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Inhaled Drug Delivery for Children on Long-term Mechanical Ventilation

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Caring for the Ventilator Dependent Child

Part of the book series: Respiratory Medicine ((RM))

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Abstract

Children requiring noninvasive and invasive chronic ventilator support are frequently prescribed therapeutic aerosols. Little guidance is available regarding the optimal ways of delivering aerosol to these children. In addition to the frequently reported factors that affect drug delivery, this population poses several challenges. The presence of humid/heated air and the passage through artificial and ventilator circuits are some of the factors that can hinder aerosol delivery. Most of the pediatric data are based on in vitro experiments and few animal studies. We will discuss the currently available data and provide suggested best practice.

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  1. College of Medicine, Arkansas Children’s Hospital, University of Arkansas for Medical Sciences, 1 Children’s Way, Slot 512-17, Little Rock, AR, 72202, USA

    Ariel Berlinski M.D.

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Correspondence to Ariel Berlinski M.D. .

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  1. Eudowood Division of Pediatric Respiratory Sciences, The Johns Hopkins University School of Medicine, BALTIMORE, Maryland, USA

    Laura M. Sterni

  2. Division of Pediatric Pulmonary and Sleep Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

    John L. Carroll

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Berlinski, A. (2016). Inhaled Drug Delivery for Children on Long-term Mechanical Ventilation. In: Sterni, L., Carroll, J. (eds) Caring for the Ventilator Dependent Child. Respiratory Medicine. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-3749-3_11

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