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Sepsis Management: Non-antibiotic Treatment of Sepsis and Septic Shock

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Sepsis

Abstract

Sepsis is a major cause of hospital admission, with high attributable mortality which is necessary to know the strategies to improve outcomes in this group of patients. Despite uncertainty in hemodynamic management, lack of effectiveness of interventions evaluated in recent clinical trials and current evidence in different treatments, the research of new therapies are increasingly directed to the treatment of organ dysfunction, the restoration of tissue perfusion and modulation of immunodeficiency in sepsis. Some results have improved, probably due to a greater focus based on early diagnosis and resuscitation with fluids, rapid delivery of effective antibiotics, and other support strategies in the care of critically ill patients. Treatment of patients with sepsis involves a series of interventions that go beyond the start of antibiotic treatment. This chapter provides information about the treatment of patients with sepsis, by so-called treatment packages or “bundles,” the start of fluids, vasopressors, and glycemic control, which are part of the interventions that seek to optimize treatment outcomes of patients with sepsis.

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  1. Department of Critical Care, Hospital Santa Clara, Cr 15 1-59 Sur, Bogotá, Colombia

    Manuel Garay-Fernández MD

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  1. Manuel Garay-Fernández MD
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Correspondence to Manuel Garay-Fernández MD .

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  1. Department of Internal Medicine Pulmonary Medicine and Critical Care Hospital Santa Clara, Universidad del Bosque, Bogotá, Colombia

    Guillermo Ortiz-Ruiz

  2. Department of Critical Care Clínica Gestión Salud, Universidad de Cartagena, Cartagena, Colombia

    Carmelo Dueñas-Castell

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Garay-Fernández, M. (2018). Sepsis Management: Non-antibiotic Treatment of Sepsis and Septic Shock. In: Ortiz-Ruiz, G., Dueñas-Castell, C. (eds) Sepsis. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-7334-7_9

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  • DOI: https://doi.org/10.1007/978-1-4939-7334-7_9

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