Staphylococcus aureus

  • Arun K. Bhunia
Part of the Food Science Text Series book series (FSTS)


Staphylococcus aureus, a natural inhabitant of the human and animal body, is mostly associated with community-acquired and nosocomial infections, which can be fatal in immunodeficient patients. Methicillin and vancomycin-resistant S. aureus can cause serious nosocomial infections in humans. S. aureus also causes mastitis in the cows and joint infection in humans, animals and poultry. Staphylococci are also responsible for food poisoning characterized by severe vomiting and cramping with or without diarrhea. S. aureus produces a large number of toxins and enzymes, of which the enterotoxins (24 serotypes of toxins are identified) are most important in the production of gastroenteritis (vomiting and diarrhea) and superantigen-associated illness. Enterotoxins are heat-stable and are produced when the temperature of food is at or above 46 °C. Consumption of preformed toxins induces vomiting with or without diarrhea within 30 min–8 h (average 3 h). The enterotoxin induces the release of 5-HT (5-hydroxytryptamine) from mast cells, which stimulates vagal nerves in the stomach lining and induces vomiting. Enterotoxins are also called superantigens, because they form a complex with MHC class II molecules on the surface of antigen-presenting cells, activating and proliferating T cells to produce massive amounts of cytokines (IL-2, IFNγ, IL-1, TNF-α) that contribute to fatal toxic shock syndrome. The genes for enterotoxin production are present in pathogenicity islands in the chromosome, in plasmids, in transposons, and in temperate bacteriophages. Toxin production is regulated by a two-component regulatory system called agrAC (accessory gene regulator). Strict hygienic practices are crucial in preventing staphylococcal food poisoning. Skin infection or systemic infection requires antibiotic therapy, while the foodborne intoxication does not require antibiotic therapy since the disease is caused by the toxin and it is mostly self-limiting.


Staphylococcus aureus Staphylococcal enterotoxin (SE) Superantigen Exfoliative toxin Vomiting Toxic shock syndrome TSST 

Further Readings

  1. 1.
    Argudín, M.Á., Mendoza, M.C. and Rodicio, M.R. (2010) Food poisoning and Staphylococcus aureus enterotoxins. Toxins 2, 1751–1773.CrossRefPubMedPubMedCentralGoogle Scholar
  2. 2.
    Balaban, N. and Rasooly, A. (2000) Staphylococcal enterotoxins. Int J Food Microbiol 61, 1–10.CrossRefPubMedGoogle Scholar
  3. 3.
    Bronner, S., Monteil, H. and Prevost, G. (2004) Regulation of virulence determinants in Staphylococcus aureus: complexity and applications. FEMS Microbiol Rev 28, 183–200.CrossRefPubMedGoogle Scholar
  4. 4.
    Bukowski, M., Wladyka, B. and Dubin, G. (2010) Exfoliative toxins of Staphylococcus aureus. Toxins 2, 1148.CrossRefPubMedPubMedCentralGoogle Scholar
  5. 5.
    Clarke, S.R. and Foster, S.J. (2006) Surface adhesins of Staphylococcus aureus. Adv Microb Physiol 51, 187–225.Google Scholar
  6. 6.
    Heilmann, C. (2011) Adhesion Mechanisms of Staphylococci. In Bacterial Adhesion: Chemistry, Biology and Physics eds. Linke, D. and Goldman, A. pp.105–123. Dordrecht: Springer Netherlands.Google Scholar
  7. 7.
    Hennekinne, J.-A., De Buyser, M.-L. and Dragacci, S. (2012) Staphylococcus aureus and its food poisoning toxins: characterization and outbreak investigation. FEMS Microbiol Rev 36, 815–836.CrossRefPubMedGoogle Scholar
  8. 8.
    Hu, D.-L. and Nakane, A. (2014) Mechanisms of staphylococcal enterotoxin-induced emesis. Eur J Pharmacol 722, 95–107.CrossRefPubMedGoogle Scholar
  9. 9.
    Kadariya, J., Smith, T.C. and Thapaliya, D. (2014) Staphylococcus aureus and staphylococcal food-borne disease: An ongoing challenge in public health. Biomed Res Int 2014, 9.CrossRefGoogle Scholar
  10. 10.
    Omoe, K., Hu, D.-L., Ono, H.K., Shimizu, S., Takahashi-Omoe, H., Nakane, A., Uchiyama, T., Shinagawa, K. and Imanishi, K.I. (2013) Emetic potentials of newly identified staphylococcal enterotoxin-like toxins. Infect Immun 81, 3627–3631.CrossRefPubMedPubMedCentralGoogle Scholar
  11. 11.
    Otto, M. (2010) Basis of virulence in community-associated methicillin-resistant Staphylococcus aureus. Annu Rev Microbiol 64, 143–162.CrossRefPubMedGoogle Scholar
  12. 12.
    Otto, M. (2014) Staphylococcus aureus toxins. Curr Opin Microbiol 17, 32–37.CrossRefPubMedGoogle Scholar
  13. 13.
    Pinchuk, I.V., Beswick, E.J. and Reyes, V.E. (2010) Staphylococcal enterotoxins. Toxins 2, 2177–2197.CrossRefPubMedPubMedCentralGoogle Scholar
  14. 14.
    Principato, M. and Qian, B.-F. (2014) Staphylococcal enterotoxins in the etiopathogenesis of mucosal autoimmunity within the gastrointestinal tract. Toxins 6, 1471–1489.CrossRefPubMedPubMedCentralGoogle Scholar
  15. 15.
    Silversides, J.A., Lappin, E. and Ferguson, A.J. (2010) Staphylococcal toxic shock syndrome: Mechanisms and management. Curr Infect Dis Rep 12, 392–400.CrossRefPubMedGoogle Scholar
  16. 16.
    Wendlandt, S., Schwarz, S. and Silley, P. (2013) Methicillin-resistant Staphylococcus aureus: A food-borne pathogen? Annu Rev Food Sci Technol 4, 117–139.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Arun K. Bhunia
    • 1
  1. 1.Molecular Food Microbiology Laboratory, Department of Food Science, Department of Comparative PathobiologyPurdue UniversityWest LafayetteUSA

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