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In-Line Particle Size Characterization of Multiparticulate Systems

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Multiparticulate Drug Delivery

Part of the book series: Advances in Delivery Science and Technology ((ADST))

Abstract

This chapter describes measurement methods of in-line particle sizing and their application on specific pharmaceutical processes. These methods use different physical measurement principles: acoustic emission, near-infrared spectroscopy, image analysis, laser diffraction, light beam reflectance and the spatial filtering technique. The contribution shows the similarities and differences of off-line and in-line particle sizing and the influence of the process and product properties on the application of an SFT probe IPP 70 (Parsum GmbH, Chemnitz, Germany) as an in-line particle size analyzer. Some case studies of pellet coating processes in fluidized beds show the real-time measurement of PSD at process time with high resolution. These in-line measurements allow the determination of the layer growth, the detection of agglomerates and of the layer thickness, therefore enabling analysis of how the critical process parameters influence the final product properties. Information about multiparticulate processes can be acquired using in-line sizing technique which in turn contributes to the scientifically founded quality assurance of pharmaceutical products and enables the creation of prediction models and thus Quality by Design.

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Author information

Authors and Affiliations

  1. Parsum GmbH, Chemnitz, Germany

    Stefan Dietrich

  2. Chemnitz University of Technology, Chemnitz, Germany

    Dieter Petrak

Authors
  1. Stefan Dietrich
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  2. Dieter Petrak
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Corresponding author

Correspondence to Stefan Dietrich .

Editor information

Editors and Affiliations

  1. VP & Chief Scientific Officer, Colorcon Inc., Harleysville, Pennsylvania, USA

    Ali R. Rajabi-Siahboomi

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© 2017 Controlled Release Society

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Dietrich, S., Petrak, D. (2017). In-Line Particle Size Characterization of Multiparticulate Systems. In: Rajabi-Siahboomi, A. (eds) Multiparticulate Drug Delivery. Advances in Delivery Science and Technology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-7012-4_12

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