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Discoidin Domain Receptors and Disease

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Abstract

The discoidin domain receptors have been implicated as contributing to normal developmental and pathologic conditions in humans. Mutations in the DDR genes have been described in a number of human diseases. Some of these are now being modeled in mice, which have afforded a better understanding for the cellular basis for the action of DDRs in various pathologic states. Herein, we first discuss the role(s) that DDR1 and DDR2 play in mouse development. Then we discuss pathologic conditions in humans where the action of DDRs has been associated with or correlated with pathologic and genomic analyses. Accumulated data indicate that the action of DDRs in various cell types have both cell-intrinsic roles as well as affecting the nature of the extracellular matrix produced or present in pathologic conditions.

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Author information

Authors and Affiliations

  1. Departments of Medicine (Oncology), The ICCE Institute, Washington University, St. Louis, MO, 63110, USA

    Gregory D. Longmore & Whitney R. Grither

  2. Departments of Cell Biology and Physiology, The ICCE Institute, Washington University, St. Louis, MO, 63110, USA

    Gregory D. Longmore

  3. Departments of Biochemistry, The ICCE Institute, Washington University, St. Louis, MO, 63110, USA

    Whitney R. Grither

Authors
  1. Gregory D. Longmore
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  2. Whitney R. Grither
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Corresponding author

Correspondence to Gregory D. Longmore .

Editor information

Editors and Affiliations

  1. Department of Pathology, Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, Michigan, USA

    Rafael Fridman

  2. Division of Cancer Biology, The Institute of Cancer Research, London, United Kingdom

    Paul H. Huang

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Longmore, G.D., Grither, W.R. (2016). Discoidin Domain Receptors and Disease. In: Fridman, R., Huang, P. (eds) Discoidin Domain Receptors in Health and Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-6383-6_6

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