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Mass Spectrometry Imaging of Pharmaceuticals: From Tablets to Tissues

  • Ivan M. KempsonEmail author
  • Clive A. PrestidgeEmail author
Chapter
Part of the Advances in Delivery Science and Technology book series (ADST)

Abstract

Drug efficacy is dependent upon effective and controlled release for delivery to the target site. The properties of a drug product effecting delivery are carefully manipulated by a variety of ingredients/excipients serving various purposes. As such, there is high dependence on the optimal construction and spatial arrangement of all ingredients. The subsequent fate of the active pharmaceutical ingredient then ultimately determines therapeutic and toxic effects. Mass spectrometry imaging offers high sensitivity, specificity, high mass resolution and high mass ranges for imaging component distributions in solid forms and in biological tissues. This chapter reviews mass spectrometry imaging techniques most commonly utilised in these research areas. Examples are then provided of imaging various components in solid form products and on the exciting area of label-free imaging of pharmaceuticals and metabolites in animal tissues. A small section is also provided on micro-array imaging of biologicals. Due to the relative immaturity of the field, a special focus on future perspectives and emerging potential concludes the chapter.

Keywords

Mass spectrometry Imaging ToF-SIMS LA-ICPMS MALDI Active pharmaceutical ingredients Excipients Analysis Small molecules Biologicals 3D Metabolism 

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Copyright information

© Controlled Release Society 2016

Authors and Affiliations

  1. 1.Future Industries InstituteUniversity of South AustraliaMawson LakesAustralia
  2. 2.School of Pharmacy and Medical SciencesUniversity of South AustraliaAdelaideAustralia

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