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Medication for Sleep Problems in Posttraumatic Stress Disorder

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Sleep and Combat-Related Post Traumatic Stress Disorder

Abstract

Several reviews on the treatment of posttraumatic stress disorder (PTSD) confirm that problems with sleep are the hallmark of this condition. This is well known to patients and prescribing clinicians that there is pressure on the use of substances (e.g., alcohol, cannabis, benzodiazepines) to alleviate sleep deprivation, reduce nightmares, and overcome the “tossing and turning” or “fighting sleep loss.” Patients with PTSD are seduced by the short-acting effect of alcohol and swindle down the negative effects related to their sleep disturbances and nightmares. Without proper guidance and feedback, this can lead to serious problems. Similar to alcohol, benzodiazepines improve sleep problems only in the short term and can cause serious sleep problems when tapering. The benzodiazepine use is well reflected in the fact that 30% of veterans with PTSD received a benzodiazepine prescription for >90 days, even though this is not recommended in guidelines, and as recent reviews and meta-analysis show, it is considered a status “relatively contraindicated” for this indication. This chapter discusses the current state of research on medication for sleep disorders in PTSD. The focus of this clinically based chapter is on the effect of drugs on sleep in patients with PTSD, in patients with depressive disorders, and also in healthy persons. Finally, an algorithm is presented that is based on the extensive literature that is presented as well as clinical guidance.

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References

  1. Abramowitz EG, Barak Y, Ben-Avi I, Knobler HY. Hypnotherapy in the treatment of chronic combat-related PTSD patients suffering from insomnia: a randomized, zolpidem-controlled clinical trial. Int J Clin Exp Hypn. 2008;56(3):270–80.

    Article  PubMed  Google Scholar 

  2. Abrams TE, Lund BC, Bernardy NC, Friedman MJ. Aligning clinical practice to PTSD treatment guidelines: medication prescribing by provider type. Psychiatr Serv. 2013 Feb 1. 2013;64(2):142–8.

    Article  PubMed  Google Scholar 

  3. Aerni A, Traber R, Hock C, Roozendaal B, Schelling G, Papassotiropoulos A, Nitsch RM, Schnyder U, de Quervain DJ. Low-dose cortisol for symptoms of posttraumatic stress disorder. Am J Psychiatry. 2004;161(8):1488–90.

    Article  PubMed  Google Scholar 

  4. Alderman CP, Gilbert AL. A qualitative investigation of long-term zopiclone use and sleep quality among Vietnam war veterans with PTSD. Ann Pharmacother. 2009;43(10):1576–82.

    Article  CAS  PubMed  Google Scholar 

  5. Alderman CP, McCarthy LC, Condon JT, Marwood AC, Fuller JR. Topiramate in combat-related posttraumatic stress disorder. Ann Pharmacother. 2009;43(4):635–41.

    Article  CAS  PubMed  Google Scholar 

  6. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 5th ed. Washington, DC: American Psychiatric Association; 2013.

    Book  Google Scholar 

  7. Ashford JW, Miller TW. Effects of trazodone on sleep in patients diagnosed with post-traumatic stress disorder (PTSD). J Contemp Psychother. 1996;26:221–33.

    Article  Google Scholar 

  8. Aukst-Margetić B, Margetić B, Tosić G, Bilić-Prcić A. Levomepromazine helps to reduce sleep problems in patients with PTSD. Eur Psychiatry. 2004;19(4):235–6.

    Article  PubMed  Google Scholar 

  9. Bajor LA, Ticlea AN, Osser DN. The Psychopharmacology Algorithm Project at the Harvard South Shore Program: an update on posttraumatic stress disorder. Harv Rev Psychiatry. 2011a;19(5):240–58.

    Article  PubMed  Google Scholar 

  10. Bajor LA, Ticlea AN, Osser DN. The Psychopharmacology Algorithm Project at the Harvard South Shore Program: an update on posttraumatic stress disorder. Harv Rev Psychiatry. 2011b;19(5):240–58. https://doi.org/10.3109/10673229.2011.614483.

    Article  PubMed  Google Scholar 

  11. Belendiuk KA, Babson KA, Vandrey R, Bonn-Miller MO. Cannabis species and cannabinoid concentration preference among sleep-disturbed medicinal cannabis users. Addict Behav. 2015;50:178–81. https://doi.org/10.1016/j.addbeh.2015.06.032.

    Article  PubMed  Google Scholar 

  12. van Bemmel A, van den Hoofdakker RH, Beersma DGM, et al. Changes in sleep polygraphic variables and clinical state in depressed patients during treatment with citalopram. Psychopharmacology. 1993;113:225–30.

    Article  PubMed  Google Scholar 

  13. Berlant JL. Topiramate in posttraumatic stress disorder: preliminary clinical observations. J Clin Psychiatry. 2001;62(Suppl 17):60–3.

    PubMed  Google Scholar 

  14. Berlant JL. Prospective open-label study of add-on and monotherapy topiramate in civilians with chronic nonallucinatory posttraumatic stress disorder. BMC Psychiatry. 2004;4:24.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  15. Berlant J, van Kammen DP. Open-label topiramate as primary or adjunctive therapy in chronic civilian posttraumatic stress disorder: a preliminary report. J Clin Psychiatry. 2002;63(1):15–20.

    Article  CAS  PubMed  Google Scholar 

  16. Berlin HA. Antiepileptic drugs for the treatment of post-traumatic stress disorder. Curr Psychiatry Rep. 2007;9(4):291–300.

    Article  PubMed  Google Scholar 

  17. Blois R, Gaillard JM. Effects of moclobemide on sleep in healthy human subjects. Acta Psychiatr Scand Suppl. 1990;360:73–5.

    Article  CAS  PubMed  Google Scholar 

  18. Bonn-Miller MO, Babson KA, Vandrey R. Using cannabis to help you sleep: heightened frequency of medical cannabis use among those with PTSD. Drug Alcohol Depend. 2014;136:162–5. https://doi.org/10.1016/j.drugalcdep.2013.12.008.

    Article  PubMed  Google Scholar 

  19. Brady K, Pearlstein T, Asnis GM, Baker D, Rothbaum B, Sikes CR, Farfel GM. Efficacy and safety of sertraline treatment of posttraumatic stress disorder: a randomized controlled trial. JAMA. 2000;283(14):1837–44.

    Article  CAS  PubMed  Google Scholar 

  20. Brophy MH. Cyproheptadine for combat nightmares in post-traumatic stress disorder and dream anxiety disorder. Mil Med. 1991;156(2):100–1.

    CAS  PubMed  Google Scholar 

  21. Brown ES, Hong SC. Antidepressant-induced bruxism successfully treated with gabapentin. J Am Dent Assoc. 1999;130(10):1467–9.

    Article  CAS  PubMed  Google Scholar 

  22. Brown RM, Khoo SY, Lawrence AJ. Central orexin (hypocretin) 2 receptor antagonism reduces ethanol self-administration, but not cue-conditioned ethanol-seeking, in ethanol-preferring rats. Int J Neuropsychopharmacol. 2013;16(9):2067–79. https://doi.org/10.1017/S1461145713000333.

    Article  CAS  PubMed  Google Scholar 

  23. Buckley T, Duggal V, Schatzberg AF. The acute and post-discontinuation effects of a glucocorticoid receptor (GR) antagonist probe on sleep and the HPA axis in chronic insomnia: a pilot study. J Clin Sleep Med. 2008;4(3):235–41.

    PubMed  PubMed Central  Google Scholar 

  24. Burstein A. Treatment of post-traumatic stress disorder with imipramine. Psychosomatics. 1984;25(9):681–3. 686–687

    Article  CAS  PubMed  Google Scholar 

  25. Burstein A, Burstein A. Treatment of night terrors with imipramine. J Clin Psychiatry. 1983;44(2):82.

    CAS  PubMed  Google Scholar 

  26. Byers MG, Allison KM, Wendel CS, Lee JK. Prazosin versus quetiapine for nighttime posttraumatic stress disorder symptoms in veterans: an assessment of long-term comparative effectiveness and safety. J Clin Psychopharmacol. 2010;30(3):225–9.

    Article  PubMed  Google Scholar 

  27. Cameron C, Watson D, Robinson J. Use of a synthetic cannabinoid in a correctional population for posttraumatic stress disorder-related insomnia and nightmares, chronic pain, harm reduction, and other indications: a retrospective evaluation. J Clin Psychopharmacol. 2014;34(5):559–64. https://doi.org/10.1097/JCP.0000000000000180.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Carey P, Suliman S, Ganesan K, Seedat S, Stein DJ. Olanzapine monotherapy in posttraumatic stress disorder: efficacy in a randomized, double-blind, placebo-controlled study. Hum Psychopharmacol. 2012;27(4):386–91.

    Article  CAS  PubMed  Google Scholar 

  29. Carter AC, Capone C, Short EE. Co-occurring posttraumatic stress disorder and alcohol use disorders in veteran populations. J Dual Diagn. 2011;7(4):285–99.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Cates ME, Bishop MH, Davis LL, Lowe JS, Woolley TW. Clonazepam for treatment of sleep disturbances associated with combat-related posttraumatic stress disorder. Ann Pharmacother. 2004;38(9):1395–9.

    Article  CAS  PubMed  Google Scholar 

  31. Chalon S, Pereira A, Lainey E, et al. Comparative effects of duloxetine and desipramine on sleep EEG in healthy subjects. Psychopharmacology. 2005;177:1–10.

    Article  CAS  Google Scholar 

  32. Clark RD, Canive JM, Calais LA, Qualls C, Brugger RD, Vosburgh TB. Cyproheptadine treatment of nightmares associated with posttraumatic stress disorder. J Clin Psychopharmacol. 1999;19(5):486–7.

    Article  CAS  PubMed  Google Scholar 

  33. Connor KM, Davidson JR, Weisler RH, Ahearn E. A pilot study of mirtazapine in post-traumatic stress disorder. Int Clin Psychopharmacol. 1999;14(1):29–31.

    Article  CAS  PubMed  Google Scholar 

  34. Connor KM, Davidson JR, Weisler RH, Zhang W, Abraham K. Tiagabine for posttraumatic stress disorder: effects of open-label and double-blind discontinuation treatment. Psychopharmacology (Berl). 2006a;184(1):21–5.

    Article  CAS  Google Scholar 

  35. Connor KM, Davidson JR, Weisler RH, Zhang W, Abraham K. Tiagabine for posttraumatic stress disorder: effects of open-label and double-blind discontinuation treatment. Psychopharmacology (Berl). 2006b;184(1):21–5.

    Article  CAS  Google Scholar 

  36. David D, De Faria L, Mellman TA. Adjunctive risperidone treatment and sleep symptoms in combat veterans with chronic PTSD. Depress Anxiety. 2006;23(8):489–91.

    Article  CAS  PubMed  Google Scholar 

  37. Davidson JR. Major depressive disorder treatment guidelines in America and Europe. J Clin Psychiatry. 2010;71(Suppl E1):e04.

    Article  PubMed  Google Scholar 

  38. Davidson J. Vintage treatments for PTSD: a reconsideration of tricyclic drugs. J Psychopharmacol. 2015;29(3):264–9. https://doi.org/10.1177/0269881114565143.

    Article  CAS  PubMed  Google Scholar 

  39. Davidson J, Walker JI, Kilts C. A pilot study of phenelzine in the treatment of post-traumatic stress disorder. Br J Psychiatry. 1987;150:252–5.

    Article  CAS  PubMed  Google Scholar 

  40. Davidson JR, Weisler RH, Malik ML, Connor KM. Treatment of posttraumatic stress disorder with nefazodone. Int Clin Psychopharmacol. 1998;13(3):111–3.

    Article  CAS  PubMed  Google Scholar 

  41. Davidson JR, Rothbaum BO, van der Kolk BA, Sikes CR, Farfel GM. Multicenter, double-blind comparison of sertraline and placebo in the treatment of posttraumatic stress disorder. Arch Gen Psychiatry. 2001;58(5):485–92.

    Article  CAS  PubMed  Google Scholar 

  42. Davidson JR, Weisler RH, Butterfield MI, Casat CD, Connor KM, Barnett S, van Meter S. Mirtazapine vs. placebo in posttraumatic stress disorder: a pilot trial. Biol Psychiatry. 2003;53(2):188–91.

    Article  CAS  PubMed  Google Scholar 

  43. Davidson JR, Brady K, Mellman TA, Stein MB, Pollack MH. The efficacy and tolerability of tiagabine in adult patients with post-traumatic stress disorder. J Clin Psychopharmacol. 2007;27(1):85–8.

    Article  CAS  PubMed  Google Scholar 

  44. Davis LL, Davidson JR, Ward LC, Bartolucci A, Bowden CL, Petty F. Divalproex in the treatment of posttraumatic stress disorder: a randomized, double-blind, placebo-controlled trial in a veteran population. J Clin Psychopharmacol. 2008a;28(1):84–8.

    Article  CAS  PubMed  Google Scholar 

  45. Davis LL, Ward C, Rasmusson A, Newell JM, Frazier E, Southwick SM. A placebo-controlled trial of guanfacine for the treatment of posttraumatic stress disorder in veterans. Psychopharmacol Bull. 2008b;41(1):8–18.

    PubMed  Google Scholar 

  46. De Berardis D, Serroni N, Marini S, Moschetta FS, Martinotti G, Di Giannantonio M. Agomelatine for the treatment of posttraumatic stress disorder: a case report. Ann Clin Psychiatry. 2012;24(3):241–2.

    PubMed  Google Scholar 

  47. De Boer M, Op den Velde W, Falger PJ, Hovens JE, De Groen JH, Van Duijn H. Fluvoxamine treatment for chronic PTSD: a pilot study. Psychother Psychosom. 1992;57(4):158–63.

    Article  PubMed  Google Scholar 

  48. De Jong J, Wauben P, Huijbrechts I, Oolders H, Haffmans J. Doxazosin treatment for posttraumatic stress disorder. J Clin Psychopharmacol. 2010;30(1):84–5.

    Article  PubMed  Google Scholar 

  49. Dieperink ME, Drogemuller L. Zolpidem for insomnia related to PTSD. Psychiatr Serv. 1999;50(3):421.

    Article  CAS  PubMed  Google Scholar 

  50. Dillard ML, Bendfeldt F, Jernigan P. Use of thioridazine in post-traumatic stress disorder. South Med J. 1993;86(11):1276–8.

    Article  CAS  PubMed  Google Scholar 

  51. Ellison JM, Stanziani P. SSRI-associated nocturnal bruxism in four patients. J Clin Psychiatry. 1993;54:432–4.

    CAS  PubMed  Google Scholar 

  52. Forbes D, Creamer M, Bisson JI, Cohen JA, Crow BE, Foa EB, ..., Ursano RJ. A guide to guidelines for the treatment of PTSD and related conditions. FOCUS. 2013;11(3):414–27.

    Google Scholar 

  53. Germain A. Sleep disturbances as the hallmark of PTSD: where are we now? Am J Psychiatry. 2013;170(4):372–82.

    Article  PubMed  PubMed Central  Google Scholar 

  54. Gillin JC, Smith-Vaniz A, Schnierow BJ, et al. An open-label, 12-week clinical and sleep EEG study of nefazodone in chronic combat-related posttraumatic stress disorder. J Clin Psychiatry. 2001;62:789–96.

    Article  CAS  PubMed  Google Scholar 

  55. Giménez S, Clos S, Romero S, Grasa E, Morte A, Barbanoj MJ. Effects of olanzapine, risperidone and haloperidol on sleep after a single oral morning dose in healthy volunteers. Psychopharmacology. 2007;190(4):507–16.

    Article  PubMed  CAS  Google Scholar 

  56. Golier JA, Caramanica K, Demaria R, Yehuda R. A pilot study of mifepristone in combat-related PTSD. Depress Res Treat. 2012;2012:393251.

    PubMed  PubMed Central  Google Scholar 

  57. Guina J, Rossetter SR, DeRHODES BJ, Nahhas RW, Welton RS. Benzodiazepines for PTSD: a systematic review and meta-analysis. J Psychiatr Pract. 2015;21(4):281–303.

    Article  PubMed  Google Scholar 

  58. Gupta S, Popli A, Bathurst E, Hennig L, Droney T, Keller P. Efficacy of cyproheptadine for nightmares associated with posttraumatic stress disorder. Compr Psychiatry. 1998;39(3):160–4.

    Article  CAS  PubMed  Google Scholar 

  59. Gursky JT, Krahn LE. The effects of antidepressants on sleep: a review. Harvard Rev Psychiat. 2000;8:298–306. Review

    Article  CAS  Google Scholar 

  60. Hamner M, Ulmer H, Horne D. Buspirone potentiation of antidepressants in the treatment of PTSD. Depress Anxiety. 1997;5(3):137–9.

    Article  CAS  PubMed  Google Scholar 

  61. Hamner MB, Brodrick PS, Labbate LA. Gabapentin in PTSD: a retrospective, clinical series of adjunctive therapy. Ann Clin Psychiatry. 2001;13(3):141–6.

    Article  CAS  PubMed  Google Scholar 

  62. Hamner MB, Faldowski RA, Robert S, Ulmer HG, Horner MD, Lorberbaum JP. A preliminary controlled trial of divalproex in posttraumatic stress disorder. Ann Clin Psychiatry. 2009;21(2):89–94.

    PubMed  Google Scholar 

  63. Haro R, Drucker-Colín R. Effects of long-term administration of nicotine and fluoxetine on sleep in depressed patients. Arch Med Res. 2004;35:499–506.

    Article  CAS  PubMed  Google Scholar 

  64. Harsch HH. Cyproheptadine for recurrent nightmares. Am J Psychiatry. 1986;143(11):1491–2.

    Article  CAS  PubMed  Google Scholar 

  65. Hertzberg MA, Feldman ME, Beckham JC, Davidson JR. Trial of trazodone for posttraumatic stress disorder using a multiple baseline group design. J Clin Psychopharmacol. 1996;16(4):294–8.

    Article  CAS  PubMed  Google Scholar 

  66. Hertzberg MA, Feldman ME, Beckham JC, Moore SD, Davidson JR. Open trial of nefazodone for combat-related posttraumatic stress disorder. J Clin Psychiatry. 1998;59(9):460–4.

    Article  CAS  PubMed  Google Scholar 

  67. Hertzberg MA, Butterfield MI, Feldman ME, Beckham JC, Sutherland SM, Connor KM, Davidson JR. A preliminary study of lamotrigine for the treatment of posttraumatic stress disorder. Biol Psychiatry. 1999;45(9):1226–9.

    Article  CAS  PubMed  Google Scholar 

  68. Hertzberg MA, Feldman ME, Beckham JC, Moore SD, Davidson JR. Three- to four-year follow-up to an open trial of nefazodone for combat-related posttraumatic stress disorder. Ann Clin Psychiatry. 2002;14(4):215–21.

    Article  PubMed  Google Scholar 

  69. Hicks JA, Argyropoulos SV, Rich AS, et al. Randomised controlled study of sleep after nefazodone or paroxetine treatment in out-patients with depression. Br J Psychiatry. 2002;180:528–35.

    Article  CAS  PubMed  Google Scholar 

  70. Hidalgo R, Hertzberg MA, Mellman T, Petty F, Tucker P, Weisler R, Zisook S, Chen S, Churchill E, Davidson J. Nefazodone in post-traumatic stress disorder: results from six open-label trials. Int Clin Psychopharmacol. 1999;14(2):61–8.

    Article  CAS  PubMed  Google Scholar 

  71. Hindmarch I, Dawson J, Stanley N. A double-blind study in healthy volunteers to assess the effects on sleep of pregabalin compared with alprazolam and placebo. Sleep. 2005;28(2):187–93.

    Article  PubMed  Google Scholar 

  72. Hogben GL, Cornfield RB. Treatment of traumatic war neurosis with phenelzine. Arch Gen Psychiatry. 1981;38(4):440–5.

    Article  CAS  PubMed  Google Scholar 

  73. Ipser JC, Stein DJ. Evidence-based pharmacotherapy of post-traumatic stress disorder (PTSD). Int J Neuropsychopharmacol. 2012;15(6):825–40.

    Article  CAS  PubMed  Google Scholar 

  74. Jacobs-Rebhun S, Schnurr PP, Friedman MJ, Peck R, Brophy M, Fuller D. Posttraumatic stress disorder and sleep difficulty. Am J Psychiatry. 2000;157(9):1525–6.

    Article  CAS  PubMed  Google Scholar 

  75. Jakovljević M, Sagud M, Mihaljević-Peles A. Olanzapine in the treatment-resistant, combat-related PTSD – a series of case reports. Acta Psychiatr Scand. 2003;107(5):394–6.

    Article  PubMed  Google Scholar 

  76. Jindal RD, Friedman ES, Berman SR, et al. Effects of sertraline on sleep architecture in patients with depression. J Clin Psychopharmacol. 2003;23:540–8.

    Article  CAS  PubMed  Google Scholar 

  77. Kevorkian S, Bonn-Miller MO, Belendiuk K, Carney DM, Roberson-Nay R, Berenz EC. Associations among trauma, posttraumatic stress disorder, cannabis use, and cannabis use disorder in a nationally representative epidemiologic sample. Psychol Addict Behav. 2015;29(3):633–8. https://doi.org/10.1037/adb0000110.

    Article  PubMed  PubMed Central  Google Scholar 

  78. Kinrys G, Worthington JJ, Wygant L, Nery F, Reese H, Pollack MH. Levetiracetam as adjunctive therapy for refractory anxiety disorders. J Clin Psychiatry. 2007;68(7):1010–3.

    Article  CAS  PubMed  Google Scholar 

  79. Kinzie JD, Leung P. Clonidine in Cambodian patients with posttraumatic stress disorder. J Nerv Ment Dis. 1989;177(9):546–50.

    Article  CAS  PubMed  Google Scholar 

  80. Kinzie JD, Sack RL, Riley CM. The polysomnographic effects of clonidine on sleep disorders in posttraumatic stress disorder: a pilot study with Cambodian patients. J Nerv Ment Dis. 1994;182(10):585–7.

    Article  CAS  PubMed  Google Scholar 

  81. Kluge M, Schüssler P, Steiger A. Duloxetine increased stage 3 sleep and suppresses rapid eye movement (REM) sleep in patients with major depression. Eur Neuropsychopharmacol. 2007;17:527–31.

    Article  CAS  PubMed  Google Scholar 

  82. Kosten TR, Frank JB, Dan E, McDougle CJ, Giller EL Jr. Pharmacotherapy for posttraumatic stress disorder using phenelzine or imipramine. J Nerv Ment Dis. 1991;179(6):366–70.

    Article  CAS  PubMed  Google Scholar 

  83. Krystal AD, Durrence HH, Scharf M, et al. Efficacy and safety of doxepin 1mg and 3 mg in a 12 week sleep and outpatient trial of elderly subjects in chronic primary insomnia. Sleep. 2010;33:1553–61.

    Article  PubMed  PubMed Central  Google Scholar 

  84. Krystal AD, Zhang W, Davidson JR, Connor KM. The sleep effects of tiagabine on the first night of treatment predict post-traumatic stress disorder response at three weeks. J Psychopharmacol. 2014;28(5):457–65. https://doi.org/10.1177/0269881113509903.

    Article  CAS  PubMed  Google Scholar 

  85. Krystal JH, Rosenheck RA, Cramer JA, Vessicchio JC, Jones KM, Vertrees JE, Horney RA, Huang GD, Stock C, Veterans Affairs Cooperative Study No. 504 Group. Adjunctive risperidone treatment for antidepressant-resistant symptoms of chronic military service-related PTSD: a randomized trial. JAMA. 2011;306(5):493–502.

    Article  CAS  PubMed  Google Scholar 

  86. Krystal JH, Pietrzak RH, Rosenheck RA, Cramer JA, Vessicchio J, Jones KM, Huang GD, Vertrees JE, Collins J, Krystal AD, Veterans Affairs Cooperative Study #504 Group. Sleep disturbance in chronic military-related PTSD: clinical impact and response to adjunctive risperidone in the veterans affairs cooperative study #504. J Clin Psychiatry. 2016;77(4):483–91. https://doi.org/10.4088/JCP.14m09585.

    Article  PubMed  Google Scholar 

  87. Kupfer DJ, Perel JM, Pollock BG, et al. Fluvoxamine versus desipramine: comparative polysomnographic effects. Biol Psychiatry. 1991;29:23–40.

    Article  CAS  PubMed  Google Scholar 

  88. Labbate LA, Douglas S. Olanzapine for nightmares and sleep disturbance in posttraumatic stress disorder (PTSD). Can J Psychiatr. 2000;45(7):667–8.

    CAS  Google Scholar 

  89. Lambert MT. Aripiprazole in the management of post-traumatic stress disorder symptoms in returning global war on terrorism veterans. Int Clin Psychopharmacol. 2006;21(3):185–7.

    Article  PubMed  Google Scholar 

  90. Landolt HP, Raimo EB, Schnierow BJ, Kelsoe JR, Rapaport MH, Gillin JC. Sleep and sleep electroencephalogram in depressed patients treated with phenelzine. Arch Gen Psychiatry. 2001;58(3):268–76.

    Article  CAS  PubMed  Google Scholar 

  91. Lee DJ, Schnitzlein CW, Wolf JP, Vythilingam M, Rasmusson AM, Hoge CW. Psychotherapy versus pharmacotherapy for posttraumatic stress disorder: systemic review and meta-analyses to determine first-line treatments. Depress Anxiety. 2016. https://doi.org/10.1002/da.22511.

  92. Legros B, Bazil CW. Effects of antiepileptic drugs on sleep architecture: a pilot study. Sleep Med. 2003;4(1):51–5.

    Article  PubMed  Google Scholar 

  93. Lerer B, Bleich A, Kotler M, Garb R, Hertzberg M, Levin B. Posttraumatic stress disorder in Israeli combat veterans. Effect of phenelzine treatment. Arch Gen Psychiatry. 1987;44(11):976–81.

    Article  CAS  PubMed  Google Scholar 

  94. Lewis JD. Mirtazapine for PTSD nightmares. Am J Psychiatry. 2002;159(11):1948–9.

    Article  PubMed  Google Scholar 

  95. Leyba CM, Wampler TP. Risperidone in PTSD. Psychiatr Serv. 1998;49(2):245–6.

    Article  CAS  PubMed  Google Scholar 

  96. van Liempt S, Vermetten E, Geuze E, Westenberg HG. Pharmacotherapy for disordered sleep in post-traumatic stress disorder: a systematic review. Int Clin Psychopharmacol. 2006;21(4):193–202.

    Article  PubMed  Google Scholar 

  97. Luthringer R, Toussaint M, Schaltenbrand N, et al. A double-blind, placebo-controlled evaluation of the effects of orally administered venlafaxine on sleep in inpatients with major depression. Psychopharmacol Bull. 1996;32:637–46.

    CAS  PubMed  Google Scholar 

  98. Mathias S, Wetter TC, Steiger A, Lancel M. The GABA uptake inhibitor tiagabine promotes slow wave sleep in normal elderly subjects. Neurobiol Aging. 2001;22(2):247–53.

    Article  CAS  PubMed  Google Scholar 

  99. Mayers AG, Baldwin DS. Antidepressants and their effect on sleep. Hum Psychopharmacol Clin Exp. 2005;20:533–59. Review

    Article  CAS  Google Scholar 

  100. McRae AL, Brady KT, Mellman TA, Sonne SC, Killeen TK, Timmerman MA, Bayles-Dazet W. Comparison of nefazodone and sertraline for the treatment of posttraumatic stress disorder. Depress Anxiety. 2004;19(3):190–6.

    Article  CAS  PubMed  Google Scholar 

  101. Mellman TA, David D, Barza L. Nefazodone treatment and dream reports in chronic PTSD. Depress Anxiety. 1999;9(3):146–8.

    Article  CAS  PubMed  Google Scholar 

  102. Mellman TA, Bustamante V, David D, Fins AI. Hypnotic medication in the aftermath of trauma. J Clin Psychiatry. 2002;63(12):1183–4.

    Article  PubMed  Google Scholar 

  103. Meltzer-Brody S, Connor KM, Churchill E, Davidson JR. Symptom-specific effects of fluoxetine in post-traumatic stress disorder. Int Clin Psychopharmacol. 2000;15(4):227–31.

    Article  CAS  PubMed  Google Scholar 

  104. Mendelson WB. A review of the evidence for the efficacy and safety of trazodone in insomnia. J Clin Psychiatry. 2005;66:469–76. Review

    Article  CAS  PubMed  Google Scholar 

  105. Minot R, Luthringer R, Macher JP. Effect of moclobemide on the psychophysiology of sleep/wake cycles: a neuroelectrophysiological study of depressed patients administered with moclobemide. Int Clin Psychopharmacol. 1993;7(3–4):181–9.

    Article  CAS  PubMed  Google Scholar 

  106. Miyazaki S, Uchida S, Mukai J, Nishihara K. Clonidine effects on all-night human sleep: opposite action of low- and medium-dose clonidine on human NREM-REM sleep proportion. Psychiatry Clin Neurosci. 2004;58(2):138–44.

    Article  CAS  PubMed  Google Scholar 

  107. Mohamed S, Rosenheck RA. Pharmacotherapy of PTSD in the U.S. Department of Veterans Affairs: diagnostic- and symptom-guided drug selection. J Clin Psychiatry. 2008;69(6):959–65.

    Article  PubMed  Google Scholar 

  108. Montgomery I, Oswald I, Morgan K, et al. Trazodone enhances sleep in subjective quality but not in objective duration. Br J Clin Pharmacol. 1983;16:139–44.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  109. Monti JM. Effect of reversible monoamine oxidase-a inhibitor (moclobemide) on sleep in depressed patients. Br J Psychiatry. 1989;6(Suppl):61–5.

    Google Scholar 

  110. Nadeem HS, Attenburrow MJ, Cowen PJ. Comparison of the effects of citalopram and escitalopram on 5-Ht-mediated neuroendocrine responses. Neuropsychopharmacology. 2004;29(9):1699–703.

    Article  CAS  PubMed  Google Scholar 

  111. Nappi CM, Drummond SP, Hall JM. Treating nightmares and insomnia in posttraumatic stress dis order: a review of current evidence. Neuropharmacology. 2012;62(2):576–85.

    Article  CAS  PubMed  Google Scholar 

  112. Neal LA, Shapland W, Fox C. An open trial of moclobemide in the treatment of post-traumatic stress disorder. Int Clin Psychopharmacol. 1997a;12(4):231–7.

    Article  CAS  PubMed  Google Scholar 

  113. Neylan TC, Metzler TJ, Schoenfeld FB, Weiss DS, Lenoci M, Best SR, Lipsey TL, Marmar CR. Fluvoxamine and sleep disturbances in posttraumatic stress disorder. J Trauma Stress. 2001;14(3):461–7.

    Article  CAS  PubMed  Google Scholar 

  114. Neylan T, Lenoci M, Maglione M, et al. The effect of nefazodone on subjective and objective sleep quality in posttraumatic stress disorder. J Clin Psychiatry. 2003;64:445–50.

    Article  CAS  PubMed  Google Scholar 

  115. Neylan TC, Lenoci M, Samuelson KW, Metzler TJ, Henn-Haase C, Hierholzer RW, Lindley SE, Otte C, Schoenfeld FB, Yesavage JA, Marmar CR. No improvement of posttraumatic stress disorder symptoms with guanfacine treatment. Am J Psychiatry. 2006;163(12):2186–8.

    Article  PubMed  Google Scholar 

  116. Nirmalani-Gandhy A, Sanchez D, Catalano G. Terazosin for the treatment of trauma-related nightmares: a report of 4 cases. Clin Neuropharmacol. 2015;38(3):109–11.

    PubMed  Google Scholar 

  117. Nishith P, Resick PA, Mueser KT. Sleep difficulties and alcohol use motives in female rape victims with posttraumatic stress disorder. J Trauma Stress. 2001;14(3):469–79.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  118. Nutt DJ. Rationale for, barriers to, and appropriate medication for the long-term treatment of depression. J Clin Psychiatry. 2010;71(Suppl E1):e02.

    PubMed  Google Scholar 

  119. Önder E, Tural U, Aker T. A comparative study of fluoxetine, moclobemide, and tianeptine in the treatment of posttraumatic stress disorder following an earthquake. Eur Psychiatry. 2006;21(3):174–9.

    Article  PubMed  Google Scholar 

  120. Pae CU, Marks DM, Han C, Masand PS, Patkar AA. Pregabalin augmentation of antidepressants in patients with accident-related posttraumatic stress disorder: an open label pilot study. Int Clin Psychopharmacol. 2009;24(1):29–33.

    Article  PubMed  Google Scholar 

  121. Parrino L, Terzano MG. Polysomnographic effects of hypnotic drugs. A review. Psychopharmacology. 1996;126(1):1–16.

    Article  CAS  PubMed  Google Scholar 

  122. Paslakis G, Gilles M, Deuschle M. Pregabalin in the treatment of posttraumatic stress disorder: a case report. Prog Neuro-Psychopharmacol Biol Psychiatry. 2011;35(4):1160–1.

    Article  Google Scholar 

  123. Paul MA, Gray G, Lange M. The impact of sertraline on psychomotor performance. Aviat Space Envir Md. 2002;73:964–70.

    CAS  Google Scholar 

  124. Pollack MH, Hoge EA, Worthington JJ, Moshier SJ, Wechsler RS, Brandes M, Simon NM. Eszopiclone for the treatment of posttraumatic stress disorder and associated insomnia: a randomized, double-blind, placebo-controlled trial. J Clin Psychiatry. 2011;72(7):892–7.

    Article  CAS  PubMed  Google Scholar 

  125. Power KG, Jerrom DW, Simpson RJ, Mitchell M. Controlled study of withdrawal symptoms and rebound anxiety after six week course of diazepam for generalised anxiety. Br Med J (Clin Res Ed). 1985;290(6477):1246–8.

    Article  CAS  Google Scholar 

  126. Quera Salva MA, Vanier B, Laredo J, Hartley S, Chapotot F, Moulin C, Lofaso F, Guilleminault C. Major depressive disorder, sleep EEG and agomelatine: an open-label study. Int J Neuropsychopharmacol. 2007;10(5):691–6.

    CAS  PubMed  Google Scholar 

  127. Ranjan S, S Chandra P, Prabhu S. Antidepressant-induced bruxism: need for buspirone? Int J Neuropsychopharmacol. 2006;9(4):485–7.

    Article  CAS  PubMed  Google Scholar 

  128. Richardson JD, Fikretoglu D, Liu A, McIntosh D. Aripiprazole augmentation in the treatment of military-related PTSD with major depression: a retrospective chart review. BMC Psychiatry. 2011;11:86. https://doi.org/10.1186/1471-244X-11-86.

    Article  PubMed  PubMed Central  Google Scholar 

  129. Riemann D, Voderholzer U, Cohrs S, Rodenbeck A, Hajak G, Rüther E, Wiegand MH, Laakmann G, Baghai T, Fischer W, Hoffmann M, Hohagen F, Mayer G, Berger M. Trimipramine in primary insomnia: results of a polysomnographic double-blind controlled study. Pharmacopsychiatry. 2002;35(5):165–74.

    Article  CAS  PubMed  Google Scholar 

  130. Rijnders RJ, Laman DM. Van Diujn H Cyproheptadine for posttraumatic nightmares. Am J Psychiatry. 2000;157(9):1524–5.

    Article  CAS  PubMed  Google Scholar 

  131. Robert R, Blakeney PE, Villarreal C, Rosenberg L, Meyer WJ 3rd. Imipramine treatment in pediatric burn patients with symptoms of acute stress disorder: a pilot study. J Am Acad Child Adolesc Psychiatry. 1999;38(7):873–82.

    Article  CAS  PubMed  Google Scholar 

  132. Robert S, Hamner MB, Kose S, Ulmer HG, Deitsch SE, Lorberbaum JP. Quetiapine improves sleep disturbances in combat veterans with PTSD: sleep data from a prospective, open-label study. J Clin Psychopharmacol. 2005;25(4):387–8.

    Article  PubMed  Google Scholar 

  133. Rodgman C, Verrico CD, Holst M, Thompson-Lake D, Haile CN, De La Garza R 2nd, Raskind MA, Newton TF. Doxazosin XL reduces symptoms of posttraumatic stress disorder in veterans with PTSD: a pilot clinical trial. J Clin Psychiatry. 2016;77(5):e561–5. https://doi.org/10.4088/JCP.14m09681.

    Article  PubMed  Google Scholar 

  134. Roehrs TA, Randall S, Harris E, Maan R, Roth T. Twelve months of nightly zolpidem does not lead to rebound insomnia or withdrawal symptoms: a prospective placebo-controlled study. J Psychopharmacol. 2012;26(8):1088–95.

    Article  CAS  PubMed  Google Scholar 

  135. Roepke S, Danker-Hopfe H, Repantis D, Behnia B, Bernard F, Hansen ML, Otte C. Doxazosin, an α-1-adrenergic-receptor antagonist, for nightmares in patients with posttraumatic stress disorder and/or borderline personality disorder: a chart review. Pharmacopsychiatry. 2017;50(1):26–31. https://doi.org/10.1055/s-0042-107794.

    CAS  PubMed  Google Scholar 

  136. Romanelli F, Adler DA, Bungay KM. Possible paroxetine-induced bruxism. Ann Pharmacother. 1996;30:1246–8.

    Article  CAS  PubMed  Google Scholar 

  137. Ross RJ, Ball WA, Sullivan KA, Caroff SN. Sleep disturbance as the hallmark of posttraumatic stress disorder. Am J Psychiatry. 1989;146(6):697–707.

    Article  CAS  PubMed  Google Scholar 

  138. Rothbaum BO, Killeen TK, Davidson JR, Brady KT, Connor KM, Heekin MH. Placebo-controlled trial of risperidone augmentation for selective serotonin reuptake inhibitor-resistant civilian posttraumatic stress disorder. J Clin Psychiatry. 2008;69(4):520–5.

    Article  CAS  PubMed  Google Scholar 

  139. Ruigt GSF, Kemp B, Groenhout CM, et al. Effect of the antidepressant org 3770 on human sleep. Eur J Clin Pharmacol. 1990;38:551–4.

    Article  CAS  PubMed  Google Scholar 

  140. Salin-Pascual RJ, Galicia-Polo L, Drucker-Colin R. Sleep changes after 4 consecutive days of venlafaxine administration in normal volunteers. J Clin Psychiatry. 1997;58:348–50.

    Article  CAS  PubMed  Google Scholar 

  141. Salviati M, Pallagrosi M, Valeriani G, Carlone C, Todini L, Biondi M. On the role of noradrenergic system in PTSD and related sleep disturbances. The use of terazosin in PTSD related nightmares: a case report. Clin Ter. 2013;164(2):133–7.

    CAS  PubMed  Google Scholar 

  142. Sanchez C, Asin KE, Artigas F. Vortioxetine, a novel antidepressant with multimodal activity: review of preclinical and clinical data. Pharmacol Ther. 2015 Jan. 2015;145:43–57.

    Article  CAS  PubMed  Google Scholar 

  143. Schmid DA, Wichniak A, Uhr M, et al. Changes in sleep architecture, spectral composition of sleep EEG, the nocturnal secretion of cortisol, ACTH, GH, prolactin, melatonin, ghrelin, and leptin, and the DEX-CRH test in depressed patients during treatment with mirtazapine. Neuropsychopharmacology. 2006;31:832–44.

    Article  CAS  PubMed  Google Scholar 

  144. Schneider E, Ziegler B, Maxion H. Gamma-aminobutyric acid (GABA) and sleep. The influence of di-n-propylacetic acid on sleep in man. Eur Neurol. 1977;15(3):146–52.

    Article  CAS  PubMed  Google Scholar 

  145. Schneier FR, Campeas R, Carcamo J, Glass A, Lewis-Fernandez R, Neria Y, Sanchez-Lacay A, Vermes D, Wall MM. Combined mirtazapine and ssri treatment of ptsd: a placebo-controlled trial. Depress Anxiety. 2015;32(8):570–9. https://doi.org/10.1002/da.22384.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  146. Sethi R, Vasudeva S. Doxazosin for the treatment of nightmares: does it really work? A case report. Prim Care Companion CNS Disord. 2012;14(5). pii: PCC.12l01356. doi: https://doi.org/10.4088/PCC.12l01356.

  147. Sharpley AL, Gregory CA, Solomon RA, Cowen PJ. Slow wave sleep and 5-HT2 receptor sensitivity during maintenance tricyclic antidepressant treatment. J Affect Disord. 1990;19(4):273–7.

    Article  CAS  PubMed  Google Scholar 

  148. Sharpley AL, Bhagwagar Z, Hafizi S, Whale WR, Gijsman HJ, Cowen PJ. Risperidone augmentation decreases rapid eye movement sleep and decreases wake in treatment-resistant depressed patients. J Clin Psychiatry. 2003;64(2):192–6.

    Article  CAS  PubMed  Google Scholar 

  149. Sharpley AL, Attenburrow ME, Hafizi S, Cowen PJ. Olanzapine increases slow wave sleep and sleep continuity in SSRI-resistant depressed patients. J Clin Psychiatry. 2005;66(4):450–4.

    Article  CAS  PubMed  Google Scholar 

  150. Shen WW, Park S. The use of monoamine oxidase inhibitors in the treatment of traumatic war neurosis: case report. Mil Med. 1983;148(5):430–1.

    CAS  PubMed  Google Scholar 

  151. Shestatzky M, Greenberg D, Lerer B. A controlled trial of phenelzine in posttraumatic stress disorder. Psychiatry Res. 1988;24(2):149–55.

    Article  CAS  PubMed  Google Scholar 

  152. Spiegel R, DeVos JE. Central effects of guanfacine and clonidine during wakefulness and sleep in healthy subjects. Br J Clin Pharmacol. 1980;10(Suppl 1):165S–8S.

    Article  PubMed  PubMed Central  Google Scholar 

  153. Spigset O, Hägg S, Bate A. Hepatic injury and pancreatitis during treatment with serotonin reuptake inhibitors: data from the World Health Organization (WHO) database of adverse drug reactions. Int Clin Psychopharmacol. 2003;18(3):157–61.

    PubMed  Google Scholar 

  154. Spoormaker VI, Montgomery P. Disturbed sleep in post-traumatic stress disorder: secondary symptom or core feature? Sleep Med Rev. 2008;12(3):169–84.

    Article  PubMed  Google Scholar 

  155. Stanovic JK, James KA, Vandevere CA. The effectiveness of risperidone on acute stress symptoms in adult burn patients: a preliminary retrospective pilot study. J Burn Care Rehabil. 2001;22(3):210–3.

    Article  CAS  PubMed  Google Scholar 

  156. Stein MB, Kline NA, Matloff JL. Adjunctive olanzapine for SSRI-resistant combat-related PTSD: a double-blind, placebo-controlled study. Am J Psychiatry. 2002;159(10):1777–9.

    Article  PubMed  Google Scholar 

  157. Stein DJ, Davidson J, Seedat S, Beebe K. Paroxetine in the treatment of post-traumatic stress disorder: pooled analysis of placebo-controlled studies. Expert Opin Pharmacother. 2003;4(10):1829–38.

    Article  CAS  PubMed  Google Scholar 

  158. Stein DJ, Pedersen R, Rothbaum BO, Baldwin DS, Ahmed S, Musgnung J, Davidson J. Onset of activity and time to response on individual CAPS-SX17 items in patients treated for post-traumatic stress disorder with venlafaxine ER: a pooled analysis. Int J Neuropsychopharmacol. 2009;12(1):23–31.

    Article  CAS  PubMed  Google Scholar 

  159. Strawn JR, Dowling BP, Geracioti TD Jr. Pregabalin treatment of posttraumatic stress disorder. J Clin Psychopharmacol. 2008;28(5):596–7.

    Article  PubMed  Google Scholar 

  160. Taylor FB. Tiagabine for posttraumatic stress disorder: a case series of 7 women. J Clin Psychiatry. 2003;64(12):1421–5.

    Article  PubMed  Google Scholar 

  161. Tol WA, Barbui C, Bisson J, Cohen J, Hijazi Z, Jones L, ..., Silove D. World Health Organization guidelines for management of acute stress, PTSD, and bereavement: key challenges on the road ahead. PLoS Med. 2014;11(12):e1001769.

    Google Scholar 

  162. Tucker P, Trautman RP, Wyatt DB, Thompson J, Wu SC, Capece JA, Rosenthal NR. Efficacy and safety of topiramate monotherapy in civilian posttraumatic stress disorder: a randomized, double-blind, placebo-controlled study. J Clin Psychiatry. 2007;68(2):201–6.

    Article  CAS  PubMed  Google Scholar 

  163. Van Liempt S. Sleep disturbances and PTSD: a perpetual circle? Eur J Psychotraumatol. 2012;3:19142.

    Article  Google Scholar 

  164. Vigo DV, Baldessarini RJ. Anticonvulsants in the treatment of major depressive disorder: an overview. Harv Rev Psychiatry. 2009;17(4):231–41.

    Article  PubMed  Google Scholar 

  165. Villarreal G, Calais LA, Cañive JM, Lundy SL, Pickard J, Toney G. Prospective study to evaluate the efficacy of aripiprazole as a monotherapy in patients with severe chronic posttraumatic stress disorder: an open trial. Psychopharmacol Bull. 2007;40(2):6–18.

    PubMed  Google Scholar 

  166. Villarreal G1, Cañive JM, Calais LA, Toney G, Smith AK. Duloxetine in military posttraumatic stress disorder. Psychopharmacol Bull. 2010;43(3):26–34.

    PubMed  Google Scholar 

  167. Walderhaug E, Kasserman S, Aikins D, Vojvoda D, Nishimura C, Neumeister A. Effects of duloxetine in treatment-refractory men with posttraumatic stress disorder. Pharmacopsychiatry. 2010;43(2):45–9.

    Article  CAS  PubMed  Google Scholar 

  168. Walsh JK, Perlis M, Rosenthal M, Krystal A, Jiang J, Roth T. Tiagabine increases slow-wave sleep in a dose-dependent fashion without affecting traditional efficacy measures in adults with primary insomnia. J Clin Sleep Med. 2006;2(1):35–41.

    PubMed  Google Scholar 

  169. Warner MD, Dorn MR, Peabody CA. Survey on the usefulness of trazodone in patients with PTSD with insomnia or nightmares. Pharmacopsychiatry. 2001;34(4):128–31.

    Article  CAS  PubMed  Google Scholar 

  170. Wells BG, Chu CC, Johnson R, Nasdahl C, Ayubi MA, Sewell E, Statham P. Buspirone in the treatment of posttraumatic stress disorder. Pharmacotherapy. 1991;11(4):340–3.

    CAS  PubMed  Google Scholar 

  171. Wiedemann K, Lauer C, Loycke A, Pollmächer T, Durst P, Machér JP, Holsboer F. Antiglucocorticoid treatment disrupts endocrine cycle and nocturnal sleep pattern. Eur Arch Psychiatry Clin Neurosci. 1992;241(6):372–5.

    Article  CAS  PubMed  Google Scholar 

  172. Wilson S, Argyropoulos S. Antidepressants and sleep. A qualitative review of the literature. Drugs. 2005;65:927–47.

    Article  CAS  PubMed  Google Scholar 

  173. Wilson SJ, Bailey JE, Alford C, et al. Sleep and daytime sleepiness the next day following single night-time dose of fluvoxamine, dothiepin and placebo in normal volunteers. J Psychopharmacol. 2000;14:378–86.

    Article  CAS  PubMed  Google Scholar 

  174. Wilson SJ, Bailey JE, Alford C, et al. Effects of 5 weeks of administration of fluoxetine and dothiepin in normal volunteers on sleep, daytime sedation, psychomotor performance and mood. J Psychopharmacol. 2002;16:321–31.

    Article  CAS  PubMed  Google Scholar 

  175. Wilson SJ, Bailey JE, Rich AS, Adrover M, Potokar J, Nutt DJ. Using sleep to evaluate comparative serotonergic effects of paroxetine and citalopram. Eur Neuropsychopharmacol. 2004;14(5):367–72.

    Article  CAS  PubMed  Google Scholar 

  176. Winokur A, Sateia M, Hayes J, et al. Acute effects of mirtazapine on sleep continuity and sleep architecture in depressed patients: a pilot study. Biol Psychiatry. 2000;48:75–8.

    Article  CAS  PubMed  Google Scholar 

  177. Winokur A, Gary KA, Rodner S, et al. Depression, sleep physiology, and antidepressant drugs. Depress Anxiety. 2001;14:19–28.

    Article  CAS  PubMed  Google Scholar 

  178. Yamadera H, Nakamura S, Suzuki H, et al. Effects of trazodone hydrochloride and imipramine on polysomnography in healthy subjects. Psychiatry Clin Neurosci. 1998;52:439–43.

    Article  CAS  PubMed  Google Scholar 

  179. Youssef NA, Marx CE, Bradford DW, Zinn S, Hertzberg MA, Kilts JD, Naylor JC, Butterfield MI, Strauss JL. An open-label pilot study of aripiprazole for male and female veterans with chronic post-traumatic stress disorder who respond suboptimally to antidepressants. Int Clin Psychopharmacol. 2012;27(4):191–6.

    Article  PubMed  Google Scholar 

  180. Zisook S, Chentsova-Dutton YE, Smith-Vaniz A, Kline NA, Ellenor GL, Kodsi AB, Gillin JC. Nefazodone in patients with treatment-refractory posttraumatic stress disorder. J Clin Psychiatry. 2000;61(3):203–8.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Psychotrauma, PsyQ, Parnassiagroup, The Hague, The Netherlands

    Joop de Jong MD

  2. Department of Psychiatry, Leiden University Medical Center, Leiden, Netherlands

    Eric Vermetten MD, PhD (Professor of Psychiatry, Adjunct Professor of Psychiatry)

  3. Colonel, Head of Research, Military Mental Health Care, Ministry of Defense, Utrecht, The Netherlands

    Eric Vermetten MD, PhD (Professor of Psychiatry, Adjunct Professor of Psychiatry)

  4. Arq Psychotrauma Research Group, Utrecht, The Netherlands

    Eric Vermetten MD, PhD (Professor of Psychiatry, Adjunct Professor of Psychiatry)

  5. Department of Psychiatry, New York School of Medicine, New York, USA

    Eric Vermetten MD, PhD (Professor of Psychiatry, Adjunct Professor of Psychiatry)

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Correspondence to Joop de Jong MD .

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  1. Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands

    Eric Vermetten

  2. Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

    Anne Germain

  3. University of California, San Francisco, California, USA

    Thomas C. Neylan

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de Jong, J., Vermetten, E. (2018). Medication for Sleep Problems in Posttraumatic Stress Disorder. In: Vermetten, E., Germain, A., Neylan, T. (eds) Sleep and Combat-Related Post Traumatic Stress Disorder. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-7148-0_29

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