Isothermal Microcalorimetry

  • S. GaisfordEmail author
Part of the Advances in Delivery Science and Technology book series (ADST)


Isothermal microcalorimeters (IMC) measure the heat change in a sample as it is held at a constant temperature—since nearly all processes, chemical and physical, occur with a change in heat, IMC analysis can be applied to the investigation of almost any material. The inherent sensitivity of the measurement means that small samples, or slow processes, may be investigated. This makes IMC a very powerful tool, especially in pharmaceutical analyses, since complex, heterogeneous samples can be studied directly. In this chapter, the basic principles of IMC are introduced, the most common experimental arrangements are defined and applications to pharmaceutical analyses are discussed. Applications discussed progress from preformulation characterization, through stability testing and amorphous content quantification to analyses of formulated products.


Isothermal microcalorimetry Solution calorimetry Isothermal titration calorimetry Preformulation Amorphous content 


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Copyright information

© Controlled Release Society 2016

Authors and Affiliations

  1. 1.UCL School of PharmacyUniversity College LondonLondonUK

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