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Reconstructive Transplantation: Evolution, Experience, Ethics, and Emerging Concepts

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Anesthesia and Perioperative Care for Organ Transplantation

Abstract

Reconstructive transplantation has had a tumultuous yet transformative evolution and stands to surpass solid organ transplantation through its life-changing and life-giving possibilities in treating disfigured and disabled recipients with unreconstructable tissue loss. Rapid progress in the fields of regenerative medicine, tissue engineering, molecular imaging, nanotechnology, drug delivery, and biomaterials may fuel further progress in vascularized composite allotransplantation (VCA), improving safety and outcomes while expanding clinical applications. The success of immunomodulation or tolerance protocols may change the future of reconstructive surgery by bringing VCA procedures into the mainstream of clinical practice and standard of care.

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Authors and Affiliations

  1. Department of Plastic Surgery, Reconstructive Transplant Program, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA, 15213-2582, USA

    Vijay S. Gorantla M.D., Ph.D.

  2. Department of Plastic Surgery and Hand Surgery, University Hospital Zurich (USZ), Zurich, Switzerland

    Jan A. Plock M.D.

  3. Plastic and Reconstructive Surgery, San Antonio Military Medical Center, United States Army Institute for Surgical Research, Pittsburgh, PA, USA

    Michael R. Davis M.D., F.A.C.S.

Authors
  1. Vijay S. Gorantla M.D., Ph.D.
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  2. Jan A. Plock M.D.
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  3. Michael R. Davis M.D., F.A.C.S.
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Correspondence to Vijay S. Gorantla M.D., Ph.D. .

Editor information

Editors and Affiliations

  1. Department of Anesthesiology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

    Kathirvel Subramaniam

  2. Department of Anesthesiology The Clinical and Translational Science Institute The McGowan Institute for Regenerative Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

    Tetsuro Sakai

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Gorantla, V.S., Plock, J.A., Davis, M.R. (2017). Reconstructive Transplantation: Evolution, Experience, Ethics, and Emerging Concepts. In: Subramaniam, K., Sakai, T. (eds) Anesthesia and Perioperative Care for Organ Transplantation. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-6377-5_44

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