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Proteomic Studies of HIV-1 and Its Posttranslational Modifications

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HIV-1 Proteomics

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Abstract

HIV requires many proteins to complete its life cycle. Many of these proteins are decorated with biologically critical modifications that alter structure and function. In fact, there are many different types of posttranslational modifications (PTMs) involved in the virus life cycle (Fig. 6.1). In this chapter, we will reintroduce the virus life cycle from the perspective of PTMs. While these modifications will be described in detail later in the chapter, we will highlight new modifications in bold as they are introduced.

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Authors and Affiliations

  1. Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, 823 Miller Research Building, 733 N. Broadway, Baltimore, MD, 21205, USA

    David R. Colquhoun Ph.D.

  2. Department of Molecular and Comparative Pathobiology, Johns Hopkins School of Medicine, 733 N. Broadway, MRB 835, Baltimore, MD, 21205, USA

    David R. M. Graham M.Sc., Ph.D.

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  1. David R. Colquhoun Ph.D.
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  2. David R. M. Graham M.Sc., Ph.D.
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Correspondence to David R. Colquhoun Ph.D. .

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Editors and Affiliations

  1. Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

    David R. M. Graham

  2. Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA

    David E. Ott

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Colquhoun, D.R., Graham, D.R.M. (2016). Proteomic Studies of HIV-1 and Its Posttranslational Modifications. In: Graham, D., Ott, D. (eds) HIV-1 Proteomics. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-6542-7_6

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