Abstract
This chapter summarizes several theoretical studies on the potential for oscillatory behavior of HIV infection at molecular and cellular levels. It discusses the biological relevance of oscillatory systems in the HIV life cycle and touches upon broader perspectives for further theoretical and experimental exploration of system dynamics. The potential interference of HIV oscillatory dynamics at different scales and levels as well as interaction and coevolution with the complex host immune system is also discussed.
Keywords
- HIV
- Mathematical kinetic model
- Systems biology
- Multiscale system
- Oscillatory dynamics
- Host-pathogen interaction
- Differential equation
- Coevolution
- Intracellular
- Population dynamics
- Mathematical modeling of HIV life cycle
- Multiscale kinetic modeling
- Oscillatory behavior of HIV infection at molecular and cellular levels
- Host-virus coevolution
- Dynamical behaviors of the host-HIV system
- Within-host organism and within-host target cell HIV dynamics
- Network motifs for oscillatory behavior
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Acknowledgments
We thank Fred D. Mast, Samuel A. Danziger, and John D. Aitchison for critical reading of the manuscript and for discussion. AVR is supported by the National Institutes of Health (P41GM109824 and P50 GM076547). PDL is supported by the National Science Foundation (DMS grant 1411853). SIB is supported by the Russian Foundation for Basic Research (Grant 14-04-91164). GAB is supported by the Russian Foundation for Basic Research (Grant 14-01-00477) and the Russian Science Foundation (Grant 15-11-00029). TMK and VAL are supported by Russian Foundation for Basic Research (Grant No 16-01-00237a) and Budget Project (No 0324-2016-0008).
Conflict of interest The authors report no conflicts of interest.
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Ratushny, A.V., De Leenheer, P., Bazhan, S.I., Bocharov, G.A., Khlebodarova, T.M., Likhoshvai, V.A. (2017). On the Potential for Multiscale Oscillatory Behavior in HIV. In: Shapshak, P., et al. Global Virology II - HIV and NeuroAIDS. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-7290-6_34
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