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Plasma Cell Neoplasms

  • Carla S. WilsonEmail author
Chapter
Part of the Atlas of Anatomic Pathology book series (AAP)

Abstract

Plasma cell neoplasms are interrelated by the finding of an expanded monoclonal plasma cell population. The degree of bone marrow involvement, the type and quantity of secreted monoclonal immunoglobulin (M protein), and associated laboratory, radiographic, and clinical findings help to classify these disorders into several entities:
  • Monoclonal gammopathy of undetermined significance (MGUS)

  • Solitary plasmacytoma

  • Plasma cell myeloma (PCM)

  • Monoclonal immunoglobulin deposition diseases The basic genetic events that lead to plasma cell oncogenesis are similar in the different plasma cell neoplasms. Underlying genetic variations likely explain the heterogeneous clinical behavior in patients with these different disorders.

Keywords

Monoclonal gammopathy of undetermined significance Plasma cell myeloma Multiple myeloma Amyloid Plasmacytoma Plasma cell leukemia Plasmablastic 

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Copyright information

© Springer Science+Business Media, LLC 2018

Authors and Affiliations

  1. 1.Department of PathologyUniversity of New Mexico Health Sciences Center and Tricore Reference LaboratoriesAlbuquerqueUSA

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