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Ambulatory Gynecology pp 297–308Cite as

Clinical Genetics for the Gynecologist

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Abstract

Family history is a well-recognized risk factor for the development of breast and gynecologic cancer. It is thought that hereditary cases account for 5–10% of all cancers. A number of well-established, highly penetrant syndromes such as Lynch syndrome and hereditary breast and ovarian cancer syndrome account for the vast majority of the hereditary cases. A number of other moderate-risk genes associated with familial syndromes have also been described. The identification of these additional genes has greatly expanded testing options; however, less is known about risk and management for these more recently described genes. This chapter describes the hereditary syndromes associated with breast and gynecologic malignancies and provides risk-reduction recommendations when available. The criteria for genetic testing, methods of genetic testing, and application of results are reviewed.

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Author information

Authors and Affiliations

  1. Department of Surgery, Ohio State University, Columbus, OH, USA

    Valerie P. Grignol

  2. The Ohio State University, Surgical Oncology and Human Genetics, Columbus, OH, USA

    Doreen M. Agnese

Authors
  1. Valerie P. Grignol
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  2. Doreen M. Agnese
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Corresponding author

Correspondence to Doreen M. Agnese .

Editor information

Editors and Affiliations

  1. Gynecologic Oncology, Presence Saint Francis Hospital, Evanston, Illinois, USA

    John V. Knaus

  2. Presence Saint Francis Hospital, Department of Medical Education, Evanston, Illinois, USA

    Marko J. Jachtorowycz

  3. Medical Education, St. Francis Hospital, Evanston, Illinois, USA

    Allan A. Adajar

  4. Presence Saint Francis Hospital, Department of Obstetrics and Gynecology, Evanston, Illinois, USA

    Teresa Tam

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Grignol, V.P., Agnese, D.M. (2018). Clinical Genetics for the Gynecologist. In: Knaus, J., Jachtorowycz, M., Adajar, A., Tam, T. (eds) Ambulatory Gynecology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-7641-6_19

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  • DOI: https://doi.org/10.1007/978-1-4939-7641-6_19

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4939-7639-3

  • Online ISBN: 978-1-4939-7641-6

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