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Fatigue in Clinical Practice

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Sleep Disorders Medicine

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Abstract

Fatigue is a common complaint encountered by practitioners of sleep medicine. It is important for clinicians to be aware of the distinction between fatigue and excessive daytime sleepiness, since the two symptoms, although they may occur together, have distinct etiologies, require different investigational approaches, and merit unique management strategies. This chapter briefly describes the nature of fatigue that occurs with various primary sleep, neurological and general medical disorders, provides a brief overview of the pathophysiology of central and peripheral fatigue, and discusses the latest recommendations for investigation and management of fatigue.

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References

  1. Miller M, Kearney N (2001) Nurses’ knowledge and attitudes towards cancer-related fatigue. Eur J Oncol Nurs 5(4):208–217

    Article  CAS  PubMed  Google Scholar 

  2. Krupp LB (2003) Fatigue. Butterworth-Heinemann, Philadephia

    Google Scholar 

  3. Aritake S, Kaneita Y, Ohtsu T, Uchiyama M, Mishima K, Akashiba T, Uchimura N, Nakaji S, Munezawa T, Ohida T (2015) Prevalence of fatigue symptoms and correlations in the general adult population. Sleep Biol Rhythms 13:146–154

    Article  Google Scholar 

  4. van’t Leven M, Zielhuis GA, van der Meer JW, Verbeek AL, Bleijenberg G (2010) Fatigue and chronic fatigue syndrome-like complaints in the general population. Eur J Public Health 20(3):251–257

    Google Scholar 

  5. Finsterer J, Mahjoub SZ (2014) Fatigue in healthy and diseased individuals. Am J Hosp Palliat Care. 31(5):562–575

    Article  PubMed  Google Scholar 

  6. Krupp L, LaRocca N, Muir-Nash J, Steinberg AD (1989) The fatigue severity scale: application to patients with multiple sclerosis and systemic lupus erythematosus. Arch Neurol 46(10):1121–1123

    Article  CAS  PubMed  Google Scholar 

  7. Albers M, Smets EM, Vercoulen JH, Garssen B, Bleijenberg G (1997) Abbreviated fatigue questionnaire; a practical tool in the classification of fatigue. Ned Tidschr Geneeskd 141:1526–1530 (Article in Dutch)

    Google Scholar 

  8. Beurskens AJ, Bultmann U, Kant I, Vercoulen JH, Bleijenberg G, Swaen GM (2000) Fatigue among working people: validity of a questionnaire measure. Occup Environ Med 57:353–357

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Chaudhuri A, Behan PO (2000) Fatigue and basal ganglia. J Neurol Sci 179(1–2):34–42

    Article  CAS  PubMed  Google Scholar 

  10. Schillings ML, Stegeman DF, Zwarts MJ (2005) Determining central activation failure and peripheral fatigue in the course of sustained maximal voluntary contractions: a model-based approach. J Appl Physiol 98(6):2292–2297

    Article  PubMed  Google Scholar 

  11. Zwarts MJ, Bleijenberg G, van Engelen BGM (2008) Clinical neurophysiology of fatigue. Clin Neurophysiol 119:2–10

    Article  CAS  PubMed  Google Scholar 

  12. Taylor JL, Todd G, Gandevia SC (2006) Evidence for a supraspinal contribution to human muscle fatigue. Clin Exp Pharmacol Physiol 33(4):400–405

    Article  CAS  PubMed  Google Scholar 

  13. Liepert J, Kotterba S, Tegenthoff M, Malin JP (1996) Central fatigue assessed by transcranial magnetic stimulation. Muscle Nerve 19:1429–1434

    Article  CAS  PubMed  Google Scholar 

  14. Ljubisavljević M, Milanović S, Radovanović S, Vukcević I, Kostić V, Anastasijević R (1996) Central changes in muscle fatigue during sustained submaximal isometric voluntary contraction as revealed by transcranial magnetic stimulation. Electroencephalogr Clin Neurophysiol 101(4):281–288

    Google Scholar 

  15. McKay WB, Tuel SM, Sherwood AM, Stokić DS, Dimitrijević MR (1995) Focal depression of cortical excitability induced by fatiguing muscle contraction: a transcranial magnetic stimulation study. Exp Brain Res 105(2):276–282

    Article  CAS  PubMed  Google Scholar 

  16. Kuppuswamy A, Clark EV, Turner IF, Rothwell JC, Ward NS (2015) Post-stroke fatigue: a deficit in corticomotor excitability? Brain. 138(Pt 1):136–148

    Article  PubMed  Google Scholar 

  17. Pellicano C, Gallo A, Li X (2010) Relationship of cortical atrophy to fatigue in patients with multiple sclerosis. Arch Neurol 67(4):447–453

    Google Scholar 

  18. Calabrese M, Rinaldi F, Grossi P, Mattisi I, Bernardi V, Favaretto A, Perini P, Gallo P (2010) Basal ganglia and frontal/parietal cortical atrophy is associated with fatigue in relapsing—remitting multiple sclerosis. Mult Scler 16(10):1220–1228

    Article  PubMed  Google Scholar 

  19. Papadopoulou A, Müller-Lenke N, Naegelin Y et al (2013) Contribution of cortical and white matter lesions to cognitive impairment in multiple sclerosis. Mult Scler 19(10):1290–1296

    Article  PubMed  Google Scholar 

  20. Yaldizli O, Penner IK, Frontzek K et al (2014) The relationship between total and regional corpus callosum atrophy, cognitive impairment and fatigue in multiple sclerosis patients. Mult Scler 20(3):356–364

    Article  PubMed  Google Scholar 

  21. Specogna I, Casagrande F, Lorusso A, Catalan M, Gorian A, Zugna L, Longo R, Zorzon M, Naccarato M, Pizzolato G, Ukmar M, Cova MA (2012) Functional MRI during the execution of a motor task in patients with multiple sclerosis and fatigue. Radiol Med. 117(8):1398–1407

    Article  CAS  PubMed  Google Scholar 

  22. Filippi M, Rocca MA, Colombo B et al (2002) Functional magnetic resonance imaging correlates of fatigue in multiple sclerosis. Neuroimage 15(3):559–567

    Article  CAS  PubMed  Google Scholar 

  23. Rocca MA, Absinta M, Valsasina P, Copetti M, Caputo D, Comi G, Filippi M (2012) Abnormal cervical cord function contributes to fatigue in multiple sclerosis. Mult Scler. 18(11):1552–1559

    Article  CAS  PubMed  Google Scholar 

  24. Bakshi R, Miletich RS, Kinkel PR, Emmet ML, Kinkel WR (1998) High-resolution fluorodeoxyglucose positron emission tomography shows both global and regional cerebral hypometabolism in multiple sclerosis. J Neuroimaging 8:228–234

    Article  CAS  PubMed  Google Scholar 

  25. Hanken K, Eling P, Kastrup A, Klein J, Hildebrandt H (2015) Integrity of hypothalamic fibers and cognitive fatigue in multiple sclerosis. Mult Scler Relat Disord 4(1):39–46

    Article  PubMed  Google Scholar 

  26. Togo F, Lange G, Natelson BH, Quigley KS (2015) Attention network test: assessment of cognitive function in chronic fatigue syndrome. J Neuropsychol. 9(1):1–9

    Article  PubMed  Google Scholar 

  27. Morrow SA, Rosehart H, Johnson AM (2015) Diagnosis and quantification of cognitive fatigue in multiple sclerosis. Cogn Behav Neurol 28(1):27–32

    Article  PubMed  Google Scholar 

  28. Johansson B, Rönnbäck L (2015) Novel computer tests for identification of mental fatigue after traumatic brain injury. NeuroRehabilitation [Epub ahead of print]

    Google Scholar 

  29. Wessely S, Chalder T, Hirsch S, Wallace P, Wright D (1997) The prevalence and morbidity of chronic fatigue and chronic fatigue syndrome: a prospective primary care study. Am J Public Health 87(9):1449–1455

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Calvo N, Sáez-Francàs N, Valero S, Alegre J, Casas M (2015) Comorbid personality disorders in Chronic Fatigue Syndrome patients: a marker of psychopathological severity. Actas Esp Psiquiatr. 43(2):58–65

    PubMed  Google Scholar 

  31. Moss-Morris R, Deary V, Castell B (2013) Chronic fatigue syndrome. Handb Clin Neurol. 110:303–314

    Article  PubMed  Google Scholar 

  32. What’s in a name? Systemic exertion intolerance disease (no authors listed) (2015) Lancet 385(9969):663

    Google Scholar 

  33. Cameron B, Flamand L, Juwana H, Middeldorp J, Naing Z, Rawlinson W, Ablashi D, Lloyd A (2010) Serological and virological investigation of the role of the herpesviruses EBV, CMV and HHV-6 in post-infective fatigue syndrome. J Med Virol 82(10):1684–1688

    Article  CAS  PubMed  Google Scholar 

  34. Nijs J, Nees A, Paul L, De Kooning M, Ickmans K, Meeus M, Van Oosterwijck J (2014) Altered immune response to exercise in patients with chronic fatigue syndrome/myalgic encephalomyelitis: a systematic literature review. Exerc Immunol Rev 20:94–116

    PubMed  Google Scholar 

  35. Morris G, Berk M, Walder K, Maes M (2015) Central pathways causing fatigue in neuro-inflammatory and autoimmune illnesses. BMC Med 6(13):28

    Article  CAS  Google Scholar 

  36. Hornig M, Gottschalk G, Peterson DL, Knox KK, Schultz AF, Eddy ML, Che X (2015) Lipkin WI5. Cytokine network analysis of cerebrospinal fluid in myalgic encephalomyelitis/chronic fatigue syndrome. Mol Psychiatry [Epub ahead of print]

    Google Scholar 

  37. Fischer DB, William AH, Strauss AC, Unger ER, Jason L, Marshall GD Jr, Dimitrakoff JD (2014) Chronic fatigue syndrome: the current status and future potentials of emerging biomarkers. Fatigue 2(2):93–109

    PubMed  PubMed Central  Google Scholar 

  38. Schillings ML, Kalkmanb JS, van der Werf SP, van Engelen BG, Bleijenberg G, Zwarts MJ (2004) Diminished central activation during maximal voluntary contraction in chronic fatigue syndrome. Clin Neurophysiol 115:2518–2524

    Article  CAS  PubMed  Google Scholar 

  39. Tanaka M, Ishii A, Watanabe Y (2013) Neural mechanisms underlying chronic fatigue. Rev Neurosci 24(6):617–628

    Article  PubMed  Google Scholar 

  40. Ortega F, Zorzanelli R (2011) Neuroimaging and the case of chronic fatigue syndrome. Cien Saude Colet 16(4):2123–2132 (Article in Portuguese)

    Google Scholar 

  41. Mariman A, Delesie L, Tobback E, Hanoulle I, Sermijn E, Vermeir P, Pevernagie D, Vogelaers D (2013) Undiagnosed and comorbid disorders in patients with presumed chronic fatigue syndrome. J Psychosom Res 75(5):491–496

    Article  PubMed  Google Scholar 

  42. Le Bon O, Fischler B, Hoffmann G et al (2000) How significant are primary sleep disorders and sleepiness in the chronic fatigue syndrome? Sleep Res Online. 3(2):43–48

    PubMed  Google Scholar 

  43. Jackson M, Bruck D (2012) Sleep abnormalities in chronic fatigue syndrome/myalgic encephalomyelitis: a review. J Clin Sleep Med 8(6):719–728

    PubMed  PubMed Central  Google Scholar 

  44. Bhat S, Chokroverty S (2013) Fatigue in neurological disorders. Sleep Med Clin. 8(2):191–212

    Article  Google Scholar 

  45. Pae CU, Marks DM, Patkar AA, Masand PS, Luyten P, Serretti A (2009) Pharmacological treatment of chronic fatigue syndrome: focusing on the role of antidepressants. Expert Opin Pharmacother 10(10):1561–1570

    Article  CAS  PubMed  Google Scholar 

  46. White PD, Goldsmith KA, Johnson AL, Potts L, Walwyn R, DeCesare JC, Baber HL, Burgess M, Clark LV, Cox DL, Bavinton J, Angus BJ, Murphy G, Murphy M, O’Dowd H, Wilks D, McCrone P, Chalder T (2011) Sharpe M; PACE trial management group. Comparison of adaptive pacing therapy, cognitive behaviour therapy, graded exercise therapy, and specialist medical care for chronic fatigue syndrome (PACE): a randomised trial. Lancet 377(9768):823–836

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  47. Veauthier C, Friedmann P (2014) Sleep disorders in multiple sclerosis and their relationship to fatigue. Sleep Med 15(1):5–14

    Article  PubMed  Google Scholar 

  48. Veauthier C (2013) Younger age, female sex, and high number of awakenings and arousals predict fatigue in patients with sleep disorders: a retrospective polysomnographic observational study. Neuropsychiatr Dis Treat 9:1483–1494

    Article  PubMed  PubMed Central  Google Scholar 

  49. Mills PJ, Kim JH, Bardwell W, Hong S, Dimsdale JE (2008) Predictors of fatigue in obstructive sleep apnea. Sleep Breath 12(4):397–399

    Article  PubMed  PubMed Central  Google Scholar 

  50. Tomfohr LM, Ancoli-Israel S, Loredo JS, Dimsdale JE (2011) Effects of continuous positive airway pressure on fatigue and sleepiness in patients with obstructive sleep apnea: data from a randomized controlled trial. Sleep 34(1):121–126

    Article  PubMed  PubMed Central  Google Scholar 

  51. Fatigue in sleep apnea (2011) the role of depressive symptoms and self-reported sleep quality. Sleep Med 12(9):832–837

    Article  Google Scholar 

  52. Aguillard RN, Riedel BW, Lichstein KL, Grieve FG, Johnson CT, Noe SL (1998) Daytime functioning in obstructive sleep apnea patients: exercise tolerance, subjective fatigue, and sleepiness. Appl Psychophysiol Biofeedback. 23(4):207–217

    Article  CAS  PubMed  Google Scholar 

  53. Droogleever Fortuyn HA, Fronczek R, Smitshoek M, Overeem S, Lappenschaar M, Kalkman J, Renier W, Buitelaar J, Lammers GJ, Bleijenberg G (2012) Severe fatigue in narcolepsy with cataplexy. J Sleep Res 21(2):163–169

    Google Scholar 

  54. Becker PM, Schwartz JR, Feldman NT, Hughes RJ (2004) Effect of modafinil on fatigue, mood, and health-related quality of life in patients with narcolepsy. Psychopharmacology 171(2):133–139

    Article  CAS  PubMed  Google Scholar 

  55. Martinez S, Guilleminault C (2004) Periodic leg movements in prepubertal children with sleep disturbance. Dev Med Child Neurol 46(11):765–770

    Article  PubMed  Google Scholar 

  56. Øyane NM, Pallesen S, Moen BE, Akerstedt T, Bjorvatn B (2013) Associations between night work and anxiety, depression, insomnia, sleepiness and fatigue in a sample of Norwegian nurses. PLoS ONE 8(8):e70228

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  57. Niu SF, Chung MH, Chen CH, Hegney D, O’Brien A, Chou KR (2011) The effect of shift rotation on employee cortisol profile, sleep quality, fatigue, and attention level: a systematic review. J Nurs Res 19(1):68–81

    Article  PubMed  Google Scholar 

  58. Tang NK, Lereya ST, Boulton H, Miller MA, Wolke D, Cappuccio FP (2015) Nonpharmacological treatments of insomnia for long-term painful conditions: a systematic review and meta-analysis of patient-reported outcomes in randomized controlled trials. Sleep [Epub ahead of print] (pii: sp-00773-14)

    Google Scholar 

  59. Paul RH, Cohen RA, Goldstein JM, Gilchrist JM (2000) Fatigue and its impact on patients with myasthenia gravis. Muscle Nerve 23:1402–1406

    Article  CAS  PubMed  Google Scholar 

  60. Askmark H, Haggård L, Nygren I, Punga AR (2012) Vitamin D deficiency in patients with myasthenia gravis and improvement of fatigue after supplementation of vitamin D3: a pilot study. Eur J Neurol 19(12):1554–1560

    Article  CAS  PubMed  Google Scholar 

  61. Drenthen J, Jacobs BC, Maathuis EM, van Doorn PA, Visser GH, Blok JH (2013) Residual fatigue in Guillain-Barre syndrome is related to axonal loss. Neurology. 81(21):1827–1831

    Article  PubMed  Google Scholar 

  62. Merkies ISJ, Schmitz PIM, Samijn JPA, van der Meché FG, van Doorn PA (1999) Fatigue in immune-mediated polyneuropathies. Neurology. 53(8):1648–1654

    Article  CAS  PubMed  Google Scholar 

  63. Ruhland JL, Shields RK (1997) The effects of a home exercise program on impairment and health-related quality of life in persons with chronic peripheral neuropathies. Phys Ther 77(10):1026–1039

    Article  CAS  PubMed  Google Scholar 

  64. Carter G, Han J, Mayadev A (2006) Modafinil reduces fatigue in Charcot-Marie-Tooth disease Type 1A: a case series. Am J Hosp Palliat Care 23(5):412–416

    Article  PubMed  Google Scholar 

  65. Kalkman S, Schillings ML, van der Werf SP et al (2005) Experienced fatigue in facioscapulohumeral dystrophy, myotonic dystrophy, and HMSN-1. J Neurol Neurosurg Psychiatry 76(10):1406–1409

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  66. Salva MQ, Blumen M, Jacquette A, Durand MC, Andre S, De Villiers M, Eymard B, Lofaso F, Heron D (2006) Sleep disorders in childhood-onset myotonic dystrophy type 1. Neuromuscul Disord 16(9–10):564–570

    Article  Google Scholar 

  67. Kent-Braun JA, Miller RG (2000) Central fatigue during isometric exercise in amyotrophic lateral sclerosis. Muscle Nerve 23:909–914

    Article  CAS  PubMed  Google Scholar 

  68. Vucic S, Cheah BC, Kiernan MC (2011) Maladaptation of cortical circuits underlies fatigue and weakness in ALS. Amyotroph Lateral Scler. 12(6):414–420

    Article  PubMed  Google Scholar 

  69. Lo Coco D, La Bella V (2012) Fatigue, sleep, and nocturnal complaints in patients with amyotrophic lateral sclerosis. Eur J Neurol 19(5):760–763

    Google Scholar 

  70. Östlund G, Wahlin Å, Sunnerhagen KS et al (2011) Post polio syndrome: fatigued patients a specific subgroup? J Rehabil Med 43(1):39–45

    Article  PubMed  Google Scholar 

  71. Trojan DA, Genrdon D, Cashman NR (1993) Anticholinesterase-responsive neuromuscular junction transmission defects in post-poliomyelitis fatigue. J Neurol Sci 114(2):170–177

    Article  CAS  PubMed  Google Scholar 

  72. Ostlund G, Borg K, Wahlin A (2005) Cognitive functioning in post-polio patients with and without general fatigue. J Rehabil Med 37(3):147–151

    Article  PubMed  Google Scholar 

  73. Bruno RL, Cohen JM, Frick NM (1994) The neuroanatomy of post-polio fatigue. Arch Phys Med Rehabil 75:498–504

    CAS  PubMed  Google Scholar 

  74. Araujo MAD, de Silva TM, Moreira GA, Pradella-Hallinan M, Tufik S, Oliveira AS (2010) Sleep disorders frequency in post-polio syndrome patients caused by periodic limb movements. Arq Neuropsiquiatr 68(1):35–38

    Article  PubMed  Google Scholar 

  75. Huang YH, Chen HC, Huang KW, Chen PC, Hu CJ, Tsai CP, Tam KW, Kuan YC (2015) Intravenous immunoglobulin for postpolio syndrome: a systematic review and meta-analysis. BMC Neurol [Epub ahead of print]

    Google Scholar 

  76. Koopman FS, Beelen A, Gerrits KH, Bleijenberg G, Abma TA, de Visser M, Nollet F (2010) Exercise therapy and cognitive behavioural therapy to improve fatigue, daily activity performance and quality of life in postpoliomyelitis syndrome: the protocol of the FACTS-2-PPS trial. BMC Neurol 18(10):8

    Article  Google Scholar 

  77. Malekzadeh A, Van de Geer-Peeters W, De Groot V, Teunissen CE, Beckerman H, TREFAMS-ACE Study Group (2015) Fatigue in patients with multiple sclerosis: is it related to pro- and anti-inflammatory cytokines? Dis Markers 758314 [Epub ahead of print]

    Google Scholar 

  78. Patejdl R, Penner IK, Noack TK, Zett UK (2015) Fatigue in patients with multiple sclerosis—pathogenesis, clinical picture, diagnosis and treatment. Fortschr Neurol Psychiatr 83(4):211–220

    Article  CAS  PubMed  Google Scholar 

  79. Dobryakova E, Genova HM, DeLuca J, Wylie GR (2015) The dopamine imbalance hypothesis of fatigue in multiple sclerosis and other neurological disorders. Front Neurol 6:52. doi:10.3389/fneur.2015.00052

  80. Powell DJ, Moss-Morris R, Liossi C, Schlotz W (2015) Circadian cortisol and fatigue severity in relapsing-remitting multiple sclerosis. Psychoneuroendocrinology. 56:120–131

    Article  CAS  PubMed  Google Scholar 

  81. Hanken K, Eling P, Kastrup A, Klein J, Hildebrandt H (2015) Integrity of hypothalamic fibers and cognitive fatigue in multiple sclerosis. Mult Scler Relat Disord. 4(1):39–46

    Article  PubMed  Google Scholar 

  82. Ziemssen T, Hoffman J, Apfel R, Kern S (2008) Effects of glatiramer acetate on fatigue and days of absence from work in first-time treated relapsing-remitting multiple sclerosis. Health Qual Life Outcomes. 6:67

    Article  PubMed  PubMed Central  Google Scholar 

  83. Penner IK, Sivertsdotter EC, Celius EG, Fuchs S, Schreiber K, Berkö S, Svenningsson A (2015) TYNERGY trial investigators. Improvement in fatigue during natalizumab treatment is linked to improvement in depression and day-time sleepiness. Front Neurol 6:18

    Google Scholar 

  84. Strober LB (2015) Fatigue in multiple sclerosis: a look at the role of poor sleep. Front Neurol. 6:21

    Article  PubMed  PubMed Central  Google Scholar 

  85. Khan F, Amatya B, Galea M (2014) Management of fatigue in persons with multiple sclerosis. Front Neurol 5:177

    Article  PubMed  PubMed Central  Google Scholar 

  86. Tanaka K, Wada-Isoe K, Yamamoto M, Tagashira S, Tajiri Y, Nakashita S, Nakashima K (2014) Clinical evaluation of fatigue in Japanese patients with Parkinson’s disease. Brain Behav 4(5):643–649

    Article  PubMed  PubMed Central  Google Scholar 

  87. Pavese N, Metta V, Bose S, Chaudhuri KR, Brooks DJ (2010) Fatigue in Parkinson’s disease is linked to striatal and limbic serotonergic dysfunction. Brain. 133(1):3434–3443

    Article  PubMed  Google Scholar 

  88. Stocchi F, Abbruzzese G, Ceravolo R, Cortelli P, D’Amelio M, De Pandis MF, Fabbrini G, Pacchetti C, Pezzoli G, Tessitore A, Canesi M, Iannacone C, Zappia M, FORTE Study Group (2014) Prevalence of fatigue in Parkinson disease and its clinical correlates. Neurology. 83(3):215–220

    Article  PubMed  Google Scholar 

  89. Skorvanek M, Gdovinova Z, Rosenberger J, Saeedian RG, Nagyova I, Groothoff JW, van Dijk JP (2015) The associations between fatigue, apathy, and depression in Parkinson’s disease. Acta Neurol Scand 131(2):80–87

    Article  CAS  PubMed  Google Scholar 

  90. Dashtipour K, Johnson E, Kani C, Kani K, Hadi E, Ghamsary M, Pezeshkian S, Chen JJ (2015) Effect of exercise on motor and nonmotor symptoms of Parkinson’s disease. Parkinsons Dis 586378. doi:10.1155/2015/586378. Epub 2015 Feb 2

  91. Maaijwee NA, Arntz RM, Rutten-Jacobs LC, Schaapsmeerders P, Schoonderwaldt HC, van Dijk EJ, de Leeuw FE (2014) Post-stroke fatigue and its association with poor functional outcome after stroke in young adults. J Neurol Neurosurg Psychiatry. doi:10.1136/jnnp-2014-308784 [Epub ahead of print] (pii: jnnp-2014-308784)

  92. Pihlaja R, Uimonen J, Mustanoja S, Tatlisumak T, Poutiainen E (2014) Post-stroke fatigue is associated with impaired processing speed and memory functions in first-ever stroke patients. J Psychosom Res 77(5):380–384

    Article  PubMed  Google Scholar 

  93. Wu D, Wang L, Teng W, Huang K, Shang X (2015) Correlation of post-stroke fatigue with glucose, homocysteine and functional disability. Acta Neurol Scand 131(6):400–404

    Article  CAS  PubMed  Google Scholar 

  94. Snaphaan L, van der Werf S, de Leeuw FE (2011) Time course and risk factors of post-stroke fatigue: a prospective cohort study. Eur J Neurol 18:611–617

    Article  CAS  PubMed  Google Scholar 

  95. Acciarresi M, Bogousslavsky J, Paciaroni M (2014) Post-stroke fatigue: epidemiology, clinical characteristics and treatment. Eur Neurol 72(5–6):255–261

    Article  PubMed  Google Scholar 

  96. Duncan F, Kutlubaev MA, Dennis MS, Greig C, Mead GE (2012) Fatigue after stroke: a systematic review of associations with impaired physical fitness. Int J Stroke 7(2):157–162

    Google Scholar 

  97. Gagner C, Landry-Roy C, Lainé F, Beauchamp MH (2015) Sleep-wake disturbances and fatigue following pediatric traumatic brain injury: a systematic review of the literature. J Neurotrauma [Epub ahead of print]

    Google Scholar 

  98. Bell KR (2015) Fatigue and traumatic brain injury. Arch Phys Med Rehabil 96(3):567–568

    Article  PubMed  Google Scholar 

  99. Schönberger M, Herrberg M, Ponsford J (2014) Fatigue as a cause, not a consequence of depression and daytime sleepiness: a cross-lagged analysis. J Head Trauma Rehabil 29(5):427–431

    Google Scholar 

  100. Johansson B1, Wentzel AP, Andréll P, Mannheimer C, Rönnbäck L (2015) Methylphenidate reduces mental fatigue and improves processing speed in persons suffered a traumatic brain injury. Brain Inj 20:1–8 [Epub ahead of print]

    Google Scholar 

  101. Sharafkhaneh A, Melendez J, Akthar F, Lan C (2013) Fatigue in cardiopulmonary conditions. Sleep Med Clin 8(2):221–227

    Article  Google Scholar 

  102. Paddison JS, Effing TW, Quinn S, Frith PA (2013) Fatigue in COPD: association with functional status and hospitalisations. Eur Respir J 41(3):565–570

    Article  PubMed  Google Scholar 

  103. Zhang Y, Sun XG, Yang WL, Tan XY, Liu JM (2013) Inspiratory fraction correlates with exercise capacity in patients with stable moderate to severe COPD. Respir Care 58(11):1923–1930

    Article  PubMed  Google Scholar 

  104. Cavalcante AG, de Bruin PF, de Bruin VM et al (2012) Restless legs syndrome, sleep impairment, and fatigue in chronic obstructive pulmonary disease. Sleep Med 13(7):842–847

    Article  PubMed  Google Scholar 

  105. Hynninen MJ, Pallesen S, Hardie J et al (2013) Insomnia symptoms, objectively measured sleep, and disease severity in chronic obstructive pulmonary disease outpatients. Sleep Med 14(12):1328–1333

    Article  PubMed  Google Scholar 

  106. Lewko A, Bidgood PL, Jewell A, Garrod R (2014) Evaluation of multidimensional COPD-related subjective fatigue following a Pulmonary Rehabilitation programme. Respir Med 108(1):95–102

    Article  PubMed  Google Scholar 

  107. Fini A, de Almeida Lopes Monteiro da Cruz D. Characteristics of fatigue in heart failure patients: a literature review. Rev Lat Am Enfermagem. 2009;17(4):557-65

    Google Scholar 

  108. Shah AB, Udeoji DU, Baraghoush A, Bharadwaj P, Yennurajalingam S, Schwarz ER (2013) An evaluation of the prevalence and severity of pain and other symptoms in acute decompensated heart failure. J Palliat Med. 16(1):87–90

    Article  PubMed  Google Scholar 

  109. Drexler H, Coats AJ (1996) Explaining fatigue in congestive heart failure. Annu Rev Med 47:241–256

    Article  CAS  PubMed  Google Scholar 

  110. Smith OR, Kupper N, Schiffer AA, Denollet J (2012) Somatic depression predicts mortality in chronic heart failure: can this be explained by covarying symptoms of fatigue? Psychosom Med 74(5):459–463

    Article  PubMed  Google Scholar 

  111. Chung CJ, Schulze PC (2011) Exercise as a nonpharmacologic intervention in patients with heart failure. Phys Sportsmed 39(4):37–43

    Article  PubMed  PubMed Central  Google Scholar 

  112. Bossola M, Di Stasio E, Antocicco M, Tazza L (2013) Qualities of fatigue in patients on chronic hemodialysis. Hemodial Int 17(1):32–40

    Article  PubMed  Google Scholar 

  113. Masoumi M, Naini AE, Aghaghazvini R, Amra B, Gholamrezaei A (2013) Sleep quality in patients on maintenance hemodialysis and peritoneal dialysis. Int J Prev Med 4(2):165–172

    PubMed  PubMed Central  Google Scholar 

  114. Horigan A, Rocchiccioli J, Trimm D (2012) Dialysis and fatigue: implications for nurses–a case study analysis. Medsurg Nurs 21(3):158–175

    PubMed  PubMed Central  Google Scholar 

  115. Pejovic S, Natelson BH, Basta M, Fernandez-Mendoza J, Mahr F, Vgontzas AN (2015) Chronic fatigue syndrome and fibromyalgia in diagnosed sleep disorders: a further test of the ‘unitary’ hypothesis. BMC Neurol. 15:53

    Article  PubMed  PubMed Central  Google Scholar 

  116. Kurzrock R (2001) The role of cytokines in cancer-related fatigue. Cancer 92:1684–1688

    Article  CAS  PubMed  Google Scholar 

  117. Butt Z, Rosenbloom SK, Abernethy AP et al (2008) Fatigue is the most important symptom for advanced cancer patients who have had chemotherapy. J Natl Compr Canc Netw 6(5):448–455

    Article  PubMed  PubMed Central  Google Scholar 

  118. Wright F, D’Eramo Melkus G, Hammer M, Schmidt BL, Knobf MT, Paul SM, Cartwright F, Mastick J, Cooper BA, Chen LM, Melisko M, Levine JD, Kober K, Aouizerat BE, Miaskowski C (2015) Predictors and trajectories of morning fatigue are distinct from evening fatigue. J Pain Symptom Manage [Epub ahead of print]

    Google Scholar 

  119. Cella D, Kallich J, McDermott A, Xu X (2004) The longitudinal relationship of hemoglobin, fatigue and quality of life in anemic cancer patients: results from five randomized clinical trials. Ann Oncol 15(6):979–986

    Article  CAS  PubMed  Google Scholar 

  120. Eton DT, Cella D (2011) Do erythropoietic-stimulating agents relieve fatigue? A review of reviews. Cancer Treat Res 157:181–194

    Article  CAS  PubMed  Google Scholar 

  121. Meneses-Echávez JF, González-Jiménez E, Ramírez-Vélez R (2015) Effects of supervised exercise on cancer-related fatigue in breast cancer survivors: a systematic review and meta-analysis. BMC Cancer 15:77

    Article  PubMed  PubMed Central  Google Scholar 

  122. Stasi R, Abriani L, Beccaglia P, Terzoli E, Amadori S (2003) Cancer-related fatigue. Cancer 98:1786–1801

    Article  PubMed  Google Scholar 

  123. Herman J (2013) Psychiatric disorders and fatigue. Sleep Med Clin 8(2):213–220

    Article  Google Scholar 

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Authors and Affiliations

  1. JFK New Jersey Neuroscience Institute, Edison, NJ, USA

    Sushanth Bhat & Sudhansu Chokroverty

  2. School of Graduate Medical Education, Seton Hall University, South Orange, NJ, USA

    Sudhansu Chokroverty

  3. Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA

    Sudhansu Chokroverty

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  1. Sushanth Bhat
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  2. Sudhansu Chokroverty
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Correspondence to Sushanth Bhat .

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  1. School of Graduate Medical Education, Seton Hall University, South Orange, New Jersey, USA

    Sudhansu Chokroverty

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Bhat, S., Chokroverty, S. (2017). Fatigue in Clinical Practice. In: Chokroverty, S. (eds) Sleep Disorders Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-6578-6_42

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  • DOI: https://doi.org/10.1007/978-1-4939-6578-6_42

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