Abstract
Continuous or frequent exposure to nociceptive input produces neuroplastic changes that allow pain perception with lower levels of stimulation. As the nervous system becomes more sensitized, receptive fields increase recruiting addition input that is perceived as pain. The allodynia (perception of pain with normal input) of an acute migraine attack is the result of a completely sensitized nervous system. Understanding central sensitization allows individuals to change their response to the input and take better control of their migraine pain.
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Young FJ. A life without pain? Hedonists take note. Clin Genet. 2008;73:31–3.
Saab CY. Pain-related changes in the brain: diagnostic and therapeutic potentials. Trends Neurosci. 2012;35:629–37.
Pergolizzi J, Ahlbeck K, Aldington D, Alon E, Coluzzi F, Dahan A, et al. The development of chornic pain: physiological CHANGE necessitates a multidisciplinary approach to treatment. Curr Med Res Opin. 2013;29(9):1127–35.
Nickel FT, Seifert F, Lanz S, Maihöfner C. Mechanisms of neuropathic pain. Eur Neuropsychopharmacol. 2012;22:81–91.
Vranken JH. Elucidation of pathophysiology and treatment of neuropathic pain. Centr Nerv Syst Agents Med Chem. 2012;12:304–14.
Malmberg AB, Basbaum AI. Partial sciatic nerve injury in the mouse as a model of neuropathic pain: behavioral and neuroanatomical correlates. Pain. 1998;76:215–22.
Sandkühler J. Models and mechanisms of hyperalgesia and allodynia. Physiol Rev. 2009;89:707–58.
Lee YC, Nassikas NJ, Clauw DJ. The role of the central nervous system in the generation and maintenance of chronic pain in rheumatoid arthritis, osteoarthritis and fibromyalgia. Arthritis Res Ther. 2011;13:211.
Staud R. Evidence for shared pain mechanisms in osteoarthritis, low back pain, and fibromyalgia. Curr Rheumatol Rep. 2011;13:513–20.
Murphy SL, Phillips K, Williams DA, Clauw DJ. The role of the central nervous system in osteoarthritis pain and implications for rehabilitation. Curr Rheumatol Rep. 2012;14:576–82.
Roussel NA, Nijs J, Meeus M, Mylius V, Fayt C, Oostendorp R. Central sensitization and altered central pain processing in chronic low back pain: fact or myth? Clin J Pain. 2013;29:625–38.
Van Oosterwijck J, Nijs J, Meeus M, Paul L. Evidence for central sensitization in chronic whiplash: a systematic literature review. Eur J Pain. 2013;17:299–312.
Marcus DA. A review of perinatal acute pain: treating perinatal pain to reduce adult chronic pain. J Headache Pain. 2006;7:3–8.
Anand K. Effects of perinatal pain and stress. Prog Brain Res. 2000;122:117–29.
Grunau R. Early pain in preterm infants. A model of long-term effects. Clin Perinatol. 2002;29:373–94.
Bouza H. The impact of pain in the immature brain. J Matern Fetal Neonatal Med. 2009;22:722–32.
Taddio A, Goldbach M, Ipp M, Stevens B, Koren G. Effect of neonatal circumcision on pain responses during vaccination in boys. Lancet. 1994;344:291–2.
Taddio A, Katz J, Ilersich AL, Gideon K. Effect of neonatal circumcision on pain response during subsequent routine vaccination. Lancet. 1997;349:559–603.
Maneyapanda SB, Venkatasubramanian A. Relationship between significant perinatal events and migraine severity. Pediatrics. 2005;116:e555–8.
Burstein R, Jakubowski M. Managing migraine associated with sensitization. Handb Clin Neurol. 2010;97:207–15.
Burstein R, Jakubowski M, Rauch SD. The science of migraine. J Vestib Res. 2011;21:305–14.
Aguggia M, Saracco MG, Cavallini M, Bussone G, Cortelli P. Sensitization and pain. Neurol Sci. 2013;34 suppl 1:37–40.
Bernstein C, Burstein R. Sensitization of the trigeminovascular pathway: perspective and implications to migraine pathophysiology. J Clin Neurol. 2012;8:89–99.
Burstein R, Collins B, Jakubowski M. Defeating migraine pain with triptans: a race against the development of cutaneous allodynia. Ann Neurol. 2004;55:19–26.
Burstein R, Jakubowski M. Analgesic triptan action in an animal model of intracranial pain: a race against the development of central sensitization. Ann Neurol. 2004;55:27–36.
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Marcus, D.A., Ready, D.M. (2017). The Sensitive Migraine Brain. In: Discussing Migraine With Your Patients. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-6484-0_3
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DOI: https://doi.org/10.1007/978-1-4939-6484-0_3
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