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Penile Cancer pp 1–11Cite as

Understanding the Pathophysiology of Penile Cancer and Its Preneoplastic Lesions

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Part of the Current Clinical Urology book series (CCU)

Abstract

Squamous cell carcinoma of the penis is a rare malignancy that can develop anywhere on the penis. The epidemiology, risk factors, and pathophysiology of penile carcinoma are described here. Human papillomavirus has been proven to play a pivotal role in a significant subset of cases and is discussed in detail. Penile intraepithelial neoplasia refers to the penile preneoplastic lesions. These lesions demonstrate variable risk to progression to invasive cancer and are reviewed in completeness.

Keywords

  • Penile cancer
  • Squamous cell carcinoma
  • Human papillomavirus
  • Penile intraepithelial neoplasia

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Author information

Authors and Affiliations

  1. Department of Genitourinary Oncology, Moffitt Cancer Center, 12902 USF Magnolia Drive, Tampa, FL, 33612, USA

    Adam S. Baumgarten M.D. & Kenan B. Ashouri M.S.

  2. Department of Urology, University of South Florida Morsani College of Medicine, 2 Tampa General Circle, 7th Floor, Tampa, FL, 33606, USA

    Barrett Z. McCormick M.D.

  3. Department of Anatomic Pathology, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL, 33612, USA

    Jasreman Dhillon M.D.

  4. Moffit Cancer Center, Center for Infection Research in Cancer, 12902 Magnolia Drive, MRC-Cancont, Tampa, FL, 33612, USA

    Anna R. Giuliano Ph.D.

  5. Department of Genitourinary Oncology, Department of Tumor Biology, Moffitt Cancer Center, 12902 Magnolia Drive Office, 12538 Tampa, FL, 33612, USA

    Philippe E. Spiess M.D., M.S., F.R.C.S(C.)

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  1. Adam S. Baumgarten M.D.
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  2. Barrett Z. McCormick M.D.
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  3. Kenan B. Ashouri M.S.
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  4. Jasreman Dhillon M.D.
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  5. Anna R. Giuliano Ph.D.
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  6. Philippe E. Spiess M.D., M.S., F.R.C.S(C.)
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Corresponding author

Correspondence to Anna R. Giuliano Ph.D. .

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Editors and Affiliations

  1. Department of Genitourinary Oncology, Department of Tumor Biology, Moffitt Cancer Center, Tampa, Florida, USA

    Philippe E. Spiess

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Baumgarten, A.S., McCormick, B.Z., Ashouri, K.B., Dhillon, J., Giuliano, A.R., Spiess, P.E. (2017). Understanding the Pathophysiology of Penile Cancer and Its Preneoplastic Lesions. In: Spiess, P. (eds) Penile Cancer. Current Clinical Urology. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6679-0_1

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  • DOI: https://doi.org/10.1007/978-1-4939-6679-0_1

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