Why Obesity in Parents Matters

  • Mark Hanson
Part of the Physiology in Health and Disease book series (PIHD)


Promoting the best possible environment for early human development offers one of the greatest missed opportunities today for improving global health, human productivity and longevity. Overweight and obesity in parents and parents-to-be are not only associated with poorer health prospects for this section of the population in the future, but also pass the risk of overweight and obesity to their children. This calls for a new initiative to improve the health of current and prospective parents, commencing with adolescent girls and women of reproductive age, but also their partners.


Obesity Parents Generations Public health Education Childhood Diabetes Cardiovascular 


  1. 1.
    Alwan A (2011) Global status report on noncommunicable diseases 2010. World Health Organization, GenevaGoogle Scholar
  2. 2.
    McKinsey Institute (2014) Overcoming obesity: an initial economic analysis. McKinsey Institute, Washington, DCGoogle Scholar
  3. 3.
    Barkin SL (2013) The relationship between executive function and obesity in children and adolescents: a systematic literature review. J Obes 2013Google Scholar
  4. 4.
    Yau PL et al (2012) Obesity and metabolic syndrome and functional and structural brain impairments in adolescence. Pediatrics 130:e856–e864CrossRefPubMedPubMedCentralGoogle Scholar
  5. 5.
    T2D Morris AP et al (2012) Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet 44: 981Google Scholar
  6. 6.
    Ng M et al (2014). Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 384(9945): 766–781Google Scholar
  7. 7.
    Han JC, Lawlor DA, Kimm SYS (2010) Childhood obesity. Lancet 375(9727):1737–1748CrossRefPubMedPubMedCentralGoogle Scholar
  8. 8.
  9. 9.
    Serdula MK et al (1993) Do obese children become obese adults? A review of the literature. Prev Med 22(2):167–177CrossRefPubMedGoogle Scholar
  10. 10.
    WHO (2014) Childhood overweight and obesity.
  11. 11.
    The Health and Social Care Information Centre (2013) Health survey for England 2013. Website last accessed 5 Jul 2016
  12. 12.
    Sebire NJ et al (2001) Maternal obesity and pregnancy outcome: a study of 287,213 pregnancies in London. Int J Obes Relat Metab Disord 25(8):1175–1182CrossRefPubMedGoogle Scholar
  13. 13.
    Hanson M, Gluckman P (2011) Developmental origins of noncommunicable disease: population and public health implications. Am J Clin Nutr 94:1754S–1758SCrossRefPubMedGoogle Scholar
  14. 14.
    Lake JK, Power C, Cole TJ (1997) Child to adult body mass index in the 1958 British birth cohort: associations with parental obesity. Arch Dis Child 77(5):376–380CrossRefPubMedGoogle Scholar
  15. 15.
    Whitaker KL et al (2010) Comparing maternal and paternal intergenerational transmission of obesity risk in a large population-based sample. Am J Clin Nutr 91(6):1560–1567CrossRefPubMedGoogle Scholar
  16. 16.
    Hughes V (2014) Epigenetics: the sins of the father. Nature 507:22–24CrossRefPubMedGoogle Scholar
  17. 17.
    Nishino Y, Gilmour S, Shibuya K (2015) Inequality in diabetes-related hospital admissions in England by socioeconomic deprivation and ethnicity: facility-based cross-sectional analysis. PLoS One 10:e0116689CrossRefPubMedPubMedCentralGoogle Scholar
  18. 18.
    McLennan AK, Jayaweera H (2014) Non-communicable diseases and risk factors in migrants from South Asian countries. COMPAS, University of Oxford, OxfordGoogle Scholar
  19. 19.
    Di Cesare M et al (2013) Inequalities in non-communicable diseases and effective responses. Lancet 381:585–597CrossRefPubMedGoogle Scholar
  20. 20.
    Faith MS et al (2012) Evaluating parents and adult caregivers as “agents of change” for treating obese children: evidence for parent behavior change strategies and research gaps a scientific statement from the American Heart Association. Circulation 125(9):1186–1207CrossRefPubMedGoogle Scholar
  21. 21.
    Owen-Jones E et al (2013) The effectiveness and cost-effectiveness of the Family Nurse Partnership home visiting programme for first time teenage mothers in England: a protocol for the Building Blocks randomised controlled trial. BMC Pediatr 13:114CrossRefPubMedPubMedCentralGoogle Scholar
  22. 22.
    Campbell F et al (2014) Early childhood investments substantially boost adult health. Science 343(6178):1478–1485CrossRefPubMedPubMedCentralGoogle Scholar
  23. 23.
    Hanson MA, Gluckman PD (2014) Early developmental conditioning of later health and disease: physiology or pathophysiology? Physiol Rev 94(4):1027–1076CrossRefPubMedPubMedCentralGoogle Scholar
  24. 24.
    Fleming TP et al (2015) Do little embryos make big decisions? How maternal dietary protein restriction can permanently change an embryo’s potential, affecting adult health. Reprod Fertil Dev 27(4):684–692CrossRefPubMedGoogle Scholar
  25. 25.
    Kapur A (2015) Links between maternal health and NCDs. Best Pract Res Clin Obstet Gynaecol 29:32–42CrossRefPubMedGoogle Scholar
  26. 26.
    Murray R, Godfrey KM, Lillycrop KA (2015) The early life origins of cardiovascular disease. Curr Cardiovasc Risk Rep 9:1–8CrossRefGoogle Scholar
  27. 27.
    Todd AS et al (2015) Overweight and obese adolescent girls: the importance of promoting sensible eating and activity behaviors from the start of the adolescent period. Int J Environ Res Public Health 12(2):2306–2329CrossRefPubMedPubMedCentralGoogle Scholar
  28. 28.
    Gluckman PD, Hanson MA (2012) Fat, fate and disease. Oxford University Press, OxfordGoogle Scholar
  29. 29.
    Gluckman PD, Hanson MA (2006) Mismatch—why our world no longer fits our bodies. Oxford University Press, OxfordGoogle Scholar
  30. 30.
    Chappell LC et al (2013) Exploration and confirmation of factors associated with uncomplicated pregnancy in nulliparous women: prospective cohort study. BMJ 347:f6398CrossRefPubMedPubMedCentralGoogle Scholar
  31. 31.
    Sermondade N et al (2012) Obesity and increased risk for oligozoospermia and azoospermia. Arch Intern Med 172(5):440–442CrossRefPubMedGoogle Scholar
  32. 32.
    Leary C, Leese HJ, Sturmey RG (2015) Human embryos from overweight and obese women display phenotypic and metabolic abnormalities. Hum Reprod 30:122–132CrossRefPubMedGoogle Scholar
  33. 33.
    Wendland EM et al (2012) Gestational diabetes and pregnancy outcomes-a systematic review of the World Health Organization (WHO) and the International Association of Diabetes in Pregnancy Study Groups (IADPSG) diagnostic criteria. BMC Pregnancy Childbirth 12(1):23CrossRefPubMedPubMedCentralGoogle Scholar
  34. 34.
    Alberico S et al (2014) The role of gestational diabetes, pre-pregnancy body mass index and gestational weight gain on the risk of newborn macrosomia: results from a prospective multicentre study. BMC Pregnancy Childbirth 14(1):23CrossRefPubMedPubMedCentralGoogle Scholar
  35. 35.
    Black MH et al (2013) The relative contribution of pre-pregnancy overweight and obesity, gestational weight gain, and IADPSG-defined gestational diabetes mellitus to fetal overgrowth. Diabetes Care 36(1):56–62CrossRefPubMedGoogle Scholar
  36. 36.
    Bowers K et al (2013) Gestational diabetes, pre-pregnancy obesity and pregnancy weight gain in relation to excess fetal growth: variations by race/ethnicity. Diabetologia 56(6):1263–1271CrossRefPubMedGoogle Scholar
  37. 37.
    Ornoy A et al (2015) Effect of maternal diabetes on the embryo, fetus, and children: congenital anomalies, genetic and epigenetic changes and developmental outcomes. Birth Defects Res C Embryo Today 105(1):53–72CrossRefPubMedGoogle Scholar
  38. 38.
    Dick B, Ferguson BJ (2015) Health for the world’s adolescents: a second chance in the second decade. J Adolesc Health 56(1):3–6CrossRefPubMedGoogle Scholar
  39. 39.
    HSCIC. Health survey for England—2013. Trend tables Scholar
  40. 40.
    Graves L et al (2014) Waist-to-height ratio and cardiometabolic risk factors in adolescence: findings from a prospective birth cohort. Pediatr Obes 9:327–3384CrossRefPubMedGoogle Scholar
  41. 41.
    Leech RM, McNaughton SA, Timperio A (2014) The clustering of diet, physical activity and sedentary behavior in children and adolescents: a review. Int J Behav Nutr Phys Act 11:4CrossRefPubMedPubMedCentralGoogle Scholar
  42. 42.
    Monti PM, Colby SM, O’Leary TA (eds) (2012) Adolescents, alcohol, and substance abuse: reaching teens through brief interventions. Guilford Press, New YorkGoogle Scholar
  43. 43.
    Huang GC et al (2014). Peer influences: the impact of online and offline friendship networks on adolescent smoking and alcohol use. J Adolesc Health 54(5): 508–514Google Scholar
  44. 44.
    Brown SL, Teufel JA, Birch DA (2007) Early adolescents perceptions of health and health literacy. J Sch Health 77:7–15CrossRefPubMedGoogle Scholar
  45. 45.
    Kulendran M et al (2013) Inhibitory control and perception of the future health in obese adolescents and normal weight adolescents. Lancet 382:S55CrossRefGoogle Scholar
  46. 46.
    Pepper GV, Nettle D (2014) Perceived extrinsic mortality risk and reported effort in looking after health. Hum Nat 25(3):378–392CrossRefPubMedGoogle Scholar
  47. 47.
    Inskip HM et al (2009) Women’s compliance with nutrition and lifestyle recommendations before pregnancy: general population cohort study. BMJ 338:b481CrossRefPubMedPubMedCentralGoogle Scholar
  48. 48.
    Stephenson J et al (2014) How do women prepare for pregnancy? Preconception experiences of women attending antenatal services and views of health professionals. PLoS One 9:e103085CrossRefPubMedPubMedCentralGoogle Scholar
  49. 49.
    Shawe J et al (2015) Preconception care policy, guidelines, recommendations and services across six European countries: Belgium (Flanders), Denmark, Italy, the Netherlands, Sweden and the United Kingdom. Eur J Contracept Reprod Health Care 20(2):77–87CrossRefPubMedGoogle Scholar
  50. 50.
    Atrash HK et al (2006) Preconception care for improving perinatal outcomes: the time to act. Matern Child Health J 10(1):3–11CrossRefPubMedCentralGoogle Scholar
  51. 51.
    Jack BW, Culpepper L (1990) Preconception care: risk reduction and health promotion in preparation for pregnancy. JAMA 264(9):1147–1149CrossRefPubMedGoogle Scholar
  52. 52.
    Johnson K et al (2006) Recommendations to improve preconception health and health care—United States. Morb Mortal Wkly Rep 55(4):1–23Google Scholar
  53. 53.
    Langford R et al (2015) Obesity prevention and the Health promoting Schools framework: essential components and barriers to success. Int J Behav Nutr Phys Act 12(1):15CrossRefPubMedPubMedCentralGoogle Scholar
  54. 54.
    Waters E et al (2014) Interventions for preventing obesity in children. Sao Paulo Med J 132(2):128–129CrossRefGoogle Scholar
  55. 55.
    Agency for Healthcare Research and Quality (2013) Childhood obesity prevention programs: comparative effectiveness review and meta-analysis. Comp Eff Rev 115, publication no. 13-EHC081-EFGoogle Scholar
  56. 56.
    Grace M et al (2012) Developing teenagers’ views on their health and the health of their future children. Health Educ 112(6):543–559CrossRefGoogle Scholar

Copyright information

© The American Physiological Society 2016

Authors and Affiliations

  1. 1.Institute of Developmental SciencesUniversity of SouthamptonSouthamptonUK
  2. 2.NIHR Nutrition Biomedical Research CentreUniversity Hospital SouthamptonSouthamptonUK

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