Abstract
This chapter covers the myeloproliferative neoplasms (MPNs) and mastocytosis. The MPNs are clonal neoplasms characterized by increased bone marrow cellularity, organomegaly, and increased effective cellular maturation resulting in elevated blood levels of one or more cell lines (erythrocytosis, leukocytosis, thrombocytosis). Though dysplasia is typically absent, the MPNs can evolve into acute leukemia or an end-stage myelofibrosis. The disease course is typically long, developing over many years. A common theme of tyrosine kinase activation unites the MPNs, including mastocytosis. There is considerable overlap of clinical, laboratory, and pathologic features for many of these neoplasms; over time, one type of MPN may develop features of another. Figures and tables willillustrate the bone marrow pathology of the MPNs and mast cell disease, including relevant clinical, laboratory, cytogenetic, and molecular genetic findings
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Suggested Reading
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Shier, L.R., George, T.I. (2018). Myeloproliferative Neoplasms and Mastocytosis. In: George, T., Arber, D. (eds) Atlas of Bone Marrow Pathology. Atlas of Anatomic Pathology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-7469-6_15
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DOI: https://doi.org/10.1007/978-1-4939-7469-6_15
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