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The Historic Evolution of Intestinal and Multivisceral Transplantation

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Anesthesia and Perioperative Care for Organ Transplantation

Abstract

This chapter focuses on the multifaceted historic evolution of visceral transplantation, with special reference to the pioneer experimental and clinical work triggered by the introduction of new premises, the availability of novel immunosuppressive drugs, and the innovation of surgical techniques. In addition, the current status of the different types of visceral transplantation is highlighted, with new insights for future consideration.

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References

  1. Starzl TE, Todo S, Tzakis A, Alessiani M, Casavilla A, Abu-Elmagd K, et al. The many faces of multivisceral transplantation. Surg Gynecol Obstet. 1991;172:335–44.

    CAS  PubMed  PubMed Central  Google Scholar 

  2. Deltz E, Muller-Hermelink HK, Ulrichs K, Thiede A, Muller-Ruchholtz W. Development of graft-versus-host reaction in various target organs after small intestine transplantation. Transplant Proc. 1981;13(1 Pt 2):1215–6.

    CAS  PubMed  Google Scholar 

  3. Fujiwara H, Grogan JB, Raju S. Total orthotopic small bowel transplantation with cyclosporine. Transplantation. 1987;44:469–74.

    Article  CAS  PubMed  Google Scholar 

  4. Abu-Elmagd KM, Costa G, Bond GJ, Soltys K, Sindhi R, Wu T, et al. Five hundred intestinal and multivisceral transplantations at a single center: major advances with new challenges. Ann Surg. 2009;250:567–81.

    PubMed  Google Scholar 

  5. Lillehei RC, Goott B, Miller FA. The physiological response of the small bowel of the dog to ischemia including prolonged in vitro preservation of the bowel with successful replacement and survival. Ann Surg. 1959;150:543–60.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Starzl TE, Kaupp Jr HA, Brock DR, Butz Jr GW, Linman JW. Homotransplantation of multiple visceral organs. Am J Surg. 1962;103:219–29.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Abu-Elmagd K, Reyes J, Todo S, Rao A, Lee R, Irish W, et al. Clinical intestinal transplantation: new perspectives and immunologic considerations. J Am Coll Surg. 1998;186:512–25. discussion 25–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Abu-Elmagd K, Reyes J, Bond G, Mazariegos G, Wu T, Murase N, et al. Clinical intestinal transplantation: a decade of experience at a single center. Ann Surg. 2001;234:404–16. discussion 16–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Abu-Elmagd KM, Costa G, Bond GJ, Soltys K, Martin L, Koritsky DA, et al. A decade of experience with a single dose of rabbit antithymocyte globulin or alemtuzumab pretreatment for intestinal and multivisceral transplantation. Clin Transpl. 2012:155–66.

    Google Scholar 

  10. Alican F, Hardy JD, Cayirli M, Varner JE, Moynihan PC, Turner MD, et al. Intestinal transplantation: laboratory experience and report of a clinical case. Am J Surg. 1971;121:150–9.

    Article  CAS  PubMed  Google Scholar 

  11. Lillehei RC, Idezuki Y, Kelly WD, Najarian JS, Merkel FK, Goetz FC. Transplantation of the intestine and pancreas. Transplant Proc. 1969;1:230–8.

    CAS  PubMed  Google Scholar 

  12. Okumura M, Fujimura I, Ferrari AA, Nakiri K, Lemos PC, de Andrea EA, et al. Transplantation of the small intestine. Case report. Rev Hosp Clin Fac Med Sao Paulo. 1969;24:39–54.

    CAS  PubMed  Google Scholar 

  13. Fortner JG, Sichuk G, Litwin SD, Beattie Jr EJ. Immunological responses to an intestinal allograft with HL-A-identical donor-recipient. Transplantation. 1972;14:531–5.

    Article  CAS  PubMed  Google Scholar 

  14. Olivier C, Rettori R, Baur O, Roux J. Orthotopic homotransplantation of the small intestine and of the right and transverse colon in man. J Chir (Paris). 1969;98:323–30.

    CAS  Google Scholar 

  15. Tattersall C, Gebel H, Haklin M, Hartsell W, Williams J. Lymphocyte responsiveness after irradiation in canine and human intestinal allografts. Curr Surg. 1989;46:16–9.

    CAS  PubMed  Google Scholar 

  16. Goulet O, Revillon Y, Nezelof C, Cerf-Bensussan N, Gallix P, Pellerin D, et al. Intestinal transplantation in children. Arch Fr Pediatr. 1988;45 Suppl 1:735–9.

    PubMed  Google Scholar 

  17. Schroeder P, Deltz E, Seifert J, Sandforth F, Thiede A. Absorptive capacity of the transplanted small bowel. Gut. 1987;28(Suppl):275–9.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Grant D, Sommerauer J, Mimeault R, Garcia B, Ghent C, Zhong R, et al. Treatment with continuous high-dose intravenous cyclosporine following clinical intestinal transplantation. Transplantation. 1989;48:151–2.

    Article  CAS  PubMed  Google Scholar 

  19. Deltz E, Schroeder P, Schweizer E, Gundlach M, Gebhardt H, Hansmann ML. Small intestine transplantation—a causal therapy in short bowel syndrome. Schweiz Rundsch Med Prax. 1990;79:1586–8.

    CAS  PubMed  Google Scholar 

  20. Goulet O, Jan D, Sarnacki S, Brousse N, Colomb V, Salomon R, et al. Isolated and combined liver-small bowel transplantation in Paris: 1987-1995. Transplant Proc. 1996;28:2750.

    CAS  PubMed  Google Scholar 

  21. Wallander J, Dahlstrom KA, Ericzon BG, Duraj F, Meurling S. Transplantation of the small intestine. A therapeutic alternative. Lakartidningen. 1995;92:1099–102.

    CAS  PubMed  Google Scholar 

  22. Todo S, Tzakis A, Reyes J, Abu-Elmagd K, Casavilla A, Nour BM, et al. Clinical small bowel or small bowel plus liver transplantation under FK 506. Transplant Proc. 1991;23:3093–5.

    CAS  PubMed  PubMed Central  Google Scholar 

  23. Starzl TE, Rowe MI, Todo S, Jaffe R, Tzakis A, Hoffman AL, et al. Transplantation of multiple abdominal viscera. JAMA. 1989;261:1449–57.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Grant D, Wall W, Mimeault R, Zhong R, Ghent C, Garcia B, et al. Successful small-bowel/liver transplantation. Lancet. 1990;335: 181–4.

    Article  CAS  PubMed  Google Scholar 

  25. Williams JW, Sankary HN, Foster PF, Loew JM, Goldman GM. Splanchnic transplantation. An approach to the infant dependent on parenteral nutrition who develops irreversible liver disease. JAMA. 1989;261:1458–62.

    Article  CAS  PubMed  Google Scholar 

  26. Margreiter R, Konigsrainer A, Schmid T, Koller J, Kornberger R, Oberhuber G, et al. Successful multivisceral transplantation. Transplant Proc. 1992;24:1226–7.

    CAS  PubMed  Google Scholar 

  27. Todo S, Tzakis AG, Abu-Elmagd K, Reyes J, Nakamura K, Casavilla A, et al. Intestinal transplantation in composite visceral grafts or alone. Ann Surg. 1992;216:223–33. discussion 33–4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Grant D, Abu-Elmagd K, Reyes J, Tzakis A, Langnas A, Fishbein T, et al. 2003 report of the intestine transplant registry: a new era has dawned. Ann Surg. 2005;241:607–13.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Fishbein TM, Kaufman SS, Florman SS, Gondolesi GE, Schiano T, Kim-Schluger L, et al. Isolated intestinal transplantation: proof of clinical efficacy. Transplantation. 2003;76:636–40.

    Article  PubMed  Google Scholar 

  30. Farmer DG, McDiarmid SV, Yersiz H, Cortina G, Vargas J, Maxfield AJ, et al. Outcomes after intestinal transplantation: a single-center experience over a decade. Transplant Proc. 2002;34:896–7.

    Article  CAS  PubMed  Google Scholar 

  31. Abu-Elmagd KM, Costa G, Bond GJ, Wu T, Murase N, Zeevi A, et al. Evolution of the immunosuppressive strategies for the intestinal and multivisceral recipients with special reference to allograft immunity and achievement of partial tolerance. Transpl Int. 2009;22:96–109.

    Article  PubMed  Google Scholar 

  32. Starzl TE, Zinkernagel RM. Transplantation tolerance from a historical perspective. Nat Rev Immunol. 2001;1:233–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Starzl TE, Murase N, Abu-Elmagd K, Gray EA, Shapiro R, Eghtesad B, et al. Tolerogenic immunosuppression for organ transplantation. Lancet. 2003;361:1502–10.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Tzakis AG, Kato T, Levi DM, Defaria W, Selvaggi G, Weppler D, et al. 100 multivisceral transplants at a single center. Ann Surg. 2005;242:480–90. discussion 91–3.

    PubMed  PubMed Central  Google Scholar 

  35. Tzakis AG, Kato T, Nishida S, Levi DM, Madariaga JR, Nery JR, et al. Preliminary experience with campath 1H (C1H) in intestinal and liver transplantation. Transplantation. 2003;75:1227–31.

    Article  CAS  PubMed  Google Scholar 

  36. Registry IT. Bi-annual report. Toronto, ON: Intestinal Transplant Association; 2012.

    Google Scholar 

  37. Abu-Elmagd KM, Kosmach-Park B, Costa G, Zenati M, Martin L, Koritsky DA, et al. Long-term survival, nutritional autonomy, and quality of life after intestinal and multivisceral transplantation. Ann Surg. 2012;256:494–508.

    Article  PubMed  Google Scholar 

  38. Nucci AM, Strohm S, Squires RH, Mazariegos GV, Sun Q, Sindhi R. Growth pre- and postimplementation of a steroid-free induction protocol in a large pediatric intestinal transplant population. J Pediatr Gastroenterol Nutr. 2011;52:601–6.

    Article  PubMed  Google Scholar 

  39. Rovera GM, Schoen RE, Goldbach B, Janson D, Bond G, Rakela J, et al. Intestinal and multivisceral transplantation: dynamics of nutritional management and functional autonomy. J Parenter Enteral Nutr. 2003;27:252–9.

    Article  Google Scholar 

  40. Sudan D, Iyer K, Horslen S, Shaw Jr B, Langnas A. Assessment of quality of life after pediatric intestinal transplantation by parents and pediatric recipients using the child health questionnaire. Transplant Proc. 2002;34:963–4.

    Article  CAS  PubMed  Google Scholar 

  41. Ngo KD, Farmer DG, McDiarmid SV, Artavia K, Ament ME, Vargas J, et al. Pediatric health-related quality of life after intestinal transplantation. Pediatr Transplant. 2011;15:849–54.

    Article  CAS  PubMed  Google Scholar 

  42. Matarese LE, Costa G, Bond G, Stamos J, Koritsky D, O'Keefe SJ, et al. Therapeutic efficacy of intestinal and multivisceral transplantation: survival and nutrition outcome. Nutr Clin Pract. 2007;22:474–81.

    Article  PubMed  Google Scholar 

  43. Rovera GM, DiMartini A, Schoen RE, Rakela J, Abu-Elmagd K, Graham TO. Quality of life of patients after intestinal transplantation. Transplantation. 1998;66:1141–5.

    Article  CAS  PubMed  Google Scholar 

  44. Rovera GM, DiMartini A, Graham TO, Hutson WR, Furukawa H, Todo S, et al. Quality of life after intestinal transplantation and on total parenteral nutrition. Transplant Proc. 1998;30:2513–4.

    Article  CAS  PubMed  Google Scholar 

  45. DiMartini A, Rovera GM, Graham TO, Furukawa H, Todo S, Funovits M, et al. Quality of life after small intestinal transplantation and among home parenteral nutrition patients. J Parenter Enteral Nutr. 1998;22:357–62.

    Article  CAS  Google Scholar 

  46. O'Keefe SJ, Emerling M, Koritsky D, Martin D, Stamos J, Kandil H, et al. Nutrition and quality of life following small intestinal transplantation. Am J Gastroenterol. 2007;102:1093–100.

    Article  PubMed  Google Scholar 

  47. Pironi L, Baxter JP, Lauro A, Guidetti M, Agostini F, Zanfi C, et al. Assessment of quality of life on home parenteral nutrition and after intestinal transplantation using treatment-specific questionnaires. Am J Transplant. 2012;12 Suppl 4:S60–6.

    Article  PubMed  Google Scholar 

  48. Idoate MA, Martinez AJ, Bueno J, Abu-Elmagd K, Reyes J. The neuropathology of intestinal failure and small bowel transplantation. Acta Neuropathol. 1999;97:502–8.

    Article  CAS  PubMed  Google Scholar 

  49. Dekaban AS. Changes in brain weights during the span of human life: relation of brain weights to body heights and body weights. Ann Neurol. 1978;4:345–56.

    Article  CAS  PubMed  Google Scholar 

  50. El-Tatawy S, Badrawi N, El Bishlawy A. Cerebral atrophy in infants with protein energy malnutrition. AJNR Am J Neuroradiol. 1983;4:434–6.

    CAS  PubMed  Google Scholar 

  51. Kawakubo K, Iida M, Matsumoto T, Mochizuki Y, Doi K, Aoyagi K, et al. Progressive encephalopathy in a Crohn’s disease patient on long-term total parenteral nutrition: possible relationship to selenium deficiency. Postgrad Med J. 1994;70: 215–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  52. Martinez AJ. The neuropathology of organ transplantation: comparison and contrast in 500 patients. Pathol Res Pract. 1998; 194:473–86.

    Article  CAS  PubMed  Google Scholar 

  53. Small SL, Fukui MB, Bramblett GT, Eidelman BH. Immunosuppression-induced leukoencephalopathy from tacrolimus (FK506). Ann Neurol. 1996;40(4):575–80.

    Article  CAS  PubMed  Google Scholar 

  54. Kulick D, Deen D. Specialized nutrition support. Am Fam Physician. 2011;83:173–83.

    PubMed  Google Scholar 

  55. Duffy JP, Kao K, Ko CY, Farmer DG, McDiarmid SV, Hong JC, et al. Long-term patient outcome and quality of life after liver transplantation: analysis of 20-year survivors. Ann Surg. 2010;252:652–61.

    PubMed  Google Scholar 

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Correspondence to Kareem Abu-Elmagd M.D., Ph.D. .

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Nassar, A. et al. (2017). The Historic Evolution of Intestinal and Multivisceral Transplantation. In: Subramaniam, K., Sakai, T. (eds) Anesthesia and Perioperative Care for Organ Transplantation. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-6377-5_38

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  • DOI: https://doi.org/10.1007/978-1-4939-6377-5_38

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