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Acute Liver Failure: Perioperative Management

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Anesthesia and Perioperative Care for Organ Transplantation

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Abstract

Management of patients with acute liver failure requires a multidisciplinary approach with intensive monitoring and intervention to achieve a successful outcome. Until the efficacy of alternative therapies is demonstrated, timely transplantation remains the treatment of choice in those at high risk for mortality.

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References

  1. Trey C, Davidson CS. The management of fulminant hepatic failure. Prog Liver Dis. 1970;3:282–98.

    CAS  PubMed  Google Scholar 

  2. Bernuau J, Rueff B, Benhamou JP. Fulminant and subfulminant liver failure: definitions and causes. Semin Liver Dis. 1986;6:97–106.

    Article  CAS  PubMed  Google Scholar 

  3. Williams Lee WM, Williams R, editors. Acute liver failure. Cambridge: Cambridge Press; 1997. p. 1–9.

    Google Scholar 

  4. Acharya SK, Dasarathy S, Kumer TL, Sushma S, Prasanna KS, Tandon A, Sreenivas V, Nijhawan S, Panda SK, Nanda SK, Irshad M, Joshi YK, Duttagupta S, Tandon RK, Tandon BN. Fulminant hepatitis in a tropical population: clinical course, cause, and early predictors of outcome. Hepatology. 1996;23:1448–55.

    Article  CAS  PubMed  Google Scholar 

  5. Sass DA, Shakil AO. Fulminant hepatic failure. Liver Transpl. 2005;11:594–605.

    Article  PubMed  Google Scholar 

  6. Wright TL. Etiology of fulminant hepatic failure: is another virus involved? Gastroenterology. 1993;104:640–3.

    CAS  PubMed  Google Scholar 

  7. Farci P, Alter HJ, Shimoda A, Govindarajan S, Cheung LC, Melpolder JC, Sacher RA, Shih JW, Purcell RH. Hepatitis C virus-associated fulminant hepatic failure. N Engl J Med. 1996;335:631–4.

    Article  CAS  PubMed  Google Scholar 

  8. Féray C, Gigou M, Samuel D, Reyes G, Bernuau J, Reynes M, Bismuth H, Bréchot C. Hepatitis C virus RNA and hepatitis B virus DNA in serum and liver of patients with fulminant hepatitis. Gastroenterology. 1993;104:549–55.

    PubMed  Google Scholar 

  9. Fagan EA. Acute liver failure of unknown pathogenesis: the hidden agenda. Hepatology. 1994;19:1307–12.

    Article  CAS  PubMed  Google Scholar 

  10. Shakil AO, Mazariegos GV, Kramer DJ. Fulminant hepatic failure. Surg Clin North Am. 1999;79:77–108.

    Article  CAS  PubMed  Google Scholar 

  11. Schiødt FV, Rochling FA, Casey DL, Lee WM. Acetaminophen toxicity in an urban county hospital. N Engl J Med. 1997;337:1112–7.

    Article  PubMed  Google Scholar 

  12. Bray GP, Harrison PM, O’Grady JG, Tredger JM, Williams R. Long-term anticonvulsant therapy worsens outcome in paracetamol-induced fulminant hepatic failure. Hum Exp Toxicol. 1992;11:265–70.

    Article  CAS  PubMed  Google Scholar 

  13. Ellis A, Wendon J. Circulatory, respiratory, cerebral, and renal derangements in acute liver failure: pathophysiology and management. Semin Liver Dis. 1996;16:379–88.

    Article  CAS  PubMed  Google Scholar 

  14. Norenberg MD. Astrocytic-ammonia interactions in hepatic encephalopathy. Semin Liver Dis. 1996;16:245–53.

    Article  CAS  PubMed  Google Scholar 

  15. Butterworth RF. Molecular neurobiology of acute liver failure. Semin Liver Dis. 2003;23:251–8.

    Article  CAS  PubMed  Google Scholar 

  16. Sherlock S. Hepatic encephalopathy. In: Sherlock S, editor. Diseases of liver and biliary system. Oxford: Blackwell Scientific Publication; 1985. p. 91–107.

    Google Scholar 

  17. Larsen FS. Cerebral circulation in liver failure: Ohm’s law in force. Semin Liver Dis. 1996;16:281–92.

    Article  CAS  PubMed  Google Scholar 

  18. Langfitt TW, Weinstein JD, Sklar FH, Zaren HA, Kassell NF. Contribution of intracranial blood volume to three forms of experimental brain swelling. Johns Hopkins Med J. 1968;122:261–70.

    CAS  PubMed  Google Scholar 

  19. Larsen FS, Adel Hansen B, Pott F, Ejlersen E, Secher NH, Paulson OB, Knudsen GM. Dissociated cerebral vasoparalysis in acute liver failure. A hypothesis of gradual cerebral hyperaemia. J Hepatol. 1996;25:145–51.

    Article  CAS  PubMed  Google Scholar 

  20. Aggarwal S, Obrist W, Yonas H, Kramer D, Kang Y, Scott V, Planinsic R. Cerebral hemodynamic and metabolic profiles in fulminant hepatic failure: relationship to outcome. Liver Transpl. 2005;11:1353–60.

    Article  PubMed  Google Scholar 

  21. Obrist WD, Wilkinson WE. Regional cerebral blood flow measurement in humans by xenon-133 clearance. Cerebrovasc Brain Metab Rev. 1990;2:283–327.

    CAS  PubMed  Google Scholar 

  22. Yonas H, Darby JM, Marks EC, Durham SR, Maxwell C. CBF measured by Xe-CT: approach to analysis and normal values. J Cereb Blood Flow Metab. 1991;11:716–25.

    Article  CAS  PubMed  Google Scholar 

  23. Aggarwal S, Kramer D, Yonas H, Obrist W, Kang Y, Martin M, Policare R. Cerebral hemodynamic and metabolic changes in fulminant hepatic failure: a retrospective study. Hepatology. 1994;19:80–7.

    Article  CAS  PubMed  Google Scholar 

  24. Wendon JA, Harrison PM, Keays R, Williams R. Cerebral blood flow and metabolism in fulminant liver failure. Hepatology. 1994;19:1407–13.

    Article  CAS  PubMed  Google Scholar 

  25. Vaquero J, Chung C, Blei AT. Cerebral blood flow in acute liver failure: a finding in search of a mechanism. Metab Brain Dis. 2004;19:177–94.

    Article  PubMed  Google Scholar 

  26. Ede RJ, Gove CD, Williams R. Increased cerebral blood flow in fulminant hepatic failure due to paracetamol overdose. In: Soeters PB, Wilson JHP, Meijer AJ, Holmes E, editors. Advances in ammonia metabolism and hepatic encephalopathy. Amsterdam: Elsevier; 1988. p. 567–70.

    Google Scholar 

  27. Jakobsen M, Enevoldsen E. Retrograde catheterization of the right internal jugular vein for serial measurements of cerebral venous oxygen content. J Cereb Blood Flow Metab. 1989;9:717–20.

    Article  CAS  PubMed  Google Scholar 

  28. Lassen NA, Lane MH. Validity of internal jugular blood for study of cerebral blood flow and metabolism. J Appl Physiol. 1961;16:313–20.

    CAS  PubMed  Google Scholar 

  29. Obrist WD, Langfitt TW, Jaggi JL, Cruz J, Gennarelli TA. Cerebral blood flow and metabolism in comatose patients with acute head injury. Relationship to intracranial hypertension. J Neurosurg. 1984;61:241–53.

    Article  CAS  PubMed  Google Scholar 

  30. Durham S, Yonas H, Aggarwal S, Darby J, Kramer D. Regional cerebral blood flow and CO2 reactivity in fulminant hepatic failure. J Cereb Blood Flow Metab. 1995;15:329–35.

    Article  CAS  PubMed  Google Scholar 

  31. Lidofsky SD, Bass NM, Prager MC, Washington DE, Read AE, Wright TL, Ascher NL, Roberts JP, Scharschmidt BF, Lake JR. Intracranial pressure monitoring and liver transplantation for fulminant hepatic failure. Hepatology. 1992;16:1–7.

    Article  CAS  PubMed  Google Scholar 

  32. Kang YG, Martin DJ, Marquez J, Lewis JH, Bontempo FA, Shaw Jr BW, Starzl TE, Winter PM. Intraoperative changes in blood coagulation and thrombelastographic monitoring in liver transplantation. Anesth Analg. 1985;64:888–96.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Mallett SV, Cox DJ. Thrombelastography. Br J Anaesth. 1992;69:307–13.

    Article  CAS  PubMed  Google Scholar 

  34. Blei AT, Olafsson S, Webster S, Levy R. Complications of intracranial pressure monitoring in fulminant hepatic failure. Lancet. 1993;341:157–8.

    Article  CAS  PubMed  Google Scholar 

  35. Vaquero J, Fontana RJ, Larson AM, Bass NM, Davern TJ, Shakil AO, Han S, Harrison ME, Stravitz TR, Muñoz S, Brown R, Lee WM, Blei AT. Complications and use of intracranial pressure monitoring in patients with acute liver failure and severe encephalopathy. Liver Transpl. 2005;11:1581–9.

    Article  PubMed  Google Scholar 

  36. Detry O, De Roover A, Honore P, Meurisse M. Brain edema and intracranial hypertension in fulminant hepatic failure: pathophysiology and management. World J Gastroenterol. 2006;12:7405–12.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Trewby PN, Hanid MA, Mackenzie RL, Mellon PJ, Williams R. Effects of cerebral oedema and arterial hypotension on cerebral blood flow in an animal model of hepatic failure. Gut. 1978;19:999–1005.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Davies MH, Mutimer D, Lowes J, Elias E, Neuberger J. Recovery despite impaired cerebral perfusion in fulminant hepatic failure. Lancet. 1994;343:1329–30.

    Article  CAS  PubMed  Google Scholar 

  39. Ede RJ, Williams RW. Hepatic encephalopathy and cerebral edema. Semin Liver Dis. 1986;6:107–18.

    Article  CAS  PubMed  Google Scholar 

  40. Ware AJ, D’Agostino AN, Combes B. Cerebral edema: a major complication of massive hepatic necrosis. Gastroenterology. 1971;61:877–84.

    CAS  PubMed  Google Scholar 

  41. Toutant SM, Klauber MR, Marshall LF, Toole BM, Bowers SA, Seelig JM, Varnell JB. Absent or compressed basal cisterns on first CT scan: ominous predictors of outcome in severe head injury. J Neurosurg. 1984;61:691–4.

    Article  CAS  PubMed  Google Scholar 

  42. Saver JL, Feldmann E. Basic transcranial doppler examination: technique and anatomy. In: Babikian VL, Wechsler LR, editors. Transcranial Doppler ultrasonography. St. Louis: Mosby Publication; 1993. p. 11–28.

    Google Scholar 

  43. DeWitt LD, Rosengart A, Teal PA. Transcranial Doppler ultrasonography: normal values. In: Babikian VL, Wechsler LR, editors. Transcranial Doppler ultrasonography. St. Louis: Mosby Publication; 1993. p. 29–38.

    Google Scholar 

  44. Abdo A, López O, Fernández A, Santos J, Castillo J, Castellanos R, González L, Gómez F, Limonta D. Transcranial Doppler sonography in fulminant hepatic failure. Transplant Proc. 2003;35:1859–60.

    Article  CAS  PubMed  Google Scholar 

  45. Aggarwal S, Kang Y, DeWolf A, Scott V, Martin M, Policare R. Transcranial Doppler: monitoring of cerebral blood flow velocity during liver transplantation. Transplant Proc. 1993;25:1799–800.

    CAS  PubMed  Google Scholar 

  46. Krishnamoorthy V, Beckmann K, Mueller M, Sharma D, Vavilala MS. Perioperative estimation of the intracranial pressure using the optic nerve sheath diameter during liver transplantation. Liver Transpl. 2013;19:246–9.

    Article  PubMed  Google Scholar 

  47. Aggarwal S, Brooks DM, Kang Y, Linden PK, Patzer II JF. Noninvasive monitoring of cerebral perfusion pressure in patients with acute liver failure using transcranial doppler ultrasonography. Liver Transpl. 2008;14:1048–57.

    Article  PubMed  Google Scholar 

  48. Larsen FS, Hansen BA, Ejlersen E, Secher NH, Clemmesen JO, Tygstrup N, Knudsen GM. Cerebral blood flow, oxygen metabolism and transcranial Doppler sonography during high-volume plasmapheresis in fulminant hepatic failure. Eur J Gastroenterol Hepatol. 1996;8:261–5.

    Article  CAS  PubMed  Google Scholar 

  49. Helmke K, Burdelski M, Hansen HC. Detection and monitoring of intracranial pressure dysregulation in liver failure by ultrasound. Transplantation. 2000;70:392–5.

    Article  CAS  PubMed  Google Scholar 

  50. Larsen FS, Knudsen GM, Hansen BA. Pathophysiological changes in cerebral circulation, oxidative metabolism and blood-brain barrier in patients with acute liver failure. Tailored cerebral oxygen utilization. J Hepatol. 1997;27:231–8.

    Article  CAS  PubMed  Google Scholar 

  51. Trewby PN, Warren R, Contini S, Crosbie WA, Wilkinson SP, Laws JW, Williams R. Incidence and pathophysiology of pulmonary edema in fulminant hepatic failure. Gastroenterology. 1978;74(5 Pt 1):859–65.

    CAS  PubMed  Google Scholar 

  52. Rosenbloom AJ. Massive ST-segment elevation without myocardial injury in a patient with fulminant hepatic failure and cerebral edema. Chest. 1991;100:870–2.

    Article  CAS  PubMed  Google Scholar 

  53. Weston MJ, Talbot IC, Horoworth PJ, Mant AK, Capildeo R, Williams R. Frequency of arrhythmias and other cardiac abnormalities in fulminant hepatic failure. Br Heart J. 1976;38:1179–88.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  54. Bihari D, Gimson AE, Waterson M, Williams R. Tissue hypoxia during fulminant hepatic failure. Crit Care Med. 1985;13:1034–9.

    Article  CAS  PubMed  Google Scholar 

  55. Bihari DJ, Gimson AE, Williams R. Cardiovascular, pulmonary and renal complications of fulminant hepatic failure. Semin Liver Dis. 1986;6:119–28.

    Article  CAS  PubMed  Google Scholar 

  56. Baudouin SV, Howdle P, O’Grady JG, Webster NR. Acute lung injury in fulminant hepatic failure following paracetamol poisoning. Thorax. 1995;50:399–402.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  57. Ring-Larsen H, Palazzo U. Renal failure in fulminant hepatic failure and terminal cirrhosis: a comparison between incidence, types, and prognosis. Gut. 1981;22:585–91.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  58. Wilkinson SP, Blendis LM, Williams R. Frequency and type of renal and electrolyte disorders in fulminant hepatic failure. Br Med J. 1974;1:186–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  59. Samson R, Trey C, Timme A, Saunders S. Fulminating hepatitis with recurrent hypoglycemia and hemorrhage. Gastroenterology. 1967;53:291–300.

    Google Scholar 

  60. Vilstrup H, Iversen J, Tygstrup N. Glucoregulation in acute liver failure. Eur J Clin Invest. 1986;16:193–7.

    Article  CAS  PubMed  Google Scholar 

  61. Polson J, Lee WM. American Association for the Study of Liver Disease. AASLD position paper: the management of acute liver failure. Hepatology. 2005;41:1179–97.

    Article  PubMed  Google Scholar 

  62. Scotto J, Opolon P, Etévé J, Vergoz D, Thomas M, Caroli J. Liver biopsy and prognosis in acute liver failure. Gut. 1973;14:927–33.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  63. Donaldson BW, Gopinath R, Wanless IR, Phillips MJ, Cameron R, Roberts EA, Greig PD, Levy G, Blendis LM. The role of transjugular liver biopsy in fulminant liver failure: relation to other prognostic indicators. Hepatology. 1993;18:1370–6.

    Article  CAS  PubMed  Google Scholar 

  64. Gazzard BG, Portmann B, Murray-Lyon IM, Williams R. Causes of death in fulminant hepatic failure and relationship to quantitative histological assessment of parenchymal damage. Q J Med. 1975;44:615–26.

    CAS  PubMed  Google Scholar 

  65. Hanau C, Munoz SJ, Rubin R. Histopathological heterogeneity in fulminant hepatic failure. Hepatology. 1995;21:345–51.

    CAS  PubMed  Google Scholar 

  66. Pereira LM, Langley PG, Hayllar KM, Tredger JM, Williams R. Coagulation factor V and VIII/V ratio as predictors of outcome in paracetamol induced fulminant hepatic failure: relation to other prognostic indicators. Gut. 1992;33:98–102.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  67. Mitchell I, Bihari D, Chang R, Wendon J, Williams R. Earlier identification of patients at risk from acetaminophen-induced acute liver failure. Crit Care Med. 1998;26:279–84.

    Article  CAS  PubMed  Google Scholar 

  68. O’Grady JG, Hambley H, Williams R. Prothrombin time in fulminant hepatic failure [letter]. Gastroenterology. 1991;100:1480–1.

    Article  Google Scholar 

  69. Ng I, Lim J, Wong HB. Effects of head posture on cerebral hemodynamics: its influences on intracranial pressure, cerebral perfusion pressure, and cerebral oxygenation. Neurosurgery. 2004;54:593–7.

    Article  PubMed  Google Scholar 

  70. Davenport A, Will EJ, Davison AM. Effect of posture on intracranial pressure and cerebral perfusion pressure in patients with fulminant hepatic and renal failure after acetaminophen self-poisoning. Crit Care Med. 1990;18:286–9.

    Article  CAS  PubMed  Google Scholar 

  71. Axelrod YK, Diringer MN. Temperature management in acute neurologic disorders. Crit Care Clin. 2006;22:767–85.

    Article  PubMed  Google Scholar 

  72. Jalan R, Olde Damink SW, Deutz NE, Hayes PC, Lee A. Moderate hypothermia in patients with acute liver failure and uncontrolled intracranial hypertension. Gastroenterology. 2004;127:1338–46.

    Article  CAS  PubMed  Google Scholar 

  73. Ede RJ, Gimson AE, Bihari D, Williams R. Controlled hyperventilation in the prevention of cerebral oedema in fulminant hepatic failure. J Hepatol. 1986;2:43–51.

    Article  CAS  PubMed  Google Scholar 

  74. Bingaman WE, Frank JI. Malignant cerebral edema and intracranial hypertension. Neurol Clin. 1995;13:479–509.

    CAS  PubMed  Google Scholar 

  75. Strauss G, Hansen BA, Knudsen GM, Larsen FS. Hyperventilation restores cerebral blood flow autoregulation in patients with acute liver failure. J Hepatol. 1998;28:199–203.

    Article  CAS  PubMed  Google Scholar 

  76. Forbes A, Alexander GJ, O’Grady JG, Keays R, Gullan R, Dawling S, Williams R. Thiopental infusion in the treatment of intracranial hypertension complicating fulminant hepatic failure. Hepatology. 1989;10:306–10.

    Article  CAS  PubMed  Google Scholar 

  77. Schubert A. Side effects of mild hypothermia. J Neurosurg Anesthesiol. 1995;7:139–47.

    Article  CAS  PubMed  Google Scholar 

  78. Córdoba J, Crespin J, Gottstein J, Blei AT. Mild hypothermia modifies ammonia-induced brain edema in rats after portacaval anastomosis. Gastroenterology. 1999;116:686–93.

    Article  PubMed  Google Scholar 

  79. Rose C, Michalak A, Pannunzio M, Chatauret N, Rambaldi A, Butterworth RF. Mild hypothermia delays the onset of coma and prevents brain edema and extracellular brain glutamate accumulation in rats with acute liver failure. Hepatology. 2000;31:872–7.

    Article  CAS  PubMed  Google Scholar 

  80. Jalan R. Intracranial hypertension in acute liver failure: pathophysiological basis of rational management. Semin Liver Dis. 2003;23:271–82.

    Article  PubMed  Google Scholar 

  81. Blei AT. The pathophysiology of brain edema in acute liver failure. Neurochem Int. 2005;47:71–7.

    Article  CAS  PubMed  Google Scholar 

  82. Jalan R, Williams R. The inflammatory basis of intracranial hypertension in acute liver failure. J Hepatol. 2001;34:940–2.

    Article  CAS  PubMed  Google Scholar 

  83. Jalan R, Pollok A, Shah SH, Madhavan K, Simpson KJ. Liver derived pro-inflammatory cytokines may be important in producing intracranial hypertension in acute liver failure. J Hepatol. 2002;37:536–8.

    Article  CAS  PubMed  Google Scholar 

  84. Munoz SJ, Moritz MJ, Martin P, Westerberg S, Northrup B, Bell R, Yang S, Radomski J. Relationship between cerebral perfusion pressure and systemic hemodynamics in fulminant hepatic failure. Transplant Proc. 1993;25:1776–8.

    CAS  PubMed  Google Scholar 

  85. De Backer D, Creteur J, Silva E, Vincent JL. Effects of dopamine, norepinephrine, and epinephrine on the splanchnic circulation in septic shock: which is best? Crit Care Med. 2003;31:1659–67.

    Article  PubMed  CAS  Google Scholar 

  86. Wendon JA, Harrison PM, Keays R, Gimson AE, Alexander GJ, Williams R. Effects of vasopressor agents and epoprostenol on systemic hemodynamics and oxygen transport in fulminant hepatic failure. Hepatology. 1992;15:1067–71.

    Article  CAS  PubMed  Google Scholar 

  87. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. N Engl J Med. 2000;342:1301–8.

    Google Scholar 

  88. Fan E, Needham DM, Stewart TE. Ventilatory management of acute lung injury and acute respiratory distress syndrome. JAMA. 2005;294:2889–96.

    Article  CAS  PubMed  Google Scholar 

  89. Bernal W, Auzinger G, Sizer E, Wendon J. Intensive care management of acute liver failure. Semin Liver Dis. 2008;28:188–200.

    Article  PubMed  Google Scholar 

  90. Mehta RL. Indications for dialysis in the ICU: renal replacement vs. renal support. Blood Purif. 2001;19:227–32.

    Article  CAS  PubMed  Google Scholar 

  91. Davenport A, Will EJ, Davison AM. Early changes in intracranial pressure during haemofiltration treatment in patients with grade 4 hepatic encephalopathy and acute oliguric renal failure. Nephrol Dial Transplant. 1990;5:192–8.

    Article  CAS  PubMed  Google Scholar 

  92. Mehta RL. Continuous renal replacement therapy in the critically ill patient. Kidney Int. 2005;67:781–95.

    Article  PubMed  Google Scholar 

  93. Van den Berghe G, Wilmer A, Hermans G, Meersseman W, Wouters PJ, Milants I, Van Wijngaerden E, Bobbaers H, Bouillon R. Intensive insulin therapy in the medical ICU. N Engl J Med. 2006;354:449–61.

    Article  PubMed  Google Scholar 

  94. Schütz T, Bechstein WO, Neuhaus P, Lochs H, Plauth M. Clinical practice of nutrition in acute liver failure—a European survey. Clin Nutr. 2004;23:975–82.

    Article  PubMed  Google Scholar 

  95. Shami VM, Caldwell SH, Hespenheide EE, Arseneau KO, Bickston SJ, Macik BG. Recombinant activated factor VII for coagulopathy in fulminant hepatic failure compared with conventional therapy. Liver Transpl. 2003;9:138–43.

    Article  PubMed  Google Scholar 

  96. Rolando N, Philpott-Howard J, Williams R. Bacterial and fungal infection in acute liver failure. Semin Liver Dis. 1996;16:389–402.

    Article  CAS  PubMed  Google Scholar 

  97. Fisher NC, Cooper MA, Hastings JG, Mutimer DJ. Fungal colonisation and fluconazole therapy in acute liver disease. Liver. 1998;18:320–5.

    Article  CAS  PubMed  Google Scholar 

  98. O’Grady JG, Alexander GJ, Hayllar KM, Williams R. Early indicators of prognosis in fulminant hepatic failure. Gastroenterology. 1989;97:439–45.

    Article  PubMed  Google Scholar 

  99. Schiodt FV, Atillasoy E, Shakil AO, Schiff ER, Caldwell C, Kowdley KV, Stribling R, Crippin JS, Flamm S, Somberg KA, Rosen H, McCashland TM, Hay JE, Lee WM. Etiology and outcome for 295 patients with acute liver failure in the United States. Liver Transpl Surg. 1999;5:29–34.

    Article  CAS  PubMed  Google Scholar 

  100. Anand AC, Nightingale P, Neuberger JM. Early indicators of prognosis in fulminant hepatic failure: an assessment of the King’s criteria. J Hepatol. 1997;26:62–8.

    Article  CAS  PubMed  Google Scholar 

  101. Pauwels A, Mostefa-Kara N, Florent C, Lévy VG. Emergency liver transplantation for acute liver failure. Evaluation of London and Clichy criteria. J Hepatol. 1993;17:124–7.

    Article  CAS  PubMed  Google Scholar 

  102. Sekiyama K, Yoshiba M, Inoue K, Sugata F. Prognostic value of hepatic volumetry in fulminant hepatic failure. Dig Dis Sci. 1994;39:240–4.

    Article  CAS  PubMed  Google Scholar 

  103. Christensen E, Bremmelgaard A, Bahnsen M, Andreasen PB, Tygstrup N. Prediction of fatality in fulminant hepatic failure. Scand J Gastroenterol. 1984;19:90–6.

    CAS  PubMed  Google Scholar 

  104. Ranek L, Andreasen PB, Tygstrup N. Galactose elimination capacity as a prognostic index in patients with fulminant liver failure. Gut. 1976;17:959–64.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  105. Scaiola A, MacMathuna P, Langley PG, Gove CD, Hughes RD, Williams R. Determination of the ketone body ratio in fulminant hepatic failure. Hepatogastroenterology. 1990;37:413–6.

    CAS  PubMed  Google Scholar 

  106. Lake JR, Sussman NL. Determining prognosis in patients with fulminant hepatic failure: when you absolutely, positively have to know the answer. Hepatology. 1995;21:879–82.

    Article  CAS  PubMed  Google Scholar 

  107. Belghiti J, Noun R, Sauvanet A. Temporary portocaval anastomosis with preservation of caval flow during orthotopic liver transplantation. Am J Surg. 1995;169:277–9.

    Article  CAS  PubMed  Google Scholar 

  108. Devlin J, Wendon J, Heaton N, Tan KC, Williams R. Pretransplantation clinical status and outcome of emergency transplantation for acute liver failure. Hepatology. 1995;21:1018–24.

    Article  CAS  PubMed  Google Scholar 

  109. Lee SG, Ahn CS, Kim KH. Which types of graft to use in patients with acute liver failure? (A) Auxiliary liver transplant (B) Living donor liver transplantation (C) The whole liver. (B) I prefer living donor liver transplantation. J Hepatol. 2007;46:574–8.

    Article  CAS  PubMed  Google Scholar 

  110. Hughes RD, Mitry RR, Dhawan A. Current status of hepatocyte transplantation. Transplantation. 2012;93:342–7.

    Article  CAS  PubMed  Google Scholar 

  111. Hara H, Gridelli B, Lin YJ, Marcos A, Cooper DK. Liver xenografts for the treatment of acute liver failure: clinical and experimental experience and remaining immunologic barriers. Liver Transpl. 2008;14:425–34.

    Article  PubMed  Google Scholar 

  112. Rademacher S, Oppert M, Jörres A. Artificial extracorporeal liver support therapy in patients with severe liver failure. Expert Rev Gastroenterol Hepatol. 2011;5:591–9.

    Article  PubMed  Google Scholar 

  113. Squires Jr RH. Acute liver failure in children. Semin Liver Dis. 2008;28:153–66.

    Article  CAS  PubMed  Google Scholar 

  114. Jin YJ, Lim YS, Han S, Lee HC, Hwang S, Lee SG. Predicting survival after living and deceased donor liver transplantation in adult patients with acute liver failure. J Gastroenterol. 2012;47:1115–24.

    Article  PubMed  Google Scholar 

  115. Taniguchi M. Liver transplantation in the MELD era—analysis of the OPTN/UNOS registry. Clin Transpl. 2012;41–65.

    Google Scholar 

  116. Bucuvalas J, Filipovich L, Yazigi N, Narkewicz MR, Ng V, Belle SH, Zhang S, Squires RH. Immunophenotype predicts outcome in pediatric acute liver failure. J Pediatr Gastroenterol Nutr. 2013;56:311–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  117. Mazariegos GV, Kramer DJ, Lopez RC, Shakil AO, Rosenbloom AJ, DeVera M, Giraldo M, Grogan TA, Zhu Y, Fulmer ML, Amiot BP, Patzer JF. Safety observations in phase I clinical evaluation of the Excorp Medical Bioartificial Liver Support System after the first four patients. ASAIO J. 2001;47:471–5.

    Article  CAS  PubMed  Google Scholar 

  118. Patzer II JF, Lopez RC, Zhu Y, Wang ZF, Mazariegos GV, Fung JJ. Bioartificial liver assist devices in support of patients with liver failure. Hepatobiliary Pancreat Dis Int. 2002;1:18–25.

    CAS  Google Scholar 

  119. Hughes R, Ton HY, Langley P, Davies M, Hanid MA, Mellon P, Silk DB, Williams R. Albumin-coated Amberlite XAD-7 resin for hemoperfusion in acute liver failure. Part II: In vivo evaluation. Artif Organs. 1979;3:23–6.

    Article  CAS  PubMed  Google Scholar 

  120. Yoshiba M, Inoue K, Sekiyama K, Koh I. Favorable effect of new artificial liver support on survival of patients with fulminant hepatic failure. Artif Organs. 1996;20:1169–72.

    Article  CAS  PubMed  Google Scholar 

  121. Clemmesen JO, Larsen FS, Ejlersen E, Schiødt FV, Ott P, Hansen BA. Haemodynamic changes after high-volume plasmapheresis in patients with chronic and acute liver failure. Eur J Gastroenterol Hepatol. 1997;9:55–60.

    Article  CAS  PubMed  Google Scholar 

  122. Mitzner SR. Extracorporeal liver support-albumin dialysis with the Molecular Adsorbent Recirculating System (MARS). Ann Hepatol. 2011;10 Suppl 1:S21–8.

    PubMed  Google Scholar 

  123. Mitzner SR, Stange J, Peszynski P, Klammt S. Extracorporeal support of the failing liver. Curr Opin Crit Care. 2002;8:171–7.

    Article  PubMed  Google Scholar 

  124. Patzer II JF. Advances in bioartificial liver assist devices. Ann N Y Acad Sci. 2001;944:320–33.

    Article  PubMed  Google Scholar 

  125. Sussman NL, Gislason GT, Conlin CA, Kelly JH. The Hepatix extracorporeal liver assist device: initial clinical experience. Artif Organs. 1994;18:390–6.

    Article  CAS  PubMed  Google Scholar 

  126. Demetriou AA, Brown Jr RS, Busuttil RW, Fair J, McGuire BM, Rosenthal P, Am Esch II JS, Lerut J, Nyberg SL, Salizzoni M, Fagan EA, de Hemptinne B, Broelsch CE, Muraca M, Salmeron JM, Rabkin JM, Metselaar HJ, Pratt D, De La Mata M, McChesney LP, Everson GT, Lavin PT, Stevens AC, Pitkin Z, Solomon BA. Prospective, randomized, multicenter, controlled trial of a bioartificial liver in treating acute liver failure. Ann Surg. 2004;239:660–7. discussion 667–70.

    Article  PubMed  PubMed Central  Google Scholar 

  127. Sussman NL, Chong MG, Koussayer T, He DE, Shang TA, Whisennand HH, Kelly JH. Reversal of fulminant hepatic failure using an extracorporeal liver assist device. Hepatology. 1992;16:60–5.

    Article  CAS  PubMed  Google Scholar 

  128. Sussman NL, Kelly JH. Improved liver function following treatment with an extracorporeal liver assist device. Artif Organs. 1993;17:27–30.

    Article  CAS  PubMed  Google Scholar 

  129. Sussman NL, Gislason GT, Kelly JH. Extracorporeal liver support. Application to fulminant hepatic failure. J Clin Gastroenterol. 1994;18:320–4.

    Article  CAS  PubMed  Google Scholar 

  130. Millis JM, Cronin DC, Johnson R, Conjeevaram H, Conlin C, Trevino S, Maguire P. Initial experience with the modified extracorporeal liver-assist device for patients with fulminant hepatic failure: system modifications and clinical impact. Transplantation. 2002;74:1735–46.

    Article  PubMed  Google Scholar 

  131. Mazariegos GV, Patzer II JF, Lopez RC, Giraldo M, Devera ME, Grogan TA, Zhu Y, Fulmer ML, Amiot BP, Kramer DJ. First clinical use of a novel bioartificial liver support system (BLSS). Am J Transplant. 2002;2:260–6.

    Article  PubMed  Google Scholar 

  132. Strom SC, Fisher RA, Thompson MT, Sanyal AJ, Cole PE, Ham JM, Posner MP. Hepatocyte transplantation as a bridge to orthotopic liver transplantation in terminal liver failure. Transplantation. 1997;63:559–69.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Anesthesiology, University of Pittsburgh Medical Center, C Wing 200 Lothrop Street, Pittsburgh, PA, 15213, USA

    Shushma Aggarwal M.D.

  2. Department of Transplant Surgery, Children’s Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA

    George V. Mazariegos M.D.

  3. Department of General Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA

    Deanna Blisard M.D.

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  1. Shushma Aggarwal M.D.
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  2. George V. Mazariegos M.D.
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  3. Deanna Blisard M.D.
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Correspondence to Shushma Aggarwal M.D. .

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Editors and Affiliations

  1. Department of Anesthesiology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

    Kathirvel Subramaniam

  2. Department of Anesthesiology The Clinical and Translational Science Institute The McGowan Institute for Regenerative Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

    Tetsuro Sakai

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Aggarwal, S., Mazariegos, G.V., Blisard, D. (2017). Acute Liver Failure: Perioperative Management. In: Subramaniam, K., Sakai, T. (eds) Anesthesia and Perioperative Care for Organ Transplantation. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-6377-5_32

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