelak A, et al. Urinary tract infections in the early posttransplant period after kidney transplantation: etiologic agents and their susceptibility. Transplant Proc. 2011;43:2991–3.

    Article  CAS  PubMed  Google Scholar 

  5. Dantas SR, Kuboyama RH, Mazzali M, et al. Nosocomial infections in renal transplant patients: risk factors and treatment implications associated with urinary tract and surgical site infections. J Hosp Infect. 2006;63(2):117–23.

    Article  CAS  PubMed  Google Scholar 

  6. Giral M, Pascuariello G, Karam G, et al. Acute graft pyelonephritis and long-term kidney allograft outcome. Kidney Int. 2002;61:1880–6.

    Article  PubMed  Google Scholar 

  7. Vidal E, Torre-Cisneros J, Blanes M, et al. Bacterial urinary tract infection after solid organ transplantation in the RESITRA cohort. Transpl Infect Dis. 2012;14:595–603.

    Article  CAS  PubMed  Google Scholar 

  8. Herrero-Martínez JM, Lumbreras C, Manrique A, et al. Epidemiology, risk factors and impact on long-term pancreatic function of infection following pancreas-kidney transplantation. Clin Microbiol Infect. 2013;19:1132–9.

    Article  PubMed  Google Scholar 

  9. Brooks RG, Hofflin JM, Jamieson SW, et al. Infectious complications in heart-lung transplant recipients. Am J Med. 1985;79:412–22.

    Article  CAS  PubMed  Google Scholar 

  10. Gullestad L, Eisjkauer H, Gustafsson F, et al. Long-term outcomes of thoracic transplant recipients following conversion to everolimus with reduced calcineurin inhibitor in a multicenter, open-label, randomized trial. Transpl Int. 2016;29:819–29.

    Article  CAS  PubMed  Google Scholar 

  11. Yun JH, Kee S-O, Jo K-W, et al. Infections after lung transplantation: time of occurrence, sites, and microbiologic etiologies. Korean J Intern Med. 2015;30:506–14.bl.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  12. Paya CV, Wiesner RH, Herman PE, et al. Risk factors for cytomegalovirus and severe bacterial infections following liver transplantation: a prospective multivariate time-dependent analysis. J Hepatol. 1993;18:185–95.

    Article  CAS  PubMed  Google Scholar 

  13. Lumbreras C, Lizasoin M, Moreno E, et al. Major bacterial infections following liver transplantation: a prospective study. Hepatogastroenterol. 1992;39:362–5.

    CAS  Google Scholar 

  14. Linares L, García GJ, Cervera C, et al. Early bacteremia after solid organ transplantation. Transplant Proc. 2009;41:2262–4.

    Article  CAS  PubMed  Google Scholar 

  15. Wingard JR, Hsu J, Hiemenz JW. Hematopoietic stem cell transplantation: an overview of infection risks and epidemiology. Infect Dis Clin North Am. 2010;24:257–72.

    Article  PubMed  Google Scholar 

  16. Mikulska M, Del Bono V, Viscoli C. Bacterial infections in hematopoietic stem cell transplantation recipients. Curr Opin Hematol. 2014;21:451–8.

    Article  CAS  PubMed  Google Scholar 

  17. Balletto E, Mikulska M. Bacterial infections in hematopoietic stem cell transplant recipients. Mediterr J Hematol Infect Dis. 2015;7:e2015045.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Zając-Spychała O, Wachowiak J, Pieczonka A, Siewiera K, Frączkiewicz J, Kałwak K, et al. Bacterial infections in pediatric hematopoietic stem cell transplantation recipients: incidence, epidemiology, and spectrum of pathogens: report of the Polish Pediatric Group for hematopoietic stem cell transplantation. Transpl Infect Dis. 2016;18:690–8.

    Article  PubMed  Google Scholar 

  19. Parasuraman R, Julian K. Urinary tract infections in solid organ transplantation. Am J Transplant. 2013;13:327–36.

    Article  CAS  PubMed  Google Scholar 

  20. Green H, Rahamimov R, Gafter U, Leibovitci L, Paul M. Antibiotic prophylaxis for urinary tract infections in renal transplant recipients: systematic review and meta-analysis. Transpl Infect Dis. 2011;13:441–7.

    Article  CAS  PubMed  Google Scholar 

  21. Espinar EJ, Miranda IM, Costa-de-Oliveira S, Rocha R, Rodrigues AG, Pina-Vaz C. Urinary tract infections in kidney transplant patients due to Escherichia coli and Klebsiella pneumoniae-producing extended-spectrum β-lactamases: risk factors and molecular epidemiology. PLoS One. 2015;10(8):e0134737.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  22. Azap Ö, Togan T, Yesilkaya A, Arslan H, Haberal M. Antimicrobial susceptibilities of uropathogen Escherichia coli in renal transplant recipients: dramatic increase in ciprofloxacin resistance. Transplant Proc. 2013;45:956–7.

    Article  CAS  PubMed  Google Scholar 

  23. Gołębiewska J, Tarasewicz A, Dębska-Ślizień A, Rutkowski B. Klebsiella spp urinary tract infections during first year after renal transplantation. Transplant Proc. 2014;46:2748–51.

    Article  PubMed  Google Scholar 

  24. Freire MP, Abdala E, Moura ML, et al. Risk factors and outcome of infections with Klebsiella pneumoniae carbapenemase-producing K. pneumoniae in kidney transplant recipients. Infection. 2015;43:315–23.

    Article  CAS  PubMed  Google Scholar 

  25. Brizendine KD, Richter SS, Cober ED, van Duin D. Carbapenem-resistant Klebsiella pneumoniae urinary tract infection following solid organ transplantation. Antimicrob Agents Chemother. 2015;59:553–7.

    Article  PubMed  CAS  Google Scholar 

  26. Pelle G, Vimont S, Levy PP, et al. Acute pyelonephritis represents a risk factor impairing long-term kidney graft function. Am J Transplant. 2007;7:899–907.

    Article  CAS  PubMed  Google Scholar 

  27. Audard V, Amor M, Desvaux D, et al. Acute graft pyelonephritis: a potential cause of acute rejection in renal transplant. Transplantation. 2005;80:1128–30.

    Article  PubMed  Google Scholar 

  28. Kamath NS, John GT, Neelakantan N, et al. Acute graft pyelonephritis following renal transplantation. Transpl Infect Dis. 2006;8:140–7.

    Article  CAS  PubMed  Google Scholar 

  29. Naik AS, Dharnidharka VR, Schnitzler MA, et al. Clinical and economic consequences of first-year urinary tract infections, sepsis, and pneumonia in contemporary kidney transplantation practice. Transpl Int. 2016;29:241–52.

    Article  PubMed  Google Scholar 

  30. Abbott KC, Swanson SJ, Richter ER, et al. Late urinary tract infection after renal transplantation in the United States. Am J Kidney Dis. 2004;44:353–62.

    Article  PubMed  Google Scholar 

  31. Fiorante S, Fernández-Ruiz M, López-Medrano F, et al. Acute graft pyelonephritis in renal transplant recipients: incidence, risk factors and long-term outcome. Nephrol Dial Transplant. 2011;26:1065–73.

    Article  PubMed  Google Scholar 

  32. Camargo LF, Esteves ABA, Ulisses LRS, Rivelli GG, Mazzali M. Urinary tract infection in renal transplant recipients: incidence, risk factors, and impact on graft function. Transplant Proc. 2014;46:1757–9.

    Article  CAS  PubMed  Google Scholar 

  33. Ariza-Heredia EJ, Beam EN, Lesnick TG, Cosio FG, Kremers WK, Razonable RR. Impact of urinary tract infection on allograft function after kidney transplantation. Clin Transpl. 2014;28:683–90.

    Article  Google Scholar 

  34. George DL, Arnow PM, Fox AS, et al. Bacterial infection as a complication of liver transplantation: epidemiology and risk factors. Rev Infect Dis. 1991;3:287–96.

    Google Scholar 

  35. Viehman JA, Clancy CJ, Clarke L, et al. Surgical site infections after liver transplantation: emergence of multidrug-resistant bacteria and implications for prophylaxis and treatment strategies. Transplantation. 2016;100:2107–14.

    Article  CAS  PubMed  Google Scholar 

  36. Kornasiewicz O, Hołówko W, Grąt M, et al. Hepatic abscess: a rare complication after liver transplant. Clin Transpl. 2016;30:1230–5.

    Article  CAS  Google Scholar 

  37. Wade JJ, Rolando N, Hayllar K, et al. Bacterial and fungal infections after liver transplantation: an analysis of 284 patients. Hepatology. 1995;21:1328–36.

    Article  CAS  PubMed  Google Scholar 

  38. Bubak ME, Porayko MK, Krom RAF, et al. Complications of liver biopsy in liver transplant patients: increased sepsis associated with choledochojejunostomy. Hepatology. 1991;14:1063–5.

    Article  CAS  PubMed  Google Scholar 

  39. Krom RAF, Kingma LM, Haagsma EB, et al. Choledochocholedochostomy, a relatively safe procedure in orthotopic liver transplantation. Surgery. 1985;97:552–6.

    CAS  PubMed  Google Scholar 

  40. Arnow PM, Zachary KC, Thistlethwaite JR, Thompson KD, Bova JL, Newell KA. Pathogenesis of early operative site infections after orthotopic liver transplantation. Transplantation. 1998;65:1500–3.

    Article  CAS  PubMed  Google Scholar 

  41. Yamamoto M, Takakura S, Iinuma Y, et al. Changes in surgical site infections after living donor liver transplantation. PLoS One. 2015;10(8):e0136559.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  42. Kotloff RM, Ahya VN, Crawford SW. Pulmonary complications of solid organ and hematopoietic stem cell transplantation. Am J Respir Crit Care Med. 2004;170(1):22–48.

    Article  PubMed  Google Scholar 

  43. Kramer MR, Marshall SE, Starnes VA, et al. Infectious complications in heart-lung transplantation. Analysis of 200 episodes. Arch Intern Med. 1993;153(17):2010–6.

    Article  CAS  PubMed  Google Scholar 

  44. Maurer JR, Tullis DE, Grossman RF, et al. Infectious complications following isolated lung transplantation. Chest. 1992;101(4):1056–9.

    Article  CAS  PubMed  Google Scholar 

  45. Cisneros JM, Munoz P, Torre-Cisneros J, et al. Pneumonia after heart transplantation: a multi-institutional study. Spanish Transplantation Infection Study Group. Clin Infect Dis. 1998;27(2):324–31.

    Article  CAS  PubMed  Google Scholar 

  46. Cervera C, Augusti C, Marcos MA, et al. Microbiologic features and outcome of pneumonia in transplanted patients. Diagn Microbiol Infect Dis. 2006;55:47–54.

    Article  PubMed  Google Scholar 

  47. Bonatti H, Pruett TL, Brandacher G, et al. Pneumonia in solid organ recipients: Spectrum of pathogens in 217 episodes. Transplant Proc. 2009;41:371–4.

    Article  CAS  PubMed  Google Scholar 

  48. Aguilar-Guisado M, Jiménez-Jambrina M, Espigado I, et al. Pneumonia in allogeneic stem cell transplantation recipients: a multicenter prospective study. Clin Transpl. 2011;25:E629–38.

    Article  Google Scholar 

  49. Giannella M, Muñoz P, Alarcón JM, et al. Pneumonia in solid organ transplant recipients: a prospective multicenter study. Transpl Infect Dis. 2014;16:232–41.

    Article  CAS  PubMed  Google Scholar 

  50. Bige N, Zafrani L, Lambert J, et al. Severe infections requiring intensive care unit admission in kidney transplant recipients: impact on graft outcome. Transpl Infect Dis. 2014;16:588–96.

    Article  CAS  PubMed  Google Scholar 

  51. Mermel LA, Maki DG. Bacterial pneumonia in solid organ transplantation. Semin Respir Infect. 1990;5(1):10–29.

    CAS  PubMed  Google Scholar 

  52. Patel SR, Kirby TJ, McCarthy PM, et al. Lung transplantation: the Cleveland Clinic experience. Cleve Clin J Med. 1993;60:303–19.

    Article  CAS  PubMed  Google Scholar 

  53. Deusch E, End A, Grimm M, et al. Early bacterial infections in lung transplant recipients. Chest. 1993;104:1412–6.52.

    Article  CAS  PubMed  Google Scholar 

  54. Aguilar-Guisado M, Givalda J, Ussetti P. Pneumonia after lung transplantation in the Resitra Cohort: a multicenter prospective study. Am J Transplant. 2007;7:1989–96.

    Article  CAS  PubMed  Google Scholar 

  55. Dudau D, Camous J, Marchand S, et al. Incidence of nosocomial pneumonia and risk of recurrence after antimicrobial therapy in critically ill lung and heart–lung transplant patients. Clin Transpl. 2014;28:27–36.

    Article  Google Scholar 

  56. Lumbreras C, Fernandez I, Velosa J, et al. Infectious complications following pancreatic transplantation: incidence, microbiological and clinical characteristics, and outcome. Clin Infect Dis. 1995;20:514–20.

    Article  CAS  PubMed  Google Scholar 

  57. Paya CV, Hermans PE. Bacterial infections after liver transplantation. Eur J Clin Microbiol Infect Dis. 1989;8:499–504.

    Article  CAS  PubMed  Google Scholar 

  58. Ramos A, Asensio A, Muñez E, et al. Incisional surgical infection in heart transplantation. Transpl Infect Dis. 2008;10:298–302.

    Article  CAS  PubMed  Google Scholar 

  59. Zanfi C, Cescon M, Lauro A, et al. Incidence and management of abdominal closure-related complications in adult intestinal transplantation. Transplantation. 2008;85:1607–9.

    Article  PubMed  Google Scholar 

  60. Loinaz C, Kato T, Nishida S, et al. Bacterial infections after intestine and multivisceral transplantation. The experience of the University of Miami (1994-2001). Hepatogastroenterology. 2006;53:234–42.

    CAS  PubMed  Google Scholar 

  61. Linhares MM, Gonzalez AM, Triviño T. Simultaneous pancreas-kidney transplantation: infectious complications and microbiological aspects. Transplant Proc. 2004;36:980–1.

    Article  CAS  PubMed  Google Scholar 

  62. Hellinger WC, Crook JE, Heckman MG, et al. Surgical site infection after liver transplantation: risk factors and association with graft loss or death. Transplantation. 2009;87:1387–93.

    Article  PubMed  Google Scholar 

  63. Michalak G, Kwiatkowski A, Bieniasz M, et al. Infectious complications after simultaneous pancreas-kidney transplantation. Transplant Proc. 2005;37:3560–3.

    Article  CAS  PubMed  Google Scholar 

  64. Perdiz LB, Furtado GH, Linhares MM, et al. Incidence and risk factors for surgical site infection after simultaneous pancreas-kidney transplantation. J Hosp Infect. 2009;72:326–31.

    Article  CAS  PubMed  Google Scholar 

  65. Shields RK, Clancy CJ, Minces L, et al. Epidemiology and outcomes of deep surgical site infections following lung transplantation. Am J Transplant. 2013;13:2137–45.

    Article  CAS  PubMed  Google Scholar 

  66. Kawecki D, Chmura A, Pacholczyk M, et al. Surgical site infections in liver recipients in the early posttransplantation period: etiological agents and susceptibility profiles. Transplant Proc. 2007;39:2800–6.

    Article  CAS  PubMed  Google Scholar 

  67. Rana MM, Sturdevant M, Patel G, Huprikar S. Klebsiella necrotizing soft tissue infections in liver transplant recipients: a case series. Transpl Infect Dis. 2013;15:157–63.

    Article  Google Scholar 

  68. Menezes FG, Wey SB, Peres CA, et al. Risk factors for surgical site infection in kidney transplant recipients. Infect Control Hosp Epidemiol. 2008;29(8):771–3.

    Article  PubMed  Google Scholar 

  69. Asensio A, Ramos A, Cuervas-Mons V, et al. Effect of antibiotic prophylaxis on the risk of surgical site infection in orthotopic liver transplant. Liver Transpl. 2008;14(6):799–805.

    Article  PubMed  Google Scholar 

  70. Peraira JR, Segovia J, Arroyo R, et al. High incidence of severe infections in heart transplant recipients receiving tacrolimus. Transplant Proc. 2003;35:1999–2000.

    Article  CAS  PubMed  Google Scholar 

  71. Freire MP, Antonopoulos IM, Piovesan AC, et al. Amikacin prophylaxis and risk factors for surgical site infection after kidney transplantation. Transplantation. 2015;99:521–7.

    Article  CAS  PubMed  Google Scholar 

  72. Freire MP, Soares Oshiro IC, Bonazzi PR, et al. Surgical site infections in liver transplant recipients in the model for end-stage liver disease era: an analysis of the epidemiology, risk factors, and outcomes. Liver Transpl. 2013;19:1011–9.

    Article  PubMed  Google Scholar 

  73. Zuckermann A, Barten MJ. Surgical wound complications after heart transplantation. Transpl Int. 2011;24:627–36.

    Article  PubMed  Google Scholar 

  74. Kuppahally S, Al-Khaldi A, Weisshaar D, et al. Wound healing complications with de novo sirolimus versus mycophenolate mofetil-based regimen in cardiac transplant recipients. Am J Transplant. 2006;6:986–92.

    Article  CAS  PubMed  Google Scholar 

  75. Husain S, Chan KM, Palmer SM, et al. Bacteremia in lung transplant recipients in the current era. Am J Transplant. 2006;6:3000–7.

    Article  CAS  PubMed  Google Scholar 

  76. Wagener MM, Yu VL. Bacteremia in transplant recipients: a prospective study of demographics, etiologic agents, risk factors, and outcomes. Am J Infect Control. 1992;20:239–47.

    Article  CAS  PubMed  Google Scholar 

  77. Rodriguez C, Munoz P, Rodriguez-Creixems M, et al. Bloodstream infections among heart transplant recipients. Transplantation. 2006;81:384–91.

    Article  PubMed  Google Scholar 

  78. Al-Hasan MN, Razonable RR, Eckel-Passowd JE, et al. Incidence rate and outcome of gram-negative bloodstream infection in solid organ transplant recipients. Am J Transplant. 2009;9:835–43.

    Article  CAS  PubMed  Google Scholar 

  79. Singh N, Gayowski T, Wagener MM, et al. Bloodstream infections in liver transplant recipients receiving tacrolimus. Clin Transpl. 1997;11:275–81.

    CAS  Google Scholar 

  80. Ye QF, Zhao J, Wan QQ, et al. Frequency and clinical outcomes of ESKAPE bacteremia in solid organ transplantation and the risk factors for mortality. Transpl Infect Dis. 2014;16:767–74.

    Article  CAS  PubMed  Google Scholar 

  81. Blennow O, Ljungman P, Sparrelid E, Mattsson J, Remberger M. Incidence, risk factors, and outcome of bloodstream infections during the pre-engraftment phase in 521 allogeneic hematopoietic stem cell transplantations. Transpl Infect Dis. 2014;16:106–14.

    Article  CAS  PubMed  Google Scholar 

  82. Wang CH, Chang FY, Chao TY, Kao WY, Ho CL, Chen YC, et al. Characteristics comparisons of bacteremia in allogeneic and autologous hematopoietic stem cell-transplant recipients with levofloxacin prophylaxis and influence on resistant bacteria emergence. J Microbiol Immunol Infect. 2016;pii: S1684–1182(16)30003–30002.

    Google Scholar 

  83. Poutsiaka DD, Price LL, Ucuzian A, Chan GW, Miller KB, Snydman DR. Blood stream infection after hematopoietic stem cell transplantation is associated with increased mortality. Bone Marrow Transplant. 2007;40:63–70.

    Article  CAS  PubMed  Google Scholar 

  84. Shigematsu A, Yamamoto S, Sugita J, et al. Increased risk of bacterial infection after engraftment in patients treated with allogeneic bone marrow transplantation following reduced-intensity conditioning regimen. Transpl Infect Dis. 2010;12:412–20.

    Article  CAS  PubMed  Google Scholar 

  85. Hong J, Moon SM, Ahn HK, et al. Comparison of characteristics of bacterial bloodstream infection between adult patients with allogeneic and autologous hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2013;19:988–99.

    Article  Google Scholar 

  86. Qureshi ZA, Paterson DL, Pakstis DL, et al. Risk factors and outcome of extended-spectrum beta-lactamase producing bloodstream infections. Int J Antimicrob Agents. 2011;37(1):26–32.

    Article  CAS  PubMed  Google Scholar 

  87. Qureshi ZA, Paterson DL, Peleg AY, et al. Clinical characteristics of bacteremia caused by extended-spectrum beta-lactamase-producing Enterobacteriaceae in the era of CTX-M-type and KPC-type beta-lactamases. Clin Microbiol Infect. 2012;18(9):887–93.

    Article  CAS  PubMed  Google Scholar 

  88. Mills JP, Talati NJ, Alby K, Han JH. The epidemiology of Carbapenem-Resistant Klebsiella pneumoniae colonization and infection among long-term acute care hospital residents. Infect Control Hosp Epidemiol. 2016;37:55–60.

    Article  PubMed  Google Scholar 

  89. Linares L, Cervera C, Hoyo I, et al. Klebsiella pneumoniae infection in solid organ transplant recipients: epidemiology and antibiotic resistance. Transplant Proc. 2010;42:2941–3.

    Article  CAS  PubMed  Google Scholar 

  90. Patel G, Huprikar S, Factor SH, et al. Outcomes of carbapenem-resistant Klebsiella pneumoniae infection and the impact of antimicrobial and adjunctive therapies. Infect Control Hosp Epidemiol. 2008;29:1099–106.

    Article  PubMed  Google Scholar 

  91. Schwaber MJ, Navon-Venezia S, Kaye KS, et al. Clinical and economic impact of bacteremia with extended-spectrumβ –lactamase- producing Enterobacteriaceae. Antimicrob Agents Chemother. 2006;50:1257–62.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  92. Lee SY, Kotapati S, Kuti JL, et al. Impact of extended-spectrum β-lactamase–producing Escherichia coli and Klebsiella species on clinical outcomes and hospital costs: a matched cohort study. Infect Control Hosp Epidemiol. 2006;27:1226–32.

    Article  PubMed  Google Scholar 

  93. Bodro M, Sabé N, Tubau F, et al. Risk factors and outcomes of bacteremia caused by drug-resistant ESKAPE pathogens in solid-organ transplant recipients. Transplantation. 2013;96:843–9.

    Article  PubMed  Google Scholar 

  94. Bergamasco MD, Barroso Barbosa M, de Oliveira GD, et al. Infection with Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae in solid organ transplantation. Transpl Infect Dis. 2012;14(2):198–205.

    Article  CAS  PubMed  Google Scholar 

  95. Paterson DL, Singh N, Rihs JD, et al. Control of an outbreak of infection due to extended-spectrum beta-lactamase-producing Escherichia coli in a liver transplantation unit. Clin Infect Dis. 2001;33:126–8.

    Article  CAS  PubMed  Google Scholar 

  96. Rebuck JA, Olsen KM, Fey PD, et al. Characterization of an outbreak due to extended-spectrum beta-lactamase-producing Klebsiella pneumoniae in a pediatric intensive care unit transplant population. Clin Infect Dis. 2000;31:1368–72.

    Article  CAS  PubMed  Google Scholar 

  97. Martins IS, Moreira BM, Riley LW, et al. Outbreak of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae infection among renal transplant recipients. J Hosp Infect. 2006;64:305–8.

    Article  PubMed  Google Scholar 

  98. Zárate MS, Gales AC, Picão RC, et al. Outbreak of OXY-2 producing Klebsiella oxytoca in a renal transplant unit. J Clin Microbiol. 2008;46:2099–101.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  99. Mathers AJ, Cox HL, Bonatti H, et al. Fatal cross infection by carbapenem-resistant Klebsiella in two liver transplant recipients. Transpl Infect Dis. 2009;11(3):257–65.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  100. Lai CC, Lin TL, Tseng SP, et al. Pelvic abscess caused by New Delhi metallo-beta-lactamase-1-producing Klebsiella oxytoca in Taiwan in a patient who underwent renal transplantation in China. Diagn Microbiol Infect Dis. 2011;71(4):474–5.

    Article  PubMed  Google Scholar 

  101. Mouloudi E, Protonotariou E, Zagorianou A, et al. Bloodstream infections caused by metallo-beta-lactamase/Klebsiella pneumoniae carbapenemase-producing K. pneumoniae among intensive care unit patients in Greece: risk factors for infection and impact of type of resistance on outcomes. Infect Control Hosp Epidemiol. 2010;31(12):1250–6.

    Article  PubMed  Google Scholar 

  102. Pouch SM, Kubin CJ, Satlin MJ, et al. Epidemiology and outcomes of carbapenem-resistant Klebsiella pneumonia bacteriuria in kidney transplant recipients. Transpl Infect Dis. 2015;17:800–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  103. Pereira MR, Scully BF, Pouch SM, et al. Risk factors and outcomes of carbapenem-resistant Klebsiella pneumonia infections in liver transplant recipients. Liver Transpl. 2015;21:1511–9.

    Article  PubMed  PubMed Central  Google Scholar 

  104. Simkins J, Muggia V, Cohen HW, Minamoto GY. Carbapenem-resistant Klebsiella pneumoniae infections in kidney transplant recipients: a case-control study. Transpl Infect Dis. 2014;16:775–82.

    Article  CAS  PubMed  Google Scholar 

  105. Balletto E, Mikulska M. Bacterial infections in hematopoietic stem cell transplant recipients. Mediterr J Hematol Infect Dis. 2015;7(1):e2015045.

    Article  PubMed  PubMed Central  Google Scholar 

  106. Zając-Spychała O, Wachowiak J, Pieczonka A, Siewiera K, Frączkiewicz J, Kałwak K, et al. Bacterial infections in pediatric hematopoietic stem cell transplantation recipients: incidence, epidemiology, and spectrum of pathogens: report of the Polish Pediatric Group for hematopoietic stem cell transplantation. Transpl Infect Dis. 2016;18(5):690–8.

    Article  PubMed  Google Scholar 

  107. Bonadio M, Morelli G, Mori S, Riccioni R, Papineschi F, Petrini M. Fluoroquinolone resistance in hematopoietic stem cell transplant recipients with infectious complications. Biomed Pharmacother. 2005;59(9):511–6.

    Article  CAS  PubMed  Google Scholar 

  108. Satlin MJ, Jenkins SG, Walsh TJ. The global challenge of carbapenem-resistant Enterobacteriaceae in transplant recipients and patients with hematologic malignancies. Clin Infect Dis. 2014;58:1274–83.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  109. Baker TM, Satlin MJ. The growing threat of multidrug-resistant gram-negative infections in patients with hematologic malignancies. Leuk Lymphoma. 2016;57:2245–58.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  110. Iredell J, Brown J, Tagg K. Antibiotic resistance in Enterobacteriaceae: mechanisms and clinical implications. BMJ. 2016;352:h6420.

    Article  PubMed  CAS  Google Scholar 

  111. Nordmann P, Naas T, Poirel L. Global spread of Carbapenemase-producing Enterobacteriaceae. Emerg Infect Dis. 2011;17:1791–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  112. Blumberg E, Green M, Covington SG, et al. Donor derived bacterial infections: report from the Disease Transmission Advisory Committee (DTAC). In: 48th Annual meeting of the Infectious Diseases Society of America. Vancouver. 2010. Available at https://idsa.confex.com/idsa/2010/webprogram/Paper3060.html.

  113. Watkins AC, Vedula GV, Horan J, et al. The deceased organ donor with an “open abdomen”: proceed with caution. Transpl Infect Dis. 2012;14:311–5.

    Article  CAS  PubMed  Google Scholar 

  114. Chung W, Pascoe N, Heseltine G, Qazi Y, Bower WA, Kuehnert M, Wise M, Zheteyeva Y. Transmission of multidrug-resistant Escherichia coli through kidney transplantation – California and Texas, 2009. MMWR. 2010;59(50):1642–6.

    Google Scholar 

  115. Mularoni A, Bertani A, Vizzini G, et al. Outcome of transplantation using organs from donors infected or colonized with carbapenem-resistant gram-negative bacteria. Am J Transplant. 2015;15:2674–82.

    Article  CAS  PubMed  Google Scholar 

  116. Mills JP, Wilck MB, Weikert BC, et al. Successful treatment of a disseminated infection with extensively drug-resistant Klebsiella pneumoniae in a liver transplant recipient with a fosfomycin-based multidrug regimen. Transpl Infect Dis. 2016;18:777–81.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  117. Giani T, Conte V, Mandalà S, et al. Cross-infection of solid organ transplant recipients by a multidrug-resistant Klebsiella pneumoniae isolate producing the OXA-48 carbapenemase, likely derived from a multiorgan donor. J Clin Microbiol. 2014;52:2702–5.

    Article  PubMed  PubMed Central  Google Scholar 

  118. Goldberg E, Bishara J, Lev S, et al. Transplantation from a donor colonized with a multidrug-resistant organism: a case report. Transpl Infect Dis. 2012;14(3):296–9.

    Article  CAS  PubMed  Google Scholar 

  119. Ariza-Heredia EJ, Patel R, Blumberg EA, et al. Outcomes of transplantation using organs from a donor infected with Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae. Transpl Infect Dis. 2012;14(3):229–36.

    Article  CAS  PubMed  Google Scholar 

  120. Ison MG, Grossi P. AST Infectious Diseases Community of Practice. Donor-derived infections in solid organ transplantation. Am J Transplant. 2013;13(Suppl 4):22–30.

    Article  PubMed  Google Scholar 

  121. Miller R, Covington S, Taranto S, et al. Communication gaps associated with donor-derived infections. Am J Transplant. 2015;15:259–64.

    Article  CAS  PubMed  Google Scholar 

  122. https://optn.transplant.hrsa.gov/media/1200/optn_policies.pdf.

  123. Craven DE. 2005 IDSA/ATS Hospital-acquired pneumonia guidelines: new principles for improving management. Johns Hopkins Adv Stud Med Proc. 2006;6(6C):S541–8.

    Google Scholar 

  124. Chan CC, Abi-Saleh WJ, Arroliga AC, et al. Diagnostic yield and therapeutic impact of flexible bronchoscopy in lung transplant recipients. J Heart Lung Transplant. 1996;15(2):196–205.

    CAS  PubMed  Google Scholar 

  125. Harris B, Geyer AI. Diagnostic evaluation of pulmonary abnormalities in patients with hematologic malignancies and hematopoietic cell transplantation. Clin Chest Med. 2017;38:317–31.

    Article  PubMed  PubMed Central  Google Scholar 

  126. Kupeli E, Akcay S, Ulubay G, Ozyurek BA, Ozdemirel TS, Haberal M. Diagnostic utility of flexible bronchoscopy in recipients of solid organ transplants. Transplant Proc. 2011;43:543–6.

    Article  CAS  PubMed  Google Scholar 

  127. Fagon JY, Chastre J, Wolff M, et al. Invasive and noninvasive strategies for management of suspected ventilator-associated pneumonia. A randomized trial. Ann Intern Med. 2000;132:621–30.

    Article  CAS  PubMed  Google Scholar 

  128. Origüen J, López-Medrano F, Fernández-Ruiz M, et al. Should asymptomatic bacteriuria be systematically treated in kidney transplant recipients? Results from a randomized controlled trial. Am J Transplant. 2016;16:2943–53.

    Article  PubMed  Google Scholar 

  129. http://clsi.org/standards/micro/microbiology-files/.

  130. van Duin D, van Delden C. AST Infectious Diseases Community of Practice. Multidrug-resistant gram-negative bacteria infections in solid organ transplantation. Am J Transplant. 2013;13(Suppl 4):31–41.

    Article  PubMed  CAS  Google Scholar 

  131. van Duin D, Cober E, Richter SS, et al. Impact of therapy and strain type on outcomes in urinary tract infections caused by carbapenem-resistant Klebsiella pneumoniae. J Antimicrob Chemother. 2015;70:1203–11.

    PubMed  Google Scholar 

  132. Souli M, Rekatsina PD, Chryssouli Z, et al. Does the activity of the combination of imipenem and colistin in vitro exceed the problem of resistance in metallo-beta-lactamase-producing Klebsiella pneumoniae isolates? Antimicrob Agents Chemother. 2009;53:2133–35.1.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  133. Urban C, Mariano N, Rahal JJ. In vitro double and triple bactericidal activities of doripenem, polymyxin B, and rifampin against multidrugresistant Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Escherichia coli. Antimicrob Agents Chemother. 2010;54:2732–4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  134. Lin KH, Chuang YC, Lee SH, Yu WL. In vitro synergistic antimicrobial effect of imipenem and colistin against an isolate of multidrugresistant Enterobacter cloacae. J Microbiol Immunol Infect. 2010;43:317–22.

    Article  PubMed  Google Scholar 

  135. Falagas ME, Rafailidis PI, Ioannidou E, et al. Colistin therapy for microbiologically documented multidrug-resistant gram-negative bacterial infections: a retrospective cohort study of 258 patients. Int J Antimicrob Agents. 2010;35:194–9.

    Article  CAS  PubMed  Google Scholar 

  136. Kasiakou SK, Michalopoulos A, Soteriades ES, et al. Combination therapy with intravenous colistin for management of infections due to multidrug-resistant gram-negative bacteria in patients without cystic fibrosis. Antimicrob Agents Chemother. 2005;49:3136–46.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  137. Michalopoulos AS, Tsiodras S, Rellos K, et al. Colistin treatment in patients with ICU-acquired infections caused by multiresistant gram-negative bacteria: the renaissance of an old antibiotic. Clin Microbiol Infect. 2005;11:115–21.

    Article  CAS  PubMed  Google Scholar 

  138. Yacoub R, Akl NK. Urinary tract infections and asymptomatic bacteriuria in renal transplantrecipients. J Glob Infect Dis. 2011;3(4):383–9.

    Article  PubMed  PubMed Central  Google Scholar 

  139. Nicolle LE, Bradley S, Colgan R, Rice JC, Schaeffer A, Hooton TM. Infectious Diseases Society of America; American Society of Nephrology; American Geriatric Society. Infectious Diseases Society of America guidelines for the diagnosis and treatment of asymptomatic bacteriuria in adults. Clin Infect Dis. 2005;40:643–54.

    Article  PubMed  Google Scholar 

  140. Freifeld AG, Freifeld AG, Bow EJ, et al. Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 update by the Infectious Diseases Society of America. Clin Infect Dis. 2011;52:e56–93.

    Article  PubMed  Google Scholar 

  141. Tolkoff-Rubin NE, Cosimi AB, Russell PS, et al. A controlled study of trimethoprim-sulfamethoxazole prophylaxis of urinary tract infection in renal transplant recipients. Rev Infect Dis. 1982;4:614–8.

    Article  CAS  PubMed  Google Scholar 

  142. Fox BC, Sollinger HW, Belzer FO, Maki DG. A prospective, randomized, double-blind study of trimethoprimsulfamethoxazole for prophylaxis of infection in renal transplantation: clinical efficacy, absortion of trimethoprimsulfamethoxazole, effects on the microflora, and the cost-benefit of prophylaxis. Am J Med. 1990;89:255–74.

    Article  CAS  PubMed  Google Scholar 

  143. Resino E, San-Juan R, Aguado JM. Selective intestinal decontamination for the prevention of early bacterial infections after liver transplantation. World J Gastroenterol. 2016;22:5950–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  144. Badger IL, Crosby HA, Kong KL, et al. Is selective bowel decontamination of the digestive tract beneficial in liver transplant patients? Interim results of a prospective, randomized trial. Transplant Proc. 1991;23:1460–1.

    CAS  PubMed  Google Scholar 

  145. Smith SD, Jackson RJ, Hannakan CJ, et al. Selective decontamination in pediatric liver transplants. A randomized prospective study. Transplantation. 1993;55:1306–9.

    Article  CAS  PubMed  Google Scholar 

  146. Safdar N, Said A, Lucey MR. The role of selective digestive decontamination for reducing infection in patients undergoing liver transplantation: a systematic review and meta-analysis. Liver Transpl. 2004;10:817–27.

    Article  PubMed  Google Scholar 

  147. Wingard JR, Hsu J, Hiemenz JW. Hematopoietic stem cell transplantation: an overview of infection risks and epidemiology. Infect Dis Clin North Am. 2010;24(2):257–72.

    Article  PubMed  Google Scholar 

  148. Bert F, Larroque B, Paugam-Burtz C, et al. Pretransplant fecal carriage of extended-spectrum β-lactamase-producing Enterobacteriaceae and infection after liver transplant, France. Emerg Infect Dis. 2012;18:908–16.

    Article  PubMed  PubMed Central  Google Scholar 

  149. Lübbert C, Becker-Rux D, Rodloff AC, et al. Colonization of liver transplant recipients with KPC-producing Klebsiella pneumoniae is associated with high infection rates and excess mortality: a case-control analysis. Infection. 2014;42:309–16.

    Article  PubMed  Google Scholar 

  150. Ullmann AJ, Schmidt-Hieber M, Bertz H, et al. Infectious diseases in allogeneic haematopoietic stem cell transplantation: prevention and prophylaxis strategy guidelines 2016. Ann Hematol. 2016;95(9):1435–55.

    Article  PubMed  PubMed Central  Google Scholar 

  151. Facility Guidance for Control of Carbapenem-resistant Enterobacteriaceae (CRE) – November 2015 Update CRE Toolkit. https://www.cdc.gov/hai/pdfs/cre/CRE-guidance-508.pdf.

  152. Sellin JH. The pathophysiology of diarrhea. Clin Transplant. 2001;15(Supple 4):29–35.

    Google Scholar 

  153. Angarone M, Ison MG. Diarrhea in solid organ transplant recipients. Curr Opin Infect Dis. 2015;28:308–16.

    Article  PubMed  Google Scholar 

  154. Arslan H, Inci EK, Azap OK, et al. Etiologic agents of diarrhea in solid organ recipients. Transpl Infect Dis. 2007;9:270–5.

    Article  CAS  PubMed  Google Scholar 

  155. Dhar JM, Al-Khader AA, Al-Sulaiman M, et al. Non-typhoid Salmonella in renal transplant recipients: a report of twenty cases and review of the literature. Q J Med. 1991;78:235–50.

    CAS  PubMed  Google Scholar 

  156. Lübbert C. Antimicrobial therapy of acute diarrhoea: a clinical review. Expert Rev Anti Infect Ther. 2016;14(2):193–206.

    Article  PubMed  CAS  Google Scholar 

  157. Washington JA 2nd, Birk RJ, Ritts RE Jr. Bacteriologic and epidemiologic characteristics of Enterobacter hafniae and Enterobacter liquefaciens. J Infect Dis. 1971;124:379–86.

    Article  PubMed  Google Scholar 

  158. Günthard H, Pennekamp A. Clinical significance of extraintestinal Hafnia alvei isolates from 61 patients and review of the literature. Clin Infect Dis. 1996;22:1040–5.

    Article  PubMed  Google Scholar 

  159. Barry JW, Dominguez EA, Boken DJ, Preheim LC. Hafnia alvei infection after liver transplantation. Clin Infect Dis. 1997;24:1263–4.

    Article  CAS  PubMed  Google Scholar 

  160. Benito MH, Hernández RS, Fernàndez-Reyes MJ, Hernando S. Sepsis induced by Hafnia alvei in a kidney transplant patient. Nefrologia. 2008;28:470–1.

    PubMed  Google Scholar 

  161. Cardile AP, Forbes D, Cirigliano V, et al. Hafnia alvei pyelonephritis in a renal transplant recipient: case report and review of an under-recognized nosocomial pathogen. Transpl Infect Dis. 2011;13:407–10.

    Article  CAS  PubMed  Google Scholar 

  162. Shubov A, Jagannathan P, Chin-Hong PV. Pantoea agglomerans pneumonia in a heart-lung transplant recipient: case report and a review of an emerging pathogen in immunocompromised hosts. Transpl Infect Dis. 2011;13(5):536–9.

    Article  CAS  PubMed  Google Scholar 

  163. Cheruvattath R, Balan V, Stewart R, et al. Kluyvera co-infection in two solid organ transplant recipients: an emerging pathogen or a colonizer bystander? Transpl Infect Dis. 2007;9(1):83–6.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Division of Infectious Diseases, Hospital of the University of Pennsylvania, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA

    Kathryn Whitaker & Emily A. Blumberg

  2. Health Quest Medical Practice, Department of Infectious Diseases, Poughkeepsie, NY, USA

    Valerie Cluzet

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  1. Kathryn Whitaker
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  1. Clinical Associate Professor of Medicine, Texas Tech University Health Sciences Center El Paso, Paul L. Foster School of Medicine, El Paso, TX, USA

    Amar Safdar

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Whitaker, K., Cluzet, V., Blumberg, E.A. (2019). Enterobacteriaceae in Transplantation. In: Safdar, A. (eds) Principles and Practice of Transplant Infectious Diseases. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-9034-4_25

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