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Thyroid Hormone Disruption and Neurodevelopment pp 119–131Cite as

Using Mouse Genetics to Investigate Thyroid Hormone Signaling in the Developing and Adult Brain

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Part of the book series: Contemporary Clinical Neuroscience ((CCNE))

Abstract

The developing and adult brain is a main target organ of thyroid hormones (including the prohormone thyroxine and its active derivative tri-iodo-thyronine or T3). Mouse genetics offers a number of promising possibilities to study their pleiotropic influence on the central nervous system, and to distinguish it from their peripheral function. In the following, we review recent advances brought by mouse genetics in our understanding of thyroid hormone signaling in the brain, both during development and in the adult. We particularly emphasize on the latest findings about thyroid hormone transporters and synthesis pathway which bring a new view on the regulation of thyroid hormone levels sensed by brain cells. Roles of the thyroid hormone receptors, which have been reviewed elsewhere are only briefly discussed.

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Acknowledgements

We thank Beatriz Morte for critical reading of the manuscript. Work in our laboratory is supported by Agence Nationale de la Recherche (Thyrogenomic2).

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Authors and Affiliations

  1. Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, Université Lyon 1, INRA, CNRS, Ecole Normale Supérieure de Lyon, 46 allée d’Italie, 69364, Lyon Cedex 07, France

    F. Chatonnet, S. Richard & F. Flamant

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  1. F. Chatonnet
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  2. S. Richard
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  3. F. Flamant
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Correspondence to F. Flamant .

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  1. Department of Integrative Physiology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan

    Noriyuki Koibuchi

  2. Laboratory of Hormonal Regulation Cardiovascular and Metabolic Disorders Program, Duke-NUS Graduate Medical School, Singapore, Singapore

    Paul M. Yen

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Chatonnet, F., Richard, S., Flamant, F. (2016). Using Mouse Genetics to Investigate Thyroid Hormone Signaling in the Developing and Adult Brain. In: Koibuchi, N., Yen, P.M. (eds) Thyroid Hormone Disruption and Neurodevelopment. Contemporary Clinical Neuroscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-3737-0_8

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