Pharmaceutical Terahertz Spectroscopy and Imaging

  • J. Axel ZeitlerEmail author
Part of the Advances in Delivery Science and Technology book series (ADST)


Terahertz spectroscopy and imaging have developed rapidly over the past decade as versatile analytical tools for the characterisation of drug delivery systems. In this chapter the technology that has enabled the recent surge of interest in using terahertz techniques is explained in terms of its basic principles and the specific implementations of pharmaceutical relevance. Using a number of examples and case studies an overview of the current state-of-the-art applications of terahertz radiation in pharmaceutics is presented. In the field of spectroscopy this ranges from polymorph detection and quantification, detailed analysis of phase transitions to amorphous stability. Important imaging applications include non-destructive coating thickness measurements, characterisation of the microstructure of tablet matrices as well as liquid transport into tablets during disintegration.


Terahertz spectroscopy Terahertz imaging Polymorph detection Solid-state properties Phase transition Amorphous Crystallinity Amorphous stability Crystallisation Film coating Tablet porosity Tablet hardness Disintegration testing 


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© Controlled Release Society 2016

Authors and Affiliations

  1. 1.Department of Chemical Engineering and BiotechnologyUniversity of CambridgeCambridgeUK

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