Immunodeficiency-Associated Lymphoproliferative Disorder
Immunodeficiency-associated lymphoproliferative disorders (LPDs) can occur in the setting of HIV infection, after transplantation (posttransplant lymphoproliferative disorder, PTLD), or in other clinical conditions including primary immunodeficiency or the use of immunosuppressive drugs (iatrogenic immunodeficiency-associated LPD). LPDs in the setting of immunodeficiency share similar morphologic features, with a broad spectrum of findings from polymorphous lymphoplasmacytic proliferations to aggressive lymphoma. In patients diagnosed with an immunodeficiency-associated LPD, a staging bone marrow is recommended as part of the initial workup. This chapter illustrates the common bone marrow findings in immunodeficiency-associated LPD.
KeywordsImmunodeficiency-associated lymphoproliferative disorder Posttransplant HIV Iatrogenic immunodeficiency Bone marrow involvement
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