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Particle Size Measurements in Aerosols

  • Regina ScherließEmail author
Chapter
Part of the Advances in Delivery Science and Technology book series (ADST)

Abstract

Pharmaceutical aerosols comprise a wide range of drug products which all are dispersed as droplets (wet aerosol) or particles (dry aerosol) in a gas for application. Hence, the device being used for dispersion plays a very important role as it impacts the dispersion efficiency and significantly influences the resulting aerosol particle size. For an aerosol’s therapeutic effect it is important how the particles behave in the gas they are dispersed in, i.e. how they distribute and deposit. Therefore, aerodynamic particle size is important in addition to a geometrical particle size—unlike many other formulations where only geometrical particle size is looked at. The chapter defines the differences in particle sizes and gives an overview of measurement techniques to determine aerodynamic particle size as well as other sizing techniques in use for aerosol particle sizing. Pharmacopoeial requirements are summarized and physiological implications as well as ideas to closer mimic the in vivo situation are discussed.

Keywords

Accessories to mimic in vivo situation Aerodynamic particle size Cascade impaction Geometric particle size Particle deposition mechanisms Pharmacopoeial requirements Sample dispersion 

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Copyright information

© Controlled Release Society 2016

Authors and Affiliations

  1. 1.Department of Pharmaceutics and BiopharmaceuticsKiel UniversityKielGermany

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