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Functional Dairy Products

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Abstract

Milk and dairy products have been part of the human diet for thousands of years, playing an important role in the nutrition and development of human populations throughout the world. Twenty-first century consumers, however, are looking for benefits beyond nutrition in their foods, choosing those that provide wellness, convenience, and improved health besides basic nutrition. In this context, the development of functional dairy products is an area of important expansion in the dairy industry, where hundreds of new products are developed each year, constituting one of the largest sectors in the global market of functional foods. Among the main principles employed in the formulation of functional dairy products, addition of probiotic microorganisms and prebiotic fibers are some of the most popular, although the use of phytosterols, conjugated linoleic acid, omega-3 fatty acids, minerals, and bioactive peptides is increasing in popularity as a means to deal with health problems that go from simply maintaining gastrointestinal health to controlling hypertension, reducing cholesterol, and enhancing immune system response, among many other health concerns. There is still a long way to go in the development of novel functional dairy products. It is expected that the global functional dairy market will keep growing in coming years, throwing a challenge that will have to be faced through collaboration between academia and industry, hopefully resulting in the development and discovery of many new functional principles.

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References

  • Abubakar A, Saito T, Kitazawa H et al (1998) Structural analysis of new antihypertensive peptides derived from cheese whey protein by proteinase K digestion. J Dairy Sci 81(12):3131–3138

    Article  CAS  Google Scholar 

  • Aït-oukhatar N, Pérès JM, Bouhallab S et al (2002) Bioavailability of caseinophosphopetide-bound iron. J Lab Clin Med 140(4):290–294

    Article  CAS  Google Scholar 

  • Allen SJ, Martinez EG, Gregorio GV et al (2010) Probiotics for treating acute infectious diarrhoea. Cochrane Database Syst Rev (11):CD003048

    Google Scholar 

  • Andersen V, Egebjerg R, Tjonneland A et al (2012) Interaction between interleukin-10 (IL-10) polymorphisms and dietary fibre in relation to risk of colorectal cancer in a Danish case-cohort study. BMC Cancer 12(1):183

    Article  CAS  Google Scholar 

  • Aoyama T, Fukui K, Nakamori T et al (2000) Effect of soy and milk whey protein isolates and their hydrolysates on weight reduction in genetically obese mice. Biosci Biotech Bioch 64(12):2594–2600

    Article  CAS  Google Scholar 

  • Arem H, Neuhouser ML, Irwin ML et al (2013) Omega-3 and omega-6 fatty acid intakes and endometrial cancer risk in a population-based case-control study. Eur J Nutr 52(3):1251–1260

    Article  CAS  Google Scholar 

  • Arruda MS, Silva FO, Egito AS et al (2012) New peptides obtained by hydrolysis of caseins from bovine milk by protease extracted from the latex Jacaratia corumbensis. Food Sci Technol-Leb 49(1):73–79

    Article  CAS  Google Scholar 

  • Asakuma S, Akahori M, Kimura K (2007) Sialyl oligosaccharides of human colostrum: changes in concentration during the first three days of lactation. Biosci Biotechnol Biochem 71(6):1447–1451

    Article  CAS  Google Scholar 

  • Aso Y, Akaza H, Kotake T et al (1995) Preventive effect of a Lactobacillus casei preparation on the recurrence of superficial bladder cancer in a double-blind trial. The BLP Study Group. Eur Urol 27(2):104–109

    CAS  Google Scholar 

  • Bassaganya-Riera J, Hontecillas R, Horne WT (2012) Conjugated linoleic acid modulates immune responses in patients with mild to moderately active Crohn’s disease. Clin Nutr 5:721–727

    Article  CAS  Google Scholar 

  • Bellomo G, Mangiagle A, Nicastro L, Frigerio G (1980) A controlled double blind study of SF68 strain as a new biological preparation for the treatment of diarrhea in pediatrics. Curr Ther Res 28:927–936

    Google Scholar 

  • Belobrajdic DP, McIntosh GH, Owens JA (2004) A high-whey-protein diet reduces body weight gain and alters insulin sensitivity relative to red meat in Wistar rats. J Nutr 134(6):1454–1458

    CAS  Google Scholar 

  • Beucher S, Levenez F, Yvon M et al (1994) Effects of gastric digestive products from casein on CCK release by intestinal cells in rat. J Nutr Biochem 5(12):578–584

    Article  CAS  Google Scholar 

  • Bijkerk CJ, Muris JW, Knottnerus JA (2004) Systematic review: the role of different types of fibre in the treatment of irritable bowel syndrome. Aliment Pharmacol Ther 19(3):245–251

    Article  CAS  Google Scholar 

  • Biller JA, Katz AJ, Flores AF et al (1995) Treatment of recurrent Clostridium difficile colitis with Lactobacillus GG. J Pediatr Gastroenterol Nutr 21(2):224–226

    Article  CAS  Google Scholar 

  • Bodner JM, Sieg J (2009) Fiber. In: Tarté R (ed) Ingredients in meat products: properties, functionality and applications. Springer Science + Business Media, LLC, New York, NY, pp 83–107

    Chapter  Google Scholar 

  • Boehm G, Stahl B (2003) Oligosaccharides. In: Mattila-Sandholm T, Saarela M (eds) Functional dairy products. CRC Press, Boca Raton, FL, pp 203–233

    Chapter  Google Scholar 

  • Boldogh I, Liebenthal D, Hughes TK et al (2003) Modulation of 4HNE-mediated signaling by proline-rich peptides from ovine colostrum. J Mol Neurosci 20(2):125–134

    Article  CAS  Google Scholar 

  • Borderías AJ, Sánchez-Alonso I, Pérez-Mateos M (2005) New applications of fibres in foods: addition to fishery products. Trends Food Sci Tech 16(10):458–465

    Article  CAS  Google Scholar 

  • Borgia MN, Sepe N, Brancato V, Borgia R (1982) A controlled clinical study on Streptococcus faecium preparation for the prevention of side reactions during long-term antibiotic treatments. Curr Ther Res 31:265–271

    Google Scholar 

  • Borruel N, Carol M, Casellas F et al (2002) Increased mucosal tumour necrosis factor alpha production in Crohn’s disease can be downregulated ex-vivo by probiotic bacteria. Gut 51(5):659–664

    Article  CAS  Google Scholar 

  • Bouhallab S, Bouglé D (2004) Biopeptides of milk: caseinophosphopeptides and mineral bioavailability. Reprod Nutr Dev 44(5):493–498

    Article  CAS  Google Scholar 

  • Bounous G, Gold P (1991) The biological activity of undenatured dietary whey proteins: role of glutathione. Clin Invest Med 14(4):296–309

    CAS  Google Scholar 

  • Burger KN, Beulens JW, van der Schouw YT et al (2012) Dietary fiber, carbohydrate quality and quantity, and mortality risk of individuals with diabetes mellitus. PLoS One 7(8):e43127

    Article  CAS  Google Scholar 

  • Burns AJ, Rowland IR (2000) Anti-carcinogenicity of probiotics and prebiotics. Curr Issues Intest Microbiol 1(1):13–24

    CAS  Google Scholar 

  • Buydens P, Debeuckelaere S (1996) Efficacy of SF68 in the treatment of acute diarrhea: a placebo-controlled trial. Scand J Gastroenterol 31(9):887–891

    Article  CAS  Google Scholar 

  • Camarri E, Belvisi A, Guidoni G et al (1981) A double-blind comparison of two different treatments for acute enteritis in adults. Chemotherapy 27(6):466–470

    Article  CAS  Google Scholar 

  • Cario E, Brown D, McKee M et al (2002) Commensal- associated molecular patterns induce selective toll like receptor trafficking from apical membrane to cytoplasmic compartments in polarized intestinal epithelium. Am J Pathol 160(1):165–173

    Article  CAS  Google Scholar 

  • Chapoy P (1985) Treatment of acute infantile diarrhea: controlled trial of Saccharomyces boulardii. Ann Pediatr 32(6):561–563

    CAS  Google Scholar 

  • Choque-Delgado GT, Thomé R, Gabriel DL et al (2012) Yacon (Smallanthus sonchifolius)-derived fructooligosaccharides improves the immune parameters in the mouse. Nutr Res 32(11):884–892

    Article  CAS  Google Scholar 

  • Chryssanthopulos C, Maridaki M (2010) Nutritional aspects of yogurt and functional dairy products. In: Fatih Y (ed) Development and manufacture or yogurt and other functional dairy products, 1st edn. CRC Press, Boca Raton, FL, pp 267–306

    Google Scholar 

  • Clifton P (2007) Plant sterols and stanols as functional ingredients in dairy products. In: Saarela M (ed) Functional dairy products, vol 2. CRC Press, Boca Raton, FL, pp 255–328

    Chapter  Google Scholar 

  • Corsetto P, Cremona A, Montorfano G et al (2012) Chemical-physical changes in cell membrane microdomains of breast cancer cells after omega-3 PUFA incorporation. Cell Biochem Biophys 64:45–59

    Article  CAS  Google Scholar 

  • Das UN (2004) Perinatal supplementation of long-chain polyunsaturated fatty acids, immune response and adult diseases. Med Sci Monit 10(5):HY19–HY25

    CAS  Google Scholar 

  • de Lorgeril M, Salen P (2012) New insights into the health effects of dietary saturated and omega-6 and omega-3 polyunsaturated fatty acids. BMC Med 10:50

    Article  CAS  Google Scholar 

  • de Vrese M, Stegelmann A, Richter B et al (2001) Probiotics: compensation for lactase insufficiency. Am J Clin Nutr 73(suppl 2):S421–S429

    Google Scholar 

  • Ding M, Carrão AC, Wargner RJ et al (2012) Vascular smooth muscle cell-derived adiponectin: a paracrine regulator of contractile phenotype. J Mol Cell Cardiol 52(2):474–484

    Article  CAS  Google Scholar 

  • Erdmann K, Cheung BWY, Schröder H (2008) The possible roles of food-derived bioactive peptides in reducing the risk of cardiovascular disease. J Nutr Biochem 19(10):643–654

    Article  CAS  Google Scholar 

  • Fasano E, Serini S, Piccioni E et al (2012) DHA induces apoptosis by altering the expression and cellular location of GRP78 in colon cancer cell lines. Biochim Biophys Acta 1822:1762–1772

    Article  CAS  Google Scholar 

  • Felley CP, Corthésy-Theulaz I, Rivero JL et al (2001) Favourable effect of an acidified milk (LC-1) on Helicobacter pylori gastritis in man. Eur J Gastroenterol Hepatol 13(1):25–29

    Article  CAS  Google Scholar 

  • Field C, Van Aerde J, Robinson L et al (2008) Effect of providing a formula supplemented with long-chain polyunsaturated fatty acids on immune in full-term neonates. Br J Nutr 99(1):91–99

    Article  CAS  Google Scholar 

  • Fitzgerald RJ, Meisel H (2003) Milk protein hydrolysates and bioactive peptides. In: Fox PF, McSweeney PKJ (eds) Advanced dairy chemistry, vol 1, 3rd edn, Proteins. Elsevier Science Publishers Ltd., London, pp 675–698

    Google Scholar 

  • Fitzgerald RJ, Murray BA (2006) Bioactive peptides and lactic fermentations. Int J Dairy Technol 59(2):118–125

    Article  CAS  Google Scholar 

  • Gan BS, Kim J, Reid G et al (2002) Lactobacillus fermentum RC-14 inhibits Staphylococcus aureus infection of surgical implants in rat. J Infect Dis 185:1369–1372

    Article  Google Scholar 

  • Gianní M, Roggero P, Baudry C et al (2012) The influence of a formula supplemented with dairy lipids and plant oils on the erythrocyte membrane omega-3 fatty acid profile in healthy full-term infants: a double-blind randomized controlled trial. BMC Pediatr 12(1):164

    Article  CAS  Google Scholar 

  • Gionchetti P, Rizzello F, Venturi A et al (2000) Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis: a double-blind, placebo-controlled trial. Gastroenterology 119(2):305–309

    Article  CAS  Google Scholar 

  • Gnädig S, Xue Y, Berdeaux O et al (2003) Conjugated linoleic acid (CLA) as a functional ingredient. In: Mattila-Sandholm T, Saarela M (eds) Functional dairy products. CRC Press, Boca Raton, FL, pp 263–289

    Chapter  Google Scholar 

  • Gómez-Ruiz JA, Ramos M, Recio I (2004) Angiotensin converting enzyme-inhibitory activity of peptides isolated from Manchego cheese: stability under simulated gastrointestinal digestion. Int Dairy J 14(12):1075–1080

    Article  CAS  Google Scholar 

  • Guandalini S, Pensabene L, Zikri MA et al (2000) Lactobacillus GG administered in oral rehydration solution to children with acute diarrhea: a multicenter European trial. J Pediatr Gastroenterol Nutr 30(1):54–60

    Article  CAS  Google Scholar 

  • Gupta V, Garg R (2009) Probiotics. Indian J Med Microbiol 27(3):202–209

    Article  CAS  Google Scholar 

  • Gupta P, Andrew H, Kirschner BS et al (2000) Is Lactobacillus GG helpful in children with Crohn’s disease? Results of a preliminary, open-label study. J Pediatr Gastroenterol Nutr 31(4):453–457

    Article  CAS  Google Scholar 

  • Gürayan GC, Cebeci A, Özer B (2010) Probiotic dairy beverages: microbiology and technology. In: Fatih Y (ed) Development and manufacture or yogurt and other functional dairy products. CRC Press, Boca Raton, FL, pp 177–178

    Google Scholar 

  • Guslandi M, Giollo P, Testoni PA (2003) A pilot trial of Saccharomyces boulardii in ulcerative colitis. Eur J Gastroenterol Hepatol 15(6):697–698

    Article  Google Scholar 

  • Gustafson DR, McMahon DJ, Morrey J et al (2001) Appetite is not influenced by a unique milk peptide: caseinomacropeptide (CMP). Appetite 36(2):157–163

    Article  CAS  Google Scholar 

  • Gustaw W, Kordowska-Wiater M, Kozioł J (2011) The influence of selected prebiotics on the growth of lactic acid bacteria for bio-yoghurt production. Acta Sci Pol Technol Aliment 10(4):455–466

    Google Scholar 

  • Heczko PB, Strus M, Kochan P (2006) Critical evaluation of probiotic activity of lactic acid bacteria and their effects. J Physiol Pharmacol 57(suppl 9):5–12

    Google Scholar 

  • Hennessy AA, Ross RP, Stanton C et al (2007) Development of dairy based functional foods enriched in conjugated linoleic acid with special to rumenic acid. In: Saarela M (ed) Functional dairy products, vol 2. CRC Press, Boca Raton, FL, pp 90–109

    Google Scholar 

  • Higurashi S, Kunieda Y, Matsuyama H et al (2007) Effect of cheese consumption on the accumulation of abdominal adipose and decrease in serum adiponectin levels in rats fed a calorie dense diet. Int Dairy J 17(10):1224–1231

    Article  CAS  Google Scholar 

  • Hilton E, Kolakowski P, Singer C et al (1997) Efficacy of Lactobacillus GG as a diarrheal preventive in travelers. J Travel Med 4(1):41–43

    Article  CAS  Google Scholar 

  • Isolauri E, Kaila M, Mykkanen H et al (1994) Oral bacteriotherapy for viral gastroenteritis. Dig Dis Sci 39(12):2595–2600

    Article  CAS  Google Scholar 

  • Jiang J, Qiu H, Zhao G, Zhou Y, Zhang Z, Zhang H et al (2012) Dietary fiber intake is associated with HbA1c level among prevalent patients with type 2 diabetes in Pudong New Area of Shanghai, China. PLoS One 7(10):e46552

    Article  CAS  Google Scholar 

  • Jiménez-Escriq A, Tenorio MD, Espinosa-Martos I et al (2008) Health promoting effects of a dietary fiber concentrate from the soybean byproduct okara in rats. J Agric Food Chem 56(16):7495–7501

    Article  CAS  Google Scholar 

  • Kaczmarczyka MM, Michael J, Miller MJ et al (2012) The health benefits of dietary fiber: beyond the usual suspects of type 2 diabetes mellitus, cardiovascular disease and colon cancer. Metabolism 61(8):1058–1066

    Article  CAS  Google Scholar 

  • Kaila M, Isolauri E, Saxelin M et al (1995) Viable versus inactivated Lactobacillus strain GG in acute rotavirus diarrhea. Arch Dis Childhood 72(1):51–53

    Article  CAS  Google Scholar 

  • Kalliomäki M, Salminen S, Kero P et al (2001) Probiotics in the primary prevention of atopic disease: a randomized, placebo-controlled trial. Lancet 357(9262):1076–1079

    Article  Google Scholar 

  • Karagiozoglou-Lampoudi T, Daskalou E, Agakidid C et al (2012) Personalized diet management can optimize compliance to a high-fiber, high-water diet in children with refractory functional constipation. J Acad Nutr Diet 112(5):725–729

    Article  Google Scholar 

  • Karagül-Yüceer Y, Avşar YK (2010) Health attributes of yogurt and functional dairy products. In: Fatih Y (ed) Development and manufacture or yogurt and other functional dairy products, 1st edn. CRC Press, Boca Raton, FL, pp 307–316

    Google Scholar 

  • Kim SB, Lim JW (2004) Calcium-binding peptides derived from tryptic hydrolysates of cheese whey protein. Asian Aust J Anim 17(10):1459–1464

    Article  CAS  Google Scholar 

  • Kim SB, Seo IS, Khan MA et al (2007) Separation of iron-binding protein from whey through enzymatic hydrolysis. Int Dairy J 17(6):625–631

    Article  CAS  Google Scholar 

  • Kim MN, Kim N, Lee SH et al (2008) The effects of probiotics on PPI-triple therapy for Helicobacter pylori eradication. Helicobacter 13(4):261–268

    Article  CAS  Google Scholar 

  • Kollaritsch H, Wiedermann G (1992) Compliance of Austrian tourists with prophylactic measures. Eur J Epidemiol 8(2):243–251

    Article  CAS  Google Scholar 

  • Korhonen H, Pihlanto A (2006) Bioactive peptides: production and functionality. Int Dairy J 16(9):945–960

    Article  CAS  Google Scholar 

  • Korhonen H, Pihlanto-Leppäla A, Rantamäki P et al (1998) Impact of processing on bioactive proteins and peptides. Trends Food Sci Tech 9(8-9):307–319

    Article  CAS  Google Scholar 

  • Krasse P, Carlsson B, Dahl C et al (2006) Decreased gum bleeding and reduced gingivitis by the probiotic Lactobacillus reuteri. Swed Dent J 30(2):55–60

    Google Scholar 

  • Kruis W, Fric P, Pokrotnieks J et al (2004) Maintaining remission of ulcerative colitis with the probiotic Escherichia coli Nissle 1917 is as effective as with standard mesalazine. Gut 53(11):1617–1623

    Article  CAS  Google Scholar 

  • Kullisaar T, Songisepp E, Mikelsaar M et al (2003) Antioxidative probiotic fermented goats’ milk decreases oxidative stress-mediated atherogenicity in human subjects. Br J Nutr 90(2):449–456

    Article  CAS  Google Scholar 

  • Lewis SJ, Potts LF, Barry RE (1998) The lack of therapeutic effect of Saccharomyces boulardii in the prevention of antibiotic related diarrhoea in elderly patients. J Infect 36(2):171–174

    Article  CAS  Google Scholar 

  • Lilly DM, Stillwell RH (1965) Probiotics: growth promoting factors produced by microorganisms. Science 147(3659):747–748

    Article  CAS  Google Scholar 

  • Ling WH, Korpela R, Mykkanen H et al (1994) Lactobacillus strain GG supplementation decrease colonic hydrolytic and reductive enzyme activities in healthy female adults. J Nutr 124(1):18–23

    CAS  Google Scholar 

  • Luchtman DW, Song C (2013) Cognitive enhancement by omega-3 fatty acids from childhood to old age: findings from animal and clinical studies. Neuropharmacology 64:550–565

    Article  CAS  Google Scholar 

  • Maeda R, Ida T, Ihara H et al (2012) Induction of apoptosis in MCF-7 cells by β-1,3-xylooligosaccharides prepared from Caulerpa lentillifera. Biosci Biotechnol Biochem 76(5):1032–1034

    Article  CAS  Google Scholar 

  • Malin M, Suomalainen H, Saxelin M et al (1996) Promotion of IgA immune response in patients with Crohn’s disease by oral bacteriotherapy with Lactobacillus GG. Ann Nutr Metab 40(3):137–145

    Article  CAS  Google Scholar 

  • Marteau PR et al (2001) Protection from gastrointestinal diseases with the use of probiotics. Am J Clin Nutr 73(suppl 2):430S–436S

    CAS  Google Scholar 

  • Mastromarino P, Macchia S, Meggiorini L et al (2009) Effectiveness of Lactobacillus-containing vaginal tablets in the treatment of symptomatic bacterial vaginosis. Clin Microbiol Infect 15(1):67–74

    Article  CAS  Google Scholar 

  • McFarland LV (2007) Meta-analysis of probiotics for the prevention of traveler’s diarrhea. Travel Med Infect Dis 5(2):97–105

    Article  Google Scholar 

  • McFarland LV, Surawicz CM, Greenberg RN et al (1995) Prevention of beta-lactam-associated diarrhea by Saccharomyces boulardii compared with placebo. Am J Gastroenterol 90(3):439–448

    CAS  Google Scholar 

  • Meisel H, FitzGerald RJ (2003) Biofunctional peptides from milk proteins: mineral binding and cytomodulatory effects. Curr Pharm Design 9(16):1289–1295

    Article  CAS  Google Scholar 

  • Mellander O (1950) The physiological importance of the casein phosphopeptide calcium salts II. Peroral calcium dosage of infants. Acta Soc Med Uppsala 55(5/6):247–255

    CAS  Google Scholar 

  • Metchnikoff E (1907) The prolongation of life: optimistic studies. William Heinemann, London

    Google Scholar 

  • Miller JB, McVeagh P (1999) Human milk oligosaccharides: 130 reason to breast-feed. Br J Nutr 82:333–335

    Article  CAS  Google Scholar 

  • Mistry N, Drobni P, Näslund J et al (2007) The anti-papillomavirus activity of human and bovine lactoferricin. Antivir Res 75(3):258–265

    Article  CAS  Google Scholar 

  • Mitsuyama K, Toyonaga A, Sata M (2002) Intestinal microflora as a therapeutic target in inflammatory bowel disease. J Gastroenterol 37(suppl 14):73–77

    Article  Google Scholar 

  • Mizuno K, Tanaka M, Nozaki S et al (2008) Antifatigue effects of coenzyme Q10 during physical fatigue. Nutrition 24(4):293–299

    Article  CAS  Google Scholar 

  • Monteiro JCV, Pimentel GD, Sousa MV (2012) Relationship between body mass index with dietary fiber intake and skinfolds: differences among body builders who train during morning and nocturne period. Nutr Hosp 27(3):929–935

    CAS  Google Scholar 

  • Moore MR, King RA (2012) Effects of omega-3 fatty acids on progestin stimulation of invasive properties in breast cancer. Horm Cancer 3(5-6):205–217

    Article  CAS  Google Scholar 

  • Morikawa K, Kondo I, Kanamaru Y et al (2007) A novel regulatory pathway for cholesterol degradation via lactostatin. Biochem Bioph Res Commun 352(3):697–702

    Article  CAS  Google Scholar 

  • Murakami M, Tonouchi H, Takahashi R et al (2004) Structural analysis of a new anti-hypertensive peptide (β-Lactosin B) isolated from a commercial whey product. J Dairy Sci 87(7):1967–1974

    Article  CAS  Google Scholar 

  • Murphy N, Norat T, Ferrari P et al (2012) Dietary fiber intake and risk of cancer of the colon and rectum in the European prospective investigation into cancer and nutrition. PLoS One 7(6):e39361

    Article  CAS  Google Scholar 

  • Myllyluoma E, Veijola L, Ahlroos T et al (2005) Probiotic supplementation improves tolerance to Helicobacter pylori eradication therapy: a placebo-controlled, double-blind randomized pilot study. Aliment Pharmacol Ther 21(10):1263–1272

    Article  CAS  Google Scholar 

  • Nagaoka S (1996) Studies on regulation of cholesterol metabolism induced by dietary food constituents or xenobiotics. J Jpn Soc Nutr Food Sci 49(6):303–313

    Article  CAS  Google Scholar 

  • Nagaoka S, Kanamaru Y, Kuzuya Y et al (1992) Comparative studies on the serum cholesterol lowering action of whey protein and soybean protein in rats. Biosci Biotech Bioch 56(9):1482–1485

    Article  Google Scholar 

  • Nagaoka S, Futamura Y, Miwa K et al (2001) Identification of novel hypocholesterolemic peptides derived from bovine milk β-lactoglobulin. Biochem Bioph Res Commun 281(1):11–17

    Article  CAS  Google Scholar 

  • Naito S, Koga H, Yamaguchi A et al (2008) Prevention of recurrence with epirubicin and Lactobacillus casei after transurethral resection of bladder cancer. J Urol 179(2):485–490

    Article  CAS  Google Scholar 

  • Newburg DS (2009) Neonatal protection by an innate immune system of human milk consisting of oligosaccharides and glycans. J Anim Sci 87:26–34

    Article  CAS  Google Scholar 

  • Nurmien ML, Sipola M, Kaarto H et al (2000) α-Lactorphin lowers blood pressure measured by radiotelemetry in normotensive and spontaneously hypertensive rats. Life Sci 66(16):1535–1543

    Article  Google Scholar 

  • O’Hara AM, Keohane J, Shanahan F (2007) Probiotics, prebiotics, and inflammatory bowel disease. In: Saarela M (ed) Functional dairy products, vol 2. CRC Press, Boca Raton, FL, pp 90–109

    Chapter  Google Scholar 

  • O’Keefe JH, Wetzel M, Moe RR et al (2001) Should an Angiotensin-converting enzyme inhibitor be standard therapy for patients with atherosclerotic disease? J Am Coll Cardiol 37(1):1–8

    Article  Google Scholar 

  • Ogawa M, Shimizu K, Nomoto K et al (2001) Protective effect of Lactobacillus casei strain Shirota on Shiga toxin-producing Escherichia coli O157:H7 infection in infant rabbits. Infect Immun 69(2):1101–1108

    Article  CAS  Google Scholar 

  • Oksanen PJ, Salminen S, Saxelin M et al (1990) Prevention of travellers’ diarrhoea by Lactobacillus GG. Ann Med 22(1):53–56

    Article  CAS  Google Scholar 

  • Oxman T, Shapira M, Klein R et al (2001) Oral administration of Lactobacillus induces cardioprotection. J Altern Complement Med 7(4):345–354

    Article  CAS  Google Scholar 

  • Palmer DJ, Sullivan T, Gold MS et al (2012) Effect of n-3 long chain polyunsaturated fatty acid supplementation in pregnancy on infant’s allergies in first year of life: randomized controlled trial. BMJ 344:e184

    Article  CAS  Google Scholar 

  • Paturi G, Nyanhanda T, Butts CA et al (2012) Effects of potato fiber and potato-resistant starch on biomarkers of colonic health in rats fed diets containing red meat. J Food Sci 77:H216–H223

    Article  CAS  Google Scholar 

  • Perälä MM, Männistö S, Kaartinen NE et al (2012) Body size at birth is associated with food and nutrient intake in adulthood. PLoS One 7(9):e46139

    Article  CAS  Google Scholar 

  • Pérez-Cano F, Ramírez-Santana C, Molero-Luis M et al (2009) Mucosal IgA increase in rats by continus CLA feeding during suckling and early infancy. J Lipid Res 50:467–476

    Article  CAS  Google Scholar 

  • Pezzilli R, Fantini L (2006) Probiotics and severe acute pancreatitis. J Pancreas 7(1):92–93

    Google Scholar 

  • Pihlanto-Leppälä A (2001) Bioactive peptides derived from bovine whey proteins: opioid and ace-inhibitory peptides. Trends Food Sci Tech 11(9-10):347–356

    Article  Google Scholar 

  • Pompella A, Visvikis A, Paolicchi A et al (2003) The changing faces of glutathione, a cellular protagonist. Biochem Pharmacol 6(8):1499–1503

    Article  CAS  Google Scholar 

  • Rastall R (2003) Enhancing the functionality of prebiotics and probiotics. In: Mattila-Sandholm T, Saarela M (eds) Functional dairy products. CRC Press, Boca Raton, FL, pp 301–332

    Chapter  Google Scholar 

  • Raza S, Graham SM, Allen SJ et al (1995) Lactobacillus GG promotes recovery from acute nonbloody diarrhea in Pakistan. Pediatr Infect Dis J 14(2):107–111

    Article  CAS  Google Scholar 

  • Reid G (2001) Probiotic agents to protect the urogenital tract against infection. Am J Clin Nutr 73(suppl 2):437–443

    Google Scholar 

  • Reidelberger RD (1994) Cholecystokinin and control of food intake. J Nutr 124(8):1327S–1333S

    CAS  Google Scholar 

  • Riediger ND, Othman RA, Suh M et al (2009) A systemic review of the roles of n-3 fatty acids in health and disease. J Am Diet Assoc 119:668–679

    Article  CAS  Google Scholar 

  • Rijnierse A, Jeurink PV, van Esch BC et al (2011) Food-derived oligosaccharides exhibit pharmaceutical properties. Eur J Pharmacol 668:S117–S123

    Article  CAS  Google Scholar 

  • Rockova S, Rada V, Nevoral J et al (2012) Inter-species differences in the growth of bifidobacteria culture on human milk oligosaccharides. Folia Microbiol (Praha) 57:321–324

    Article  CAS  Google Scholar 

  • Rombaldi Bernardi J, de Souza Escobar R, Francisco Ferreira C, Pelufo Silveira P (2012) Fetal and neonatal levels of omega-3: effects on neurodevelopment, nutrition, and growth. Sci World J 2012:202473, 8 pages

    Google Scholar 

  • Saito T, Nakamura T, Kitazawa H et al (2000) Isolation and structural analysis of antihypertensive peptides that exists naturally in Gouda cheese. J Dairy Sci 83(7):1434–1440

    Article  CAS  Google Scholar 

  • Sakaguchi M, Koseki M, Wakamatsu M et al (2006) Effects of systemic administration of beta-casomorphin-5 on learning and memory in mice. Eur J Pharmacol 530(1-2):81–87

    Article  CAS  Google Scholar 

  • Sakamoto I, Igarashi M, Kimura K et al (2001) Suppressive effect of Lactobacillus gasseri OLL 2716 (LG21) on Helicobacter pylori infection in humans. J Antimicrob Chemother 47(5):709–710

    Article  CAS  Google Scholar 

  • Salvini F, Riva E, Salvatici E et al (2011) A specific prebiotic mixture added to starting infant formula has long-lasting bifidogenic effects. J Nutr 141:1335–1339

    Article  CAS  Google Scholar 

  • Sangwan V, Tomar SK, Singh RR et al (2011) Galactooligosaccharides: novel components of designer foods. J Food Sci 76(4):R103–R111

    Article  CAS  Google Scholar 

  • Saxelin M, Pessi T, Salminen S (1995) Fecal recovery following oral administration of Lactobacillus strain GG (ATCC 53103) in gelatin capsules to healthy volunteers. Int J Food Microbiol 25(2):199–203

    Article  CAS  Google Scholar 

  • Saxelin M, Korpela R, Mäyrä-Mäkinen A (2003) Introduction: classifying functional dairy products. In: Mattila-Sandholm T, Saarela M (eds) Functional dairy products. CRC Press, Boca Raton, FL, pp 1–16

    Chapter  Google Scholar 

  • Scarpignato C, Rampal P (1995) Prevention and treatment of traveler’s diarrhea: a clinical pharmacological approach. Chemotherapy 41(suppl 1):48–81

    Article  Google Scholar 

  • Schmidt WP (2004) Model of the epidemic of childhood atopy. Med Sci Monit 10(2):HY5–HY9

    Google Scholar 

  • Schouten B, van Esch BC, Hofman GA et al (2010) Oligosaccharide-induced whey-specific CD25+ regulatory T-cells are involved in the suppression of cow milk allergy in mice. J Nutr 140:835–841

    Article  CAS  Google Scholar 

  • Shestakov A, Jensen H, Nordström I (2012) Lactoferricin but not lactoferrin inhibit herpes simplex virus type 2 infection in mice. Antivir Res 93(3):340–345

    Article  CAS  Google Scholar 

  • Sheu BS, Cheng HC, Kao AW et al (2006) Pretreatment with Lactobacillus- and Bifidobacterium-containing yogurt can improve the efficacy of quadruple therapy in eradicating residual Helicobacter pylori infection after failed triple therapy. Am J Clin Nutr 83(4):864–869

    CAS  Google Scholar 

  • Shornikova AV, Isolauri E, Burnakova L et al (1997) A trial in the Karelian Republic of oral rehydration and Lactobacillus GG for treatment of acute diarrhea. Acta Paediatr 86(5):460–465

    Article  CAS  Google Scholar 

  • Sipola M, Finckenberg P, Vapaatalo H et al (2002) α-lactorphin and β-lactorphin improve arterial function in spontaneously hypertensive rats. Life Sci 71(11):1245–1253

    Article  CAS  Google Scholar 

  • Slavin JL (2008) Position of the American Dietetic Association: health implications of dietary fiber. J Am Diet Assoc 108:1716–1731

    Article  Google Scholar 

  • Slavin J, Jacobs DR (2010) Dietary fiber: all fibers are not alike. In: Wilson T et al (eds) Nutrition and health: nutrition guide for physicians. C. Humana Press, a part of Springer Science + Business Media, LLC., New York, NY, pp 13–22

    Chapter  Google Scholar 

  • Smacchi E, Gobbetti M (1998) Peptides from several Italian cheeses inhibitory to proteolytic enzymes of lactic acid bacteria, Pseudomonas fluorescens ATCC 948 and to the angiotensin I-converting enzyme. Enzyme Microb Tech 22(8):687–694

    Article  CAS  Google Scholar 

  • Stricker T, Braegger CP (2006) Oral probiotics prevent necrotizing enterocolitis. J Pediatr Gastroenterol Nutr 42(4):446–447

    Article  Google Scholar 

  • Sugita T, Togawa M (1994) Efficacy of Lactobacillus preparation Biolactis powder in children with rotavirus enteritis. Jpn J Pediatr 47:2755–2762

    Google Scholar 

  • Szajewska H, Kotowska M, Murkowicz JZ et al (2001) Efficacy of Lactobacillus GG in prevention of nosocomial diarrhea in infants. J Pediatr 138(3):361–365

    Article  CAS  Google Scholar 

  • Taira T, Hilakivi LA, Aalto J et al (1990) Effect of beta-casomorphin on neonatal sleep in rats. Peptides 11(1):1–4

    Article  CAS  Google Scholar 

  • Takahashi M, Moriguchi S, Suganuma H et al (1997) Identification of Casoxin C, an ileum-contracting peptide derived from bovine k-casein, as an agonist for C3a receptors. Peptides 18(3):329–336

    Article  CAS  Google Scholar 

  • Teschemacher H, Koch G, Brantl V (1997) Milk protein-derived opioid receptor ligands. Biopolymers 43(2):99–117

    Article  CAS  Google Scholar 

  • Thorsdottir I, Hill J, Ramel A (2004) Omega-3 fatty acid supply from milk associates with lower type 2 diabetes in men and coronary heart disease in women. Prev Med 39:630–634

    Article  CAS  Google Scholar 

  • Turunen AW, Jula A, Suominen AL (2013) Fish consumption, omega-3 fatty acids, and environmental contaminants in relation to low-grade inflammation and early atherosclerosis. Environ Res 120:43

    Article  CAS  Google Scholar 

  • Uenishi H, Kabuko T, Seto Y et al (2012) Isolation and identification of casein-derived dipeptidyl-peptidase 4 (DPP-4)-inhibitory peptide LPQNIPPL from Gouda-type cheese and its effect on plasma glucose in rats. Int Dairy J 22(1):24–30

    Article  CAS  Google Scholar 

  • Van de Rest O, van Hooijdonk LW, Doets E et al (2012) B vitamins and n-3 fatty acids for brain development and function: review of human studies. Ann Nutr Metab 60:272–292

    Article  CAS  Google Scholar 

  • Vanderhoof JA, Whitney DB, Antonson DL et al (1999) Lactobacillus GG in the prevention of antibiotic associated diarrhea in children. J Pediatr 135(5):564–568

    Article  CAS  Google Scholar 

  • Varzakas TH, Arvanitoyannis IS (2010) Functional bioactive dairy ingredients. In: Fatih Y (ed) Development and manufacture or yogurt and other functional dairy products. CRC Press, Boca Raton, FL, pp 197–222

    Google Scholar 

  • Vedin I, Cederholm T, Freund-Levi Y et al (2012) Effects of DHA-Rich n-3 fatty acid supplementation on gene expression in blood mononuclear leukocytes: the OmegAD study. PLoS One 7(4):e35425

    Article  CAS  Google Scholar 

  • Vegarud GE, Lagsrud T, Svenning C (2000) Mineral-binding milk proteins and peptides: occurrence, biochemical and technological characteristics. Br J Nutr 84(1):S91–S98

    CAS  Google Scholar 

  • Walstra P, Wouters JTM, Geurts TJ (2006) Dairy science and technology, 2nd edn. CRC Press, Boca Raton, FL

    Google Scholar 

  • Wollowski I, Rechkemmer G, Pool-Zobel BL (2001) Protective role of probiotics and prebiotics in colon cancer. Am J Clin Nutr 73(suppl 2):451S–455S

    CAS  Google Scholar 

  • Wunderlich PF, Braun L, Fumagalli I et al (1989) Double-blind report on the efficacy of lactic acid-producing Enterococcus SF68 in the prevention of antibiotic-associated diarrhoea and in the treatment of acute diarrhoea. J Int Med Res 17(4):333–338

    Article  CAS  Google Scholar 

  • Yamamoto T, Shiraki M (2012) Anti-inflammatory effect of conjugated linoleic acid in patients with Crohn’s disease. Clin Nutr 32(1):147

    Article  CAS  Google Scholar 

  • Yamazaki K, Tsunoda A, Sibusawa M et al (2000) The effect of an oral administration of Lactobacillus casei strain Shirota on azoxymethane-induced colonic aberrant crypt foci and colon cancer in the rat. Oncol Rep 7(5):977–982

    CAS  Google Scholar 

  • You L, Zhao M, Regenstein JM et al (2011) In vitro antioxidant activity and in vivo anti-fatigue effect of loach (Misgurnus anguillicaudatus) peptides prepared by papain digestion. Food Chem 124(1):188–194

    Article  CAS  Google Scholar 

  • Zhang J, Li L, Song P et al (2012a) Randomized controlled trial of oatmeal consumption versus noodle consumption on blood lipids of urban Chinese adults with hypercholesterolemia. Nutr J 11(1):54

    Article  CAS  Google Scholar 

  • Zhang W, Miao J, Ma C et al (2012b) β-casomorphin-7 attenuates the development of nephropathy in type I diabetes via inhibition of epithelial-mesenchymal transition of renal tubular epithelial. Peptides 36(2):186–191

    Article  CAS  Google Scholar 

  • Zhang H, Zhou L, Shi W et al (2012c) A mechanism underlying the effects of polyunsaturated fatty acids on breast cancer. Int J Mol Med 30:487–494

    CAS  Google Scholar 

  • Zweytick D, Tumer S, Blondelle SE et al (2008) Membrane curvature stress and antibacterial activity of lactoferricin derivatives. Biochem Bioph Res Commun 369(2):395–400

    Article  CAS  Google Scholar 

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Ortiz, Y., García-Amézquita, E., Acosta, C.H., Sepúlveda, D.R. (2017). Functional Dairy Products. In: Barbosa-Cánovas, G., et al. Global Food Security and Wellness. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-6496-3_5

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