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Part of the book series: Atlas of Anatomic Pathology ((AAP))

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Abstract

A variety of vascular proliferations, both benign and malignant, can occur in the breast. Overall, they represent only a minority of tumours originating in the breast. Benign vascular lesions other than incidental perilobular haemangiomas are extremely rare in the breast. Malignant vascular lesions (angiosarcomas) are also rare, constituting less than 1 % of all breast neoplasms; they may be primary, or they may be secondary tumours occurring after radiation treatment. Also seen in association with radiation therapy are “atypical vascular lesions” affecting the skin of the breast. The relationship between atypical vascular lesions and radiation-associated angiosarcoma is controversial and remains to be elucidated. This chapter reviews the most common vascular lesions in the breast, with an emphasis on their diagnostic features and potential interpretive pitfalls.

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References

  1. Guo T, Zhang L, Chang NE, Singer S, Maki RG, Antonescu CR. Consistent MYC and FLT4 gene amplification in radiation-induced angiosarcoma but not in other radiation-associated atypical vascular lesions. Genes Chromosomes Cancer. 2011;50:25–33.

    Google Scholar 

  2. Fletcher CDM, McGrogan G, Fox SB. Angiosarcoma. In: Lakhani SR, Ellis IO, Schnitt SJ, Tan PH, van de Vijver MJ, editors. WHO classification of tumours of the breast. Lyon: IARC Press; 2012. p. 135–46.

    Google Scholar 

  3. Liberman L, Dershaw DD, Kaufman RJ, Rosen PP. Angiosarcoma of the breast. Radiology. 1992;183:649–54.

    Article  CAS  PubMed  Google Scholar 

  4. Goh LW, Wong SL, Tan PH. Four cases of echogenic breast lesions: a case series and review. Singapore Med J. 2016;57:339–43.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Yang WT, Hennessy BT, Dryden MJ, Valero V, Hunt KK, Krishnamurthy S. Mammary angiosarcomas: imaging findings in 24 patients. Radiology. 2007;242:725–34.

    Article  PubMed  Google Scholar 

  6. Fraga-Guedes C, André S, Mastropasqua MG, Botteri E, Toesca A, Rocha RM, et al. Angiosarcoma and atypical vascular lesions of the breast: diagnostic and prognostic role of MYC gene amplification and protein expression. Breast Cancer Res Treat. 2015;151:131–40.

    Article  CAS  PubMed  Google Scholar 

  7. Patel RM, Goldblum JR, Hsi ED. Immunohistochemical detection of human herpes virus-8 latent nuclear antigen-1 is useful in the diagnosis of Kaposi sarcoma. Mod Pathol. 2004;17:456–60.

    Article  PubMed  Google Scholar 

  8. Pantanowitz L, Dezube BJ. Kaposi sarcoma in unusual locations. BMC Cancer. 2008;8:190.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Rao P, Lahat G, Arnold C, Gavino AC, Lahat S, Hornick JL, et al. Angiosarcoma: a tissue microarray study with diagnostic implications. Am J Dermatopathol. 2013;35:432–7.

    Article  PubMed  Google Scholar 

  10. Kallen ME, Nunes Rosado FG, Gonzalez AL, Sanders ME, Cates JM. Occasional staining for p63 in malignant vascular tumors: a potential diagnostic pitfall. Pathol Oncol Res. 2012;18:97–100.

    Article  PubMed  Google Scholar 

  11. Nascimento AF, Raut CP, Fletcher CD. Primary angiosarcoma of the breast: clinicopathologic analysis of 49 cases, suggesting that grade is not prognostic. Am J Surg Pathol. 2008;32:1896–904.

    Article  PubMed  Google Scholar 

  12. Ghareeb ER, Bhargava R, Vargo JA, Florea AV, Beriwal S. Primary and radiation-induced breast angiosarcoma: clinicopathologic predictors of outcomes and the impact of adjuvant radiation therapy. Am J Clin Oncol. 2016;39:463–7.

    Google Scholar 

  13. Pandey M, Sutton GR, Giri S, Martin MG. Grade and prognosis in localized primary angiosarcoma. Clin Breast Cancer. 2015;15:266–9.

    Article  PubMed  Google Scholar 

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Tan, P.H., Sahin, A.A. (2017). Vascular Lesions. In: Atlas of Differential Diagnosis in Breast Pathology. Atlas of Anatomic Pathology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-6697-4_8

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  • DOI: https://doi.org/10.1007/978-1-4939-6697-4_8

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4939-6695-0

  • Online ISBN: 978-1-4939-6697-4

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