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Genetic Syndromes of Renal Hypertension

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Book cover Core Concepts in Hypertension in Kidney Disease

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Abstract

Numerous molecular pathways for hypertension have been identified through advances in genetic mapping and sequencing techniques since the early 1990s. Particularly, the study of rare hypertension syndromes led to understanding of blood pressure-regulating pathways and identification of novel drug targets. The most common mechanism underlying many of these mostly inherited syndromes is increased renal sodium reabsorption, highlighting the importance of the kidney in regulating blood pressure. Increased activation of the mineralocorticoid signaling pathway and the malfunctioning of the sympathetic nervous system have both been implicated in inducing renal hypertension as well, while complementary studies examining lower blood pressure phenotypes have identified novel pathways exclusively linked to renal sodium wasting. The investigation and understanding of rare inherited syndromes of renal hypertension have important implications on improving both diagnosis and treatment of hypertension in the general population.

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  1. Graduate Medical Education, Manatee Memorial Hospital, Bradenton, FL, USA

    Hakan R. Toka MD, PhD

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  1. Global and Continuing Education, Harvard Medical School, Boston, Massachusetts, USA

    Ajay K. Singh

  2. VA Medical Center, Indiana University School of Medicine, Indianapolis, Indiana, USA

    Rajiv Agarwal

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Toka, H.R. (2016). Genetic Syndromes of Renal Hypertension. In: Singh, A., Agarwal, R. (eds) Core Concepts in Hypertension in Kidney Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-6436-9_11

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