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Intraductal Proliferative Lesions

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Atlas of Differential Diagnosis in Breast Pathology

Part of the book series: Atlas of Anatomic Pathology ((AAP))

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Abstract

Intraductal proliferative epithelial lesions are a heterogeneous group that have in common an epithelial proliferation within the terminal ductal lobular unit of the breast. They affect women over a broad age range and are associated with varying risks of subsequent breast cancer. Some lesions, such as ductal carcinoma in situ (DCIS), may be direct but non-obligate precursors to invasive carcinoma.

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References

  1. Abdel-Fatah TM, Powe DG, Hodi Z, Reis-Filho JS, Lee AH, Ellis IO. Morphologic and molecular evolutionary pathways of low nuclear grade invasive breast cancers and their putative precursor lesions: further evidence to support the concept of low nuclear grade breast neoplasia family. Am J Surg Pathol. 2008;32:513–23.

    Article  PubMed  Google Scholar 

  2. Gomes DS, Porto SS, Balabram D, Gobbi H. Inter-observer variability between general pathologists and a specialist in breast pathology in the diagnosis of lobular neoplasia, columnar cell lesions, atypical ductal hyperplasia and ductal carcinoma in situ of the breast. Diagn Pathol. 2014;9:121.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Tan PH, Ho BC, Selvarajan S, Yap WM, Hanby A. Pathological diagnosis of columnar cell lesions of the breast: are there issues of reproducibility? J Clin Pathol. 2005;58:705–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Lim CN, Ho BC, Bay BH, Yip G, Tan PH. Nuclear morphometry in columnar cell lesions of the breast: is it useful? J Clin Pathol. 2006;59:1283–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Said SM, Visscher DW, Nassar A, Frank RD, Vierkant RA, Frost MH, et al. Flat epithelial atypia and risk of breast cancer: a Mayo cohort study. Cancer. 2015;121:1548–55.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Calhoun BC, Sobel A, White RL, Gromet M, Flippo T, Sarantou T, Livasy CA. Management of flat epithelial atypia on breast core biopsy may be individualized based on correlation with imaging studies. Mod Pathol. 2015;28:670–6.

    Article  PubMed  Google Scholar 

  7. Dialani V, Venkataraman S, Frieling G, Schnitt SJ, Mehta TS. Does isolated flat epithelial atypia on vacuum-assisted breast core biopsy require surgical excision? Breast J. 2014;20:606–14.

    Article  PubMed  Google Scholar 

  8. Schnitt SJ, Ellis IO, van de Vijver MJ, Sgroi D, Lakhani SR, Simpson J, et al. Intraductal proliferative lesions: introduction and overview. In: Lakhani SR, Ellis IO, Schnitt SJ, Tan PH, van de Vijver MJ, editors. WHO classification of tumours of the breast. Lyon: IARC; 2012. p. 82–94.

    Google Scholar 

  9. Tan PH, Ho JT, Ng EH, Chiang GS, Low SC, Ng FC, Bay BH. Pathologic-radiologic correlations in screen-detected ductal carcinoma in situ of the breast: findings of the Singapore breast screening project. Int J Cancer. 2000;90:231–6.

    Article  CAS  PubMed  Google Scholar 

  10. Schwartz GF, Patchefsky AS, Finklestein SD, Sohn SH, Prestipino A, Feig SA, Singer JS. Nonpalpable in situ ductal carcinoma of the breast. Predictors of multicentricity and microinvasion and implications for treatment. Arch Surg. 1989;124:29–32.

    Article  CAS  PubMed  Google Scholar 

  11. Tan PH, Lui GG, Chiang G, Yap WM, Poh WT, Bay BH. Ductal carcinoma in situ with spindle cells: a potential diagnostic pitfall in the evaluation of breast lesions. Histopathology. 2004;45:343–51.

    Article  CAS  PubMed  Google Scholar 

  12. Francis A, Thomas J, Fallowfield L, Wallis M, Bartlett JM, Brookes C, Roberts T, Pirrie S, Gaunt C, Young J, Billingham L, Dodwell D, Hanby A, Pinder SE, Evans A, Reed M, Jenkins V, Matthews L, Wilcox M, Fairbrother P, Bowden S, Rea D. Addressing overtreatment of screen detected DCIS; the LORIS trial. Eur J Cancer. 2015;51(16):2296–303.

    Google Scholar 

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Tan, P.H., Sahin, A.A. (2017). Intraductal Proliferative Lesions. In: Atlas of Differential Diagnosis in Breast Pathology. Atlas of Anatomic Pathology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-6697-4_9

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  • DOI: https://doi.org/10.1007/978-1-4939-6697-4_9

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4939-6695-0

  • Online ISBN: 978-1-4939-6697-4

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