Abstract
Myelodysplastic/myeloproliferative neoplasms (MDS/MPN) are a group of entities comprised of clonal myeloid neoplasms with shared myeloproliferative and myelodysplastic features:
-
Chronic myelomonocytic leukemia (CMML) (Figs. 17.1, 17.2, 17.3, 17.4, 17.5, 17.6, 17.7, 17.8, 17.9, and 17.10)
-
Atypical chronic myeloid leukemia (aCML) (Figs. 17.11, 17.12, 17.13, 17.14, 17.15, and 17.16)
-
Juvenile myelomonocytic leukemia (JMML) (Figs. 17.17, 17.18, 17.19, 17.20, 17.21, and 17.22)
-
Myelodysplastic/myeloproliferative neoplasm, unclassifiable (MDS/MPN, U) (Figs. 17.23, 17.24, 17.25, and 17.26)
-
Myelodysplastic/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis (MDS/MPN-RS-T) (Figs. 17.27, 17.28, 17.29, 17.30, and 17.31)
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Suggested Reading
Arber DA, Orazi A, Hasserjian R, Thiele J, Borowitz MJ, Le Beau MM, et al. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood. 2016;127:2391–405.
Elliott MA, Tefferi A. Chronic neutrophilic leukemia 2016: update on diagnosis, molecular genetics, prognosis, and management. Am J Hematol. 2016;91:341–9.
Foucar K. Myelodysplastic/myeloproliferative neoplasms. Am J Clin Pathol. 2009;132:281–9.
Geyer JT, Orazi A. Myeloproliferative neoplasms (BCR-ABL1 negative) and myelodysplastic/myeloproliferative neoplasms: current diagnostic principles and upcoming updates. Int J Lab Hematol. 2016;38:12–9.
Karow A, Baumann I, Niemeyer CM. Morphologic differential diagnosis of juvenile myelomonocytic leukemia—pitfalls apart from viral infection. J Pediatr Hematol Oncol. 2009;31:380.
Mughal TI, Cross NC, Padron E, Tiu RV, Savona M, Malcovati L, et al. An International MDS/MPN Working Group’s perspective and recommendations on molecular pathogenesis, diagnosis and clinical characterization of myelodysplastic/myeloproliferative neoplasms. Haematologica. 2015;100:1117–30.
Orazi A, Bennett JM, Germing U, Brunning RD, Bain BJ, Thiele J, et al. Myelodysplastic/myeloproliferative neoplasms. In: Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, et al., editors. WHO classification of tumours of haematopoietic and lymphoid tissues. 4th ed. IARC, Lyon; 2008. p. 75–86.
Patnaik MM, Parikh SA, Hanson CA, Tefferi A. Chronic myelomonocytic leukaemia: a concise clinical and pathophysiological review. Br J Haematol. 2014;165:273–86.
Savona MR, Malcovati L, Komrokji R, Tiu RV, Mughal TI, Orazi A, et al. An international consortium proposal of uniform response criteria for myelodysplastic/myeloproliferative neoplasms (MDS/MPN) in adults. Blood. 2015;125:1857–65.
Stieglitz E, Taylor-Weiner AN, Chang TY, Gelston LC, Wang YD, Mazor T, et al. The genomic landscape of juvenile myelomonocytic leukemia. Nat Genet. 2015;47:1326–33.
Wang SA, Hasserjian RP, Fox PS, Rogers HJ, Geyer JT, Chabot-Richards D, et al. Atypical chronic myeloid leukemia is clinically distinct from unclassifiable myelodysplastic/myeloproliferative neoplasms. Blood. 2014;123:2645–51.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer Science+Business Media, LLC
About this chapter
Cite this chapter
Rupp, A.P., Chabot-Richards, D. (2018). Myelodysplastic/Myeloproliferative Neoplasms (MDS/MPN). In: George, T., Arber, D. (eds) Atlas of Bone Marrow Pathology. Atlas of Anatomic Pathology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-7469-6_17
Download citation
DOI: https://doi.org/10.1007/978-1-4939-7469-6_17
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4939-7467-2
Online ISBN: 978-1-4939-7469-6
eBook Packages: MedicineMedicine (R0)