Abstract
The mechanisms for the maintenance of chronic pain are complex and multifactorial. Advances in the study of pain transmission and processing have begun to unravel the cellular mechanisms that underlie the maintenance of chronic pain. Factors that maintain chronic pain have been demonstrated in their peripheral and central nervous system. This chapter provides an overview of the key concepts in the mechanisms of chronic pain.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Suggested Reading
Cohen SA. Pathophysiology of pain. In: Principles and practice of pain medicine. 2nd ed. Philadelphia: Saunders; 2004.
Dougherty PM, Raja SN, Boyette-Davis J. Neurochemistry of somatosensory and pain processing. In: Essentials of pain medicine. 3rd ed. Philadelphia: Saunders; 2011. p. 8–15.
Levine JD, Reichling DB. Peripheral mechanisms of inflammatory pain. In: Textbook of pain. Edinburgh: Churchill Livingstone; 1999. p. 59.
Woolf CJ, Salter MW. Neuronal plasticity: increasing the gain in pain. Science. 2000;288:1765.
Woolf CJ, Thompson SW. The induction and maintenance of central sensitization is dependent on N-methyl-D-aspartic acid receptor activation: implications for the treatment of post-injury pain hypersensitivity states. Pain. 1991;44:293.
Woolf CJ; American College of Physicians, American Physiological Society. Pain: moving from symptom control toward mechanism-specific pharmacologic management. Ann Intern Med. 2004;140:441.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2017 Springer Science+Business Media LLC
About this chapter
Cite this chapter
Jusino, E., Chang Chien, G.C., Minzter, B.H. (2017). Mechanisms of Chronic Pain. In: Pope, J., Deer, T. (eds) Treatment of Chronic Pain Conditions. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-6976-0_2
Download citation
DOI: https://doi.org/10.1007/978-1-4939-6976-0_2
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4939-6974-6
Online ISBN: 978-1-4939-6976-0
eBook Packages: MedicineMedicine (R0)