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Prevention of Perioperative Infections in Organ Transplant Recipients

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Abstract

Solid organ transplant has become a therapeutic option for selected end-stage organ diseases. Advances in surgical techniques and immunosuppression and administration of effective antimicrobial prophylaxis against opportunistic pathogens have significantly improved survival among organ transplant recipients. Nevertheless, infections during the peritransplant period remain a major cause of morbidity and mortality. In the early posttransplant period, organ recipients are vulnerable to nosocomial-acquired infections, donor-transmitted infections, and, most importantly, surgical site infections. These infections are largely preventable. Understanding the epidemiology, risk factors, and microbiology of early-onset posttransplant infections, and surgical techniques and complications are essential for clinicians in caring for solid organ transplant recipients.

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References

  1. Fishman JA. Infection in solid-organ transplant recipients. N Engl J Med. 2007;357:2601–14.

    Article  CAS  PubMed  Google Scholar 

  2. Owens CD, Stoessel K. Surgical site infections: epidemiology, microbiology and prevention. J Hosp Infect. 2008;70 Suppl 2:3–10.

    Article  PubMed  Google Scholar 

  3. Humar A, Matas AJ. Surgical complications after kidney transplantation. Semin Dial. 2005;18:505–10.

    Article  PubMed  Google Scholar 

  4. Albano L, Bretagne S, Mamzer-Bruneel MF, et al. Evidence that graft-site candidiasis after kidney transplantation is acquired during organ recovery: a multicenter study in France. Clin Infect Dis. 2009;48:194–202.

    Article  PubMed  Google Scholar 

  5. Laouad I, Buchler M, Noel C, et al. Renal artery aneurysm secondary to Candida albicans in four kidney allograft recipients. Transplant Proc. 2005;37:2834–6.

    Article  CAS  PubMed  Google Scholar 

  6. Potti A, Danielson B, Sen K. “True” mycotic aneurysm of a renal artery allograft. Am J Kidney Dis. 1998;31:E3.

    Article  CAS  PubMed  Google Scholar 

  7. Parasuraman R, Julian K, AST Infectious Diseases Community of Practice. Urinary tract infections in solid organ transplantation. Am J Transplant. 2013;13 Suppl 4:327–36.

    Article  CAS  PubMed  Google Scholar 

  8. Abbott KC, Oliver III JD, Hypolite I, et al. Hospitalizations for bacterial septicemia after renal transplantation in the United States. Am J Nephrol. 2001;21:120–7.

    Article  CAS  PubMed  Google Scholar 

  9. Abbott KC, Swanson SJ, Richter ER, et al. Late urinary tract infection after renal transplantation in the United States. Am J Kidney Dis. 2004;44:353–62.

    Article  PubMed  Google Scholar 

  10. Chuang P, Parikh CR, Langone A. Urinary tract infections after renal transplantation: a retrospective review at two US transplant centers. Clin Transplant. 2005;19:230–5.

    Article  PubMed  Google Scholar 

  11. Fujita S, Watanabe J, Reed AI, et al. Case of emphysematous pyelonephritis in a renal allograft. Clin Transplant. 2005;19: 559–62.

    Article  PubMed  Google Scholar 

  12. Saemann M, Horl WH. Urinary tract infection in renal transplant recipients. Eur J Clin Invest. 2008;38 Suppl 2:58–65.

    Article  PubMed  Google Scholar 

  13. de Souza RM, Olsburgh J. Urinary tract infection in the renal transplant patient. Nat Clin Pract Nephrol. 2008;4:252–64.

    Article  PubMed  Google Scholar 

  14. Schmaldienst S, Dittrich E, Horl WH. Urinary tract infections after renal transplantation. Curr Opin Urol. 2002;12:125–30.

    Article  PubMed  Google Scholar 

  15. Chuang YW, Chen CH, Cheng CH, et al. Severe emphysematous pyelonephritis in a renal allograft: successful treatment with percutaneous drainage and antibiotics. Clin Nephrol. 2007;68:42–6.

    Article  CAS  PubMed  Google Scholar 

  16. Rafat C, Vimont S, Ancel PY, et al. Ofloxacin: new applications for the prevention of urinary tract infections in renal graft recipients. Transpl Infect Dis. 2011;13:344–52.

    Article  CAS  PubMed  Google Scholar 

  17. Kawecki D, Kwiatkowski A, Michalak G, et al. Urinary tract infections in the early posttransplant period after simultaneous pancreas-kidney transplantation. Transplant Proc. 2009;41: 3148–50.

    Article  CAS  PubMed  Google Scholar 

  18. Fisher JF, Sobel JD, Kauffman CA, Newman CA. Candida urinary tract infections—treatment. Clin Infect Dis. 2011;52 Suppl 6:S457–66.

    Article  PubMed  Google Scholar 

  19. Franco A, Prados MC, Perdiguero M, Olivares J. Fungus ball: a cause of early obstructive uropathy in renal transplantation. Clin Nephrol. 1992;38:294.

    CAS  PubMed  Google Scholar 

  20. Bratzler DW, Dellinger EP, Olsen KM, et al. Clinical practice guidelines for antimicrobial prophylaxis in surgery. Surg Infect (Larchmt). 2013;14:73–156.

    Article  Google Scholar 

  21. Eckhoff DE, Sollinger HW. Surgical complications after simultaneous pancreas-kidney transplant with bladder drainage. Clin Transpl. 1993;185–91.

    Google Scholar 

  22. Humar AAH. Risks and epidemiology of infections after pancreas or kidney-pancreas transplantation. 3rd ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2010.

    Google Scholar 

  23. Humar A, Kandaswamy R, Granger D, Gruessner RW, Gruessner AC, Sutherland DE. Decreased surgical risks of pancreas transplantation in the modern era. Ann Surg. 2000;231:269–75.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Humar A, Ramcharan T, Kandaswamy R, Gruessner RW, Gruessner AG, Sutherland DE. The impact of donor obesity on outcomes after cadaver pancreas transplants. Am J Transplant. 2004;4:605–10.

    Article  PubMed  Google Scholar 

  25. Humar A, Ramcharan T, Kandaswamy R, et al. Pancreas after kidney transplants. Am J Surg. 2001;182:155–61.

    Article  CAS  PubMed  Google Scholar 

  26. Benedetti E, Gruessner AC, Troppmann C, et al. Intra-abdominal fungal infections after pancreatic transplantation: incidence, treatment, and outcome. J Am Coll Surg. 1996;183:307–16.

    CAS  PubMed  Google Scholar 

  27. Kawecki D, Kwiatkowski A, Michalak G, et al. Surgical site infections in the early posttransplant period after simultaneous pancreas-kidney transplantation. Transplant Proc. 2009;41:3143–7.

    Article  CAS  PubMed  Google Scholar 

  28. Verni MP, Leone JP, DeRoover A. Pseudoaneurysm of the Y-graft/iliac artery anastomosis following pancreas transplantation: a case report and review of the literature. Clin Transplant. 2001;15:72–6.

    Article  CAS  PubMed  Google Scholar 

  29. Troppmann C. Complications after pancreas transplantation. Curr Opin Organ Transplant. 2010;15:112–8.

    Article  PubMed  Google Scholar 

  30. Troppmann C, Gruessner AC, Dunn DL, Sutherland DE, Gruessner RW. Surgical complications requiring early relaparotomy after pancreas transplantation: a multivariate risk factor and economic impact analysis of the cyclosporine era. Ann Surg. 1998;227:255–68.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Sollinger HW, Messing EM, Eckhoff DE, et al. Urological complications in 210 consecutive simultaneous pancreas-kidney transplants with bladder drainage. Ann Surg. 1993;218:561–8. discussion 8–70.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Sollinger HW, Sasaki TM, D’Alessandro AM, et al. Indications for enteric conversion after pancreas transplantation with bladder drainage. Surgery. 1992;112:842–5. discussion 5–6.

    CAS  PubMed  Google Scholar 

  33. Singh RP, Farney AC, Rogers J, et al. Analysis of bacteremia after pancreatic transplantation with enteric drainage. Transplant Proc. 2008;40:506–9.

    Article  CAS  PubMed  Google Scholar 

  34. Barone GW, Hudec WA, Sailors DM, Ketel BL. Prophylactic wound antibiotics for combined kidney and pancreas transplants. Clin Transplant. 1996;10:386–8.

    CAS  PubMed  Google Scholar 

  35. Pfundstein J, Roghmann MC, Schwalbe RS, et al. A randomized trial of surgical antimicrobial prophylaxis with and without vancomycin in organ transplant patients. Clin Transplant. 1999;13:245–52.

    Article  CAS  PubMed  Google Scholar 

  36. George DL, Arnow PM, Fox AS, et al. Bacterial infection as a complication of liver transplantation: epidemiology and risk factors. Rev Infect Dis. 1991;13:387–96.

    Article  CAS  PubMed  Google Scholar 

  37. Hadley S, Samore MH, Lewis WD, Jenkins RL, Karchmer AW, Hammer SM. Major infectious complications after orthotopic liver transplantation and comparison of outcomes in patients receiving cyclosporine or FK506 as primary immunosuppression. Transplantation. 1995;59:851–9.

    Article  CAS  PubMed  Google Scholar 

  38. Kusne S, Dummer JS, Singh N, et al. Infections after liver transplantation. An analysis of 101 consecutive cases. Medicine (Baltimore). 1988;67:132–43.

    Article  CAS  Google Scholar 

  39. Hau T, Hoffman R, Simmons RL. Mechanisms of the adjuvant effect of hemoglobin in experimental peritonitis. I. In vivo inhibition of peritoneal leukocytosis. Surgery. 1978;83:223–9.

    CAS  PubMed  Google Scholar 

  40. Huprikar S. Update in infectious diseases in liver transplant recipients. Clin Liver Dis. 2007;11:337–54.

    Article  PubMed  Google Scholar 

  41. Asensio A, Ramos A, Cuervas-Mons V, et al. Effect of antibiotic prophylaxis on the risk of surgical site infection in orthotopic liver transplant. Liver Transpl. 2008;14:799–805.

    Article  PubMed  Google Scholar 

  42. Paya CV, Hermans PE, Washington II JA, et al. Incidence, distribution, and outcome of episodes of infection in 100 orthotopic liver transplantations. Mayo Clin Proc. 1989;64:555–64.

    Article  CAS  PubMed  Google Scholar 

  43. Hollenbeak CS, Alfrey EJ, Sheridan K, Burger TL, Dillon PW. Surgical site infections following pediatric liver transplantation: risks and costs. Transpl Infect Dis. 2003;5:72–8.

    Article  CAS  PubMed  Google Scholar 

  44. Reid GE, Grim SA, Sankary H, Benedetti E, Oberholzer J, Clark NM. Early intra-abdominal infections associated with orthotopic liver transplantation. Transplantation. 2009;87:1706–11.

    Article  PubMed  Google Scholar 

  45. Said A, Safdar N, Lucey MR, et al. Infected bilomas in liver transplant recipients, incidence, risk factors and implications for prevention. Am J Transplant. 2004;4:574–82.

    Article  PubMed  Google Scholar 

  46. Safdar N, Said A, Lucey MR, et al. Infected bilomas in liver transplant recipients: clinical features, optimal management, and risk factors for mortality. Clin Infect Dis. 2004;39:517–25.

    Article  PubMed  Google Scholar 

  47. Singh N, Gayowski T, Rihs JD, Wagener MM, Marino IR. Evolving trends in multiple-antibiotic-resistant bacteria in liver transplant recipients: a longitudinal study of antimicrobial susceptibility patterns. Liver Transpl. 2001;7:22–6.

    Article  CAS  PubMed  Google Scholar 

  48. Pappas PG, Silveira FP. Candida in solid organ transplant recipients. Am J Transplant. 2009;9 Suppl 4:S173–9.

    Article  PubMed  Google Scholar 

  49. Pappas PG, Alexander BD, Andes DR, et al. Invasive fungal infections among organ transplant recipients: results of the Transplant-Associated Infection Surveillance Network (TRANSNET). Clin Infect Dis. 2010;50:1101–11.

    Article  PubMed  Google Scholar 

  50. Neofytos D, Fishman JA, Horn D, et al. Epidemiology and outcome of invasive fungal infections in solid organ transplant recipients. Transpl Infect Dis. 2010;12:220–9.

    Article  CAS  PubMed  Google Scholar 

  51. Singh N, Husain S. Invasive aspergillosis in solid organ transplant recipients. Am J Transplant. 2009;9 Suppl 4:S180–91.

    Article  PubMed  Google Scholar 

  52. Ghanekar A, Grant D. Small bowel transplantation. Curr Opin Crit Care. 2001;7:133–7.

    Article  CAS  PubMed  Google Scholar 

  53. Reyes J, Abu-Elmagd K, Tzakis A, et al. Infectious complications after human small bowel transplantation. Transplant Proc. 1992;24:1249–50.

    CAS  PubMed  PubMed Central  Google Scholar 

  54. Tzakis AG, Kato T, Levi DM, et al. 100 multivisceral transplants at a single center. Ann Surg. 2005;242:480–90. discussion 91–3.

    PubMed  PubMed Central  Google Scholar 

  55. Timpone Jr JG, Girlanda R, Rudolph L, Fishbein TM. Infections in intestinal and multivisceral transplant recipients. Infect Dis Clin North Am. 2013;27:359–77.

    Article  PubMed  Google Scholar 

  56. Primeggia J, Matsumoto CS, Fishbein TM, Karacki PS, Fredette TM, Timpone JG. Infection among adult small bowel and multivisceral transplant recipients in the 30-day postoperative period. Transpl Infect Dis. 2013;15:441–8.

    CAS  PubMed  Google Scholar 

  57. Guaraldi G, Cocchi S, Codeluppi M, et al. Outcome, incidence, and timing of infectious complications in small bowel and multivisceral organ transplantation patients. Transplantation. 2005;80: 1742–8.

    Article  PubMed  Google Scholar 

  58. Loinaz C, Kato T, Nishida S, et al. Bacterial infections after intestine and multivisceral transplantation. The experience of the University of Miami (1994–2001). Hepatogastroenterology. 2006;53:234–42.

    CAS  PubMed  Google Scholar 

  59. Loinaz C, Kato T, Nishida S, et al. Bacterial infections after intestine and multivisceral transplantation. Transplant Proc. 2003;35: 1929–30.

    Article  CAS  PubMed  Google Scholar 

  60. Fishbein TM. Intestinal transplantation. N Engl J Med. 2009;361:998–1008.

    Article  CAS  PubMed  Google Scholar 

  61. Sigurdsson L, Reyes J, Kocoshis SA. Intestinal transplantation in children. Curr Gastroenterol Rep. 1999;1:259–65.

    Article  CAS  PubMed  Google Scholar 

  62. Sigurdsson L, Reyes J, Kocoshis SA, Mazariegos G, Abu-Elmagd K, Green M. Bacteremia after intestinal transplantation in children correlates temporally with rejection or gastrointestinal lymphoproliferative disease. Transplantation. 2000;70:302–5.

    Article  CAS  PubMed  Google Scholar 

  63. Akhter K, Timpone J, Matsumoto C, Fishbein T, Kaufman S, Kumar P. Six-month incidence of bloodstream infections in intestinal transplant patients. Transpl Infect Dis. 2012;14:242–7.

    Article  CAS  PubMed  Google Scholar 

  64. Florescu DF, Islam KM, Grant W, et al. Incidence and outcome of fungal infections in pediatric small bowel transplant recipients. Transpl Infect Dis. 2010;12:497–504.

    Article  CAS  PubMed  Google Scholar 

  65. Montoya JG, Giraldo LF, Efron B, et al. Infectious complications among 620 consecutive heart transplant patients at Stanford University Medical Center. Clin Infect Dis. 2001;33:629–40.

    Article  CAS  PubMed  Google Scholar 

  66. Ramos A, Asensio A, Munez E, et al. Incisional surgical infection in heart transplantation. Transpl Infect Dis. 2008;10:298–302.

    Article  CAS  PubMed  Google Scholar 

  67. Carrier M, Perrault LP, Pellerin M, et al. Sternal wound infection after heart transplantation: incidence and results with aggressive surgical treatment. Ann Thorac Surg. 2001;72:719–23. discussion 23–4.

    Article  CAS  PubMed  Google Scholar 

  68. Zuckermann A, Barten MJ. Surgical wound complications after heart transplantation. Transpl Int. 2011;24:627–36.

    Article  PubMed  Google Scholar 

  69. Chou NK, Wang JL, Chi NH, et al. Surgical treatment of mediastinitis after cardiac transplantation. Transplant Proc. 2008;40:2629–30.

    Article  CAS  PubMed  Google Scholar 

  70. Munoz P, Ceron I, Valerio M, et al. Invasive aspergillosis among heart transplant recipients: a 24-year perspective. J Heart Lung Transplant. 2014;33:278–88.

    Article  PubMed  Google Scholar 

  71. Zaoutis TE, Webber S, Naftel DC, et al. Invasive fungal infections in pediatric heart transplant recipients: incidence, risk factors, and outcomes. Pediatr Transplant. 2011;15:465–9.

    Article  PubMed  Google Scholar 

  72. Fernandez-Sabe N, Cervera C, Farinas MC, et al. Risk factors, clinical features, and outcomes of toxoplasmosis in solid-organ transplant recipients: a matched case-control study. Clin Infect Dis. 2012;54:355–61.

    Article  PubMed  Google Scholar 

  73. Fishman JA. Pneumocystis carinii and parasitic infections in transplantation. Infect Dis Clin North Am. 1995;9:1005–44.

    CAS  PubMed  Google Scholar 

  74. Derouin F, Pelloux H, ESCMID Study Group on Clinical Parasitology. Prevention of toxoplasmosis in transplant patients. Clin Microbiol Infect. 2008;14:1089–101.

    Article  CAS  PubMed  Google Scholar 

  75. Tissot F, Pascual M, Hullin R, et al. Impact of targeted antifungal prophylaxis in heart transplant recipients at high risk for early invasive fungal infection. Transplantation. 2014;97(11):1192–7.

    Article  CAS  PubMed  Google Scholar 

  76. Pelaez T, Munoz P, Guinea J, et al. Outbreak of invasive aspergillosis after major heart surgery caused by spores in the air of the intensive care unit. Clin Infect Dis. 2012;54:e24–31.

    Article  CAS  PubMed  Google Scholar 

  77. Aguilar-Guisado M, Givalda J, Ussetti P, et al. Pneumonia after lung transplantation in the RESITRA Cohort: a multicenter prospective study. Am J Transplant. 2007;7:1989–96.

    Article  CAS  PubMed  Google Scholar 

  78. Ruiz I, Gavalda J, Monforte V, et al. Donor-to-host transmission of bacterial and fungal infections in lung transplantation. Am J Transplant. 2006;6:178–82.

    Article  CAS  PubMed  Google Scholar 

  79. Minari A, Husni R, Avery RK, et al. The incidence of invasive aspergillosis among solid organ transplant recipients and implications for prophylaxis in lung transplants. Transpl Infect Dis. 2002;4:195–200.

    Article  CAS  PubMed  Google Scholar 

  80. Luong ML, Chaparro C, Stephenson A, et al. Pretransplant Aspergillus colonization of cystic fibrosis patients and the incidence of post-lung transplant invasive aspergillosis. Transplantation. 2014;97:351–7.

    Article  CAS  PubMed  Google Scholar 

  81. Schaenman JM. Is universal antifungal prophylaxis mandatory in lung transplant patients? Curr Opin Infect Dis. 2013;26:317–25.

    Article  CAS  PubMed  Google Scholar 

  82. Gordon SM, Avery RK. Aspergillosis in lung transplantation: incidence, risk factors, and prophylactic strategies. Transpl Infect Dis. 2001;3:161–7.

    Article  CAS  PubMed  Google Scholar 

  83. Kramer MR, Denning DW, Marshall SE, et al. Ulcerative tracheobronchitis after lung transplantation. A new form of invasive aspergillosis. Am Rev Respir Dis. 1991;144:552–6.

    Article  CAS  PubMed  Google Scholar 

  84. Avery RK. Prophylactic strategies before solid-organ transplantation. Curr Opin Infect Dis. 2004;17:353–6.

    Article  PubMed  Google Scholar 

  85. Helmi M, Love RB, Welter D, Cornwell RD, Meyer KC. Aspergillus infection in lung transplant recipients with cystic fibrosis: risk factors and outcomes comparison to other types of transplant recipients. Chest. 2003;123:800–8.

    Article  PubMed  Google Scholar 

  86. Nunley DR, Grgurich WF, Keenan RJ, Dauber JH. Empyema complicating successful lung transplantation. Chest. 1999;115:1312–5.

    Article  CAS  PubMed  Google Scholar 

  87. Mehrad B, Paciocco G, Martinez FJ, Ojo TC, Iannettoni MD, Lynch III JP. Spectrum of Aspergillus infection in lung transplant recipients: case series and review of the literature. Chest. 2001;119:169–75.

    Article  CAS  PubMed  Google Scholar 

  88. Horvath J, Dummer S, Loyd J, Walker B, Merrill WH, Frist WH. Infection in the transplanted and native lung after single lung transplantation. Chest. 1993;104:681–5.

    Article  CAS  PubMed  Google Scholar 

  89. Yeldandi V, Laghi F, McCabe MA, et al. Aspergillus and lung transplantation. J Heart Lung Transplant. 1995;14:883–90.

    CAS  PubMed  Google Scholar 

  90. Westney GE, Kesten S, De Hoyos A, Chapparro C, Winton T, Maurer JR. Aspergillus infection in single and double lung transplant recipients. Transplantation. 1996;61:915–9.

    Article  CAS  PubMed  Google Scholar 

  91. Bhaskaran A, Hosseini-Moghaddam SM, Rotstein C, Husain S. Mold infections in lung transplant recipients. Semin Respir Crit Care Med. 2013;34:371–9.

    Article  PubMed  Google Scholar 

  92. Shields RK, Clancy CJ, Minces LR, et al. Epidemiology and outcomes of deep surgical site infections following lung transplantation. Am J Transplant. 2013;13:2137–45.

    Article  CAS  PubMed  Google Scholar 

  93. Ferrer J, Roldan J, Roman A, et al. Acute and chronic pleural complications in lung transplantation. J Heart Lung Transplant. 2003;22:1217–25.

    Article  PubMed  Google Scholar 

  94. Herridge MS, de Hoyos AL, Chaparro C, Winton TL, Kesten S, Maurer JR. Pleural complications in lung transplant recipients. J Thorac Cardiovasc Surg. 1995;110:22–6.

    Article  CAS  PubMed  Google Scholar 

  95. Boffa DJ, Mason DP, Su JW, et al. Decortication after lung transplantation. Ann Thorac Surg. 2008;85:1039–43.

    Article  PubMed  Google Scholar 

  96. Neoh CF, Snell GI, Kotsimbos T, et al. Antifungal prophylaxis in lung transplantation—a world-wide survey. Am J Transplant. 2011;11:361–6.

    Article  CAS  PubMed  Google Scholar 

  97. Williams K, Mansh M, Chin-Hong P, Singer J, Arron ST. Voriconazole-associated cutaneous malignancy: a literature review on photocarcinogenesis in organ transplant recipients. Clin Infect Dis. 2014;58:997–1002.

    Article  PubMed  Google Scholar 

  98. Silveira FP, Kusne S, AST Infectious Diseases Community of Practice. Candida infections in solid organ transplantation. Am J Transplant. 2013;13 Suppl 4:220–7.

    Article  CAS  PubMed  Google Scholar 

  99. Singh N, Husain S, AST Infectious Diseases Community of Practice. Aspergillosis in solid organ transplantation. Am J Transplant. 2013;13 Suppl 4:228–41.

    Article  CAS  PubMed  Google Scholar 

  100. Razonable RR, Humar A, AST Infectious Diseases Community of Practice. Cytomegalovirus in solid organ transplantation. Am J Transplant. 2013;13 Suppl 4:93–106.

    Article  CAS  PubMed  Google Scholar 

  101. Wilck MB, Zuckerman RA, AST Infectious Diseases Community of Practice. Herpes simplex virus in solid organ transplantation. Am J Transplant. 2013;13 Suppl 4:121–7.

    Article  CAS  PubMed  Google Scholar 

  102. Small LN, Lau J, Snydman DR. Preventing post-organ transplantation cytomegalovirus disease with ganciclovir: a meta-analysis comparing prophylactic and preemptive therapies. Clin Infect Dis. 2006;43:869–80.

    Article  CAS  PubMed  Google Scholar 

  103. Kalil AC, Levitsky J, Lyden E, Stoner J, Freifeld AG. Meta-analysis: the efficacy of strategies to prevent organ disease by cytomegalovirus in solid organ transplant recipients. Ann Intern Med. 2005;143:870–80.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. University of Pittsburgh Medical Center, Pittsburgh, PA, USA

    Reem Almaghrabi M.D. & M. Hong Nguyen M.D.

  2. Pittsburgh VA Health Care System, Pittsburgh, PA, USA

    Cornelius J. Clancy M.D. & M. Hong Nguyen M.D.

  3. Department of Medicine, University of Pittsburgh Medical School, Scaife Hall, Suite 871, Pittsburgh, PA, USA

    Cornelius J. Clancy M.D.

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  1. Reem Almaghrabi M.D.
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  2. Cornelius J. Clancy M.D.
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  3. M. Hong Nguyen M.D.
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Correspondence to M. Hong Nguyen M.D. .

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  1. Department of Anesthesiology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

    Kathirvel Subramaniam

  2. Department of Anesthesiology The Clinical and Translational Science Institute The McGowan Institute for Regenerative Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

    Tetsuro Sakai

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Almaghrabi, R., Clancy, C.J., Nguyen, M.H. (2017). Prevention of Perioperative Infections in Organ Transplant Recipients. In: Subramaniam, K., Sakai, T. (eds) Anesthesia and Perioperative Care for Organ Transplantation. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-6377-5_2

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