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Global Virology II - HIV and NeuroAIDS pp 519–532Cite as

NeuroAIDS: A Review of Gene Expression in Neurons, Astrocytes, and Oligodendrocytes

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Abstract

Modern biotechnology techniques with focus on RNA and protein gene expression have fundamentally altered our view of the pathogenesis of neurological diseases, in general, and HIV-associated neurocognitive disorders (HAND), in particular. Extensive analysis of gene expression enables scientists to assess the simultaneous expression modes of enormous groups of genes. The alterations in adjustment and expression modes of these genes in relation to pathophysiology of NeuroAIDS and HAND provide us with crucial clues into molecular mechanisms of development of AIDS invasion to and infection of human nervous system and how such a vast process affects different tissues within the peripheral immune system and the nervous system. The present chapter focuses on the latest findings in gene expression patterns during pathophysiology of HAND with emphasis on their potential application for treatment of these patients. Specifically, through this chapter we concentrate on the gene expression by the cells within the central nervous system (CNS), neurons, astrocytes, and oligodendrocytes during pathogenesis of HAND.

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Author information

Authors and Affiliations

  1. Department of Neurology, Louisiana State University HSC, Shreveport, LA, USA

    Jeanie McGee DHEd

  2. Department of Neurology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA, USA, 71130

    Alireza Minagar MD

Authors
  1. Jeanie McGee DHEd
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  2. Alireza Minagar MD
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Corresponding author

Correspondence to Alireza Minagar MD .

Editor information

Editors and Affiliations

  1. Department of Internal Medicine, Division of Infectious Diseases and International Health, University of South Florida, Tampa, Florida, USA

    Paul Shapshak

  2. Department of Neurology, UCLA David Geffen School of Medicine, Los Angeles, California, USA

    Andrew J. Levine

  3. Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico, USA

    Brian T. Foley

  4. Department of Internal Medicine, Division of Infectious Diseases and International Health, University of South Florida, Morsani College of Medicine, Tampa, Florida, USA

    Charurut Somboonwit

  5. Department of Neurology, UCLA David Geffen School of Medicine, Los Angeles, California, USA

    Elyse Singer

  6. Department of Oral Biology and Medicine, UCLA School of Dentistry, Los Angeles, California, USA

    Francesco Chiappelli

  7. Department of Internal Medicine, Division of Infectious Diseases and International Health, University of South Florida, Morsani College of Medicine, Tampa, Florida, USA

    John T. Sinnott

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McGee, J., Minagar, A. (2017). NeuroAIDS: A Review of Gene Expression in Neurons, Astrocytes, and Oligodendrocytes. In: Shapshak, P., et al. Global Virology II - HIV and NeuroAIDS. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-7290-6_20

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